discab research news · tardigrade. approximately one-sixth of the genes in the tardigrade genome...

Newsle&er December 2015 Christmas Issue 5 page 1

DISCAB Research News

Contents p.1: Introduction p.2: Research Breakthroughs p.6. News and Views p.10. Highlighting DISCAB p.12. Recent DISCAB Publications p.16. conferences and funding p.17. Job opportunities p..22. Humour p.23. Cell-fie of the day

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We welcome you to the 5th and Christmas edition of DISCAB Research News.

“We wish you a Merry Christmas, We wish you a Merry Christmas, We wish you a Merry Christmas

and A Happy New Year

See you next year and

don’t get too fat!

DISCAB Research News Team

2 Research breakthroughs


that nanoscale TRAIL liposomes conjugated to human natural killer cells enhance their endogenous therapeutic potential in killing cancer cells cultured in engineered lymph node microenvironments. In this work, it is shown that liposomes decorated with apoptosis-inducing ligand TRAIL and an antibody against a mouse natural killer cell marker are carried to the tumor draining inguinal lymph nodes and prevent the lymphatic spread of a subcutaneous tumor in mice. It is shown that targeting natural killer cells with TRAIL liposomes enhances their retention time within the tumor draining lymph nodes to induce apoptosis in cancer cells. It is concluded that this approach can be used to kill cancer cells within the tumor draining lymph nodes to prevent the lymphatic spread of cancer. * The most amazing organisms show how its done. Evidence for extensive horizontal gene transfer

from the draft genome of a tardigrade Boothby TC et al., PNAS 2015; 23.

doi: 10.1073/pnas.1510461112

Horizontal gene transfer (HGT), or the transfer of genes between species, has been recognized recently as more pervasive than previously suspected. Here, we report evidence for an unprecedented degree of HGT into an animal genome, based on a draft genome of a tardigrade, Hypsibius dujardini. Tardigrades are microscopic eight-legged animals that are famous for their ability to survive extreme conditions. Genome sequencing, direct confirmation of physical linkage, and phylogenetic analysis revealed that a large fraction of the H. dujardini genome is derived from diverse bacteria as well as plants, fungi, and Archaea. We estimate that approximately one-sixth of tardigrade genes entered by HGT, nearly double the fraction found in the most extreme cases of HGT into animals known to date. Foreign genes have supplemented, expanded, and even replaced some metazoan gene families within the tardigrade genome. Our results demonstrate that an

unexpectedly large fraction of an animal genome can be derived from foreign sources. We speculate that animals that can survive extremes may be particularly prone to acquiring foreign genes. Significance. Despite fascinating scientists for over 200 years, little at the molecular level is known about tardigrades, microscopic animals resistant to extreme stresses. We present the genome of a tardigrade. Approximately one-sixth of the genes in the tardigrade genome were found to have been acquired through horizontal transfer, a proportion nearly double the proportion of previous known cases of extreme horizontal gene transfer (HGT) in animals. Foreign genes have impacted the composition of the tardigrade genome: supplementing, expanding, and replacing endogenous gene families, including those families implicated in stress tolerance. Our results extend recent findings that HGT is more prevalent in animals than previously suspected, and they suggest that organisms that survive extreme stresses might be predisposed to acquiring foreign genes.



DISCAB Newsle&er 6 News and Views


DISCAB Newsle&er 10 HighlighIng DISCAB Research


Team “Beta-Lactamase”

The scientific activities of this group headed by Professor Gianfranco Amicosante, and aided and abetted by Professor Maria Grazia Perilli, are based on the identification and characterisation of resistance mechanisms to antibiotics in Gram-negative and Gram-positive bacteria. Contact e.mails: [email protected] [email protected] The main research interests of the group are: -Molecular epidemiology and characterisation of beta-lactam-resistant clinical isolates. -Molecular mechanisms underlying the transferability of resistance determinants. -Physiological aspects of beta-lactamase production on resistance. -Biochemical characterisation of beta-lactamases and investigation the structural and functional relationships of these enzymes. Recent Publications

- Bottoni C., Marcoccia F., Compagnoni C., Colapietro M., Sabatini A., Celenza G., Segatore B., Maturo M.G., Amicosante G., Perilli M. Identification of new natural CphA metallo-β-lactamases CphA4 and CphA5 in Aeromonas veronii and Aeromonas hydrophila isolates frm municipal sewage in central Italy. Antimicrob. Agents Chemother. 59: 4990-4993, 2015

- Barbarini D, Russello G, Brovarone F,

Capatti C, Colla R, Perilli M, Moro ML, Carretto E. Evaluation of carbapenem-resistant Enterobacteriaceae in an Italian setting: Report from the trench. Infect Genet Evol. 30: 8-14, 2015.

- Perilli M, Sabatini A, Pontieri E, Celenza G, Segatore B, Bottoni C, Bellio P, Mancini A, Marcoccia F, Brisdelli F, Amicosante G. OXA-23 Carbapenemase in Multidrug-Resistant Acinetobacter baumannii ST2 Type: First Identification in L'Aquila Hospital (Italy). Microb Drug Resist. 21: 97-101, 2015

International Meetings

- F. Marcoccia, C. Bottoni, A. Sabatini, M.

Colapietro, G. Celenza, P. Bellio, G. Amicosante, M. Perilli. Substitution L209F in NDM-1 Metallo-β-lactamase drastically reduces enzyme activity versus carbapenems. 25th ECCMID. Copenhagen, Denmark. 25-28 April 2015

!

DISCAB Newsle&er 11 HighlighIng DISCAB Research


New Arrivals

My name is Alex Loftus and I am a visiting undergraduate student from The University of Manchester undertaking a one-year placement in the Bone Biopathology Lab headed by Professor Anna Teti, under the supervision of Professor Nadia Rucci, University of L’Aquila. I work as part of a small group investigating the role of extracellular vesicles (EVs) - small, membrane-bound containers of a range of biomolecules released by cells with an important role in intracellular communication - in bone tumourigenesis. To this end, we use a range of techniques at the transcriptomic and proteomic levels to assess the molecular profile of EVs and to observe the changes in cells exposed to EVs. Additionally, we test the therapeutic properties of our EVs in vivo. This is an exciting, fast-developing field that is likely to have a major impact on our understanding of disease progression, and one that may present novel therapeutic targets. I hope that my time spent at UNIVAQ will provide me with a strong foundation to progress as a scientist, and using the skills and experience that I will gain from working in this lab, I aim to continue after my degree to pursue a PhD - either within in the field of cancer or in the role EVs in health and disease.


12 Recent DISCAB publicaIons

Ruscitti P, Ciccia F, Cipriani P, Guggino G, Di Benedetto P, Rizzo A, Liakouli V, Berardicurti O, Carubbi F, Triolo G, Giacomelli R. The CD68+/H-ferritin+ cells colonize the lymph nodes of the patients with Adult onset Still's disease and are associated with increased extracellular level of H-ferritin in the same tissue. Correlation with disease severity and implication for pathogenesis. Clin Exp Immunol. 2015 Nov 5. doi: 10.1111/cei.12738. [Epub ahead of print] PMID: 26540556 Abstract Objectives In this work, we aimed to evaluate the levels of ferritin enriched in H subunits (H-ferritin) and ferritin enriched in L subunits (L-ferritin) and the cells expressing these 2 molecules, in the lymph node (LN) biopsies obtained from adult onset Still's disease (AOSD) patients, and the possible correlation among these data and the severity of the disease. Methods Ten patients with AOSD underwent LN biopsy. All the samples were stained by immunofluorescence. A statistical analysis was performed to estimate the possible correlation among both H-ferritin and L-ferritin tissue expression and the clinical picture of the disease. Furthermore, the same analysis was performed to evaluate the possible correlation among the number of CD68+/H-ferritin+ or CD68+/L-ferritin+ cells and the clinical picture. Results Immunofluorescence analysis demonstrated an increased tissue H-ferritin expression, in the LNs of AOSD patients. This increased expression correlated with the severity of the disease. An increased number of CD68 macrophages expressing H-ferritin was observed in LN samples of our patients. Furthermore, we observed that the number of CD68+/H-ferritin+ cells significantly correlated with the severity of clinical picture. Conclusions Our data showed an imbalance between the levels of H- and L-ferritin in LNs of AOSD patients and the evidence of increased number of CD68+/H-ferritin+ cells in the same organs. Furthermore, a correlation among both the tissue H-ferritin levels and the CD68+/H-ferritin+ cells and the clinical picture was observed. This article is protected by copyright. All rights reserved. Corona G, Rastrelli G, Limoncin E, Sforza A, Jannini EA, Maggi M. Interplay Between Premature Ejaculation and Erectile Dysfunction: A Systematic Review and Meta-Analysis. J Sex Med. 2015 Nov 9. doi: 10.1111/jsm.13041. [Epub ahead of print] PMID: 26552599. INTRODUCTION: The specific determinants and underlying factors linking erectile dysfunction (ED) andremature ejaculation (PE) have yet to be clearly identified. AIM: The aim of this study was to review and meta-analyze all available data

regarding the link between ED and PE. METHODS: An extensive Medline Embase and Cochrane search was performed including the following words: "premature ejaculation" and "erectile dysfunction". MAIN OUTCOME MEASURES: All observational trials comparing the risk of ED in relation to PE were included. Data extraction was performed independently by two of the authors (G.R, G.C.), and conflicts resolved by the third investigator (M.M.). RESULTS: Out of 474 retrieved articles, 18 were included in the study for a total of 57,229 patients, of which 12,144 (21.2%) had PE. The presence of PE, however defined, was associated with a significant increase in ED risk (odds ratio: 3.68[2.61;5.18]; P!<!0.0001). Meta-regression analysis showed that the risk of ED in PE subjects was higher in older individuals as well as in those with a lower level of education and in those who reported a stable relationship less frequently. In addition, subjects with PE and ED more often reported anxiety and depressive symptoms and a lower prevalence of organic associated morbidities, including diabetes mellitus, hypertension and dyslipidemia. All the latter associations were confirmed even after adjustment for age. Finally the risk of PE-related ED increased with the increased proportion of acquired ejaculatory problems (adj r!=!0.414; P!<!0.0001 after the adjustment for age). CONCLUSIONS: In conclusion, the present data showed that ED and PE are not distinctly separate entities, but should be considered from a dimensional point of view. Understanding this dimensional perspective might help sexual health care professionals in providing the most appropriate therapeutic approach to realistically increase patient related outcomes in sexual medicine. Esposito A, Francone M, Faletti R, Centonze M, Cademartiri F, Carbone I, De Rosa R, Di Cesare E, La Grutta L, Ligabue G, Lovato L, Maffei E, Marano R, Midiri M, Pontone G, Natale L, De Cobelli F. Lights and shadows of cardiac magnetic resonance imaging in acute myocarditis. Insights Imaging. 2015 Nov 10. [Epub ahead of print] PMID: 26555392 Abstract Cardiac magnetic resonance (CMR) is considered a primary tool for the diagnosis of acute myocarditis, due to its unique potential for non-invasive identification of the various hallmarks of the inflammatory response, with relevant impact on patient management and prognosis. Nonetheless, a marked variation in sensitivity and negative predictive value has been reported in the literature, reflecting the intrinsic drawbacks of current diagnostic criteria, which are based mainly on the use of conventional CMR pulse sequences. As a consequence, a negative exam cannot



reliably exclude the diagnosis, especially in patients who do not present an infarct-like onset of disease. The introduction of new-generation mapping techniques further widened CMR potentials, allowing quantification of tissue changes and opening new avenues for non-invasive workup of patients with inflammatory myocardial disease. Favi E, Iesari S, Cina A, Citterio F. Spontaneous renal allograft rupture complicated by urinary leakage: case report and review of the literature. BMC Urol. 2015 Nov 18;15:114. doi: 10.1186/s12894-015-0109-3. BACKGROUND: For more than forty years, graftectomy has been the standard treatment of spontaneous renal transplant rupture. However, recent evidences suggest that graft salvage strategies can be safely pursued, even in difficult cases. CASE PRESENTATION: We report on a thirty-nine-year-old woman who received a deceased donor kidney transplant and experienced spontaneous allograft rupture due to acute rejection. The rupture was further complicated by urinary leakage. The kidney and the ureter were successfully repaired. Eight years after transplantation, graft function is still excellent. CONCLUSION: Due to the lack of transplantable organs and the long time usually spent on the waiting list, graftectomy should be only considered in case of refractory haemodynamic instability or compromised graft viability. Guglielmi G, Masciocchi C. Interventional MSK special feature: an introduction. Br J Radiol. 2016 Jan;89(1057):20150978. Epub 2015 Nov 26. PMID: 26607652 Masciocchi C, Zugaro L, Arrigoni F, Gravina GL, Mariani S, La Marra A, Zoccali C, Flamini S, Barile A. Radiofrequency ablation versus magnetic resonance guided focused ultrasound surgery for minimally invasive treatment of osteoid osteoma: a propensity score matching study. Eur Radiol. 2015 Nov 26. [Epub ahead of print] PMID: 26612546 OBJECTIVES: To compare outcomes in pain relief and motor functional recovery in patients with an osteoid osteoma treated by magnetic resonance guided focused ultrasound surgery (MRgFUS) or radiofrequency ablation (RFA) using a propensity score matching study design. METHODS: Thirty patients with osteoid osteomas were included in this institutional review board (IRB)-approved study. MRgFUS was performed in

15 subjects. These subjects were matched by propensity analysis with a group of 15 subjects treated by RFA. Pain relief in terms of complete response (CR) and motor functional recovery were measured. RESULTS: A similar proportion of subjects treated by MRgFUS (94 %) or RFA (100 %) experienced CR 12 weeks after treatment, with no significant difference. The improvement in pain control following MRgFUS or RFA paralleled with improved motor functional recovery. The treatment failure rate was 6.6 % in the MRgFUS group and 0 % in the RFA group. No major complications were observed following either ablative treatment. CONCLUSIONS: Although this study involved a limited number of patients, MRgFUS favourably improves perceived pain and motor functional recovery, with no major complications. No difference was found in the achievement of primary and secondary outcome measures with respect to RFA. Splendiani A, Felli V, Di Sibio A, Gennarelli A, Patriarca L, Stratta P, Di Cesare E, Rossi A, Massimo G. Magnetic resonance imaging and magnetic resonance spectroscopy in a young male patient with anti-N-methyl-D-aspartate receptor encephalitis and uncommon cerebellar involvement: A case report with review of the literature. Neuroradiol J. 2015 Nov 27. pii: 1971400915609333. [Epub ahead of print] PMID: 26613928 We report a case of a 17-year-old man presenting with new onset psychiatric symptoms. Magnetic resonance imaging (MRI) and proton magnetic resonance (MR) spectroscopy revealed some lesions in the right cerebellar hemisphere and ipsilateral cerebellar tonsil suggestive of encephalitis. An extensive workup was negative for both infectious and neoplastic diseases and he was afterward diagnosed with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. This disorder is an autoimmune encephalitis, highly lethal but curable, predominantly found in young female with ovarian teratoma. He received methylprednisolone. His clinical findings gradually improve and he made a complete recovery. Accordingly, repeated brain MRI and proton MR spectroscopy showed a gradual reduction of the lesions; MRI taken six months after starting therapy showed complete resolution of the lesions. Our case shows that, although rare, anti-NMDAR encephalitis should be considered also in young men for whom a rapid onset of psychiatric neurological disorders cannot be explained by more frequent causes. Our report underlines also the usefulness of MRI and proton MR spectroscopic findings in the diagnosis and follow-up of this disease.



Gravina GL, Mancini A, Sanita P, Vitale F, Marampon F, Ventura L, Landesman Y, McCauley D, Kauffman M, Shacham S, Festuccia C. KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and surviving in prostate cancer models. BMC Cancer. 2015 Dec 1;15(1):941. doi: 10.1186/s12885-015-1936-z. PMID: 26620414 BACKGROUND AND AIMS: Increased expression of Chromosome Region Maintenance (CRM-1)/exportin-1 (XPO-1) has been correlated with poor prognosis in several aggressive tumors, making it an interesting therapeutic target. Selective Inhibitor of Nuclear Export (SINE) compounds bind to XPO-1 and block its ability to export cargo proteins. Here, we investigated the effects of a new class of SINE compounds in models of prostate cancer. MATERIAL AND METHODS: We evaluated the expression of XPO-1 in human prostate cancer tissues and cell lines. Next, six SINE (KPT-127, KPT-185, KPT-205, KPT-225, KPT-251 and KPT-330) compounds having different potency with broad-spectrum, tumor-selective cytotoxicity, tolerability and pharmacokinetic profiles were tested in a panel of prostate cancer cells representing distinct differentiation/progression states of disease and genotypes. Two SINE candidates for clinical trials (KPT-251 and KPT-330) were also tested in vivo in three cell models of aggressive prostate cancer engrafted in male nude mice. RESULTS AND CONCLUSIONS: XPO-1 is overexpressed in prostate cancer compared to normal or hyperplastic tissues. Increased XPO-1 expression, mainly in the nuclear compartment, was associated with increased Gleason score and bone metastatic potential supporting the use of SINEs in advanced prostate cancer. SINE compounds inhibited proliferation and promoted apoptosis of tumor cells, but did not affect immortalized non-transformed prostate epithelial cells. Nuclei from SINE treated cells showed increased protein localization of XPO-1, survivin and cyclin D1 followed by degradation of these proteins leading to cell cycle arrest and apoptosis. Oral administration of KPT-251 and KPT-330 in PC3, DU145 and 22rv1 tumor-bearing nude mice reduced tumor cell proliferation, angiogenesis and induced apoptosis. Our results provide supportive evidence for the therapeutic use of SINE compounds in advanced/castration resistant prostate cancers and warrants further clinical investigation. Recchia F, Candeloro G, Rosselli M, Bratta M, Pasta V, D'Orazi V, Fumagalli LA, Rea S. Adjuvant Ovarian Suppression, High-dose Chemotherapy and Immunotherapy for

Premenopausal Patients with High-risk Breast Cancer. Anticancer Res. 2015 Dec;35(12):6847-53. PMID: 26637906 BACKGROUND: Premenopausal patients with breast cancer and more than 10 positive axillary nodes (BC>10) have a poor prognosis: In these patients the best adjuvant therapy (CT) has not yet been established. PATIENTS AND METHODS: Forty-two BC>10 received, in sequence, the following adjuvant treatments: luteinizing hormone releasing hormone (LH-RH) analog for 5 years; anthracycline-based induction chemotherapy; radiation therapy; platinum-based high-dose CT, with autologous bone marrow transplantation; immunotherapy with interleukin 2 (IL2) and 13-cis retinoic acid (RA); anastrazole given 5 years to estrogen receptor-positive patients. Primary endpoints of the study were disease-free survival (DFS) and overall (OS) survival. A secondary endpoint was toxicity. RESULTS: The median age of patients was 41 years, and the mean number of positive axillary nodes was 14. Estrogen and progesterone receptors were positive in 57% and 29% of patients respectively, while 14% of patients had triple-negative disease. With a median follow-up of 120 months for patients remaining alive at the end of study, median DFS and OS, had not yet been reached. The 20-year DFS and OS rates were 63.8%, and 81.6%, respectively. One to two years after the end of the therapy, three patients had had four full-term pregnancies. CONCLUSION: Treatment with LH-RH analog, high-dose CT, peripheral blood progenitor cells and IL2 with RA for patients with BC>10 is feasible, has moderate toxicity, while preserving ovarian function, seems to improve the expected DFS and OS for these high-risk patients. Del Vecchio F, Gallo F, Di Marco A, Mastroiaco V, Caianiello P, Zazzeroni F, Alesse E, Tessitore A. Bioinformatics approach to predict target genes for dysregulated microRNAs in hepatocellular carcinoma: study on a chemically-induced HCC mouse model. BMC Bioinformatics. 2015 Dec 10;16(1):408. PMID: 26652480 BACKGROUND: Hepatocellular carcinoma (HCC) is an aggressive epithelial tumor which shows very poor prognosis and high rate of recurrence, representing an urgent problem for public healthcare. MicroRNAs (miRNAs/miRs) are a class of small, non-coding RNAs that attract great attention because of their role in regulation of processes such as cellular growth, proliferation, apoptosis. Because of the thousands of potential interactions between a single miR and target mRNAs, bioinformatics prediction tools are very useful to facilitate the task for individuating and



selecting putative target genes. In this study, we present a chemically-induced HCC mouse model to identify differential expression of miRNAs during the progression of the hepatic injury up to HCC onset. In addition, we describe an established bioinformatics approach to highlight putative target genes and protein interaction networks where they are involved. RESULTS: We describe four miRs (miR-125a-5p, miR-27a, miR-182, miR-193b) which showed to be differentially expressed in the chemically-induced HCC mouse model. The miRs were subjected to four of the most used predictions tools and 15 predicted target genes were identified. The expression of one (ANK3) among the 15 predicted targets was further validated by immunoblotting. Then, enrichment annotation analysis was performed revealing significant clusters, including some playing a role in ion transporter activity, regulation of receptor protein serine/threonine kinase signaling pathway, protein import into nucleus, regulation of intracellular protein transport, regulation of cell adhesion, growth factor binding, and regulation of TGF-beta/SMAD signaling pathway. A network construction was created and links between the selected miRs, the predicted targets as well as the possible interactions among them and other proteins were built up. CONCLUSIONS: In this study, we combined miRNA expression analysis, obtained by an in vivo HCC mouse model, with a bioinformatics-based workflow. New genes, pathways and protein interactions, putatively involved in HCC initiation and progression, were identified and explored. Alunno A, Carubbi F, Cafaro G, Pucci G, Battista F, Bartoloni E, Giacomelli R, Schillaci G, Gerli R. Targeting the IL-23/IL-17 axis for the treatment of psoriasis and psoriatic arthritis. Expert Opin Biol Ther. 2015 Dec;15(12):1727-37. doi: 10.1517/14712598.2015.1084284. Epub 2015 Sep 7. PMID: 26653110 INTRODUCTION: A growing amount of data supporting the pathogenic role of the IL-23/IL-17 axis in inflammatory/autoimmune disorders has provided the rationale to target the system for therapeutic purpose. Several compounds have been and are currently under intense investigation in psoriasis and psoriatic arthritis (PsA) yielding impressive results. AREAS COVERED: In this review article, we provide an overview of currently available data on the IL-23/IL-17 system as a target for treatment for psoriasis and PsA. We searched MEDLINE for articles on drug therapy for psoriasis and PsA published between 1 January 2010 and 31 May 2015. One of these agents, ustekinumab, has been recently approved for the treatment of psoriasis and PsA, and a number of IL-23/IL-17-targeted compounds under

investigation in these diseases. EXPERT OPINION: As our knowledge of the role of the IL-23/IL-17 axis in the pathogenesis of psoriasis and PsA deepens, it enables the development of more targeted therapies in the management of these conditions. Early data on IL-23/IL-17 targeting drugs appear promising, although incomplete. Given the key role IL-23/IL-17 in host defence, the safety profile of targeted drugs should be thoroughly assessed in future studies.

DISCAB Newsle&er 16


Conferences and funding

Medical Research Grant Application Guidelines : Progeria Research Foundation The foundation is proving several grants such as Innovator Awards, Established Innovator Award, and Specialty Award. Details are provided here: https://www.google.fr/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&cad=rja&uact=8&ved=0CCEQFjAAahUKEwip8Z_pvenGAhUJVxQKHdYHAPo&url=http%3A%2F%2Fwww.progeriaresearch.org%2Fassets%2Ffiles%2FGrant-App-April-2014.docx&ei=CsusVanEGomuUdaPgNAP&usg=AFQjCNFfgI5_ciZ2i6jtYawkM-2D5HFIfw&sig2=KZtoMnZl_8DTYdf666SOrg AFM Telethon: Call for proposals Several call for proposals are being made available by AFM Telethon. They have published a call for proposals for Spinal Muscular Atrophy and Collagen VI Call for Projects. http://www.afm-telethon.com/research/calls-for-proposals/current-calls-for-proposals.html CCG Funding Opportunities The National Cancer Institute (NCI) has published three companion Funding Opportunity Announcements (FOAs) for Genomic Data Analysis Network Centers to support programs of the Center for Cancer Genomics (CCG). The FOAs are managed by CCG and solicit applications for a Processing Genomic Data Center, aVisualization Genomic Data Center, and a Specialized Genomic Data Center. Access each of the solicitations. http://www.cancer.gov/about-nci/organization/ccg/funding Mini-Symposium on Macrofages January 27, 2015 University of L’Aquila Coppito 2, Room: C2/10 10:00-11:00am for further information contact: Prof A. Teti: tel +39 0862 433511/13 e.mail: [email protected]

17 Job OpportuniIes


ACADEMIC POSITIONS Endowed Professorships in Human Health Michigan Technological University, Provost and VP for Academic Affairs, Houghton, MI, United States http://www.AcademicKeys.com/r?job=74821&o=473248&t=ME151204m-6e Non-Tenure Track Clinical Instructor/Assistant Pro. University of Delaware, College of Health Sciences: School of Nursing, Newark, USA. http://www.AcademicKeys.com/r?job=74780&o=473248&t=ME151204m-6e Asst. Prof. Dept. of Behavioral Health and Nutr... University of Delaware, College of Health Sciences: Behavioral Health & Nutrition, Newark, DE, USA http://www.AcademicKeys.com/r?job=74775&o=473248&t=ME151204m-6e Tenure-Track Assistant/Associate Prof. in Adapted ... University of Delaware, College of Health Sciences: Behavioral Health & Nutrition, Newark, DE, USA http://www.AcademicKeys.com/r?job=74773&o=473248&t=ME151204m-6e Open Rank Faculty Positions - Communication Sci. a.. University of Delaware, Coll. of Health Sciences: Communication Sci. and Disorders, Newark, DE, USA http://www.AcademicKeys.com/r?job=74772&o=473248&t=ME151204m-6e 2 Faculty Positions for fMRI researchers, Asst. Pr... University of Delaware, College of Arts & Sciences: Interdisciplinary, Newark, DE, USA http://www.AcademicKeys.com/r?job=74768&o=473248&t=ME151204m-6e Continuing, Non-tenure Track, Instructor/Assistan.. University of Delaware, College of Health Sciences: Medical Laboratory Sciences, Newark, DE, USA http://www.AcademicKeys.com/r?job=74761&o=473248&t=ME151204m-6e Assistant/Associate Professor- Clinical Exercise P... University of Delaware, Coll. of Health Sciences: Kinesiology & Applied Physiology, Newark, DE, USA http://www.AcademicKeys.com/r?job=74758&o=473248&t=ME151204m-6e linical Instructor Exercise Physiology (Continuin... University of Delaware, Coll. of

Health Sciences: Kinesiology & Applied Physiology, Newark, DE, USA http://www.AcademicKeys.com/r?job=74753&o=473248&t=ME151204m-6e Tenure Track Faculty Position- Biomechanics University of Delaware, Coll. of Health Sciences: Kinesiology & Applied Physiology, Newark, DE, USA http://www.AcademicKeys.com/r?job=74747&o=473248&t=ME151204m-6e Tenure-Track Assistant/Associate Prof. - Three Pos... University of Delaware, College of Health Sciences: School of Nursing, Newark, DE, United States http://www.AcademicKeys.com/r?job=74745&o=473248&t=ME151204m-6e Assoc. and Full Professor- Behavioral Health and N.. University of Delaware, College of Health Sciences: Behavioral Health & Nutrition, Newark, DE, USA http://www.AcademicKeys.com/r?job=74743&o=473248&t=ME151204m-6e CNTT Assist/Assoc. Prof- Nurse Simulation University of Delaware, College of Health Sciences: School of Nursing, Newark, DE, USA http://www.AcademicKeys.com/r?job=74742&o=473248&t=ME151204m-6e Tenure Track Faculty Position, Dept. of Physical T.. University of Delaware, College of Health Sciences: Physical Therapy, Newark, DE, United States http://www.AcademicKeys.com/r?job=74737&o=473248&t=ME151204m-6e Two Open-Rank, Tenure-Track Positions in Epidemiology University of Michigan, Ann Arbor, School of Public Health, Department of Epidemiology, Ann Arbor, USA http://www.AcademicKeys.com/r?job=74615&o=473248&t=ME151204m-6e Associate or Full Professor, Regular Title Series University of Kentucky, 7H852:NEUROLOGY, Lexington, KY, USA http://www.AcademicKeys.com/r?job=74519&o=473248&t=ME151204m-8e Assistant/Associate Prof. (Tenure Track) in Mental... Temple University College of Public Health, Rehabilitation Sciences, Philadelphia, PA, United States


18 Grants, Awards and Job OpportuniIes

http://www.AcademicKeys.com/r?job=74442&o=473248&t=ME151204m-6e Assistant/Associate/Full Professor, Clinical Title... University of Kentucky, 7H600:Pathology, Lexington, KY, United States http://www.AcademicKeys.com/r?job=74400&o=473248&t=ME151204m-6e Research Asst. or Associate Professor, Tenure-track University of South Carolina, College of Nursing, Columbia, SC, United States http://www.AcademicKeys.com/r?job=74346&o=473248&t=ME151204m-6e Anticipated Faculty Positions 2016-2017 (Recreatio... Kean University, School of Physical Education, Recreation and Health, Union, NJ USA http://www.AcademicKeys.com/r?job=74287&o=473248&t=ME151204m-6e Anticipated Faculty Positions 2016-2017 Kean University, Coll. of Education, School of Communication Disorders and.., Union, NJ USA http://www.AcademicKeys.com/r?job=74275&o=473248&t=ME151204m-6e Assistant/Associate Professor: Epidemiology San Diego State University, Graduate School of Public Health, San Diego, CA, United States http://www.AcademicKeys.com/r?job=74130&o=473248&t=ME151204m-6e General OBGYN Faculty West Virginia University School of Medicine -- Department of Obstetrics & Gynecology Morgantown, WV, United States http://www.AcademicKeys.com/r?job=74037&o=473248&t=ME151204m-8e Clinical Title Series Faculty University of Kentucky 7N900:Health Sciences - Clinical Science Lexington, KY, United States http://www.AcademicKeys.com/r?job=74010&o=473248&t=ME151204m-6e CMHS premedical teaching/research faculty - Rank: UAE University College of Medicine and Health Sciences Al Ain, Abu Dhabi, United Arab Emirates http://www.AcademicKeys.com/r?job=73999&o=473248&t=ME151204m-6e NEW! - CMHS premedical teaching/research faculty - Rank: ...

UAE University College of Medicine and Health Sciences Al Ain, Abu Dhabi, United Arab Emirates http://www.AcademicKeys.com/r?job=73998&o=473248&t=ME151204m-8e Asst. Professor, Dept. of Psychiatry, Posting No. 463 United Arab Emirates University, Dept. of Psychiatry, College of Medicine & Health Sciences Al Ain, Abu Dhabi, United Arab Emirates http://www.AcademicKeys.com/r?job=73997&o=473248&t=ME151204m-6e Assistant/Associate Prof. in General (Internal) Me... United Arab Emirates University, The Dept. of Internal Medicine, Coll. of Medicine and Hea... Al Ain, Abu Dhabi, United Arab Emirates http://www.AcademicKeys.com/r?job=73995&o=473248&t=ME151204m-6e Assistant/Associate Prof. in General (Internal) Me... United Arab Emirates University, The Dept. of Internal Medicine, Coll. of Medicine and Hea... Al Ain, Abu Dhabi, United Arab Emirates http://www.AcademicKeys.com/r?job=73994&o=473248&t=ME151204m-8e Regenerative Medicine, Rank DOQ University of Nebraska Medical Center Surgery, Omaha, NE, United States http://www.AcademicKeys.com/r?job=73839&o=473248&t=ME151204m-6e Assistant/Associate, Tenure Track Eligible (T/TE) ... The University of Arizona Department of Community, Environment, and Policy, Tucson, AZ, United States http://www.AcademicKeys.com/r?job=73709&o=473248&t=ME151204m-7e Assistant, Associate, or Full Professor, Regular T... University of Kentucky, 7H025:Cancer Center - Core Support Lexington, KY, United States http://www.AcademicKeys.com/r?job=73608&o=473248&t=ME151204m-2e Assistant, Associate, or Full Professor, Regular T..., University of Kentucky 7H025:Cancer Center - Core Support Lexington, KY, United States http://www.AcademicKeys.com/r?job=73607&o=473248&t=ME151204m-8e Assistant, Associate, or Full Professor, Regular T... University of Kentucky 7H025:Cancer Center-Core Support

18 Job OpportuniIes



Assistant Professor/Associate Professor/Professor. University of Kentucky 7H300:Radiology, Lexington, KY, USA http://www.AcademicKeys.com/r?job=72173&o=473248&t=ME151204m-8e Assistant/Associate Professor University of Kentucky, 7H850:Surgery/General Lexington, KY,USA http://www.AcademicKeys.com/r?job=72172&o=473248&t=ME151204m-8e Assistant, Associate, or Full Professor, Regular Title Se... University of Kentucky, 7H025:Cancer Center - Core Support, Lexington, KY,USA http://www.AcademicKeys.com/r?job=71626&o=473248&t=ME151204m-8e Assistant Professor of Radiology University of Kentucky, 7H300:Radiology Lexington, KY, United States http://www.AcademicKeys.com/r?job=71519&o=473248&t=ME151204m-8e Faculty Physician-Clinical Title Series University of Kentucky, 7H460: Family and Community Medicine, Lexington, KY, USA http://www.AcademicKeys.com/r?job=71223&o=473248&t=ME151204m-8e Assistant Professor University of Kentucky 7H950:Rehabilitation Medicine Lexington, KY, United States http://www.AcademicKeys.com/r?job=71121&o=473248&t=ME151204m-8e Assistant Professor-OBGYN-MFM University of Kentucky, 7H503:Obestetrics & Gyncecology- Maternal Fetal, Lexington, KY,USA http://www.AcademicKeys.com/r?job=70951&o=473248&t=ME151204m-8e Assistant Professor. University of Kentucky 7H051:Cardiovascular Research Center Lexington, KY, United States http://www.AcademicKeys.com/r?job=70898&o=473248&t=ME151204m-8e Assistant Professor. University of Kentucky 7H051:Cardiovascular Research Center Lexington, KY, United States http://www.AcademicKeys.com/r?job=70894&o=473248&t=ME151204m-8e

Diversity. University of Nevada School of Medicine, University of Nevada School of Medicine Las Vegas, NV, United States http://www.AcademicKeys.com/r?job=70862&o=473248&t=ME151204m-8e Faculty Position Opening. National Taiwan University, Institute of Medical Device and Imaging Taipei, Taiwan, Taiwan http://www.AcademicKeys.com/r?job=70784&o=473248&t=ME151204m-8e Faculty Physician-Clinical Title Series University of Kentucky. 7H460:Family and Community Medicine, Lexington, KY, USA http://www.AcademicKeys.com/r?job=70704&o=473248&t=ME151204m-8e Multiple Tenured Associate/Full Professors of Epidemiology. Indiana University, Bloomington School of Public Health -- Dept. of Epidemiology and Bios.. Bloomington, IN, United States http://www.AcademicKeys.com/r?job=70314&o=473248&t=ME151204m-8e Tenure-track Assistant/Associate Professor of BIOSTATISTICS. Indiana University, Bloomington School of Public Health, Dept. of Epidemiology and Biosta... Bloomington, IN, United States http://www.AcademicKeys.com/r?job=70303&o=473248&t=ME151204m-8e Tenured Associate/Full Professor in BIOSTATISTICS. Indiana University, Bloomington School of Public Health, Dept. of Epidemiology and Biosta... Bloomington, IN, United States http://www.AcademicKeys.com/r?job=70298&o=473248&t=ME151204m-8e Medical Assisting Instructor Carrington College, Academics Mesquite, TX, USA http://www.AcademicKeys.com/r?job=70267&o=473248&t=ME151204m-8e Assistant Professor. University of Kentucky 7H859:ORTHOPAEDIC SURGERY, Lexington, KY,USA http://www.AcademicKeys.com/r?job=70170&o=473248&t=ME151204m-8e Gynecologic Oncologist. West Virginia University School of Medicine -- Department of Obstetrics & Gynecology. Morgantown, WV, United States http://www.AcademicKeys.com/r?job=70152&o=473248&t=ME151204m-8e

19 Job OpportuniIes



Lexington, KY, United States http://www.AcademicKeys.com/r?job=73606&o=473248&t=ME151204m-8e Assistant/Associate Prof. of Nursing - CSU Northridge, California State University, Northridge Department of Nursing, Northridge, CA, USA http://www.AcademicKeys.com/r?job=73596&o=473248&t=ME151204m-7e Asst. or Assoc. Professor of Health Information Tech. University of South Carolina Health Services Policy and Management Columbia, SC, United States http://www.AcademicKeys.com/r?job=73532&o=473248&t=ME151204m-7e Lecturer / Asst. Prof. of Surgery, Posting No. 1218 Coll. of Medicine and Health Sciences (CMHS), UAE University, Surgery, Al Ain, Al Ain, United Arab Emirates http://www.AcademicKeys.com/r?job=73498&o=473248&t=ME151204m-7e Lecturer / Asst. Prof. of Surgery, Posting No. 1218, Coll. of Medicine and Health Sciences (CMHS), UAE University, Surgery, Al Ain, Al Ain, United Arab Emirates http://www.AcademicKeys.com/r?job=73497&o=473248&t=ME151204m-8e Instructor/Assistant/Associate Prof. - Histopathol... Coll. of Medicine and Health Sci. (CMHS) United Arab Emir.., Pathology - (CMHS) Al Ain, Al Ain, United Arab Emirates http://www.AcademicKeys.com/r?job=73493&o=473248&t=ME151204m-7e Instructor/Assistant/Associate Prof. - Histopathol., Coll. of Medicine and Health Sci. (CMHS) United Arab Emir.. Pathology - (CMHS) Al Ain, Al Ain, United Arab Emirates http://www.AcademicKeys.com/r?job=73492&o=473248&t=ME151204m-8e Assistant Professor, Department of Public Health California State University, Los Angeles Department of Public Health, Los Angeles, CA, United States http://www.AcademicKeys.com/r?job=73482&o=473248&t=ME151204m-7e Outpatient Psychiatry Faculty, West Virginia University, Department of Behavioral Medicine and Psychiatry, Morgantown, WV, United States http://www.AcademicKeys.com/r?job=73387&o=473248&t=ME151204m-2e

Associate or Full Professor Faculty Position (Tenure Track), Temple University College of Public Health Social and Behavioral Sciences Philadelphia, PA, United States http://www.AcademicKeys.com/r?job=73175&o=473248&t=ME151204m-7e Clinical Track Associate/Assistant Prof. in Biostatistics. The Ohio State University Division of Biostatistics, Columbus, OH, USA http://www.AcademicKeys.com/r?job=73120&o=473248&t=ME151204m-7e Assistant Professor - Family Medicine, Posting No. 1222, United Arab Emirates Univ. - Coll. of Medicine & Health Sci. Family Medicine Al Ain, Al Ain, United Arab Emirates, United Arab Emirates http://www.AcademicKeys.com/r?job=73097&o=473248&t=ME151204m-7e Professor/Associate Professor/Assistant Professor. Al Jouf University, College of Medicine Al Jouf, Saudi Arabia http://www.AcademicKeys.com/r?job=72979&o=473248&t=ME151204m-8e Faculty Physician-Clinical Title Series University of Kentucky, 7H460:FAMILY AND COMMUNITY MEDICINE, Lexington, KY, USA http://www.AcademicKeys.com/r?job=72842&o=473248&t=ME151204m-8e Faculty Physician-Clinical Title Series University of Kentucky. 7H460:FAMILY AND COMMUNITY MEDICINE, Lexington, KY, USA http://www.AcademicKeys.com/r?job=72841&o=473248&t=ME151204m-8e Assistant Professor. University of Kentucky 7H859:Orthopaedic Surgery, Lexington, KY, United States http://www.AcademicKeys.com/r?job=72706&o=473248&t=ME151204m-8e Assistant Professor. University of Kentucky 7H950:Rehabilitation Medicine Lexington, KY,USA http://www.AcademicKeys.com/r?job=72705&o=473248&t=ME151204m-8e Medical Assisting Instructor Mornings 8:00 am - 12:30 (Pa.) Carrington College Academics USA http://www.AcademicKeys.com/r?job=72480&o=473248&t=ME151204m-8e

20 Job OpportuniIes

Assistant Professor of Medicine (75741) University of Kentucky. 7H369: Internal Medicine – Hospitalist, Lexington, KY, United States http://www.AcademicKeys.com/r?job=70074&o=473248&t=ME151204m-8e Assistant Professor of Medicine (75742) University of Kentucky, 7H369: Internal Medicine – Hospitalist, Lexington, KY, United States http://www.AcademicKeys.com/r?job=70073&o=473248&t=ME151204m-8e Urogynecology Faculty. West Virginia University School of Medicine -- Department of Obstetrics & Gynecology, Morgantown, WV, United States http://www.AcademicKeys.com/r?job=69771&o=473248&t=ME151204m-8e Full-Time General Internal Medicine Clinician Educator. UAB Montgomery, UAB Montgomery Internal Medicine Residency Program Montgomery, AL, USA http://www.AcademicKeys.com/r?job=65768&o=473248&t=ME151204m-8e POST-DOCTORAL POSITIONS Global HIV Implementation Sci. Research Training F.., Columbia University, ICAP New York, NY, USA http://www.AcademicKeys.com/r?job=74165&o=473248&t=ME151204m-6e Postdoctoral Fellow-Cookstoves and Air Pollution E.., Colorado State University. Environmental and Radiological Health Sciences, Fort Collins, CO, USA http://www.AcademicKeys.com/r?job=73347&o=473248&t=ME151204m-7e



21 Job OpportuniIes

23 Humour


22 Humour

Cell-‐fie of the day 23


DNA Inside the nucleus-24 colour whole chromosome FISH. The colours denote all the chromosomes tagged with different combinations of floutophores

Credit: Kirti Prakash, Institute of Molecular Biology, Mainz

discab research news · tardigrade. approximately one-sixth of the genes in the tardigrade genome...

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