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    Biology II

    DIGESTIVE SYSTEM

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    FUNCTIONS OF THE DIGESTIVE SYSTEM

    Ingestion The taking in of food.

    Digestion Physical and chemical breakdown of

    food into smaller molecules.

    Absorption Movement of nutrients into the

    bloodstream.

    Defecation Removal of indigestible waste.

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    MOUTH ANATOMY

    Three pairs of salivary glands empty secretions intothe mouth

    1. Parotid glands

    2. Submandibular glands

    3. Sublingual glands

    Functions of saliva:

    Dissolves chemicals in food so they

    can be detected by the taste buds.

    Moistens food so that it can be swallowed.

    Contains salivary amylase, a digestive enzyme.

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    DIGESTION IN THE MOUTH

    There are two types of digestion:

    Mechanical digestion, which is the physical process

    of breaking food into smaller pieces.

    Chemical digestion, when enzymes catalyze

    chemical reactions that lead to the breakdown of

    food molecules.

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    DIGESTION IN THE MOUTH

    Mechanical digestion in the mouth occurs throughmastication, or the chewing and grinding of food by

    the teeth.

    Chemical digestion occurs when salivary amylase

    catalyzes the breakdown of starch (polysaccharide)into maltose (disaccharide).

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    Teeth

    (Incisors)

    Hard Palate

    Soft Palate

    Uvula

    Tongue

    Frenulum

    Palatine

    Tonsils

    Palatal

    Arches

    Vestibule (betweenlower lip and gingiva)

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    TEETH

    The outermost layer of the tooth is enamel. Made of calcium phosphate, the hardest biologically-made

    substance.

    Most of the inner tooth is dentin, which is similar to

    bone except without any living cells.

    The living cells of the tooth are located in the pulp

    cavity.

    All blood vessels and nerves into this cavity come through

    the root canals at the base of the tooth.

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    Crown

    (Enamel)

    Pulp Cavity

    Gingiva

    Bone Tissue

    (Mandible)

    Root

    Canal

    Dentin

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    TOOTH DISORDERS

    Cavities orcaries occur when

    naturally-occuring bacteria withinthe mouth overgrow due to thepresence of food particles.

    The bacteria produce acid as a wasteproduct, which dissolves the calciumphosphate enamel.

    If cavities are allowed to becometoo deep, a root canal will cleanout and dissolve all the tissue in the

    pulp cavity, leaving an antibioticpaste behind.

    The tooth no longer has any living cellsat this point.

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    TYPES OF TEETH

    Incisors are blade-shaped teeth at the front of themouth.

    Clipping or cutting.

    Cuspids (canines) are cone-shaped with a pointed

    tip.

    Tearing or slashing.

    Bicuspids and molars have flattened tops.

    Crushing, mashing, or grinding.

    Wisdom teeth are an additional set of molars that

    often develop in locations where they cannot erupt.

    Vestigial structures.

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    Incisors

    Cuspid

    Bicuspids

    Incisors

    Cuspid

    Bicuspids

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    PHARYNX

    Food is formed into achewed,moistened ball called a bolus.

    The bolus is pushed back toward

    the pharynx with the tongue.

    While swallowing, all

    passageways except to the

    esophagus are blocked.

    The uvula moves backwards,

    blocking the nasal cavity.

    The epiglottis folds down, blocking

    the trachea.

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    ESOPHAGUS

    The bolus movesthrough the

    esophagus by a

    series of smooth

    muscle contractionscalled peristalsis.

    The bolus

    eventually enters

    the stomachthrough the cardiac

    sphincter.

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    Esophagus

    Fundus

    CardiacSphincter

    Lesser

    Curvature

    Greater

    Curvature

    Body (Rugae)

    Pyloric

    RegionPyloricSphincter

    Duodenum

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    STOMACH

    The stomach is a muscular organ made of foursections:

    Cardiac Region closest to the esophagus and heart.

    Fundus Superior bulge in stomach.

    Body Middle section Pyloric Inferior region, closest to the small intestines.

    The stomach has internal folds called rugae, thatincrease the surface area for digestion.

    The innermost lining of the stomach is simplecolumnar epithelium.

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    STOMACH

    The cardiac sphincteris a ring of smooth

    muscle intended to allow

    food into the stomach,

    but not out. Exceptions include

    vomiting, heartburn, acid

    reflux.

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    STOMACH

    Presence of food in the stomach stimulates the releaseof the hormone gastrin.

    Gastrin causes the stomach glands to produce:

    Pepsinogen, an inactive enzyme produced by chief cells.This converts to pepsin, an active enzyme that breaks downproteins into amino acids.

    A layer ofmucus to protect the stomach from being dissolvedor digested.

    Hydrochloric acid lowers the pH of the stomach contents,

    which activates pepsin. This is produced by parietal cells. No absorption occurs in the stomach, except for aspirin

    and alcohol.

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    Mucus

    Cells

    RugaeChief

    Cells

    Parietal

    Cells

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    STOMACH-INTESTINES

    The partially digested food is now referred to aschyme.

    The stomach will release small amounts (30mL) of

    chyme into the small intestine at a time through the

    pyloric sphincter.

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    SMALL INTESTINES

    The first section ofthe small intestines

    is the duodenum.

    This is where most

    of the actual

    digestion occurs.

    Digestive secretions

    from the pancreas

    and liver (gallbladder) are both

    sent here.

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    Falciform Ligament

    Liver

    Duodenum

    Gall Bladder

    Pancreas

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    DUODENUM

    The pancreas releases bicarbonate and enzymes

    into the duodenum:

    Bicarbonate neutralizes the stomach acid, stopping the

    action of pepsin..

    Pancreatic amylase (starch maltose)

    Lipase (Lipids Fatty acids)

    Nuclease(DNA / RNA Nucleotides)

    Trypsin(Protein Amino acids)

    The liver releases bile, which separates fats intosmaller droplets to increase the rate of digestion by

    lipase.

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    JEJUNUM-ILEUM

    Food is moved throughthe small intestine by

    peristalsis, just like in

    the esophagus.

    Absorption of the end-products of digestion

    occurs all along the

    jejunum and ileum.

    Villi are present in all cells

    along the intestines to

    increase the surface area

    for absorption.

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    JEJUNUM-ILEUM

    Active transport movesthe substances

    (monosaccharides,

    amino acids, fatty acids,

    etc) across the cells of

    the intestines into theblood.

    Substances are then

    transported to the liver

    by the hepatic portal

    vein.

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    LARGE INTESTINE

    The beginning of the large intestine is the cecum. The appendix is attached here.

    Three segments of the large intestine:

    Ascending colon

    Transverse colon

    Descending colon

    Ends with the rectum.

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    Oral Cavity

    Sublingual GlandSubmandibular

    Gland

    Esophagus

    Parotid Gland

    UvulaTongue

    Pharynx

    Trachea

    Diaphragm

    SpleenLiver

    Stomach

    Pancreas Transverse ColonDescending Colon

    Jejunum

    Sigmoid Colon

    Rectum

    Anus

    Ascending Colon

    ileum

    Appendix

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    LARGE INTESTINE

    No digestive enzymes are present here. Bacteria that reside in the large intestine digest some

    of the remaining nutrients, producing vitamins K, B,

    and some gases.

    Water and vitamins are absorbed, while theremaining material is eliminated as feces.

    Undigested food residue

    Mucus

    Bacteria

    Water

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    LARGE INTESTINE

    Movement through the largeintestine is slow, but powerful.

    Peristalsis occurs 3-4 times per day.

    A buildup of feces in the rectum

    causes the defecation reflex. The internal anal sphincter (involuntary

    smooth muscle) is relaxed.

    The external anal sphincter (voluntary

    muscle) must be relaxed beforedefecation can actually occur.

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    ACCESSORY ORGANS

    The pancreas, in addition to producing digestiveenzymes, also controls blood sugar.

    Islets of Langerhans contain the cells that actually

    produce these hormones.

    Insulin Stimulates the absorption of glucose from bloodand production of glycogen for storage.

    Glucagon Stimulates the breakdown of glycogen into

    glucose, raising blood sugar.

    The liver, in addition to making bile, detoxifies anypoisons absorbed by the digestive tract.

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    APPENDIX

    The appendix is a small dead-end tube connected tothe beginning of the ascending colon.

    The appendix is believed to be a vestigial structure. It used

    to be a larger cecum an organ that herbivores use to

    ferment and digest cellulose.

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    CONNECTIVE TISSUE

    The stomach is held in place with the otherabdominal organs by the greater and lesser

    omentum

    The intestines are held together by mesentary.

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    MUMPS

    A viral infection that causespainful swelling of the salivary

    glands, especially the parotid

    gland.

    Airborne and highlycontagious.

    Can be vaccinated against.

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    HEARTBURN

    Influx of stomach acid into the esophagus. Can be the result of excessive acid production in the

    stomach, or a faulty cardiac sphincter.

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    PEPTIC ULCERS

    An erosion of the innerstomach or duodenum lining.

    Causes include:

    Inflammation from bacterial

    infection.

    Certain painkillers (aspirin,

    ibuprofen) can inhibit the

    production of stomach mucus.

    Stress (not fully understood why)

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    VOMITING

    There are multiple sources ofstimulation that can lead to

    vomiting.

    Irritation of the gastrointestinal

    tract.

    Irritation of the pharynx (gag

    reflex)

    Multiple trigger zones in the brain.

    The actual process of vomitinghas several physiologic steps.

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    VOMITING

    Salivary glands increase production of saliva toprotect teeth from acid erosion.

    A deep breath is taken to prevent aspiration.

    Inhalation of foreign substances, such as vomit, can lead to

    serious respiratory infections like pneumonia.

    Retroperistalsis (reverse peristalsis) sweeps the

    digestive tract contents through a relaxed pyloric

    sphincter, into the stomach.

    Abdominal muscles contract, cardiac sphincter

    relaxes, and contents exit through the esophagus.

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    DIARRHEA

    Diarrhea is the presence of abnormally loose orliquid feces.

    There are multiple types of diarrhea, all of which are

    caused by an excess of water inside the intestines.

    Some bacteria (Cholera, E. coli O157:H7) produce a toxinthat creates an ion imbalance in the intestines. This results

    in an osmotic flow of water into the intestines.

    Laxatives often contain an ion (like magnesium) that will

    intentionally create an osmotic imbalance.

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    LACTOSE INTOLERANCE

    People that are lactose intolerant donot produce the lactase enzyme.

    The gene that produces this enzyme shuts

    off after infancy, when breastfeeding ends.

    Undigested lactose eventually reachesthe large intestine, causing an osmotic

    imbalance (diarrhea).

    Bacteria are able to ferment the

    lactose, producing excessive amountsof gas.

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    DIABETES

    The pancreas stops producing or does not produceenough insulin, resulting in high blood sugar levels.

    Type I Diabetes is the result of the immune system

    destroying the insulin-producing cells of the pancreas.

    No insulin is produced. The patient is dependent on insulininjections.

    Type II Diabetes occurs when there is an insulin

    deficiency in the body, or the cells do not respond

    properly to insulin. Most common cause is obesity.