“Drug Addiction is a Brain Disease”

8th Drug Abuse Research SymposiumJune 14, 2013

8:30 am – 3:45pmCharles Drew University of Medicine and Science

Keck Lecture Hall1731 E. 120th Street, Los Angeles, CA 90059

NIH R24DA017298 Minority Institution Drug Abuse Research

Program (MIDARP) at Charles Drew University of Medicine & Science

Drug Addiction is a Brain Disease and it Matters

Funded September 2004Competitive renewal funded September 2008Program officer: Vishnudutt Purohit, Ph.D.

NIH R24DA017298 Diversity Institution Drug Abuse Research

Program (DIDARP) at Charles Drew University of Medicine & ScienceMetabolic Effects of Nicotine: It

Matters Submitted September 2012

Excellent score, but no funding available-May 2013Bridge money generously supplied by Dr. Shurtleff

and NIDA June 2013Program officer: Vishnudutt Purohit, Ph.D.

DIDARP Specific Aims

• To increase the number of high quality drug addiction research projects related to the metabolic effects of nicotine to allow CDU to develop expertise and acquire preliminary data to be able to compete for NIDA P01, P50 or R01 grants;

• To continue to foster interest in substance abuse research among under-represented students and other trainees by providing meaningful educational and research experiences; and

• To continue to enhance the research infrastructure at CDU to support substance abuse research.

DIDARP Theme

• The theme of the training and education program is “Metabolic Effects of Nicotine: It Matters ”

• Incorporates expertise at CDU in both the basic and clinical aspects of substance abuse.

• Lead to collaborations with UCLA, Western University, CSU-DH, CSU-SB, Cal-tech, UTEP

MIDARP Student Involvement

• Students rotating in basic science labs and on clinical projects

• CSUDH-undergraduate/Master’s students• CSUDH-Bridges Program -El Camino

College, Compton College• King-Drew Magnet High School• CDU medical students and MPH students

Research Day Goals• Highlight substance abuse research at CDU and its affiliates

• Exposure of student and trainee research on substance abuse

• Expose potential trainees to potential substance abuse mentors

• Bring together substance abuse researchers for future seminars and funding opportunities

• Exposure of research on substance abuse at CDU to research and teaching faculty, physicians from the surrounding community including MLK-Ambulatory Care Clinic and health clinics, drug abuse counselors, medical students, allied health professionals, community based health organization leaders, and other health care professionals

Research Day: New this year

• Live streaming to UTEP auditorium• Live streaming to CSU-SB and Meharry

personal computers• Website:

http://www.cdrewu.edu/research/DrugAddictionResearch

• Slides, biosketch and pictures available shortly

• Talks available next week• CME credit for Dr. Shurtleff’s Talk

Research Day Highlights• CE process and evaluations

– Grant Hovik, MA

•  CME evaluations– Jeonathan Rodriguez

• 8:45 – 9:00 am University Welcome

• David M. Carlisle, MD, PhD – President, Charles Drew University

• Jay Vadgama, PhD Interim Executive Vice President for Research and Health Affairs

KEYNOTE SPEAKER

• 9:00 -10:00 Update on NIDA supported Drug Abuse and Addiction Research (CME event)

• David Shurtleff, Ph.D.

Research Day Morning TalksCLINICAL/BEHAVIORAL SCIENCES AND POLICY RESEARCH SUBSTANCE ABUSE

• 10:00-10:20 am Harm Reduction and Drug Policy Reform

• Laura Thomas, MPH, MPP

 

• 10:20 -10:35 am Discrimination, Stress, and Substance Use Disorders among Latina/os

• Angie Denisse Otiniano Verissimo, Ph.D., M.P.H.

• 10:35 -10:50 am MORNING BREAK

Research Day Morning TalksCLINICAL/BEHAVIORAL SCIENCES AND

POLICY RESEARCH SUBSTANCE ABUSE (2)

• 10:50-11:15 am Understanding Medical Marijuana Laws

• Priscillia Hunt, Ph.D.

• 11:15 -11:30 am Correlates of Hepatitis C Virus among Injection Drug Users and their Sex Partners in Ciudad Juárez, CHIH

• Oralia Loza, Ph.D.

Research Day Morning TalksCLINICAL/BEHAVIORAL SCIENCES AND

POLICY RESEARCH SUBSTANCE ABUSE (3)

• 11:30 -11:45 am Brain Structure in Methamphetamine Dependence

• Angelica Morales

 

• 11:45 -12:00 pm Enhancing the Referral-Making Process to Twelve-step Programs

• Cory Dennis, MSW

• 12:00 -12:10 pm A participatory randomized intervention to promote and enhance nicotine dependence treatment in a low-income community using community peer-motivators

• Payam Sheikhattari, MD, MPH

• 12:10 -12:20 pm Obesity and Marijuana intake have a detrimental effect on sexual function in male mice

• Maria Sanchez, B.S.

STUDENT/TRAINEE ORAL PRESENTATIONS

Lunch Break

• 12:20-1:15 PM • No food or drinks in the auditorium• Audience will go to lunch in shifts• Trainees will meet with Dr. Shurtleff outside

STUDENT/TRAINEE ORAL PRESENTATIONS

• 1:15-1:25 pm Decreased Dopamine D2 Receptor Availability and COMT gene expression using microPET and microarray in mice that prefer Alcohol

• Tiffany Morton, B.S.

 • 1:25-1:35 pm Diet and Nicotine on Cancer

Proliferation • Desean Lee, B.S., M.S.

Afternoon Session

• 1:35 -1:45 pm Overview of UTEP DIDARP program• Eddie Castañeda, PhD

BASIC SCIENCE RESEARCH

• 1:45-2:05 pm Neurochemical mechanisms mediating enhanced vulnerability to tobacco use: Implications from animal models (via videoconference)

• Laura O’Dell, Ph.D.• 2:05-2:20 pm AFTERNOON BREAK

 • 2:20 -2:40 pm Changes in the Brain During Chronic

Exposure to Nicotine• Henry A. Lester, PhD

BASIC SCIENCE RESEARCH

• 2:40 -3:00 pm Nicotine plus High Fat Diet Induces Hepatic and Muscle Steatosis*

• Amiya Sinha-Hikim, Ph.D.

• 3:00-3:10 pm Additive effects of nicotine and high-fat diet on hepatic steatosis and hepatocellular apoptosis in mice: Involvement of caspase 2 and inducible nitric oxide synthase-mediated intrinsic pathway signaling (student/trainee presentation)

• Rasheed Ivey, B.S., M.S.

• 3:10 -3:30 pm Addiction and reward parameters in PC2 null mice*• Theodore Friedman, MD, PhD Kabirullah Lutfy, Ph.D., Desean Lee,

M.S

CLOSING REMARKS• 3:30- - 3:45 pm • PRESENTATION OF PRIZE FOR TOP STUDENT

PRESENTATION AND POST-CONFERENCE EVALUATIONS Theodore Friedman, MD, PhD

Instructions to Speakers

• Please adhere to your time limits• We will give you 5 and 1 minute warnings• Please speak into the microphone• Allow time for questions• Repeat the question

Instructions to Speakers

• MICROPHONE #1 - The lapel or lavalier wireless microphone will need to be clipped to your clothing and is best when placed on a shirt lapel or tie (for men) or a neckline (for women) that is just below the neck and mid-chest (chest-pocket level). The microphone is attached to a small box that fits into either a shirt pocket (for men) or a pants pocket (for men or women) or clips to the hemline of a skirt or pants (for men or women).

• MICROPHONE #2 - The handheld wireless microphone is the standard size and shape and should be held near your mouth (between 6” to 12” is usually recommended) at all times during your presentation.

Web and Podcasts

• Web streaming and podcast (MP4) should be available, check out the home page at http://www.cdrewu.edu/research/DrugAddictionResearch to download.

• Please make sure we have your email

Evaluations

Pacific Southwest Addiction Technology Transfer Center Survey– Pre-conference evaluations (green)– Post-conference evaluations (blue)– Turn in completed forms at registration table

CDU CME-turn in questions and evaluations at the registration table

• David Shurtleff, PhD• NIDA• DIDARP Advisory Committee• Barbara Rowden, M.P.H.• Sylvia Merino, Romulo de Castro Jr, Darlene Parker-

Kelly, Christian Mendez (AV)• Michael Jones, Cecilia Cooper; La Vonne Gordon, Isidra Person-

Lynn, Jeonathan Rodriguez

• Student helpers-Petra Duran, Genesis Duran, Adaku Ume, Rasheed Ivey, Desean Lee, Liliana Rodriguez, Monica DesNoyers

• Tom Freese, Grant Hovik& Beth Rutkowski, UCLA Integrated Substance Abuse Programs/ Pacific Southwest Addiction Technology Transfer Center

• UCLA graduate training program• Eydie London, PhD• Maria Reschke-Ascent Therapeutics• NAPAFASA

Substance Abuse Research at Charles Drew University

For more information about substance abuse research and student opportunities at CDU, contact Dr. Friedman at 310-668-5197 or

theodorefriedman@cdrewu.edu