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NATIONAL CANCER INSTITUTE. DIAGNOSTIC IMAGING PROGRAM. National Institutes of Health National Cancer Institute. Diagnostic Imaging Program. Diagnostic Imaging Program: Update. Money Organizational comments Current Programs Future Plans Concluding comments. NIH Funding for Imaging. - PowerPoint PPT Presentation

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  • DIAGNOSTIC IMAGING PROGRAMNATIONAL CANCER INSTITUTE

  • National Institutes of Health

    National Cancer Institute

    Diagnostic Imaging Program

  • Diagnostic Imaging Program: UpdateMoneyOrganizational commentsCurrent ProgramsFuture PlansConcluding comments

  • NIH Funding for Imaging$Millions

  • DIP Grant Funding$M

  • Diagnostic Imaging Program(DIP)DiagnosticImagingBranchFunctionalImagingBranchImage-guidedTherapyBranchOffice ofImagingTechnologyDivision of Cancer Treatment and Diagnosis(DCTD)CancerDiagnosisProgram(CDP)Develop-mentalTherapeuticsProgram(DTP)CancerTherapyEvaluationProgram(CTEP)RadiationResearchProgram(RRP)NCI

  • Organization10 FTEsD Sullivan, L Clarke, J Hoffman, A Menkens, B Croft, M Torres, J Smith, L Cooley, S Bowles, L Banh3 Part-timeE Staab, J Tatum, C LanglotzFurther expansion is space limited

  • Positions available(of importance to imaging)NCRR Director of BioengineeringNHLBI Program DirectorNCI Scientific Review Administrator

  • Radiology 1999; 212:609-614

  • Recent Programs

    Programs

    Awards

    Amount

    RFA: CA-97-020: Cooperative Trials in Diagnostic Imaging (ACRIN)

    2 U01

    $ 3.0 M yr. 1

    $ 22 M Tot

    RFA: CA-98-024: Development And Application of Imaging In Therapeutic Studies

    9 R01s

    $ 2.8 M yr. 1

    $ 11.6 M Tot

    CA-98-023: Small Animal Imaging Resource Programs (SAIRPs)

    5 U01s

    $ 5.3 M yr. 1

    $ 15.3 M Tot

  • Current Programs(1)

    Program

    Awards

    Amount

    RFA: CA 99- 002 Planning Grants Molecular and Cellular Imaging Centers (Pre-ICMICs):

    6-8 P20s

    $ 2.4 yr. 1

    $ 7.2 M Tot

    RFA: CA 99- 004: Molecular and Cellular Imaging Centers: (ICMICs)

    2 P50s per year

    $4.0 M yr. 1

    $48.0 M Tot

    RFA CA-99-015: Diagnostic Imaging and Guided Therapy in Prostate Cancer (Phased Innovation Award)

    6-8 R21/R33

    $1.6 M yr.1

    $13.6Tot

    PAR-99-149: Diagnostic Imaging and Guided Therapy in Prostate Cancer: SBIR/STTR Initiative

    R43/R44

    Payline

  • Current Programs(2)

    Program

    Awards

    Amount

    PA: 99-082/ 083: Development and Testing of Digital Mammography Displays and Workstations

    R0I/ SBIR/STTR).

    Payline

    PA: 98-008: Exploratory/Developmental Grants for Diagnostic Cancer Imaging

    R21s

    $5.7 M yr. 1

    PAR-99-101: Innovative Technologies for the Molecular Analysis of Cancer: Phase Innovation Award

    R21/R33 SBIR/STTR (PAR-99-100)

    Payline

    PAR-99-102: Applications Of Innovative Technologies For The Molecular Analysis Of Cancer: Phased Technology Application Award

    R21/R33 SBIR/STTR (PAR-99-103)

    Payline

    PAR-99-010: Bioengineering Research Partnership Programs (BRP)

    R01s

    Payline

    PAR-99-009: Bioengineering Research Grants (BRG)

    R01s

    Payline

    BAA No. N01-CM-97065-32 Novel Technologies for Noninvasive Detection, Diagnosis and Treatment of Cancer

    Contracts

    $ 4 M yr.1

    $16 M Tot

  • Collaborative Programs

    Program

    Awards

    Amount

    PA 98-092: Shared Resources for Scientists Outside NCI Cancer Centers

    R01 or P01

    Payline

    NLM 99-103: Visible Human Project Image Processing Tools (NLM)

    Contracts

    RFA: AI-99-004: New Imaging Technologies For Autoimmune Diseases

    R01s

    $3.5 M yr. 1

    $17.5 M Tot

    RFA: CA-99-013: Cancer Intervention and Surveillance Modeling Network (CISNET)

    U01s

    $1.5 M yr. 1

    $6.0 M Tot

  • CTEP Collaborative Programs

    Program

    Awards

    CTEP Protocol Review

    Contracts

    U01s

    CA-98-007: Pediatric Brain Tumor Clinical Trials Consortium

    U01, imaging required

    RFA for new Centers

    U54s imaging required

    RFP for Phase I & II clinical trials

    Contracts imaging required

  • DIP Standards ActivitiesDICOM / Working Group on Clinical Trials DataRSNA - IHE / RSNA - image archive collaborationsStructured reporting collaborations: DICOM, SNOMED, ACR, RSNAImage database standards: RFA

  • NCI - Imaging Industry Relations ForumClear description of HCFA decision rulesPolicy for conditional coverage of emerging imaging technologiesRe-evaluation of FDA policies, esp. re: tracers or procedures of low riskAssure full range of NCI support mechanisms for imaging science.

  • NCI Training Activities

  • R 25Cancer Education and Career Development Program

  • R 25 Cancer Education and Career Development ProgramMultidisciplinaryInstitutional awardSalary support for PI and core facultyTrainee salary up to $75,000Research support up to $20,000 per trainee5 yr. grant, renewable8% indirect

  • K07 / K08 / K23K 07 Epidemiology (limited use by radiology)K 08 Clinician: Bench science(limited use by radiology)K23 Clinician: Patient-oriented (hands-on; obtain consent form)(no imaging applications yet)Salary $75,000/ Research $30,000

  • T32 Training Grants - ImagingFrom 1/97-10/99 (6 NCI deadlines) 6.5% of applications submitted were imaging-related 57.1% of imaging-related T32s were funded 54.2% of T32 applications submitted to NCI were funded

  • T32 Training Grants - ImagingYrsPITitle 24Kuhl, DavidCancer Research Training in Nuclear Medicine 17Wagner, HenryRes. Training in Use of Tracer Principles in Oncology 14Brady, ThomasNuclear Magnetic Research 10Zerhouni, EliasResearch Training in Oncology Imaging 7Glazer, GaryAdvanced Techniques for Cancer Imaging 5Clouse, MelvinDeaconess Research Training in Cancer Radiology 4Baum, StanleyTraining in Innovative Cancer Imaging Technologies 3Hawkins, RandallResearch Training in Diagnostic Oncology 2Wehrli, FelixTraining in Quantitative Magnetic Resonance Imaging 23Hoffman, EdwardResearch Training in Biomedical Physics 23Bedford, JoelRadiological Sciences Basic to Cancer Research 21DeLuca, PaulU.W. Radiological Sciences Training Program 18Alpert, NathanielPostgraduate Program in Radiological Science 10Doi, KunioResearch Training in Medical Physics

  • Research Training Grant InformationCall Brian Kimes301 496 8537email:bk34t@nih.gov

  • Future Plans - DevicesProposed PA: R21/R33 for imaging technology developmentRFP for ultrasound research interfaceRFA for spiral CT image databaseProposed program to support production of beta units for clinical trialsProposed additional Centers with technology development component

  • Future Plans - Pharmaceuticals (Imaging agents)Pharmaceutical categories of interest:1. Non-PET tracers2. PET tracers3. Bulk agents (pharmacologic effect)4. Radiolabeled therapeutic agents (non-sealed-source agents)

  • Future Plans - Pharmaceuticals (Imaging agents)Proposed program to support development of novel imaging probes.Proposed program to support R & D necessary for IND, and provide supply needed for clinical trials.

  • Concluding CommentsMolecular imaging is future priorityDIP funding increased 40 %More applications lead to more fundingPatient accrual needs attentionRewards for team science need attentionThink R25 for research training grants

  • Sources of NCI imaging information to publicWebsite: URL = www.nci.nih.gov/dip/

    Email Newsletter

  • Handouts availableURLs of interestTraining program informationCopy of Acad Rad article: Radiologic Sciences Research in the Next CenturyDIP NewsletterEverything you ever wanted to know Cancer information pamphlets

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