Failed Back Surgery Syndrome – Part 1

Diagnosis and Evaluation

Failed Back Surgery Syndrome – Part 1

Diagnosis and Evaluation

Richard K. Osenbach, M.D.

Division of Neurosurgery

Duke University Medical Center

Richard K. Osenbach, M.D.

Division of Neurosurgery

Duke University Medical Center Brought to you by

Chronic Pain – Scope of the ProblemChronic Pain – Scope of the Problem

9% – 28% of the population suffers from moderate to severe chronic non-cancer pain

American Pain Society (2002); Chronic pain in America: roadblocks to relief

86 million Americans suffer from chronic pain

66 million Americans partially/totally disabled

8 million disabled by LBP65,000 cases of permanent disability diagnosed annually

100 billion dollars in annual economic losses

40 million physician visits per year

515 million lost workdays annually

Business Week (1999)

9% – 28% of the population suffers from moderate to severe chronic non-cancer pain

American Pain Society (2002); Chronic pain in America: roadblocks to relief

86 million Americans suffer from chronic pain

66 million Americans partially/totally disabled

8 million disabled by LBP65,000 cases of permanent disability diagnosed annually

100 billion dollars in annual economic losses

40 million physician visits per year

515 million lost workdays annually

Business Week (1999)Brought to you by

Pain TypesPain TypesNOCICEPTIVE PAIN

results from ongoing activation of mechanical, thermal, or chemical nociceptors

typically opioid-responsive

eg. pain related to mechanical instability

NEUROPATHIC PAIN

spontaneous or evoked pain that occurs in the absence of ongoing tissue damage

typically opioid-resistant***

eg. pain secondary to nerve root injury

NOCICEPTIVE PAIN

results from ongoing activation of mechanical, thermal, or chemical nociceptors

typically opioid-responsive

eg. pain related to mechanical instability

NEUROPATHIC PAIN

spontaneous or evoked pain that occurs in the absence of ongoing tissue damage

typically opioid-resistant***

eg. pain secondary to nerve root injury Brought to you by

Neuropathic PainNeuropathic Pain

Pain in absence of ongoing tissue damage

Pain in an area of sensory loss

Paroxysmal or spontaneous pain

Characteristics of pain: burning, pulsing, stabbing

Allodynia, hyperalgesia, or dysesthesias

Delay in onset following injury

Presence of major neurological deficit

Poor response to opioids

Pain in absence of ongoing tissue damage

Pain in an area of sensory loss

Paroxysmal or spontaneous pain

Characteristics of pain: burning, pulsing, stabbing

Allodynia, hyperalgesia, or dysesthesias

Delay in onset following injury

Presence of major neurological deficit

Poor response to opioids

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Biopsychosocial Model of PainBiopsychosocial Model of Pain

Pain Behavior

Suffering

Pain

Nociception

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Failed Back Surgery SyndromeFailed Back Surgery SyndromeFBSS is a term applied to a heterogeneous group of individuals who share only one characteristic - continued back and/or extremity pain following one or more spinal operations

15% of patients will experience persistent or recurrent symptoms

Spectrum of abnormalities ranging from purely organic to purely psychological, but in most cases consists of a physiological abnormality complicated by psychological factors

FBSS is perhaps the prototypical example of chronic pain as a biopsychosocial disorder

FBSS is a term applied to a heterogeneous group of individuals who share only one characteristic - continued back and/or extremity pain following one or more spinal operations

15% of patients will experience persistent or recurrent symptoms

Spectrum of abnormalities ranging from purely organic to purely psychological, but in most cases consists of a physiological abnormality complicated by psychological factors

FBSS is perhaps the prototypical example of chronic pain as a biopsychosocial disorder

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Failed Back Patient ProfileFailed Back Patient Profile

Pain and suffering often disproportionate to any identifiable disease process

Depression

Physical deconditioning

Inappropriate use of physician-prescribed medications

Superstitious beliefs about bodily functions

Failure to work or perform expected physical and cognitive activities

No active medical problems that can be remediated with the expectation of relief of pain

Pain and suffering often disproportionate to any identifiable disease process

Depression

Physical deconditioning

Inappropriate use of physician-prescribed medications

Superstitious beliefs about bodily functions

Failure to work or perform expected physical and cognitive activities

No active medical problems that can be remediated with the expectation of relief of pain

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The “Ds” of FBSSThe “Ds” of FBSS

Disuse

Deconditioning

Drug misuse

Dependence

Depression

Disability

Disuse

Deconditioning

Drug misuse

Dependence

Depression

DisabilityBrought to you by

Post-operative Causes of Back PainPost-operative Causes of Back Pain

Deconditioning Trauma

Muscle spasm Wrong level fused

Myofascial pain Insufficient levels fused

Spinal instability Pseudomeningocele

Diskogenic pain Graft donor site pain

Facet arthropathy Psychosocial factors

Infection

Pseudarthrosis

Loose hardware

Arachnoiditis

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Post-operative Causes of Leg PainPost-operative Causes of Leg Pain

Retained disk fragment Arachnoiditis

Recurrent HNP Synovial cyst

Far lateral disk Root sleeve meningocele

Lateral recess stenosis Loose hardware

Inadequate decompression Facet fracture

Wrong level decompressed Psychosocial factors

Nerve root injury

Retained foreign body

Epidural fibrosis Brought to you by

Goals of Chronic Pain Management in Patients with FBSS

Goals of Chronic Pain Management in Patients with FBSS

Functional improvement

Functional improvement

Functional improvement!!!Improvement in physical activities and exercise tolerance

Reduction in narcotic use

Reduction in healthcare consumption

Return to work

Pain reduction

Functional improvement

Functional improvement

Functional improvement!!!Improvement in physical activities and exercise tolerance

Reduction in narcotic use

Reduction in healthcare consumption

Return to work

Pain reductionBrought to you by

Principles of Chronic Pain ManagementPrinciples of Chronic Pain Management

1. “Single most important ingredient is the existence of health care providers who are willing to work together as a team.”

2. Providers must take an interest in chronic disease and not be overly focused on acute illness as is fostered by the biomedical model

3. Commitment of the provider to the patient

1. “Single most important ingredient is the existence of health care providers who are willing to work together as a team.”

2. Providers must take an interest in chronic disease and not be overly focused on acute illness as is fostered by the biomedical model

3. Commitment of the provider to the patient

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Principles of Chronic Pain ManagementPrinciples of Chronic Pain Management

4. Patient must be motivated to change their lives and must be willing to do the therapeutic work

5. Treatment represents the beginning of a journey to reclaim one’s life from the pain problem; long-term support is required to maintain success

6. Patient selection is a key to success. Attempting to treat the untreatable results in demoralization of the treatment team

4. Patient must be motivated to change their lives and must be willing to do the therapeutic work

5. Treatment represents the beginning of a journey to reclaim one’s life from the pain problem; long-term support is required to maintain success

6. Patient selection is a key to success. Attempting to treat the untreatable results in demoralization of the treatment team

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Multidisciplinary Pain ManagementMultidisciplinary Pain ManagementCollaborative efforts of a group of providers

PhysiciansNursesPsychologistsPhysical TherapistsVocational counselorsSocial workersSupport staff

Team work is essentialExtensive interactions between team membersAdequate space

Collaborative efforts of a group of providersPhysiciansNursesPsychologistsPhysical TherapistsVocational counselorsSocial workersSupport staff

Team work is essentialExtensive interactions between team membersAdequate space Brought to you by

Multidisciplinary Pain ProgramsMultidisciplinary Pain ProgramsNo single accepted formatGeneric concept and plan common to all programs of this typeBased on biopsychosocial model of painComplaint of pain generated by a combination of events in any particular patientSimultaneously address all issues Present patient with a single treatment program that encompasses all the TREATABLE issues

No single accepted formatGeneric concept and plan common to all programs of this typeBased on biopsychosocial model of painComplaint of pain generated by a combination of events in any particular patientSimultaneously address all issues Present patient with a single treatment program that encompasses all the TREATABLE issues

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Common Features of Multidisciplinary Pain Management

Common Features of Multidisciplinary Pain Management

Physical therapy and rehabilitation

Medication management

Patient education about pain and body function

Psychological treatments

Coping skills training

Vocational assessment

Therapies targeted toward improving the likelihood of return to work

Surgical interventions for selected patients

Physical therapy and rehabilitation

Medication management

Patient education about pain and body function

Psychological treatments

Coping skills training

Vocational assessment

Therapies targeted toward improving the likelihood of return to work

Surgical interventions for selected patients Brought to you by

Multidisciplinary Pain Clinic PersonnelMultidisciplinary Pain Clinic PersonnelPhysicians

Neurosurgeon

Orthopedic surgeon

Anesthesiologist

Neurologist

Physiatrist

Internal medicine

Psychiatrist

Addictionologist

Nurses

Psychologists

Physicians

Neurosurgeon

Orthopedic surgeon

Anesthesiologist

Neurologist

Physiatrist

Internal medicine

Psychiatrist

Addictionologist

Nurses

Psychologists

Physical Therapist

Occupational Therapist

Vocational counselor

Social worker

Dietician

Recreational staff

Administrative support staff

Physical Therapist

Occupational Therapist

Vocational counselor

Social worker

Dietician

Recreational staff

Administrative support staff

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Failed Back Surgery SyndromeSurgical Complications

Failed Back Surgery SyndromeSurgical Complications

Disk space infection

Iatrogenic instability

Nerve root injury

Retained disk fragment

Recurrent disk herniation

Inadequate decompression

Complications of fusion and instrumentation

Adhesive arachnoiditis

Disk space infection

Iatrogenic instability

Nerve root injury

Retained disk fragment

Recurrent disk herniation

Inadequate decompression

Complications of fusion and instrumentation

Adhesive arachnoiditis

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Failed Back Surgery SyndromePhysician Decision Making

Failed Back Surgery SyndromePhysician Decision Making

Poor patient selection

Poor patient selection

Poor patient selection

Poor patient selection

Poor patient selection

Poor patient selection

Poor patient selection

Poor patient selection

Poor patient selection

Poor patient selection

Poor patient selection

Poor patient selection

Poor patient selection

Poor patient selection Brought to you by

The most common cause of failed back syndrome is poor judgment on the part of the physician.

Surgery prescribed as a last resort, with a hope and a prayer that it might alleviate the pain.

The most common cause of failed back syndrome is poor judgment on the part of the physician.

Surgery prescribed as a last resort, with a hope and a prayer that it might alleviate the pain.

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When in doubt, it’s a good idea to take a history and examine the patient

When in doubt, it’s a good idea to take a history and examine the patient

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Evaluation of the Patient with FBSSEvaluation of the Patient with FBSS

Detailed pain history including prior treatments and MOST IMPORTANTLY the outcome of each

Obtain appropriate imaging studies (including those on which surgical decisions were based)

Attempt to establish the underlying cause of the pain; however……….

Detailed pain history including prior treatments and MOST IMPORTANTLY the outcome of each

Obtain appropriate imaging studies (including those on which surgical decisions were based)

Attempt to establish the underlying cause of the pain; however……….

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DO NOT get caught up in an endless search for THE PAIN GENERATORDO NOT get caught up in an endless search for THE PAIN GENERATOR

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Romancing the Pain GeneratorRomancing the Pain Generator

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Pain HistoryPain History

Where is it located?

Does the pain radiate?

When did it start and under what circumstances?

What is the quality of the pain?

What is the severity of the pain (VAS scores)

What factors make it worse?

What factors make it better?

Are there associated symptoms?

Where is it located?

Does the pain radiate?

When did it start and under what circumstances?

What is the quality of the pain?

What is the severity of the pain (VAS scores)

What factors make it worse?

What factors make it better?

Are there associated symptoms? Brought to you by

Pain HistoryPain History

Effect of pain on sleep

Medications taken for pain

Health professionals consulted

Patient’s beliefs concerning the cause of pain

Expectations of outcome of treatment

Family expectations

Pain reduction required for “reasonable activities

Effect of pain on sleep

Medications taken for pain

Health professionals consulted

Patient’s beliefs concerning the cause of pain

Expectations of outcome of treatment

Family expectations

Pain reduction required for “reasonable activitiesBrought to you by

Treatment HistoryTreatment History

What therapies have been tried and what were the outcomes?

Physical therapy

Injections Epidural steroids, nerve root blocks, facet blocks,

etc

Medication history

What drugs?

Dose?

How long?

Effect?

What therapies have been tried and what were the outcomes?

Physical therapy

Injections Epidural steroids, nerve root blocks, facet blocks,

etc

Medication history

What drugs?

Dose?

How long?

Effect?Brought to you by

Physical ExaminationPhysical Examination

Rarely diagnostic

Principally serves to establish the current level of physical impairment

Lack of physical abnormality should not be used to deny a patient evaluation and therapy if indicated

Rarely diagnostic

Principally serves to establish the current level of physical impairment

Lack of physical abnormality should not be used to deny a patient evaluation and therapy if indicated

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Examination of the Lumbar SpineExamination of the Lumbar Spine

Inspection, palpation, and evaluation of ROM

Abnormalities of muscle tone

Local tenderness

Reduced ROM

Neurological exam

Muscle strength

Sensation

Reflexes

Nerve root tension signs

Sciatic and femoral stretch test

Inspection, palpation, and evaluation of ROM

Abnormalities of muscle tone

Local tenderness

Reduced ROM

Neurological exam

Muscle strength

Sensation

Reflexes

Nerve root tension signs

Sciatic and femoral stretch testBrought to you by

Imaging StudiesImaging StudiesStatic plain radiographs

Spinal alignmentFlexion/extension views

InstabilityComputed tomography (CT)

Bony surgical defects Hardware placementFusion mass

Magnetic resonance imaging (MRI)Soft tissue and neural structures

Radionuclide imagingTechnetium99 bone scanIndium111 WBC scan

Static plain radiographsSpinal alignment

Flexion/extension viewsInstability

Computed tomography (CT)Bony surgical defects Hardware placementFusion mass

Magnetic resonance imaging (MRI)Soft tissue and neural structures

Radionuclide imagingTechnetium99 bone scanIndium111 WBC scan

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Surgically-Correctable PathologySurgically-Correctable Pathology

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Surgically-Correctable PathologySurgically-Correctable Pathology

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Electrophysiological StudiesElectrophysiological Studies

EMG is likely of greater utility in FBSS than in primary low back pain and sciatica

Greatest use is for establishing the presence of a peripheral neuropathy

May be helpful for defining a feigned neurological deficit

Rarely using in decision-making regarding treatment

EMG is likely of greater utility in FBSS than in primary low back pain and sciatica

Greatest use is for establishing the presence of a peripheral neuropathy

May be helpful for defining a feigned neurological deficit

Rarely using in decision-making regarding treatment

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Diagnostic BlockadeDiagnostic BlockadeRationale is straightforwardIn practice, it is much more complicatedSpecificity may be lowSingle blocks (positive or negative) have a high error ratePlacebo controls provide the most accurate informationMultiple blocks using different agents

Rationale is straightforwardIn practice, it is much more complicatedSpecificity may be lowSingle blocks (positive or negative) have a high error ratePlacebo controls provide the most accurate informationMultiple blocks using different agents

BLOCKS ARE ADJUNCTS AND SHOULD NEVER BE SUBSTITUTED FOR SOUND CLINICAL JUDGEMENT !

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Sensitivity and Specificity of Diagnostic Blocks

Sensitivity and Specificity of Diagnostic Blocks

Differences in pain processing

Technical aspects

Incorrect needle placement

Large volumes of anesthetic

Effects local anesthetics

Psychological issues

Environmental cues, expectations, anxiety, etc.

Placebo response

Differences in pain processing

Technical aspects

Incorrect needle placement

Large volumes of anesthetic

Effects local anesthetics

Psychological issues

Environmental cues, expectations, anxiety, etc.

Placebo response

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Facet BlockFacet Block

Blockade of the innervation of the facet joint will relieve

pain in some patients with facet disease

Blockade of the innervation of the facet joint will relieve

pain in some patients with facet diseaseBrought to you by

Facet BlockFacet Block

Rarely useful in patient with FBSS

Transitional facet disease above a fused level

Anatomy obliterated and accurate block not possible

Blockade of pseudarthrosis may sometimes be useful

Rarely useful in patient with FBSS

Transitional facet disease above a fused level

Anatomy obliterated and accurate block not possible

Blockade of pseudarthrosis may sometimes be useful

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Selective Nerve Root BlockSelective Nerve Root BlockMust be done accurately to provide any useful information

One root at a time

Small volume of local anesthetic without steroids

Confirm the presence of an adequate block

Confirm findings on repetitive blocks

Must be done accurately to provide any useful information

One root at a time

Small volume of local anesthetic without steroids

Confirm the presence of an adequate block

Confirm findings on repetitive blocksBrought to you by

Therapeutic HeatTherapeutic Heat

Increases muscle temperature, decrease spindle sensitivity, increases blood flowPain relief, increase in tissue extensibility, reduction of muscle spasmSuperficial heat

Greatest effect 0.5cm from skinDeep heat

Ultrasound diathermy Heat up to 5cm deep to skin Treatment of deep soft tissues

HydrotherapyBuoyancy minimizes stress to joints

Increases muscle temperature, decrease spindle sensitivity, increases blood flowPain relief, increase in tissue extensibility, reduction of muscle spasmSuperficial heat

Greatest effect 0.5cm from skinDeep heat

Ultrasound diathermy Heat up to 5cm deep to skin Treatment of deep soft tissues

HydrotherapyBuoyancy minimizes stress to joints Brought to you by

Cold TherapyCold Therapy

Affects muscle spindle and may modulate neurotransmitters

Provides longer pain relief than heat

Ice and gel packs, vapocoolant sprays, cold baths

Particularly useful for trigger points,

Treatment of choice for acute injuries

Affects muscle spindle and may modulate neurotransmitters

Provides longer pain relief than heat

Ice and gel packs, vapocoolant sprays, cold baths

Particularly useful for trigger points,

Treatment of choice for acute injuries

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TENSTENS

Electrical energy transmitted from skin surface

Rationale based on “Gate Theory” of pain

Most effective at high-frequency, low-intensity

“Acupuncture TENS” – high-intensity, low-frequency

Questionable benefit for chronic back pain

Electrical energy transmitted from skin surface

Rationale based on “Gate Theory” of pain

Most effective at high-frequency, low-intensity

“Acupuncture TENS” – high-intensity, low-frequency

Questionable benefit for chronic back pain

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Therapeutic Exercise and MassageTherapeutic Exercise and Massage

Essential for restoration of function

“Hurt” vs. “Harm”

Stretching exercises

Strengthening exercises

Aerobic exercises

Therapeutic massage

Essential for restoration of function

“Hurt” vs. “Harm”

Stretching exercises

Strengthening exercises

Aerobic exercises

Therapeutic massage

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Anticonvulsant Agents (AEDS)Anticonvulsant Agents (AEDS)

Similarities in pathophysiology of neuropathic pain and epilepsy

All AEDS ultimately act on ion channels

Efficacy of AEDS most clearly established for neuropathic conditions characterized by episodic lancinating pain

Most clinical studies have focused on DPN and PHN

Use of AEDS in patients with FBSS is nearly entirely empiric

Similarities in pathophysiology of neuropathic pain and epilepsy

All AEDS ultimately act on ion channels

Efficacy of AEDS most clearly established for neuropathic conditions characterized by episodic lancinating pain

Most clinical studies have focused on DPN and PHN

Use of AEDS in patients with FBSS is nearly entirely empiric Brought to you by

Antidepressant AnalgesicsAntidepressant Analgesics

Relieves all components of neuropathic pain

Clear separation of analgesic and antidepressant effects

Although other agents (eg anti-epileptics)) may be regarded as 1st line therapy over antidepressants, there is no good evidence for this practice

More selective agents are either less effective or not useful (serotonergic, noradrenergic)

Relieves all components of neuropathic pain

Clear separation of analgesic and antidepressant effects

Although other agents (eg anti-epileptics)) may be regarded as 1st line therapy over antidepressants, there is no good evidence for this practice

More selective agents are either less effective or not useful (serotonergic, noradrenergic)

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Guidelines for Use of Antidepressants in Pain Management

Guidelines for Use of Antidepressants in Pain Management

Eliminate all other ineffective analgesicsStart low and titrate slowly to effect or toxicityNortriptyline or amitriptyline for initial treatmentMove to agents with more noradrenergic effectsConsider trazodone in patients with poor sleep patternTry more selective agents if mixed agents ineffectiveDo NOT prescribe monoamine oxidase inhibitorsTolerance to anti-muscarinic side effects usually takes weeks to developWithdraw therapy gradually to avoid withdrawal syndrome

Eliminate all other ineffective analgesicsStart low and titrate slowly to effect or toxicityNortriptyline or amitriptyline for initial treatmentMove to agents with more noradrenergic effectsConsider trazodone in patients with poor sleep patternTry more selective agents if mixed agents ineffectiveDo NOT prescribe monoamine oxidase inhibitorsTolerance to anti-muscarinic side effects usually takes weeks to developWithdraw therapy gradually to avoid withdrawal syndrome

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Antidepressants for LBP-RCTAntidepressants for LBP-RCTAuthor Agent No. Effect Comments

Jenkins et al., 1976 Imipramine 50mg

4 weeks

44/59 No Parallel design

Alcott et al., 1982 Imipramine 150mg

8 weeks

41/50 No Parellel design; poss role for pain

Godkin et al., 1990 Trazadone 200mg 42 No Parellel design

Serotonergic agent

Usha et al., 1996 Fluoxetine 20mg

Elavil 25mg

Placebo

4 weeks

59 Yes Parallel design

Fluoxetine more effective with fewer SE

Atkinson et al., 1998 Nortriptyline 100mg

Inert placebo

57/78 Yes Parallel design

Non-depressed pts

Dickens et al., 2000 Paroxetine 20mg 61/92 No Parellel design

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Opioid Therapy - RCTOpioid Therapy - RCTPain Type Study Control Results

Nociceptive Arner & Meyerson, 1988 Placebo Pos

Kjaersgaard-Anderson, 1990 Paracetamol Pos***

Neuropathic Arner & Meyerson, 1988 Placebo Neg

Dellemijn & Vanneste, 1997 Placebo/Valium Pos

Kupers, et al., 1991 Placebo Pos

Rowbotham et al., 1991 Placebo Pos

Idiopathic Arner & Meyerson, 1988 Placebo Neg

Kupers, et al., 1991 Placebo Neg

Moulin et al., 1996 Benztropine Pos***

Unspecified Arkinstall et al., 1995 Placebo Pos***

Mays et al., 1987 Placebo/Bupiv Pos

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Opioid Therapy – Prospective Uncontrolled Studies

Opioid Therapy – Prospective Uncontrolled Studies

Pain Type Reference ResultsNociceptive McQuay et al., 1992 Pos

Neuropathic Fenollosa et al., 1992 Pos

McQuay et al., 1992 Mixed

Urban et al., 1986 Pos

Idiopathic McQuay et al., 1992 Neg

Mixed/Unspecified Auld et al. 1985 Pos

Gilmann & Lichtigfeld, 1981 Pos

Penn and Paice, 1987 Pos

Plummer et al., 1991 Mixed

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Tramadol for LBPTramadol for LBP

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NSAIDS for Chronic LBPNSAIDS for Chronic LBP

One systematic reviews of 2 studies within framework of Cochrane Collaboration

NSAID vs. PlaceboBetter short-term pain relief

NSAID vs. Acetominophen (N=4)No difference in short-term pain reliefBetter overall improvement

One systematic reviews of 2 studies within framework of Cochrane Collaboration

NSAID vs. PlaceboBetter short-term pain relief

NSAID vs. Acetominophen (N=4)No difference in short-term pain reliefBetter overall improvement

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CorticosteroidsCorticosteroids

Useful in the short term for treatment of radicular pain

Limited role in the long-term treatment of FBSS

Epidural or transforaminal steroids for selected patients

Cochrane Review (Nelemans, et al., 2002)

Most trials included patients with radicular pain

No significant difference in pain relief after 6 weeks or 6 months between ESI and placebo

Useful in the short term for treatment of radicular pain

Limited role in the long-term treatment of FBSS

Epidural or transforaminal steroids for selected patients

Cochrane Review (Nelemans, et al., 2002)

Most trials included patients with radicular pain

No significant difference in pain relief after 6 weeks or 6 months between ESI and placebo

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Topical TreatmentsTopical Treatments

Aspirin preparationsEg. aspirin in chloroform

Local anestheticsTopical 5% lidocaine patch

EMLAEutectic mixture of local anesthetics

Capsaicin

Aspirin preparationsEg. aspirin in chloroform

Local anestheticsTopical 5% lidocaine patch

EMLAEutectic mixture of local anesthetics

CapsaicinBrought to you by

Lidocaine Patch for LBPLidocaine Patch for LBP

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CannabinoidsCannabinoidsStrong laboratory data supporting an analgesic effect of cannabinoidsEfficacy of cannabinoids in human has been modest at bestEffectiveness hampered by unfavorable therapeutic indexCampbell (2001) – systematic review of 9 clinical trials of cannabinoids

Cancer pain (5), Chronic non-cancer pain (2), acute pain (2)Analgesic effect estimated equivalent to 50-120mg codeineAdverse effects reported in all studies

RCT have shown modest benefits when compared with placeboIncreased incidence of psychiatric illness and cognitive dysfunction

Strong laboratory data supporting an analgesic effect of cannabinoidsEfficacy of cannabinoids in human has been modest at bestEffectiveness hampered by unfavorable therapeutic indexCampbell (2001) – systematic review of 9 clinical trials of cannabinoids

Cancer pain (5), Chronic non-cancer pain (2), acute pain (2)Analgesic effect estimated equivalent to 50-120mg codeineAdverse effects reported in all studies

RCT have shown modest benefits when compared with placeboIncreased incidence of psychiatric illness and cognitive dysfunction

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Botulinum Toxin for Chronic LBPWorld Congress

Botulinum Toxin for Chronic LBPWorld Congress

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Multidisciplinary Treatment OutcomesMultidisciplinary Treatment Outcomes

Decrease in pain self-rating by about 30%

Opioid consumption reduced by about 60%

Pain-related physician visits decrease by 60%

Physical activities increase by 300%

Gainful employment occurs in 60%

Decrease in pain self-rating by about 30%

Opioid consumption reduced by about 60%

Pain-related physician visits decrease by 60%

Physical activities increase by 300%

Gainful employment occurs in 60%Brought to you by

Comprehensive Pain ManagementPain Reduction

Comprehensive Pain ManagementPain Reduction

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Rosomoff Comprehensive Pain Center, 1999-2005

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Comprehensive Pain ManagementFunctional Improvement

Comprehensive Pain ManagementFunctional Improvement

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Rosomoff Comprehensive Pain Center, 1999-2005Brought to you by

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Comprehensive Pain ManagementQOL Improvement

Comprehensive Pain ManagementQOL Improvement

Rosomoff Comprehensive Pain Center, 1999-2005Brought to you by

Comprehensive Pain ManagementEmployed/Work Ready

Comprehensive Pain ManagementEmployed/Work Ready

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708090

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Discharge 3 Months 1 Year

Rosomoff Comprehensive Pain Center, 1999-2005

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Comprehensive Pain ManagementOpioid Usage

Comprehensive Pain ManagementOpioid Usage

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Rosomoff Comprehensive Pain Center, 1999-2005

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Comprehensive Pain ManagementPatient Satisfaction

Comprehensive Pain ManagementPatient Satisfaction

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Rosomoff Comprehensive Pain Center, 1999-2005Brought to you by

Treatment OutcomesFlor et. al., Pain 1992Treatment Outcomes

Flor et. al., Pain 1992

Metanalysis of 65 studies with 3,089 patients

Average pain reduction 20% (0-60%)

Return to work 67%

Standard treatments (24%)

Dramatic reductions in health care consumption and additional surgery

Steig et al (Pain 1986) - $280,000 savings in health care expenses up to retirement

Okifuji et al (1998) – 280 million saving per year if patients receiving standard medical/surgical treatments were treated in a multidisciplinary clinic

Metanalysis of 65 studies with 3,089 patients

Average pain reduction 20% (0-60%)

Return to work 67%

Standard treatments (24%)

Dramatic reductions in health care consumption and additional surgery

Steig et al (Pain 1986) - $280,000 savings in health care expenses up to retirement

Okifuji et al (1998) – 280 million saving per year if patients receiving standard medical/surgical treatments were treated in a multidisciplinary clinic Brought to you by

So What’s The Problem?So What’s The Problem?

It is difficult to obtain funding and reimbursement for this type of healthcare , despite the fact that more outcome data are available than for any other type of chronic pain treatment

It is difficult to obtain funding and reimbursement for this type of healthcare , despite the fact that more outcome data are available than for any other type of chronic pain treatment

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“The only antidote for mental suffering

is physical pain”

“The only antidote for mental suffering

is physical pain”“That’s the most

ridiculous thing I’ve ever heard.”

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This platform has been started by Parveen Kumar Chadha with the vision that nobody should suffer the way he has suffered because of lack and improper healthcare facilities in India. We need lots of funds manpower etc. to make this vision a reality please contact us. Join us as a member for a noble cause.

This platform has been started by Parveen Kumar Chadha with the vision that nobody should suffer the way he has suffered because of lack and improper healthcare facilities in India. We need lots of funds manpower etc. to make this vision a reality please contact us. Join us as a member for a noble cause.

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