diagenode epigentic solutions
TRANSCRIPT
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Diagenode Epigenetic Solutions
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Business focusDeveloping and commercializing well-differentiated, high-value products for epigenetics research (and diagnostics in Europe)
Core competenciesStrong industry and application expertise; sonication experts; R&D and scientific leadership in epigenetics
Commercial successHigh-profile customer base, market leadership in epigenetics, trusted reputation in sonication; quality ChIP-grade antibodies & kits
Innovative productsSX-8G IP-Star™ and SX-8G IP-Star™ Compactautomated systems for ChIP and methylation assays and Bioruptor®NGS for the next generation sequencing market
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Diagenode Overview
• Privately held Belgian Biotech company
• Started in June 2003• Located at the building• Subsidiary in US: Diagenode Inc• 40 employees
Diagenode complete epigenetic solutions
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Diagenode Belgium
Diagenode Inc.USA
Where we are
Sales offices
Distributors
© Diagenode. All rights reserved. Confidential not for replication or duplication.
Diagenode complete epigenetic solutions
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© Diagenode. All rights reserved. Confidential not for replication or duplication.
Diagenode: R&D Innovation and CollaborationReinforce Industry Leadership
Recent EU Consortium Grants in Epigenetic Researchs Including Diagenode as Co-Investigator
EU Grants Awarded
Diagenode complete epigenetic solutions
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DNA/RNA/cDNA Chromatin
Shearing with Bioruptor®
(controlled size fragments)
ChIP assay with Diagenode’s kits
Shearing with Bioruptor®
(controlled size fragments)
MeDIP, MethylCap assay with Diagenode’s kits
ChIP or Methylation Assay automation with IP-star
Next-gen sequencing library prep. Automation
with IP-Star
From sample to results
Diagenode complete epigenetic solutions
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Diagenode Bioruptor Shearing systems and SX-8G IP-Star Automated Platforms
for Epigenetic Applications
Diagenode complete epigenetic solutions
A key company goal:
Making epigenetics accessible, automated and
consistent
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Over 200 publications cite the Bioruptor in many biological applications
Bioruptor® Sonicator product range
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11: 115 bp
10: 135 bp
9: 183 bp
8: 200 bp
7: 234 bp
6: 319 bp
5: 476 bp
3: 848 bp
2: 1038 bp
1: 1230 bp
4: 696 bp
Bioruptor®
NGS produces DNA fragments in a broad size range from 100 bp to 1200 bp
Bioruptor®NGS for Next Generation Sequencing market
© Diagenode. All rights reserved. Confidential not for replication or duplication.
Bioruptor®NGS and Bioruptor® Standard are compatible with
PGM™ system
Bioruptor® Sonicator product range
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Broadest range ever for consistent DNA hydroxymethylation and DNA methylation studies
Kits & reagents
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Low Cell ChIP kit One Day CIP kit
1000Cell nr
1x106 2x106 10x1065x106
High Cell ChIP kit
Recover more DNA from a single ChIP experiment in a Magnetic format
Kits for Chromatin Immunoprecipitation
Kits & reagents
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Diagenode is recognized as the “best-in-class” epigenetic antibody company
ChIP-seq comparison of different batches
H3K9/14ac
H3K9/14ac
H3K9/14ac
Kits & reagents
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SX-8G IP-Star® CompactSX-8G IP-Star®
Diagenode Automated Platforms for Epigenetic Applications
SX-8G IP-Star™ Automated Platforms forEpigenetic Applications
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25 SX-8G IP-Star Units around the world
SX-8G IP-Star™ Automated Platforms forEpigenetic Applications
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SX-8G IP-Star™ Automated Platforms forEpigenetic Applications
Intuitive touch screen panelSoftware training not required
Ideal systems for protocol optimization: researcher can define key experimental parameters
SX-8G IP-Star™ Compact
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Mixing is achieved by continuous pipetting ofreagents throughout the incubation
Washing is achieved by capturing the beads with the magnet and dispensing reagents.
Magnetic separation technology
SX-8G IP-Star™ Automated Platforms forEpigenetic Applications
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Bioruptor™
Sonicator
IP-Star™
SX-8G IP-Star™ Automated Platforms forEpigenetic Applications
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Dispense only bead , antibody and chromatin in the reagents manually in a 12x 200-µl tubes strip
1
12
(Front view)
Easy and fast reagents preparation!
Reagents preparation in tube strips
SX-8G IP-Star™ Automated Platforms forEpigenetic Applications
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Fully validation of SX-8G IP-Star Automated by researchers
SX-8G IP-Star™ Automated Platforms forEpigenetic Applications
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SX-8G IP-Star™ Automated Platforms forEpigenetic Applications
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A key company goal:
Making epigenetics easy, accessible, automated and
consistent
Diagenode Bioruptor Shearing systems and SX-8G IP-Star Automated Platforms
for Epigenetic Applications
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THANK YOU FOR YOUR ATTENTION