detox what i.foresman
TRANSCRIPT
What is What is
““detoxing” or detoxing” or
“cleansing“cleansing””??
The Liver is the MajorThe Liver is the MajorDetoxifying OrganDetoxifying Organ
The liver utilizes a two-phase system in detoxifying the body of harmful substances:
• 11stst:: Transforms toxins into more water-soluble compounds that are then carried through the blood to the liver for further processing, or to the kidney for elimination.
• 22nd:nd: Completing the detoxification in the liver and sending the toxins back to the kidney for elimination, or into the bile for elimination via the GI tract.
Phase I & Phase IIPhase I & Phase II
• The congested or sluggish liver is characterized by a diminished bile flow, while impaired liver (hepatic) detoxification refers to decreased phase 1 and/or phase 2 enzyme activity.
• Phase 1 detoxification rates that are in excess of phase 2 activity will also cause toxicity problems due to excessive accumulation of activated intermediates.
Imbalanced DetoxificationImbalanced Detoxification
Phase ICYP P450
Phase IIConjugation
Damage to DNA, RNA, Proteins
Reactive IntermediateNon-Polar Xenobiotic
InertWater-Soluble
Metabolite
Detox enzyme capacity is Detox enzyme capacity is highly variablehighly variable
• Many phase 1 enzymes are induced by their substrates.
• These are often xenobiotics.• This leads to more rapid production of
reactive intermediates.• Many substances including xenobiotics,
drugs and even nutrients (grapefruit) can inhibit some phase 1 enzymes.
• This inhibition leads to an accumulation of their substrates in the bloodstream and increased storage in fatty tissues.
Phase 2Phase 2
• Phase 2 enzymes are highly dependent on energy and on adequate dietary protein.
• Phase 2 enzymes can be induced by numerous substances found in fruits, vegetables, spices and herbs.
• Both phase 1 and 2 are highly dependent on adequate nutritional status for their activity
excretoryderivatives
Supportive Nutrients for Detoxification Pathways Supportive Nutrients for Detoxification Pathways
Lipid-soluble molecule
polarwater-soluble( )
Bile
Feces/stools
Serum
Kidneys
Urine
ATPglutathioneglycinetaurineglutamineornithineargininemethyl donorsN-acetylcysteinecysteinemethionine
riboflavin (vit. B2)niacin (vit. B3)pyridoxine (vit. B6)folic acidvitamin B12glutathionebranched-chain amino
acidsflavonoidsphospholipids
Phase II[conjugation
pathways]
Phase I[cytochrome P450
enzymes]
ActivatedIntermediates
Genetic VariationsGenetic Variations
• There are numerous genetic variations in the activity of both phase 1 and phase 2 enzymes.
• This, along with nutritional status and total toxic load, may help explain why detoxification abilities for a particular substance may vary as much as 100-fold or more between different individuals.
Causes of Impaired Causes of Impaired Detoxication: SummaryDetoxication: Summary
• Overwhelming toxic load (exogenous + endogenous)
• Impaired excretion (constipation or increased transit time; renal dysfunction)
• Inefficient fuels (macronutrient imbalance)• Deficiency of detoxifying substances
(antioxidants, cofactors, conjugating agents)
• Genetic Variation
Is Detox right for you?Is Detox right for you?Detoxification can be beneficial for
those with one or more of the following conditions:
Parasite infestationRecurring headachesBad breathHemorrhoidsIrritabilityFrequent coldsProtruding belly
Chronic constipationFrequent gas & bloatingExcess weightFrequent fatigueImpaired digestionIrritable Bowel Syndrome (IBS)Candida infection
Common Signs & Symptoms Common Signs & Symptoms Linked to Linked to
Chronic Toxicant ExposureChronic Toxicant Exposure
• Marked sensitivity to environmental chemicals, odors, medications, and/or nutritional supplements
• Chronic, debilitating fatigue and lethargy• Depression, anxiety and/or mood swings• Cognitive dysfunction (poor memory and
concentration; learning disorders)
Common Signs & Symptoms Common Signs & Symptoms Linked to Linked to
Chronic Toxicant ExposureChronic Toxicant Exposure
• Recurrent headaches• Muscle aches and weakness• Paresthesias and neuropathic pain• Recurrent infections• Infertility
Disorders Linked ToDisorders Linked To Toxicant Exposure Toxicant Exposure
• Chronic Fatigue Syndrome• Fibromyalgia• Multiple Chemical
Sensitivity• Allergies, Asthma • Atherosclerosis• Cancer
What about chronic GI What about chronic GI problemsproblems
• These patients may have leaky gut, IgG-mediated food allergies and inflammation.
• Their liver is constantly burdened by toxins and allergens arriving from the gut.
• These patients need to go on a 4R program to restore normal gut function and relieve the burden on the liver before they can become well.
[ The Road to Immunity By Stephen Bock]
Potential Benefits of Potential Benefits of the Detoxification Programthe Detoxification Program
• Increased Energy & Vitality• Weight Loss• Breaking Weight Loss Plateaus• Better gut function• Clearer thinking• Improved Skin• Better Sleep• Improved Mood
What are you waiting for?
