dermatopathology. outline benign epithelial tumors acne keloids disorders of pigmentation disorders...
TRANSCRIPT
Dermatopathology
Outline
• Benign epithelial tumors• Acne• Keloids• Disorders of pigmentation• Disorders of sunlight exposure• Chronic dermatoses• Disorders of epidermal Appendages• Infections
Seborrheic keratosis.(stuck on appearance)
Seborrheic keratosis.
Seborrheic keratosis.,Summary• Proliferation of squamous cells
• Multiple,velvet like, tan to brown colored lesions• Chest ,face ,back• “Stuck on” appearance• Biopsy shows melanin in the cytoplasm• Non malignant
• Not related to seborrheic dermatitis• Not related to actinic keratosis
Acne,summary
• Acute and chronic inflammation• Adolescent, young people
• excessive production of sebum• Infection and inflammation
• Propionebacterium acnes
Keloid
Proliferation and increased deposition of collagen in the dermis. Keloids.
How does Keloid differ from hypertrophic scars?
Benign nevus
Benign nevus
Halo nevus, Freckles,
Vitiligo, antibodies against melanocytes
Tatoos, Gross and microscopic
Diseases associated with sun exposure
• Melanoma• Actinic keratosis• Squamous cell carcinoma• Basal Cell carcinoma• Basal cell carcinoma is the most common.• Melanoma is the most aggressive
Melanoma
Excisional biopsy from Melanoma
Note the prominent nuclear material and pleomorphism
Melanoma
• Most important signs are change in color,size or shape
• The extent of vertical growth or depth of the tumor is a predictor of tumor activity
Basal Cell carcinoma
Basal Cell carcinoma
• Slow growing
• Rare metastasis• Pearly, silvery tumors
• May ulcerate(rodent ulcers)
Squamous cell carcinoma of the skin
Squamous cell carcinoma of the skin
• P53 mutation• Actinic keratoses
Psoriasis
Psoriasis
• Chronic dermatoses• Also arthritis, enteritis, myopathy• Elbow ,knees,scalp• Silver scales on the skin• Nail changes are common(onycholysis
separation of nail plate from nail bed)• Morphology :extensive sacles or parakeratosis.
Lifting of the scales leads to bleeding(Auspitz sign)
Molluscum Contagiosum
Molluscum Contagiosum
• Single most important risk factor, AIDs
• Etiologic agent Pox virus
• Characteristic umbilicated lesions.
Erythema Nodusom
Erythema Nodusom
• Commonest example of a panniculitis• Inflammatory reaction affecting subcutaneus
fat.• Streptpyogenes,Histoplasmosis,Sarcoidosis,Co
ccidiodomycosis,OCPs,sulphanamides Crohn’s disease)
• Red, itchy, painful skin lesions common on the shin.
Toxic epidermal necrolyis
TEN,SJS and Erythema multiformes
Recognize and identify the distinguishing feature of• Erythema
multiformes(etiology,drugs,mycoplasma,Herpes simplex,E.T.C) Appearance target lesions.
Variant of erythema multiformes • TEN (Toxic epidermal necrolysis)>30% BSA(body
surface area affected)• Steven-Johnson Syndrome>10% BSA affected
Purpura
Petechia, purpura, Echymosis
• List the distinguishing features of petechiae ,Purpura and Echymosis.
Impetigo
I wish you guys success• At age 4, success is…not peeing your
pants.• At age 12, success is…having friends.• At age 20, success is…having sex.• At age 35, success is…making money.• At age 60, success is…having sex.• At age 70, success is…having friends.• At age 80, success is…not peeing your
pants
Thank you!!!