TWENTISEVENTH (27ND) ANNUAL REPORT (July, 2017 to June, 2018)

DEPARTMENT OF

VETERINARY PHARMACOLOGY AND TOXICOLOGY

DGCN COLLEGE OF VETERINARY & ANIMAL SCIENCES

CSK HIMACHAL PRADESH KRISHI

VISHVAVIDYALAYA,

PALAMPUR - 176062 {HP}

(2018)

1. INTRODUCTION

The discipline of Veterinary Pharmacology & Toxicology came into existence as one of the

constituents of the erstwhile Department of Physiology and Pharmacology at the time of the

inception of the College in July, 1986. The discipline gained the status of an independent

Department of Pharmacology & Toxicology w.e.f. July 1st, 1991 becoming one of the core

subjects in the Veterinary profession.

The Department attained the status of Postgraduate Department with the start of PG

program leading to M.V.Sc. in Veterinary Pharmacology & Toxicology w.e.f. July 1996–97.

Since then 29 students have been passed out with M.V.Sc. degree. The thrust areas of the

Department are:

• Studies on the efficacy of medicinal plants of Himachal Pradesh for animal disease control

• Studies on the poisonous plants of Himachal Pradesh and their antidotal therapy

It is evident from this 27nd Annual Report that the Department is making steady progress

since its establishment in 1991. However, there is shortage of teaching and technical supporting

staff. In order to meet the future challenges and as per new VCI recommendations, the faculty

and technically trained supporting staff need to be provided.

2. TEACHING

a) Undergraduates Courses:

S. No. Course Title Course No. Cr. Hrs. Name of Teacher(s)

1st Semester

1. General and Systemic

Veterinary Pharmacology

VPT-311 2+1 Dr. Prashant S Daundkar

Dr. Dinesh Sharma

2. Veterinary

Chemotherapy

VPT-411 2+0 Dr. Dinesh Sharma

Dr. Prashant S Daundkar

3. Drug Designing 2+0 Dr. Dinesh Sharma

2nd Semester

1. Veterinary

Neuropharmacology

VPT-321 2+1 Dr. Pallavi Bhardwaj

Dr. Prashant S Daundkar

2. Veterinary Toxicology VPT-421 2+0 Dr. Prashant S Daundkar

Dr. Pallavi Bhardwaj

3. Veterinary Clinical

Biochemistry and

Laboratory Diagnosis-II

VLD-421 0+1 Dr. Prashant S Daundkar

b) Postgraduate Courses: Nil

c) Numbers of students graduated:

Degree During last academic year Accumulated total

M.V. Sc. Nil 29

Ph.D. Nil Nil

d) National and International Level Competition: UG/MSc/PhD: Nil

e) Student got admission in National and International institutes: Nil

f) Student got job/placement in India or abroad: Nil

3. RESEARCH

a. Postgraduate Research

i) Ongoing Masters Programme: Nil

ii) Ongoing Doctoral Programme: Nil

iii) Postgraduate Research Salient Achievements: Nil

b. Research Projects in Progress: Nil

c. Summary of research finding during the year

➢ Degradation kinetics and stress degradation study of amoxicillin trihydrate was performed

in vitro in veterinary preparations (Intamox 3.5 & Moxikind-SB 4.5) using high

performance liquid chromatography (HPLC). The degradation rate constants of

amoxicillin trihydrate were 29.05, 34.03 & 37.19 per hour under acidic, alkaline and

oxidative conditions, respectively.

➢ Half-life (0.0245, 0.0391, 0.0251 h) and shelf-life (0.0037, 0.0059, 0.0038 h) of Intamox

3.5 was significantly higher than t1/2 (0.159, 0.204, 0.0186 h) and t90 (0.0024, 0.0031,

0.0028 h) of Moxikind-SB 4.5 under acidic, alkaline and oxidative conditions,

respectively.

➢ After studying stress stability and degradation kinetics of both veterinary preparations,

Intamox 3.5 was found to be more stable than Moxikind-SB 4.5 under varying conditions

of pH at 250C.

d. Establishment of research collaboration with national and international institutes: Nil

e. Scientific Publications and Presentations

i) Publications

1. Bhardwaj, Pallavi, Singh, G., Singla, Saloni, Sharma, S.K., and Rampal, S. (2017). Safety

Assessment of Marbofloxacin Following Repeated Intramuscular Administration in Goats.

Toxicology International. 24 (3): 288-291. (NAAS Rating = 5.3)

2. Daundkar, P.S., Bhaskar, Vemu, Dumka, V.K., Sharma, S.K. and Kuldeep, Gupta. (2017).

Amelioration of Quinalphos-Induced Oxidative Stress by Emblica officinalis Fruit Extracts

in Rats. Toxicology International 24 (3) 301-308. (NAAS Rating = 5.3)

3. Kaur, R., Gill, K., Daundkar, P. & Singh, S. 2017. Evaluation of Sub-acute Exposure of

Bifenthrin on Oxidative Profile of Bubalus bubalis. International Journal of Livestock

Research, 7(7), 184-189. (NAAS Rating = 5.36)

4. Rajdeep Kaur, Daundkar Prashant S., Kamalpreet Kaur Gill, Simerjot Singh and S. P. S.

Saini. (2017). Sub-acute exposure of fenvalerate in buffalo calves: Toxicokinetic evaluation.

Toxicology International. 24 (2) 162-166. (NAAS Rating = 5.3)

ii). Presentations

1. Bhardwaj Pallavi, Lonare M.K., Singh G, Kaur Rajdeep, Dumka V.K. and Rampal S.

Marbofloxacin: Disposition and safety profile in goats. 2017. 37th Annual conference of

society of Toxicology (STOX), India at PGIMER, Chandigarh w.e.f Nov. 18-19, 2017.

(Poster Presentation)

2. Pallavi Bhardwaj, Kaur Gurpreet, Arora A. K. and Rampal S. “Plasmid mediated quinolone

resistance (PMQR) and efflux pumps: possible mechanisms for emergence of resistance in E.

coli against marboloxacin” in XVII Annual conference of the Indian Society of Veterinary

Pharmacology and Toxicology held at LLRUVAS, Hisar, U.P. w.e.f Dec. 20-22, 2017.

December 20-22, 2017. (Oral Presentation)

3. Pallavi Bhardwaj, Singla Saloni, Saini S.P.S, Kaswan S, Dinesh M.B. and Rampal S.

“Pharmacokinetic behavior and pharmacokinetic/pharmacodynamic iintegration of

marbofloxacin after single and repeated intramuscular administration in goats” in XVII

Annual conference of the Indian Society of Veterinary Pharmacology and Toxicology held at

LLRUVAS, Hisar, U.P. w.e.f Dec. 20-22, 2017. (Poster Presentation)

4. Prashant S. Daundkar and Dinesh Sharma. Delivered on ‘Degradation kinetics and stress

degradation study of amoxicillin trihydrate in veterinary preparations using High

Performance Liquid Chromatography (HPLC)’ in the 21st Punjab Science congress, held at

PAU, Ludhiana w.e.f Feb. 7-9, 2018. (Oral presentation in Young scientist session)

5. Pallavi Bhardwaj and Prashant S. Daundkar. “Herbal Bioenhancers: Revolutionary Concept

in Pharmacotherapeutics” in Conference on “Doubling Farmers’ Income: challenges and

strategies” at CSKHPKV, Palampur w.e.f April, 23-24, 2018. (Poster Presentation)

6. Pallavi Bhardwaj and Rampal S. "Herbal Bioenhancers as an Adjunct Therapy with

Antimicrobials: A Strategy to Combat Antimicrobial Resistance" in the 7th International

Conference on Agriculture, Horticulture and Plant Sciences held at Shimla, H.P. organized

by Society of Tropical Agriculture w.e.f June 28-29, 2018. (Oral Presentation)

iii). Manuals, Books, Booklets and Bulletin

1. Practical Manual for “Veterinary Pharmacology Paper-1 (2017)” by Dinesh Sharma, Pallavi

Bhardwaj and Prashant S Daundkar.

f. Technologies or patent Developed /Registered/Research infrastructure developed: Nil

4. EXTENSION AND OUTREACH ACTIVITIES

a. Extension Publication

1. पल्लवी भारद्वाज. 2017. पशुओ ंमें वववभन प्रकार की ववषाक्तायें: प्रारवभभक लक्षण, प्रबंधन एवं बचाव. पववतीय खेती बाड़ी.3-

4:16-19

b. Radio talk/TV Telecast: Nil

c. Clinical camps/trainings/extension camps/animal health camps: Nil

d. Clinical cases (routine and referrals)/disease investigations/disease outbreaks

investigated

5. PARTICIPATION IN WORKSHOP/ CONFERENCES, TRAININGS ETC.

a) Trainings: Nil

b) Conferences/workshops/seminars/symposia:

6. WORKSHOP/SEMINAR/TRAININGS ETC. ORGANIZED: Nil

S.

No

Types of samples Species Important findings and remarks

Bovine

1 Rumen Content 2 Positive for high nitrate/nitrite content

2 Fodder sample 3 Two samples positive for high nitrate/nitrite content

Total 5

S.

No.

Date Title Name of

Participants

Nature of

participation

1. Nov. 18-19,

2017.

37th Annual conference of society of

Toxicology (STOX), India at PGIMER,

Chandigarh

Dr. Pallavi

Bhardwaj

Poster

Presentation

2. Dec. 20-22,

2017

XVII Annual conference of the Indian

Society of Veterinary Pharmacology and

Toxicology at LLRUVAS, Hisar, U.P.

Dr. Pallavi

Bhardwaj

Oral and

Poster

Presentation

3. Feb. 7-9,

2018

21st Punjab Science Congress, at PAU,

Ludhiana

Dr. Prashant

S. Daundkar

Oral

Presentation

4. April, 23-

24, 2018.

Conference on “Doubling Farmers’

Income: challenges and strategies” at

CSKHPKV, Palampur

Dr. Pallavi

Bhardwaj

Dr. Prashant

S. Daundkar

Poster

Presentation

5. June 28-29,

2018

7th International Conference on

Agriculture, Horticulture and Plant

Sciences at Shimla, H.P.

Dr. Pallavi

Bhardwaj

Oral

Presentation

7. HONOURS AND AWARDS

1. Dr. Pallavi Bhardwaj bagged “Dr. R Natarajan Award-2017” in XVII Annual conference

of the Indian Society of Veterinary Pharmacology and Toxicology, December 20-22,

2017.

2. Dr. Pallavi Bhardwaj got “Best Poster Award” in XVII Annual conference of the Indian

Society of Veterinary Pharmacology and Toxicology, December 20-22, 2017.

3. Dr. Pallavi Bhardwaj got “Young Scientist Award” in 7th International Conference on

Agriculture, Horticulture and Plant Sciences, June 28-29, 2018.

4. Dr. Pallavi Bhardwaj is elected as Executive member of the Society of Toxicology (India),

for 2016-18.

5. Dr. Pallavi Bhardwaj is elected as Executive member of the Indian Society of Veterinary

Pharmacology and Toxicology, for 2018-2020.

8. FACULTY VISITS ABROAD: Nil

9. INCOME GENERATED BY COMMERCIAL UNITS AND SERVICE WINDOWS:

Nil

10. EXTRA CURRICULUM DUTY: NCC/NSS/HOSTEL WARDEN/SPORTS ETC.: Nil

11. MISCELLANEOUS

1. Dr. Pallavi Bhardwaj is acting as Co-PI in the project entitled “Outreach Programme on

Ethno Veterinary Medicine”

2. Dr. Pallavi Bhardwaj acted as Rapporteur in XVII Annual conference of the Indian

Society of Veterinary Pharmacology and Toxicology, December 20-22, 2017.

3. Dr. Dinesh Sharma acted as paper setter for Pharmacist Examination for Abhilashi

University and Pharmacist College, Kotla Barog

4. Dr. Pallavi Bhardwaj acted as paper setter/evaluator for GADVASU, Ludhiana and

Nanaji Deshmukh Veterinary Science University, Jabalpur

5. Dr. Pallavi Bhardwaj acted as Member of Announcement Committee and conducted

Stage Comparing in the closing ceremony of 25th Annual Athletic Meet held on May, 5-

6, 2018.

6. Faculty members of the Dept. are actively involved in various extra-curricular activities

at the University and College level viz. Entrance Examination Supervision Duty, Anti-

ragging Duty, Oath Taking Ceremony, World Veterinary Day, Shramdan Activity etc.

12. TWO PICTURES

ANNEXURES

Annexure – I (Faculty position)

S. No. Name Designation

1. Dr. Pallavi Bhardwaj Assistant Professor

2. Dr. Dinesh Sharma Assistant Professor

(on study leave)

3. Dr. Prashant S Daundkar Assistant Professor

Annexure – II (Staff position)

S. No. Name Designation

1. Sh. Joginder Sharma Junior Technician

2. Sh. Naginder Kumar Contractual worker

3. Sh. Desh Raj Junior Asstt. (presently working in

Dean’s Office, DGCN COVAS)

4. Sh. Karam Chand Beldar (presently on secondment in

Swan River Flood Management

Project, Haroli, Una, H.P.

Annexure –III (Budget in Rs.)

S. No. Scheme Salaries TA Contingency TOTAL (Rs.)

1. SFS-001-53 - - 18881.00 18881.00

2. CDA-008-53 - - 59000.00 59000.00

3. CDA-009-53 - - 56500.00 56500.00

4. CDA-013-53 - - 45000.00 45000.00

ACKNOWLEDGEMENTS

I appreciate all the faculty members, office and laboratory staff of the department for their

support, devotion and assistance. The encouragement and the support extended by the Hon’ble

Vice-Chancellor, Dean COVAS, Dean PGS, Director of Research & Director of Extension

Education of the University to this Department is gratefully acknowledged. I thank Dr. Pallavi

Bhardwaj, Assistant Professor of the department for compiling this 27th Annual Report of the

Department.

Dr. Mandeep Sharma

Professor & Head