department of pharmaceutical chemistry courses specifications€¦ · introduction to ans...

Department of Pharmaceutical Chemistry

Courses Specifications

2017-2018

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Contents

Medicinal Chemistry-1 ....................................................................................... 2

Medicinal Chemistry-2 ....................................................................................... 7

Medicinal Chemistry-3 ..................................................................................... 12

Drug Design and Development......................................................................... 17

Pharmaceutical Organic Chemistry-1 ............................................................. 22

Pharmaceutical Organic Chemistry-2 ............................................................. 27

Physical Chemistry ............................................................................................ 33

Pharmaceutical Analytical Chemistry-1 ......................................................... 38

Pharmaceutical Analytical Chemistry-2 ......................................................... 43

Quality Control .................................................................................................. 49

Food Analysis ..................................................................................................... 56

General physics .................................................................................................. 60

Mathematics ....................................................................................................... 65

Advanced instrumental analysis ...................................................................... 69

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Delta University for Science and Technology

Quality Assurance Center

Course Specifications

1. Basic Information:

Course Title: Medicinal Chemistry-1

Course Code: PC 331

Program on which the course is given: B. Pharm.

Department offering the course: Pharmaceutical Chemistry

Academic year/ level: Fall semester 2017/2018 Level three

Prerequisite: Pharmaceutical Organic Chemistry-2 (PC 211)

Credit hours: Lecture: 2 Practical: NA Total: 2

2. Course Aims:

To enable the student to gain an understanding of the physicochemical properties of drugs and

their biotransformation, the structures and uses of different chemotherapeutic agents, their

modes of action; the correlation between chemical structures and biological activities.

3. Intended Learning Outcomes (ILOs):

a. Knowledge and understanding:

At the end of this course, student should be able to:

A2

a1. Recognize the physico-chemical properties of drugs.

a2. Explain how chemical properties of drugs will influence in vivo and in vitro

behavior.

A5 a3. Realize how drug-receptor interactions occur and relate chemical structure to

biological activity.

A13

a4. Illustrate the different metabolic biotransformation pathways of drugs.

a5. Classify different chemotherapeutic agents; identify their chemistry,

nomenclature, molecular mode of action and their spectrum of activity.

b. Intellectual Skills:


B16 b1. Think critically about the chemistry of drug molecules and relate the specific

structural features to target receptor affinity.

B9 b2. Select the proper drugs for various disease conditions based on

understanding structural activity relationship and drug chemistry.

B16

b3. Specify the pharmacological class of given chemical structures.

b4. Predict the major pharmacological action and therapeutic activity of a given

drug bases on the molecular structure.

b5. Conclude pathways of metabolic degradation based on vulnerability of drug

functional groups to metabolizing enzymes.

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c. Professional and Practical Skills:


C9 c1. Raise the awareness on rationale use of chemotherapeutic agents based on an

understanding of drug chemistry.

C10 c2. Describe proper use of antibiotics and prescribe therapeutic

recommendations based on an understanding of drug chemistry.

C13

c3. Deduce relative receptor affinity, metabolic vulnerability and distribution

potential based on drug chemistry.

c4. Examine potential drug-drug, and drug-food interactions, and potential side

effects based on the structural features of drugs.

C21 c5. Manage side effects and toxicity of chemotherapeutic agents and apply

oncology supportive case.

d. General and Transferable Skills:


D3 d1. Work effectively as a part of a team to perform the required tasks.

D6 d2. Develop the skills required for continued self-professional development and

self-learning.

D11 d3. Generate effective and reasonable solutions for rising problems based on the

available information.

4. Contents:

4.1.Lectures:

Study

week Topics

No. of

Credit Hours

1.

Introduction

Physicochemical Properties and Drug Action

Major processes involved in drug action

Physicochemical parameters

2

2.

Introduction

Physicochemical Properties and Drug Action


Drug-Receptor interactions

2

3. Drug Metabolism : phase I , phase II 2

4.

Chemotherapeutic Agents

Antibacterial Agents

Mechanisms of antibacterial action

Antibiotics:

Antibiotics which inhibit cell wall synthesis

Penicillins, Cephalosporins, Non classical β-lactams

+ Quiz 1

2

5.

Antibiotics which impair protein synthesis

Aminoglycosides,Tetracyclines

Macrolides, Chloramphenicol

2

6. Agents which act on nucleic acid transcription and replication

Quinolones and fluoroquinolones 2

7. Antifungal agents

Azoles, Antifungal Antibiotics. 2

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4.2.Practical: Not applicable

5. Teaching and Learning Methods:

5.1. Lectures using data show and whiteboard and Tutorials

5.2. Researches and Homework

5.3. Learning Management System (LMS)

6. Student Assessment Methods:

6.1.Assessment methods:

1. Written exam to assess knowledge, understanding, intellectual and professional

skills.

2. Practical exam to assess professional and practical skills.

3. Course work to assess knowledge, understanding, intellectual skills, general &

transferable skills.

4. Oral exam to assess knowledge, understanding, intellectual skills, general skills

and confidence.

5. Quizzes to assess knowledge, understanding and intellectual skills.

6.2.Assessment schedule:

Assessment 1 Quiz 1 4th week


Assessment 3 Assignment all over the term

Assessment 3 Oral exam 14th & 15th weeks

Assessment 4 Written exam 14th & 15th weeks

6.3.Weighing of Assessments:

1. Course work:

- Quiz 1 10

- Quiz 2 10

8. Quiz 2

9.

Antiviral Agents

Nucleoside Antagonists, Non-Nucleoside inhibitors of

reverse transcriptase

2

10. Antiviral Agents

Protease Inhibitors, Neuroaminidase inhibitors 2

11. Cancer chemotherapy: Antineoplastic drugs:

Tumor Cell Properties, Alkylating Agents 2

12. Antimetabolites 2

13. Miscellaneous Agents 2

14. Final Exam

Total:

2 credit hours 15.

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- Assignment 5

2. Final-Term Exam 65

3. Oral Exam 10

Total 100%

7. List of References:

No. Reference Type

1.

"Wilson and Gisvold’s Textbook of Organic Medicinal and

Pharmaceutical Chemistry" Twelfth Edition, (J. H. Block and J. M.

Beale Jr; Editors), Lippincott Williams & Wilkins, Philadelphia, PA,

2012.

Foye’s Principles of Medicinal Chemistry", 8th edition, (David

A.Williams, Thomas L Lemke & ,William O .Foye Editors),

Lippincott Williams & Wilkins, 2013.

textbook

2. http://www.phc.vcu.edu/othercoolsites.html

http://pharmacy.creighton.edu/ website

8. Matrix of course contents versus ILOs:

8.1. Lectures:

Study

week Course Contents

ILOs

K&U IS P&PS G&TS

1.

Introduction

Physicochemical Properties and Drug

Action

Major processes involved in drug

action


a1, a2 b1 c3, c4 --

2.

Introduction

Physicochemical Properties and Drug

Action


Drug-Receptor interactions

a1, a2,

a3 b1 c3, c4 --

3. Drug Metabolism : phase I , phase II a4 b5 c3 --

4.

Chemotherapeutic Agents

Antibacterial Agents

Mechanisms of antibacterial action

Antibiotics:

Antibiotics which inhibit cell wall synthesis

Penicillins, Cephalosporins,

Non classical β-lactams

a3, a4,

a5

b1, b2,

b3, b4,

b5

c1, c2,

c3, c4 d1

5.

Antibiotics which impair protein synthesis

Aminoglycosides,Tetracyclines

Macrolides, Chloramphenicol

a2, a3,

a4, a5

b1, b2,

b3, b4,

b5

c1, c2,

c3, c4 d2

6.

Agents which act on nucleic acid

transcription and replication

Quinolones and fluoroquinolones

a2, a3,

a4, a5

b2, b3,

b4

c1, c2,

c3, c4 d3

http://www.phc.vcu.edu/othercoolsites.html

http://pharmacy.creighton.edu/

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7. Antifungal agents

Azoles, Antifungal Antibiotics.

a3, a4,

a5

b2, b3,

b4

c1, c3,

c4 d2, d3

9.

Antiviral Agents

Nucleoside Antagonists, Non-

Nucleoside inhibitors of reverse

transcriptase

a2, a3,

a4, a5

b2, b3,

b4

c1, c3,

c4 d1, d3

10.

Antiviral Agents

Protease Inhibitors, Neuroaminidase

inhibitors

a1, a3,

a4, a5

b2, b3,

b4

c1, c3,

c4 d2, d3

11.

Cancer chemotherapy:

Antineoplastic drugs:

Tumor Cell Properties,

Alkylating Agents

a2, a3,

a4, a5

b1, b2,

b3, b4

c1, c3,

c4, c5 d1,d3

12. Antimetabolites a2, a3,

a4, a5

b1, b2,

b3, b4

c1, c3,

c4, c5 d2, d3

13. Miscellaneous Agents a2, a3,

a4, a5

b2, b3,

b4

c1, c3,

c4, c5

d1, d2,

d3

Name Signature

Course Coordinator: Prof. Dr. Dina El-Sherbiny

Head of Department: Prof. Dr. Dalia Rashad El-Wasseef

Approval Date 10 / 9 /2017

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Course Code: PC 332



Academic year/ level: Spring Semester 2017/2018 Level three

Prerequisite: Medicinal Chemistry-1

Credit hours: Lecture: 2 Practical: 1 Total: 2

2. Course Aims:

This course aims to enable the student to gain an understanding of the following areas of

study: drugs affecting the autonomic system, cardiovascular (CVS) systems, diuretics,

antihistamines, antiulcers and local anesthetics, their mode of action, the correlation between

chemical structures and biological activities, different synthetic pathways of representative

examples, the metabolic biotransformation and evaluation of the contents of pharmaceutical

preparations.




A5

a1. Identify drug receptor interaction and molecular effect of drugs acting on

autonomic nervous system

a2. Recognize the structure activity relationships (SAR) of Cardiovascular drugs

and other drugs to optimize drug action.

A13 a3.

Recall nomenclature, therapeutic uses & metabolic pathways of Autonomic

and cardiovascular drugs.

a4. Describe different theories of mechanisms of action of the studied drugs.



B9 b1. Select proper drugs for various autonomic and CVS disease conditions based

on their pharmacological activity.

B16

b2. Predict Chemical properties of the studied drugs based on molecular structure.

b3. Conclude the major pharmacological action and biotransformation of a given

drug based on the chemical structure.

b4. Relate the specific structural features of drug to target receptor affinity

B3 b5. Determine suitable methods of drug analysis based on their chemical

structure.

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C2 c1. Handle and dispose chemicals.

C8 c2 Manipulate laboratory instruments and equipment safely and

Efficiently.

C9 c3. Raise public awareness of rational use of CVS drugs.

C13 c4. Examine risks concerning drug interactions, adverse reaction and

incompatibilities.

C14 c5. Use different quantitative chemical methods for assay of pharmaceutical

preparations.



D3 d1. Support a team work in the application of the analytical methods for

determination of different dosage forms.

D6 d2. Develop the skills required for self-learning.



4. Contents:

4.1.Lectures:

Study

week Topics

No. of

Credit Hours

1. Introduction to ANS :Adrenergic drugs 2

2. Cholinergic drugs 2

3. CVS:

Antihypertensives 2

4. Antihypertensives + Quiz 1 2

5. H1–antagonists 2

6. Antiulcer drugs 2

7. Local anesthetics 2

8. Quiz 2

9. Diuretics 2

10. Antiarrhythmics 2

11. Anticoagulants 2

12. Antihyperlipidimics 2

13. Antianginal 2

14. Final Exam

Total:

2 credit hours 15.

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4.2.Practical:

Study

week Topics

No. of

Credit Hours

1. Colorimetric assay of epinephrine 1

2. Spectrophotometric assay of ranitidine 1

3. Spectrophotometric assay of furosemide 1

4. Colorimetric assay of benzocaine 1

5. Practical exam 1

6. Chemdraw 2D 1

7. Chemdraw 2D 1

8. Quiz 2

9. Chemdraw 2D 1

10. Chemdraw 3D 1

11. Chemdraw 3D 1

12. Chemdraw 3D 1

13. Practical Exam 1

14. Final Exam

Total:

1 credit hour 15.


5.1. Lecture using data Show and white board.

5.2. Homework and assignments.

5.3. Laboratory equipment.

5.4. Computers and computer lab.

5.5. Learning Management System (LMS).




skills.





and confidence.


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Assessment 3 Assignment (research) all over the term

Assessment 4 Practical exam 13th week




1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment (research) 5


3. Oral Exam 10


Total 100%


No. Reference Type

1.

-"Wilson and Gisvold’s Textbook of Organic Medicinal and

Pharmaceutical Chemistry" 12th Edition, (J. H. Block and J. M.

Beale Jr; Editors), Lippincott Williams & Wilkins, Philadelphia, PA,

2012.

-Foye’s Principles of Medicinal Chemistry", 8th edition, (David



-Textbook of Medicinal Chemistry Vol I, V. Alagarsamy 2nd Ed.,

Elsevier 2013

textbook

2. http://www.phc.vcu.edu/othercoolsites.html website


8.1.Lectures:

Study


ILOs

K&U IS P&PS G&TS

1. Introduction to ANS :Adrenergic drugs a1, a2,

a3, a4

b1, b2,

b4 c4 --

2. Cholinergic drugs a1, a2,

a3, a4

b1, b2,

b3, b4 c4 --

3. CVS:

Antihypertensives

a2, a3,

a4

b1, b2,

b3, b4 c3, c4 --

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4. Antihypertensives a2, a3,

a4

b2, b3,

b4 c3, c4 --

5. H1–antagonists a2, a3,

a4 b2, b4 c4 d2,d3

6. Antiulcer drugs a2, a3,

a4

b2, b3,

b4 c4 d2,d3

7. Local anesthetics a2, a3,

a4

b3, b4,

b5 c4 d2,d3

9. Diuretics a2, a3,

a4

b1, b3,

b4 c3, c4 d2,d3

10. Antiarrhythmics a2, a3,

a4

b1, b3,

b4 c3, c4 d2,d3

11. Anticoagulants a2, a3,

a4

b1, b3,

b4 c3, c4 d2,d3

12. Antihyperlipidimics a2, a3,

a4

b1, b3,

b4 c3, c4 d2,d3

13. Antianginal a2, a3,

a4

b1, b3,

b4 c3, c4 d2,d3

8.2.Practical:

Study


ILOs

K&U IS P&PS G&TS

1. Colorimetric assay of epinephrine -- b1 c1,c2, c5 --

2. Spectrophotometric assay of ranitidine -- b1 c1,c2, c5 --

3. Spectrophotometric assay of

furosemide -- b1 c1,c2, c5 --

4. Colorimetric assay of benzocaine -- b1 c1,c2, c5 d1, d2,

d3

6. Chemdraw 2D -- -- c2 d2, d3



10. Chemdraw 3D -- -- c2 d2, d3

11. Chemdraw 3D -- -- c2 d2, d3

12. Chemdraw 3D -- -- c2 d2, d3

Name Signature

Course Coordinator: Prof. Dalia Rashad El-Wasseef

Head of Department: Prof. Dalia Rashad El-Wasseef

Approval Date 05/2/2018

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Course Code: PC 433



Academic year/ level: Fall Semester 2017/2018 Level Four

Prerequisite: Medicinal Chemistry-2 (PC 332)


2. Course Aims:

This course aims to enable the student to gain an understanding of the following area of study:

analgesics , Antiaging , CNS depressant and CNS stimulant drugs, Insulin and related drugs,

male and female sex hormones adrenocorticoids their modes of action; the correlation

between chemical structures and biological activities drugs and their biotransformation




A5

a1. Describe pharmacodynamics and drug receptor interactions of analgesics

CNS and hormones.

a2. Illustrate structure activity relationship (SAR) of different pharmacologically

active analgesics, CNS and hormonal drugs.

A13

a3. Identify nomenclature, therapeutic uses of the studied drugs.

a4. Distinguish different biotransformation pathways of selected drug in each

pharmacologically studied classes.

a5 Describe different theories of drug mechanisms of action of CNS, analgesics

and hormones.



B9 b1. Predict proper drugs for various diseases based on their pharmacological

activity.

B15 b2. Estimate health hazards concerning CNS drugs and narcotics use and misuse.

B16

b3. Evaluate chemical properties of drugs in different classes based on molecular

structure.

b4. Conclude the major pharmacological action of a given drug bases on the

chemical structure.

b5. Relate the specific structural features of drug to target receptor affinity.

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C9 c1. Raise awareness on drug abuse and misuse of narcotics and Hormones

C10 c2 Describe proper use of CNS drugs, analgesics and hormones based on an

understanding of drug chemistry.

C13 c3.

Examine risks concerning drug interactions, adverse reactions and

incompatibility in different drug classes acting on CNS.

c4. Deduce relative receptor affinity, metabolic vulnerability and distribution

potential based on drug chemistry.



D3 d1. Work effectively as a part of a team.

D6 d2. Develop the skills required for self-learning.

D9 d3. Acquire effective time management.

4. Contents:

4.1. Lectures:

Study

week Topics

No. of

Credit Hours

1.

Opioid Analgesics

Morphine analogs, Morphinans, Benzomorphans,

4-Phenylpiperdines, Opioid Antagonists

2

2.

Nonsteroidal Anti-inflammatory Drugs

Salicylates, Paracetamol and related drugs

Aryl and heteroarylacetic acid, N-Aryl anthranilic acid

Oxicams, Selective COX-2 inhibitors

Drugs used in the management of Gout and hyperuricemia

2

3.

Hormones

Insulin & Male sex hormones

Female sex hormones, Adrenocorticoids

2

4. Central Dopaminergic Signaling agents

Anti-Parkinsonian Drugs + Quiz 1 2

5. CNS stimulants 2

6. Tricyclic antidepressants 2

7. Central Nervous System Depressants

Anxiolytic, Sedatives and Hypnotic agents, Benzodiazepines 2

8. Quiz 2

9. Barbiturates 2

10. General anaesthetics & antiaging 2

11. Antipsychotics

Phenothiazines, Thioxanthenes 2

12. Anticonvulsant& central muscle relaxants 2

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4.2. Practical: Not applied


5.1. Lectures

5.2. Homework and Assignments

5.3. learning management system (LMS)




skills.




and confidence.





Assessment 3 Assignment all over the term




1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment 5


3. Oral Exam 10

Total 100%

13. Anti-Alzheimer Drugs 2

14. Final Exam

Total:

2 credit hours 15.

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No. Reference Type

1.

Burger's Medicinal Chemistry, Drug Discovery, and

Development, 7th Edition,2010,Donald J Abraham, David

P.Rotella,Wiley

"Wilson and Gisvold’s Textbook of Organic Medicinal and

Pharmaceutical Chemistry" Twelfth Edition, (J. H. Block and J.

M. Beale Jr; Editors), Lippincott Williams & Wilkins,

Philadelphia, PA, 2012.


A.Williams, 8th edition Thomas L Lemke & ,William O .Foye

Editors), Lippincott Williams & Wilkins, 2013.

textbook

2. http://www.phc.vcu.edu/othercoolsites.html

http://pharmacy.creighton.edu/ website


8.1.Lectures:

Study


ILOs

K&U IS P&PS G&TS

1.

Opioid Analgesics

Morphine analogs, Morphinans,

Benzomorphans,

4-Phenylpiperdines, Opioid

Antagonists

a1,a2,

a3,a4,a5

b1, b2,

b3,b4,

b5

c1 --

2.

Nonsteroidal Anti-inflammatory Drugs

Salicylates, Paracetamol and related

drugs

Aryl and heteroarylacetic acid, N-Aryl

anthranilic acid

Oxicams, Selective COX-2 inhibitors

Drugs used in the management of Gout

and hyperuricemia

a1,a2,

a3,a4,a5

b1,

b3,b4,

b5

c2, c4 --

3.

Hormones

Insulin and related Drugs & Male sex

hormones

Female sex hormones,

Adrenocorticoids

a1,a2,

a3,a4,a5

b1, b4,

b5

c1 , c2,

c4 --

4. Central Dopaminergic Signaling agents

Anti-Parkinsonian Drugs+ Antiaging

a1,a2,

a3,a4,a5

b1, b2,

b3,b4,

b5

c2, c3,

c4 --

5. CNS stimulants a1,a2,

a3,a4,a5

b1, b2,

b3,b4,

b5

c2, c3,

c4

d1, d2,

d3

6. Tricyclic antidepressants a1,a2,

a3,a4,a5

b1, b2,

b4, b5

c2, c3,

c4

d1, d2,

d3

http://pharmacy.creighton.edu/

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7.

Central Nervous System Depressants

Anxiolytic, Sedatives and Hypnotic

agents, Benzodiazepines

a1,a2,

a3,a4,a5

b1, b2,

b4, b5

c2, c3,

c4

d1, d2,

d3

9. Barbiturates a1,a2,

a3,a4,a5

b1, b2,

b3,b4,

b5

c2, c3,

c4

d1, d2,

d3

10. General anaesthetics a1,a2,

a3,a4,a5

b1, b2,

b3,b4,

b5

c2, c3,

c4

d1, d2,

d3

11. Antipsychotics

Phenothiazines, Thioxanthenes

a1,a2,

a3,a4,a5

b1, b2,

b3,b4,

b5

c2, c3,

c4

d1, d2,

d3

12. Anticonvulsant& central muscle

relaxants

a1,a2,

a3,a4,a5

b1, b2,

b3,b4,

b5

c2, c3,

c4

d1, d2,

d3

13. Anti-Alzheimer Drugs a1,a2,

a3,a4,a5

b1, b2,

b3,b4,

b5

c2, c3,

c4

d1, d2,

d3

Name Signature

Course Coordinator: Prof. Dalia Rashad El-Wasseef


Approval Date 10/ 9 /2017

17 | P a g e





Course Title: Drug Design and Development

Course Code: PC 434



Academic year/ level: Spring Semester 2017/2018 Level Four

Prerequisite: Medicinal Chemistry-2 ( PC 332)


2. Course Aims:

Dominating the different strategies of drug design and development including molecular

modification and quantitative structure-activity relationship, understanding the drug-receptor

interaction, molecular modeling strategy, and providing a broad and thorough background in

drug design based on drug metabolism.




A5

a1. Identify different drug sources, drug discovery, drug targets, and drug-

receptor interaction.

a2. Outline different phases involved in the development of new drugs.

a3. State the role of QSAR and molecular modeling in the design of new drugs.

a4. Recognize the effect of bioisosterism and stereochemistry on drug action.

a5. Describe the pharmacokinetic issue in drug design and the concept of drug

latentiation.



B6 b1. Integrate the principles of bioinformatics, molecular modeling and other

tools to design new drugs.

B16

b2. Predict the physical, chemical properties and biological activity of organic

compounds based on molecular structure and drug-design theories.

b3. Predict the lipophilic and hydrophilic characters of the targeted drugs based

on molecular structure.

b4. Relate the specific structural features of drug to target receptor affinity

(QSAR).

b5. Modify the pharmacokinetic characters of drugs to control relative onset and

duration of action based on drug chemistry.

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C15

c1. Prescribe a case history of the discovery and development of modern drugs.

c2. Modify the chemical structure of a given drug to give optimum receptor

binding affinity based on molecular modeling theories.

c3. Manipulate the basic concepts of drug design, development and targeting.

c4. Examine a drug structure and deduce relative receptor affinity.

c5. Deduce metabolic vulnerability, distribution potential, possible and optimal

delivery systems based on the chemical structure of a given drug.



D3 d1. Work effectively as a part of a team to perform the required tasks.

D6 d2. Develop the skills required for continued self-professional development and

self-learning.



4. Contents:

4.1.Lectures:

Study

week Topics

No. of

Credit Hours

1.

Introduction to Drug Discovery and Drug Development

Phases involved in Development of New Drugs

Drug withdrawal, Sources of Drugs

2

2.

Drug receptors and binding sites

Methodology in Drug Design:

Molecular modeling and docking

2

3.

Molecular simplification (Bond disconnection and design of

fragments of the lead).

Molecular association and design of rigid analogs.

2

4. Skeletal variation (Changing size and shape)

Bioisosterism and stereochemistry + Quiz 1 2

5. Molecular modification based on drug metabolism. 2

6. QSAR

Topliss scheme and Craig plot 2

7. Prodrugs for increased drug absorption and distribution. 2

8. Quiz 2

9. Prodrugs for increased drug water solubility. 2

10. Prodrugs for site specification and targeting. 2

11. Prodrugs for controlled and slow drug release. 2

19 | P a g e

4.2. Practical: Not applicable


5.1. Lectures

5.2. Tutorials

5.3. Researches and Homework

5.4. Learning Management System




skills.




and confidence.





Assessment 3 Assignment (research) all over the term




1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment (research) 5


3. Oral Exam 10

Total 100%

12. Prodrugs for reducing toxicity and side effects. 2

13. Bioprecursor Produgs+ Mutual Prodrugs. 2

14. Final Exam

Total:

2 credit hours 15.

20 | P a g e


No. Reference Type

1.

“An Introduction to Medicinal Chemistry”, 5th edition, Graham L.

Patrick editor, Oxford university press INC., New York, USA,

2013. ISBN: 9780199697397.




“The Organic Chemistry of Drug Design and Drug action" 2nd

Edition, Richard. B. Silverman, Editor, Academic Press, 2004.

textbook

2. https://www.pdfdrive.com/medicinal-chemistry-books.html website


8.1. Lectures:

Study


ILOs

K&U IS P&PS G&TS

1.

Introduction to Drug Discovery and Drug

Development

Phases involved in Development of New

Drugs

Drug withdrawal, Sources of Drugs

a1, a2 b1 c1, c3 ---

2. Drug receptors and binding sites

Molecular modeling and docking a1, a3

b1, b2,

b3, c2,c3, c4 --

3.

Molecular simplification (Bond

disconnection and design of fragments of

the lead).

Molecular association and design of rigid

analogs.

a3 b2, b3 c2, c4 --

4.

Skeletal variation (Changing size and

shape)

Bioisosterism and stereochemistry

+ Quiz 1

a3, a4 b2, b3 c2, c4 --

5. Molecular modification based on drug

metabolism. a5 b5 c5 d1

6. QSAR

Topliss scheme and Craig plot a3 b4 c2,c4 d1, d2

7. Prodrugs for increased drug absorption and

distribution. a3, a5 b5 c2, c4,c5 d1, d2

21 | P a g e

9. Prodrugs for increased drug water

solubility. a5 b5 c2, c5 d1, d3

10. Prodrugs for site specification and

targeting. a5 b5 c2, c5 d1, d3

11. Prodrugs for controlled and slow drug

release a5 b5 c2, c4,c5

d1, d2,

d3

12. Prodrugs for reducing toxicity and side

effects. a5 b5 c2, c4 d1

13. Bioprecursor Produgs + Mutual Prodrugs. a5 b5 c2, c4,c5 d2, d3

Name Signature

Course Coordinator: Prof. Dr. Dina El-Sherbiny

Head of Department: Prof. Dr. Dalia R. El-Wasseef

Approval Date 05/ 2 /2018

22 | P a g e





Course Title: Pharmaceutical Organic Chemistry-1

Course Code: PC 111



Academic year/ level: Spring Semester 2017/2018 First Level

Prerequisite: Physical Chemistry (PC102)


2. Course Aims:

The aim of the course is to provide students with proper understanding of the basic principles

of organic reactions. In addition, providing a good idea about the stereochemistry of the chiral

organic compounds. The students will be capable to identify certain aliphatic organic

compounds and recognize their chemical properties, synthesis and reactions.




A1.

a1. Represent various structural and molecular formulae of different aliphatic

organic compounds.

a2. Name the aliphatic chemical structures according to trivial and IUPAC

nomenclature.

a3. Recognize the chemical properties of various classes of aliphatic organic

compounds.

A4.

a4. Identify different organic functionalities, their properties, introduction and

transformation to each other, concerning aliphatic organic compounds.

a5. Recognize the stereochemistry of the chiral organic molecules through

studying the asymmetric aspects.



B5. b1. Predict the IUPAC name of structures of aliphatic organic compounds.

b2. Select appropriate methods for synthesis of aliphatic organic compounds.

B16.

b3.

Think critically about the chemistry of aliphatic organic molecules and relate

their specific structural features to possible synthesis, identification and

physicochemical properties.

b4. Analyze the organic chemistry data and principles essential for

comprehension of other applied chemistry sciences

23 | P a g e



C4.

c1. Identify different functional groups of organic compounds

c2. Perform identification chemical tests effectively and safely

c3. Handle chemicals and equipment safely

C11. c4. Record data and write practical chemical reports



D3. d1. Work effectively in a team

D6. d2. Practice self-learning and long-life learning

4. Contents:

4.1.Lectures:

4.2.Practical:

Study

week Topics

No. of

Credit Hours

1. Lab safety 1

2. Physical Characters and Solubility 1

3. Physical Characters and Solubility 1

Study

week Topics

No. of

Credit Hours

1. Basic Concepts of Organic Chemistry 2

2. Alkanes 2

3. Alkenes 2

4. Alkynes + Quiz 1 2

5. Alkyl halides and Nucleophilic Substitution Reactions 2

6. Alcohols and Ethers 2

7. Aliphatic Amines 2

8. Quiz 2

9. Aliphatic Aldehydes and Ketones 2

10. Aliphatic carboxylic acids & their derivatives 2

11. Stereochemistry

Definition, Concepts and types 2

12. Stereochemistry

Conformational Isomers 2

13. Stereochemistry

Configurational Isomers 2

14. Final Written and Oral exam

Total:

2 credit hours 15.

24 | P a g e

4. General Reactions: Sodalime 1

5. General Reactions: Na2CO3, Element Test 1

6. General Reactions: FeCl3 1

7. Alcohols 1

8. Quiz 2

9. Aldehydes and Ketones 1

10. Aldehydes and Ketones 1

11. Aromatic Carboxylic Acids and Salts 1

12. Aliphatic Carboxylic Acids and Salts 1


14. Final Written and Oral exam

Total:

1 credit hour 15.


5.1. Lectures

5.2. Laboratory classes

5.3. Homework

5.4. LMS (Moodle), online webinar and Facebook group discussion




skills.





and confidence.





Assessment 3 Assignment/activity (homework) all over the term




25 | P a g e


1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment/activity (homework) 5


3. Oral Exam 10


Total 100%


No. Reference Type

1. Organic Chemistry, T. W. Graham Solomons, Craig B. Fryhle, and

Scott A. Snyder11th Ed., 2014. textbook

2.

A Microscale Approach to Organic Laboratory Techniques, Donald

L. Pavia, Gary M. Lampman, George S. Kriz, Randall G. Engel, 4th

Ed., 2016.

textbook

3. Vogel's Quantitative Chemical Analysis, J. Mendham, R.C. Denney,

J. D. Barnes, M.J.K. Thomas, 6th Ed., 2006. textbook

4. http://www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/intro1.htm website

5. http://www.organic-chemistry.org/ website

6. www.orgsyn.org website


8.1. Lectures:

Study


ILOs

K&U IS P&PS G&TS

1. Basic Concepts of Organic Chemistry a1, a2 b1 -- --

2. Alkanes a1, a4 b1-b4 c1, c2 d1, d2

3. Alkenes a1-a4 b1-b4 c1, c2 d1, d2

4. Alkynes a1-a4 b1-b4 c1, b2 d1, d2

5. Alkyl halides

Nucleophilic Substitution Reactions a1-a4 b1-b4 c1-c4 d1, d2

6. Alcohols and Ethers a1-a3 b1-b3 c1-c4 d1, d2

7. Aliphatic Amines a1-a4 b1-b4 c1-c4 d1, d2

9. Aliphatic Aldehydes and Ketones a1-a3 b1-b4 c1-c4 d1, d2

10. Aliphatic carboxylic acids & their

derivatives a1-a4 b1-b4 c1-c4 d1, d2

http://www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/intro1.htm

http://www.organic-chemistry.org/

http://www.orgsyn.org/

26 | P a g e

11. Stereochemistry

Definition, Concepts and types

a1-a5 b3, b4 -- d1, d2 12. Stereochemistry

Conformational Isomers

13. Stereochemistry

Configurational Isomers

8.2.Practical:

Study


ILOs

K&U IS P&PS G&TS

1. Lab safety -- -- c2,c3 --

2. Physical Characters and Solubility -- -- c1-c4 --

3. Physical Characters and Solubility -- -- c1-c4 --

4. General Reactions: Sodalime a3, a4 -- c1-c4 d1,d2

5. General Reactions: Na2CO3

Element Test a3, a4 -- c1-c4 d1,d2

6. General Reactions: FeCl3 a3, a4 -- c1-c4 d1,d2

7. Alcohols a3, a4 b3 c1-c4 d1,d2

9. Aldehydes and Ketones a3, a4 b3 c1-c4 d1,d2

10. Aldehydes and Ketones a3, a4 b3 c1-c4 d1,d2

11. Aromatic Carboxylic Acids and Salts a3, a4 b3 c1-c4 d1,d2

12. Aliphatic Carboxylic Acids and Salts a3, a4 b3 c1-c4 d1,d2

Name Signature

Course Coordinator: Dr. Mohammad AbdulWahhab

Head of Department: Prof. Dr. Dalia Rashad El-Wasseef


27 | P a g e





Course Title: Pharmaceutical Organic Chemistry-2

Course Code: PC 211



Academic year/ level: Fall Semester 2017/2018 Second Level

Prerequisite: Pharmaceutical Organic Chemistry-1 (PC 111)


2. Course Aims:

The aim of the courses is to provide students with proper understanding of the basic principles

of aromaticity and heterocyclic chemistry. In addition, providing students with reactions and

mechanisms of aromatic compounds. The students will also be capable to synthesize certain

organic compounds and recognize their physicochemical properties.




A1.

a1. Represent various structural and molecular formulae of different aromatic

and heterocyclic organic compounds.

a2. Name the majority of aromatic and heterocyclic structures according to

trivial and IUPAC nomenclature.

A4.

a3. Enumerate the methods of identification, synthesis, and purification of

different aromatic and heterocyclic compounds.

a4. Identify different organic functionalities, their properties, and introduction;

concerning aromatic and heterocyclic compounds.

a5. Outline different transformation of functional groups concerning aromatic

and heterocyclic compounds.



B5. b1. Design appropriate methods for synthesis of selected aromatic and

heterocyclic compounds.

B16.

b2. Predict the best method for purification of aromatic compounds.

b3. Relate specific structural features of aromatic and heterocyclic compounds to

possible synthesis, identification and physicochemical properties.

b4. Analyze the organic chemistry data and principles essential for

comprehension of other applied chemistry sciences.

28 | P a g e



C4.

c1. Perform chemical synthesis of selected organic compounds effectively and

safely.

c2. Carry out different purification methods for selected aromatic and

heterocyclic compounds.

c3. Determine the physicochemical characteristics of different aromatic

compounds.

c4. Handle chemicals and equipment concerning synthesis of aromatic

compounds.

C11. c5. Record data and write practical chemical reports.



D3. d1. Work effectively in a team.

D6. d2. Practice self-learning and long-life learning.

4. Contents:

4.1.Lectures:

Study

week Topics

No. of

Credit Hours

1. Aromatic Compounds: Structure of benzene, The concept of

Aromaticity, Nomenclature of aromatic compounds 2

2. Electrophilic Aromatic Substitution, Reactivity and

Orientation. 2

3.

Aryl Halides: Nomenclature of Aryl Halides, Structure of

Aryl Halides, Physical Properties of Aryl Halides, Preparation

of Aryl Halides, Nucleophilic Aromatic Substitution.

2

4.

Arenes, isolated and fused aromatic ring system.

Quiz 1 2

5.

Aromatic Nitro Compounds: Physical properties of nitro

compounds, Preparation of nitro compounds, Reactions of

nitro compounds, Importance of nitro compounds in synthetic

pathways.

2

6.

Aromatic Amines and Diazonium salts: Nomenclature of

amines, Structure of amines and the basicity concept, Physical

properties of amines. Preparation of amines. Reactions of

amino compounds and diazonium salts.

2

7. Phenols: Structure of phenols. Classification and Physical

Properties of phenols. Preparation and reactions of phenols. 2

8. Quiz 2

9.

Aromatic Aldehydes and Ketones: Structure of aldehydes and

ketones. Nomenclature aldehydes and ketones and their

reactions.

2

10. Aromatic carboxylic acids 2

29 | P a g e

4.2.Practical:

Study

week Topics

No. of

Credit Hours

1. Lab safety and lab equipment 1

2. Crystallization 1

3. Synthesis of iodoform 1

4. Synthesis of azodye 1

5. Synthesis of ethyl acetate 1

6. Synthesis of methyl salicylate 1

7. Synthesis of nitrotoluene 1

8. Quiz 2

9. Synthesis of nitronaphthalene 1

10. Synthesis of acetanilide 1

11. Synthesis of ozazone 1

12. Synthesis of Phenyl urea 1


14. Final Exam

Total:

1 credit hour 15.


5.1. Lectures

5.2. Laboratory classes

5.3. Homework

5.4. LMS (Moodle) and Facebook study group

Classification, nomenclature, preparation and reactions

11. Heterocyclic Chemistry Nomenclature, Classification of

heterocycles and Reactivity of heterocycles. 2

12.

Five-membered Heterocycles Typical reactivity of five

membered heterocycles, Synthesis and Reactions of Pyrrole,

Thiophen and Furan.

2

13. Six membered heterocycles.

Synthesis and Reactions 2

14. Final Exam

Total:

2 credit hours 15.

30 | P a g e




skills.





and confidence.










1. Course work:

- Quiz 1 10

- Quiz 2 10



3. Oral Exam 10


Total 100%


No. Reference Type

1. Organic Chemistry, T. W. Graham Solomons, Craig B. Fryhle, and

Scott A. Snyder11th Ed., 2014. textbook

2. Vogel's Quantitative Chemical Analysis, J. Mendham, R.C. Denney,

J. D. Barnes, M.J.K. Thomas, 6th Ed., 2006 textbook

3. Heterocyclic Chemistry, J. A. Joule, K. Mills, 5th Ed., 2010 textbook

4. http://www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/intro1.htm website

5. http://www.organic-chemistry.org/ website

6. www.orgsyn.org website

http://www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/intro1.htm

http://www.organic-chemistry.org/

http://www.orgsyn.org/

31 | P a g e


8.1. Lectures:

Study


ILOs

K&U IS P&PS G&TS

1. Aromatic Compounds

a1, a2 b2, b3 c1-c5 --

2. Electrophilic Aromatic Substitution

3. Aryl Halides a1-a3 b1-b4 c3 --

4. Arenes, isolated and fused aromatic

ring system a1-a4 b1-b4 c1-c5 d1, d2

5. Aromatic Nitro compounds a1-a5 b1-b4 c3 d1, d2

6. Aromatic Amines and Aromatic

diazonium Salts a1-a5 b1-b4 c1-c5 d1, d2

7. Phenols a1-a5 b1-b4 c3 d1, d2

9. Aromatic Aldehydes and Ketones a1-a5 b1-b4 c3 d1, d2

10. Aromatic Carboxylic Acids a1-a5 b1-b4 c3 d1, d2

11.

Heterocyclic Chemistry a1-a5 b1,b3,b4 c1-c4 d1, d2 12.

13.

8.2.Practical:

Study


ILOs

K&U IS P&PS G&TS

1. Lab safety and lab equipment -- -- c5 --

2. Purification methods a3,a4 b1, b2 c2 --

3. Synthesis of iodoform a3,a4 b1, b2 c1-c5 d1,d2

4. Synthesis of azodye a3,a4 b1, b2 c1-c5 d1,d2

5. Synthesis of ethyl acetate a3,a4 b1, b2 c1-c5 d1,d2

6. Synthesis of methyl salicylate a3,a4 b1,b2 c1-c5 d1,d2

7. Synthesis of nitrotoluene a3,a4 b1,b2 c1-c5 d1,d2

9. Synthesis of nitronaphthalene a3,a4 b1,b2 c1-c5 d1,d2

32 | P a g e

10. Synthesis of acetanilide a3,a4 b1, 2 c1-c5 d1,d2

11. Synthesis of ozazone a3,a4 b1, b2 c1-c5 d1,d2

12. Synthesis of Phenylurea a3,a4 b1, b2 c1-c5 d1,d2

Name Signature

Course Coordinator: Dr. Mohammad AbdulWahhab



33 | P a g e





Course Title: Physical Chemistry

Course Code: PC 102


Department offering the course: Pharmaceutical Chemistry Dept.

Academic year/ level: Fall Semester 2017/2018 Level : 1

Prerequisite: None

Credit hours: Lecture: 2 Practical: 1 Total: 3 hours

2. Course Aims:

To study the basic concepts on some topics such as atomic and molecular structure, types of

bonds, periodic table, chemical calculations, and types of chemical reactions and

understanding the basic principles of thermochemistry and thermodynamics of chemical

reactions.




A1 a1. Identify the principles of basic theories of thermochemistry, thermodynamics,

physical and chemical properties

A2 a2. Recognize the physicochemical properties of pharmaceutical elements

A4 a3. Enumerate the theories of identification of chemicals

A13 a4. Recall the chemical properties of chemical compounds



B3 b1. Determine suitable methods for analysis of chemical compounds according to

elemental species.

B5 b2. Determine appropriate methods for identification of various chemicals

B13 b3. Interpret experimental data based on relevant chemical principles

b4. Conclude practical data depending on structural principles

34 | P a g e



C2 c1. Handle and dispose chemicals safely

C4 c2. Select appropriate methods for identification of chemicals

C11 c3. Conduct experimental studies, including: analysis and interpretation of the

results

C14 c4. Employ different qualitative chemical methods for assay of raw materials



D3 d1. Work effectively as a part of a team to perform the required tasks

D9 d2. Acquire effective time management skills

D10 d3. Implement writing and presentation skills

4. Contents:

4.1.Lectures:

4.2.Practical:

Study

week Topics

No. of

Credit Hours

1. Handling of chemicals and safety in laboratories 1

2. Determination of carbonate group 1

3. Determination of sulphur group 1

4. Determination of phosphate group 1

Study

week Topics

No. of

Credit Hours

1. Periodic table 2

2. Energy levels and their characterization 2

3. Electronic configuration 2

4. Properties of periodic table elements + (Quiz 1) 2

5. Chemical bonding 2

6. Types of chemical reactions 2

7. Introduction to quantitative analysis 2

8. Quiz 2

9. Thermochemistry and Thermochemical equations 2

10. Water calorimeter, application of Hess’s law 2

11. Thermodynamics 2

12. Properties of electromagnetic radiations 2

13. Laws of photochemistry 2

14. Final Exam

Total:

2 credit hours 15.

35 | P a g e

5. Determination of nitrate group 1

6. Revision on anions 1

7. Determination of group 1 1

8. Quiz 2





13. Practical Exam

14. Final Exam

Total:

1 credit hour 15.


5.1. Lectures

5.2. Practical Experiments

5.3. Learning Management System (L.M.S)

5.4. Homework



1. Written exam To assess knowledge, understanding, and intellectual skills

2. Practical exam To assess professional and practical skills.

3. Course work To assess knowledge, understanding, intellectual skills, general &


4. Quizzes To assess knowledge, understanding and intellectual skills.




Assessment 3 Assignment/Activity (Research Activity) all over the term




1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment/activity (research activity) 5



Total 100%

36 | P a g e


No. Reference Type

1. Analytical Chemistry, Gary D. Christian, 6th ed. John Wiely and

Sons,2004, New York. Textbook

2. Fundamentals of Analytical Chemistry, 9th ed. 2014, Douglas,A.

Skoog and Donald M. West.Sounder’s College Publishing, Japan.

Textbook

3. Dean’s Analytical Chemistry Handbook, Pradyot Patanik, Second

Edition, 2004, McGraw Hill, New York

Textbook


8.1. Lectures:

Study


ILOs

K&U IS P&PS G&TS

1. Periodic table a1, a2 -- -- --

2. Energy levels and their characterization a1, a2 b4 -- --

3. Electronic configuration a1, a2,

a3 b4 -- --

4. Properties of periodic table elements a2, a4 b3, b4 c1, --

5. Chemical bonding a1, a2 b4 -- --

6. Types of chemical reactions a1, a3 b1, b2 c2, c3,

c4 d3

7. Introduction to quantitative analysis a1, a4 b1, b2 c2, c3 d3

9. Thermochemistry and Thermochemical

equations a1, a2 b3, b4 c1, c3 --

10. Water calorimeter, application of

Hess’s law

a1, a2,

a3 b2, b3 c1, c3 --

11. Thermodynamics a1, a2 b3, b4 c1, c3 --

12. Properties of electromagnetic

radiations a1 b4 c3 d3

13. Laws of photochemistry a1 b4 c3 d3

8.2. Practical:

Study


ILOs

K&U IS P&PS G&TS

1. Handling of chemicals and safety in

laboratories a1, a2 --- c1 ---

2. Determination of carbonate group a1, a2 b1, b2 c2, c4 d1, d2

37 | P a g e

3. Determination of sulphur group a1, a2 b1, b2 c2, c4 d1, d2

4. Determination of phosphate group a1, a2 b1, b2 c2, c4 d1, d2

5. Determination of nitrate group a1, a2 b1, b2 c2, c4 d1, d2

6. Revision on anions a1, a2 b1, b2 c2,c3 c4 d1, d2,

d3

7. Determination of group 1 a1, a2 b1, b2 c2, c4 d1, d2





Name Signature

Course Coordinator: Dr. Mary Wahba

Head of Department: Prof. Dr. Dalia El Wasseef


38 | P a g e





Course Title: Pharmaceutical Analytical Chemistry-1

Course Code: PC 121


Department offering the course: Pharmaceutical Chemistry Dept.

Academic year/ level: Spring Semester 2017/2018 Level: 1

Prerequisite: Physical Chemistry (PC 102)


2. Course Aims:

To study the basic principles of the quantitative chemical analysis including acid-base,

precipitimetry and complexometric titration and cover the applications of these methods to

pharmaceutical compounds




A1 a1. Identify the basics of Quantitative analytical chemistry

a2. Outline the principles of volumetric analysis

A3 a3. Manage the different types of titrimetric methods

A4 a4. Describe the theories of standardization of chemicals

a5. Describe different analytical techniques for evaluation of pharmaceuticals



B3

b1. Determine suitable volumetric methods for analysis of drugs

b2. Investigate appropriate methods for analysis of some chemical compounds

by acid-base titration

B5 b3.

Conduct appropriate methods for determination of various chemical

compounds

b4. Select suitable methods for standardization of various chemical compounds



C2 c1. Perform analytical experiments safely

c2. Handle chemicals appropriately

39 | P a g e

C4 c3.

Employ appropriate methods for identification of some chemical

compounds.

c4. Implement suitable methods for standardization of chemicals

C14 c5. Employ different quantitative chemical methods for assay of raw materials






4. Contents:

4.1.Lectures:

4.2.Practical:

Study

week Topics

No. of

Credit Hours

1. Introduction to volumetric analysis 1

2. Handling of accurate measures 1

3. Determination of HCl #NaOH 1

4. Determination of HCl/acetic acid mixture 1

5. Determination of NaOH/Na2CO3 mixture 1

6. Determination of ammonium chloride by back titration 1

Study

week Topics

No. of

Credit Hours

1. Introduction to analytical chemistry, introduction to

volumetric analysis 2

2. Acid-base theories and calculations 2

3. Buffers 2

4. Acid-base indicators + Quiz 1 2

5. Titration curves 2

6. Applications of acid-base titration 2

7. Precipitimetry titration: introduction and solubility product

Ksp, titration curves for Argentometric methods 2

8. Quiz 2

9. Precipitimetry applications: Mohr’s method, Volhard method,

Fajan’s method, Liebig’s method 2

10. Complexometric titration: introduction, types of bonds,

chelating and sequestering agents 2

11. Complexometric titration: stability of complexes, EDTA

titration curves 2

12. Types of EDTA titrations 2

13. Titration of mixtures and metal ion indicators 2

14. Final Exam

Total:

2 credit hours 15.

40 | P a g e

7. Determination of aspirin by back titration 1

8. Quiz 2

9. Introduction to complexometry 1

10. Determination of MgSO4 #EDTA 1

11. Determination of Ca/Mg mixture #EDTA 1

12. Determination of NaCl by Mohr’s method 1


14. Final Exam

Total:

1 credit hours 15.


5.1. Lectures

5.2. Practical experiments


5.4. Homework

5.5. Brain storming



1. Written exam To assess knowledge, understanding, intellectual and professional

skills.




4. Oral exam To assess knowledge, understanding, intellectual skills, general skills

and confidence.





Assessment 3 Assignment/activity (research activity.) all over the term





1. Course work:

- Quiz 1 10

- Quiz 2 10


41 | P a g e


3. Oral Exam 10


Total 100%


No. Reference Type


Sons,2004, New York. Textbook

2. Dean’s Analytical Chemistry Handbook, Pradyot Patanik, Second

Edition, 2004, McGraw Hill, New York Textbook

3. Fundamentals of Analytical Chemistry, 9th ed., 2014, Douglas,A.

Skoog and Donald M. West.Sounder’s College Publishing, Japan. Textbook


8.1. Lectures:

Study


ILOs

K&U IS P&PS G&TS

1.

Introduction to analytical

chemistry, introduction to

volumetric analysis

a1,a2 -- -- --

2. Acid-base theories and

calculations a3,a4,a5 b1, b4 c3 --

3. Buffers a1 b1,b2 -- d2

4. Acid-base indicators + Quiz 1 a1,a2 b1,b2 c3,c4 d2

5. Titration curves a1,a2,a3 b1,b2 c5 d2

6. Applications of acid-base

titration a1,a2,a3 b3,b1,b2 c3,c4,c5 d2

7.

Precipitimetry titration:

introduction and solubility

product Ksp, titration curves for

Argentometric methods

a1,a2,a3 b1,b2 c3,c4 d2

9.

Precipitimetry applications:

Mohr’s method, Volhard

method, Fajan’s method,

Liebig’s method

a1,a2,a3 b1,b2 c1,

c3,c5 d2

10.

Complexometric titration:

introduction, types of bonds,

chelating and sequestering

agents

a1,a2, a5 b1,b2 c3,c4 d2

11.

Complexometric titration:

stability of complexes, EDTA

titration curves

a2,a4,a5 b1,b2 c3,c4 d2

42 | P a g e

12. Types of EDTA titrations a1,a2, a5 b1,b2

c3,c4 d2

13. Titration of mixtures and metal

ion indicators

a1,a2,a4 b3,b1,b2 c3,

c4,c5

d2

8.2. Practical:

Study


ILOs

K&U IS P&PS G&TS

1. Introduction to volumetric analysis a2 -- c3 --

2. Handling of accurate measures a1,a2 b4 c1,c2 --

3. Determination of HCl #NaOH a3 b1,b3 c2,c3,c5 d3

4. Determination of HCl/acetic acid

mixture a2,a3 b1,b3,b4 c1, c3,c5 d1

5. Determination of NaOH/Na2CO3

mixture a2,a3 b3,b4 c1,c2, c5 d3

6. Determination of ammonium

chloride by back titration a2,a3 b1,b3,b4 c1,c2,c3 d2

7. Determination of aspirin by back

titration a2,a3 b2,b5 c2, c4,c5 d2

9. Introduction to complexometry a2,a3 b1,b3,b4 c3,c4,c5 d1

10. Determination of MgSO4 #EDTA a2,a3 b1,b3 c1,c2,c5 d3

11. Determination of Ca/Mg mixture

#EDTA a2,a3 b3,b4 c1,c2,c5 d2

12. Determination of NaCl by Mohr’s

method a2,a3 b1,b3 c1,c2,c5 d1

Name Signature

Course Coordinator: Dr. Mary Wahba

Head of Department: Prof. Dr Dalia El Wasseef


43 | P a g e





Course Title: Pharmaceutical Analytical Chemistry-2

Course Code: PC 222



Academic year/ level: Spring Semester 2017/2018 Level two

Prerequisite: Pharmaceutical Analytical Chemistry-1 (PC 121)


2. Course Aims:

To study the principle of quantitative chemical methods of analysis, Demonstrate basic

principles of redox reactions, Covers conductometric methods of analysis, Provides basic

concepts of spectroscopy




A3 a1. Identify the different analytical techniques as spectrophotometry and

conductometry.

A4 a2. Enumerate the theories of evaluation of pharmaceuticals by redox reactions

a3. Describe the theories of standardization of chemicals

A7 a4. Recognize the principles of various instruments and techniques used in

pharmaceutical analysis

A13 a5. Explain the chemical properties of pharmaceutically active ingredients.



B3 b1. Determine suitable methods of analysis of drugs as raw materials

b2. Verify appropriate methods of analysis of pharmaceutical compounds

B5

b3. Design appropriate methods for evaluation of various chemical compounds

b4. Develop suitable methods for standardization of various chemical

b5. Adopt appropriate analytical methods for standardization of pharmaceutical

compounds

44 | P a g e



C2 c1. Handle and dispose chemicals safely

C4 c2.

Select appropriate methods for identification of active substances from

different origins

c3. Implement suitable methods for standardization of active materials

C8 c4. Manipulate pharmaceutical instruments and equipment safely and efficiently

and solve commonly encountered problems in pharmaceutical analysis.

C14 c5. Employ different quantitative chemical methods for assay of raw materials






4. Contents:

4.1.Lectures:

Study

week Topics

No. of

Credit Hours

1. Redox reactions, Introduction, Factors affecting redox

potential, Methods for detection of end point: 2

2. REDOX STANDARDS & APPLICATIONS:

(A) OXIDIZING AGENTS, KMnO4: Advantages and

disadvantages, Applications

2

3. Ce(SO4)2:Advantages and disadvantages.Applications:

K2Cr2O7:Advantages and disadvantages, Applications 2

4.

KBrO3:Preparation of standard Br2, applications:

I2: Properties. Iodimetry & Iodometry. Applications

Quiz 1

2

5. REDUCING AGENTS

(1) FeSO4. (2) Na2S2O3 2

6. Pharmaceutical Applications 2

7. Electro chemistry

Introduction to electrochemistry 2

8. Quiz 2

9. Galvanic and electrolysis cells 2

10. Conductometry: theory and application 2

11. Spectrophotometry

Introduction Components of spectrophotometer 2

45 | P a g e

4.2.Practical:

Study

week Topics

No. of

Credit Hours

1. Introduction to redox titration 1

2. Determination of KMnO4 # oxalic acid 1

3. Determination of K2CrO4 by iodometry 1

4. Determination of CuSO4 by iodometry 1

5. Andrews method 1

6. Determination of H2O2 1

7. Determination of ascorbic acid 1

8. Quiz 2

9. Introduction to spectrophotometry 1

10. Drawing of absorption spectrum and calibration curve 1

11. Drawing of absorption spectrum of KMnO4 by

spectrophotometry 1

12. Drawing of calibration curve of KMnO4 by spectrophotometry 1


14. Final Exam

Total:

1 credit hour 15.


5.1. Lectures

5.2. Practical experiments


5.4. homework

5.5. Brain storming

12. Types of spectrophotometers:

Beer-Lambert law 2

13. Factors affecting absorption spectrum: Applications 2

14. Final Exam

Total:

2 credit hours 15.

46 | P a g e


6.1. Assessment methods:


skills.





and confidence.


6.2. Assessment schedule:



Assessment 3 Assignment/activity (research activity) all over the term





1. Course work:

- Quiz 1 10

- Quiz 2 10



3. Oral Exam 10


Total 100%


No. Reference Type


Sons, 2004, New York. textbook

2. Fundamentals of Analytical Chemistry, 9th ed., 2014, Douglas, A.

Skoog and Donald M. West.Sounder’s College Publishing, Japan. textbook

47 | P a g e


8.1. Lectures:

Study


ILOs

K&U IS P&PS G&TS

1.

Redox reactions,

Introduction, Factors

affecting redox potential,

Methods for detection of

end point:

a2,a3 b1 c2 --

2.

REDOX STANDARDS &

APPLICATIONS:

(A) OXIDIZING AGENTS,

KMnO4: Advantages and


a3 b5 c2,c3 d2

3.

Ce(SO4)2:Advantages and

disadvantages.Applications:

K2Cr2O7:Advantages and


a2,a3 b2,b3,b5 c2,c5 d3

4.

KBrO3:Preparation of standard

Br2., Applications:

I2:Properties., Iodimetry &

Iodometry. Applications

a1,a2,a3 b1,b4,b5 c2,c3,c5 d2

5. REDUCING AGENTS

(1) FeSO4.

(2) Na2S2O3

a2,a3,a5 b1, b3, b5 c2,c3,c5 d2

6. Pharmaceutical Applications a1,a2,a5 b2, b3, b5 c2,c3,c5 d3

7.

Electro chemistry

Introduction to

electrochemistry

a1,a4 b1,b2 c3,c4,c5 d2

9. Galvanic and electrolysis cells a1,a4 b1,b2 c3,c4,c5 d2

10. Conductometry: theory and

application a1,a4,a5 b1,b2 c2,c3,c4 d3

11.

Spectrophotometry

Introduction Components of

spectrophotometer

a1,a4,a5 b1,b2 c2,c3, c5 d2

12. Types of spectrophotometers:

Beer-Lambert law a1,a4,a5 b1,b2 c2, c4,c5 d3

13. Factors affecting absorption

spectrum: Applications a1,a4,a5 b1,b2 c2,c3, c5 d2

48 | P a g e

8.2.Practical:

Study


ILOs

K&U IS P&PS G&TS

1. Introduction to redox titration a2 b1,b3 c1,c2 --

2. Determination of KMnO4 # oxalic

acid a2,a5 b1,b3 c1, c3,c5 d2

3. Determination of K2CrO4 by

iodometry a2,a5 b1,b3 c1, c3,c5 d2

4. Determination of CuSO4 by

iodometry a2,a5 b1,b3 c1, c3,c5 d2

5. Andrews method a2,a5 b1,b3 c1, c3,c5 d2

6. Determination of H2O2 a2,a5 b1,b3 c1, c3,c5 d1

7. Determination of ascorbic acid a2,a5 b2 c1, c3,c5 d2

9. Introduction to spectrophotometry a1,a3,a5 b1,b3 c1, c3,c5 d1

10. Drawing of absorption spectrum

and calibration curve a1, a4,a5 b1,b3 c1, c4,c5 d3

11. Drawing of absorption spectrum of

KMnO4 by spectrophotometry a1, a4,a5 b1,b3 c1, c3,c4 d1

12. Drawing of calibration curve of

KMnO4 by spectrophotometry a1,a4 b1,b3 c1, c4,c5 d3

Name Signature

Course Coordinator: Dr. Mohamed El Awady



49 | P a g e





Course Title: Quality Control

Course Code: PC 522



Academic year/ level: Fall Semester 2017/2018 Level: Five

Prerequisite: Pharmaceutical Analytical Chemistry-2 (PC 222)


2. Course Aims:

To inform students with the quality assurance establishments, the relevant activities

and good laboratory practice (GLP) guidelines. In addition, to learn the students what are the

quality management and quality control activities in pharmaceutical industries and in clinical

investigation units. Furthermore, to illustrate quality assurance and regulatory matters

referring. principals of analytical techniques and the evaluation of official monographs. The

practical module is designed to familiarize undergraduates with the validation parameters

according to ICH guidelines, evaluation of impurities in pharmaceutical compounds and

estimation of the some pharmaceutical dosage forms using spectrophotometric technique




A3 a1. Recognize the different analytical techniques using GLP guidelines and

validation procedures.

A7 a2. Recall the principles of various instruments and techniques in pharmaceutical

industry

A23 a3. Identify the principles of quality assurance of pharmaceutical processes

A24 a4. Distinguish appropriate quality control criteria to different aspects of

pharmaceutical industry

A20 a5. Summarize the approval process of newly introduced pharmaceutical

products



B2 b1. Discriminate between good laboratory practices (GLPs) and good measurement

practices (GMPs) in quality control laboratories.

50 | P a g e

B3 b2. Examine suitable methods of analysis and quality control of drugs as raw material

and in dosage forms

B5 b3. Determine appropriate methods for evaluation and standardization of various

pharmaceutical compounds

B13 b4. Interpret experimental data based on relevant pharmaceutical and statistical

principles



C8

c1. Manipulate pharmaceutical instruments and equipment safely and efficiently

c2 Solve commonly encountered problems in pharmaceutical manufacturing

processes

C14 c3. Employ different quantitative chemical methods for quality control

c4 Assay of raw materials and pharmaceutical preparations




D4 d2. Collect, evaluate and present data in accordance with standard statistical methods


D13 d4. Comply with quality measures in conducting tasks

4. Contents:

4.1.Lectures:

Study

week Topics

No. of

Credit Hours

1. General introduction to quality assurance and quality control

(definitions, responsibilities, and advantages) 2

2.

The role of quality control in pharmaceutical industry (receipt,

sampling process, sampling tools, testing, and analysis)

Laboratory data, retained samples, control of starting material

acceptance, laboratory reagent, stability study, laboratory

documentation.

2

3.

Good laboratory practices (GLPs), good measurement

practices (GMPs),

Standard operating procedures (SOPs) (definition, rules, basic

structure of SOPs, styles and examples)

2

4.

Laboratory notebooks (worksheets), protocol for specific

purposes (PSP)

Quality assessment:

Internal method for quality assessment (analysis of duplicate

samples, the analysis of blanks, analysis of standards, and spike

recoveries) + (Quiz 1)

2

51 | P a g e

4.2.Practical:

Study

week Topics

No. of

Credit Hours

1. Introduction to quality control and standard operating procedure &

monographs and how to use British Pharmacopeia CD?. 1

2. Validation parameters: Accuracy 1

3. Validation parameters: Precision 1

4. Validation parameters: Linearity and Range 1

5. Spectrophotometric validation of aspirin tablets 1

6. Spectrophotometric validation of theophylline injection 1

7. Validation parameters: Specificity and Robustness 1

8. Quiz 2

9. Evaluation of impurities in pharmaceutical compounds 1

10. Limit test for salicylic acid in aspirin tablet 1

11. Limit test for chloride 1

12. Limit test for sulfate and iron 1

13. Practical Exam

14. Final Exam

Total:

1 credit hour 15.

5.

Quality assessment:

i- External method for quality assessment (proficiency

standards)

Evaluating quality assurance data

i- Prescriptive approach

2

6.

Evaluating quality assurance data:

Performance based approach (construction of property control

charts, interpreting control charts, using control charts for quality

assurance)

2

7. Different chromatographic techniques (1) 2

8. Quiz 2

9. Different chromatographic techniques (2) 2

10. Interpretation of chromatograms 2

11. Validation procedures 2

12. Official methods of analysis 2

13. Bioavailability testing & Documentation 2

14. Final Exam

Total:

2 credit hours 15.

52 | P a g e


5.1. Lectures

5.2. Practical Experiments

5.3. Learning Management System (L.M.S)

5.4. Homework



1. Written exam To assess knowledge, understanding, and intellectual skills




4. Oral exam To assess knowledge, understanding, intellectual skills, general skills and

confidence.





Assessment 3 Assignment/Activity (Research Activity) all over the term





1. Course work:

- Quiz 1 10

- Quiz 2 10



3. Oral Exam 10


Total 100%


No. Reference Type

1. Harvey, D., Modern analytical chemistry. Vol. 381. 2000: McGraw-

Hill New York. Textbook

53 | P a g e

2.

ICH guidelines Q10 (Pharmaceutical Quality System).

WHO Guidelines for Sampling of Pharmaceutical Products and

Related Materials.

Guidelines

3. BP 2013, CD. Pharmacopeia

4.

www.who.int/medicines/areas/quality_safety/.../QualityAssurancePha

rmVol2.pdf &

http://whqlibdoc.who.int/trs/WHO_TRS_929_eng.pdf

Website


8.1. Lectures:

Study


ILOs

K&U IS P&PS G&TS

1.

General introduction to quality

assurance and quality control

(definitions, responsibilities, and

advantages)

a3, a4 -- -- --

2.

The role of quality control in

pharmaceutical industry (receipt,

sampling process, sampling tools,

testing, and analysis)

Laboratory data, retained samples,

control of starting material

acceptance, laboratory reagent,

stability study, laboratory

documentation.

a3, a4,

a5 b1 ,b2 c2 d2, d4

3.

Good laboratory practices (GLPs),

good measurement practices

(GMPs),

Standard operating procedures

(SOPs) (definition, rules, basic

structure of SOPs, styles and

examples)

a1, a3,

a5 b1, b3 c1, d1, d3

4.

Laboratory notebooks

(worksheets), protocol for specific

purposes (PSP)

Quality assessment:

Internal method for quality assessment

(analysis of duplicate samples, the

analysis of blanks, analysis of

standards, and spike recoveries)

a1, a3,

a4, a5 b2, b3 c3 d2, d4

5.

Quality assessment:

ii- External method for quality

assessment (proficiency

standards)

Evaluating quality assurance data

ii- Prescriptive approach

a3, a4,

a5 b2, b4 c2 d2, d4

http://www.who.int/medicines/areas/quality_safety/.../QualityAssurancePharmVol2.pdf

http://www.who.int/medicines/areas/quality_safety/.../QualityAssurancePharmVol2.pdf

http://whqlibdoc.who.int/trs/WHO_TRS_929_eng.pdf

54 | P a g e

6.

Evaluating quality assurance data:

Performance based approach

(construction of property control

charts, interpreting control charts,

using control charts for quality

assurance)

a3, a4,

a5 b2, b4 c2 d2, d4

7. Different chromatographic techniques

(1) a2 b2, b3 c2, c3 -

9. Different chromatographic techniques

(2) a2 b2, b3 c2, c3 -

10. Interpretation of chromatograms a2 b2, b3 c2, c3 d2

11. Validation procedures a1, a3 b4 c4 d2, d4

12. Official methods of analysis a3 b2, b3 c3, c4 d4

13. Bioavailability testing &

Documentation a4 b2, b3 c3 d4

8.2.Practical:

Study


ILOs

K&U IS P&PS G&TS

1.

Introduction to quality control and

standard operating procedure &

monographs and how to use British

Pharmacopeia CD?

a3 b2, b3 -- --

2. Validation parameters: Accuracy a1, a3 b4 c4 d2, d4

3. Validation parameters: Precision a1, a3 b4 c4 d2, d4

4. Validation parameters: Linearity and

Range a1, a3 b4 c4 d2, d4

5. Spectrophotometric determination of

aspirin tablets a2 b2 c1, c3, c4 d1, d2

6. Spectrophotometric determination of

furosemide injection a2 b2 c1, c3, c4 d1, d2

7. Validation parameters: Specificity and

Robustness a1, a3 b4 c4 d2, d4

9. Evaluation of impurities in

pharmaceutical compounds a2 b2 c4 d4

55 | P a g e

10. Limit test for salicylic acid in aspirin

tablet a2 b2 c4 d4

11. Limit test for chloride a2 b2 c4 d4

12. Limit test for sulfate and iron a2 b2 c4 d4

Name Signature

Course Coordinator: Dr. Mohamed Kaddah



56 | P a g e





Course Title: Food Analysis

Course Code: PC 524



Academic year/ level: Spring Semester 2017/2018 Level five

Prerequisite: None


2. Course Aims:

To study the basic principles of the procedures commonly used to analyze food and to use the

laboratory techniques related to these procedures. In addition, to make the students well-

informed with the chemical composition of different food products and the official guidelines

for sampling and analysis of food products including analysis of specific food components,

e.g. lipids, proteins, water, carbohydrates, vitamins, minerals….etc




A1 a1. Identify the principles of food chemistry.

A2 a2. Recognize the physico-chemical characteristics of food substances

A7 a3.

Recall the principles of various instruments and techniques including

manufacturing and storing processes in food industry.

A13 a4. Recall the chemical properties of food products

A15 a5. Define the basis of nutrition facts labelling



B3 b1. Determine suitable methods of analysis raw food materials

b2. Verify appropriate methods of analysis and quality control of food products

B5 b3.

Design appropriate methods for isolation, identification and evaluation of

various food products

b4. Develop suitable methods for standardization of chemical food components

B13 b5. Interpret experimental data based on relevant chemical principles

57 | P a g e



C4

c1. Select appropriate methods of analysis and quality control of food products

c2. Implement appropriate methods for isolation, identification and evaluation of

various food products

c3 Utilize suitable methods for extraction of active materials from foods of

different origins

C8 c4

Manipulate analytical instruments and solve commonly encountered

problems in food manufacturing processes

C11 c5

Conduct research studies, including: analysis, interpretation and presentation

of results



D4 d1. Present data in accordance with standard statistical methods

D6 d2. Develop the skills required for continued self learning


4. Contents:

4.1.Lectures:

4.2.Practical: Not applicable

Study

week Topics

No. of

Credit Hours

1. General introduction on food analysis, official sources of

information 2

2. Governmental regulations and international standards. 2

3. Nutrition labeling and its official FDA regulations. 2

4. Sampling and sampling plan in food analysis

Quiz 1 2

5. Moisture and total solids analysis. 2

6. Ash analysis and specific minerals analysis. 2

7. Protein analysis. 2

8. Quiz 2

9. Analysis of lipids (fats & oils): Determination of total lipid

content 2

10. Analysis of lipids (fats & oils): Determination of lipid

composition & oxidation. 2

11. Carbohydrate analysis. 2

12. Analysis of drinking water. 2

13. Applications 2

14. Final Exam

Total:

2 credit hours 15.

58 | P a g e


5.1. Lectures


5.3. Indirect learning (Homework & assignments)

5.4. Brain storming




skills.







Assessment 3 Assignment/activity (research activity) all over the term



1. Course work:

- Quiz 1 10

- Quiz 2 10



Total 100%


No. Reference Type

1. Food Analysis (Fourth Edition, 2010) by S. Suzanne Nielsen Textbook

2. www.fda.org Website

3. AOAC International Periodical

59 | P a g e


8.1. Lectures:

Study


ILOs

K&U IS P&PS G&TS

1.

General introduction on food

analysis, official sources of

information

a1 b4 -- d2

2. Governmental regulations and

international standards. a1,a2,a5 b3,b4 c1,c2,c3 d2

3. Nutrition labeling and its

official FDA regulations. a1,a5 b3,b4 c1,c2, c4 d2

4. Sampling and sampling plan in

food analysis a3,a5 b3,b4 c4 d2

5. Moisture and total solids

analysis. a2,a3 b1, b2, b4 c2,c3,c4 d1,d3

6. Ash analysis and specific

minerals analysis. a2,a3,a4 b1,b3,b5 c1, c2,c4 d1,d3

7. Protein analysis. a3,a4 b3,b4,b5 c1,c3,c5 d1,d3

9.

Analysis of lipids (fats & oils):

Determination of total lipid

content

a3,a4 b1,b2, b4 c1, c2,c3 d1,d3

10.

Analysis of lipids (fats & oils):

Determination of lipid

composition & oxidation.

a2,a3 b3,b4,b5 c1, c2,c5 d1,d2

11. Carbohydrate analysis. a1,a2,a4 b1, b2,b3 c1,c4,c5 d1,d3

12. Analysis of drinking water. a3,a4 b1,b3,b4 c1, c2, c5 d2,d3

13. Applications a3,a4 b1,b2,b4 c2,c4,c5 d1,d2

Name Signature

Course Coordinator: Dr. Samah Abo El-Abbas



60 | P a g e





Course Title: General physics

Course Code: PC 103


Department offering the course: Pharmaceutical chemistry

Academic year/ level: Spring Semester 2017/2018 Level 1

Prerequisite: Non

Credit hours: Lecture: Practical: Total:

2. Course Aims:

2.1 To understand the general physics concepts which is related to pharmaceutical field.

2.2 Cover the basic branches in solid and liquid mechanics, hydrostatics, hydrodynamics as

well as thermodynamics, electricity, magnetism, sound waves and application of these

concepts in pharmacy.




A1

a1 Describe the concepts of solid mechanics, electricity, and optics, and give

examples to their applications in pharmacy

a2

Develop a clear understanding of basic concepts of radioactivity and nuclear

medicine and Outline the different types of magnetism and nuclear magnetic

resonance

A7

a3 Identify different types of waves and outline the properties of sound waves

a4 Discuss the meaning of thermodynamics laws, heat, temperature and its effect on

drug stability.



B2

b1 Asses safety aspects of electric force, the electric field and the electric potential,

and Identify chemical properties of drug by sound and ultrasound waves

b2 Determine the photon and heat effect on drug, degradation and investigate

different mechanical properties of matter.

B16 b3 Differentiate between the meaning of the temperature and the quantity of heat.

b4 Investigate the spectroscopic analysis and the atomic structure.

61 | P a g e



C11

c1 Analyze the physical parameters graphically and experimentally, and Utilize the

physics concepts , techniques ,and tools in solving problems

c2

Illustrate the electric field intensity and the electric potential and its applications

in pharmaceutical industry, and measure the power and focal length of the mirror

and lenses.

C15 c3

Apply the bio-magnetic field theory in the magnetic resonance imaging, and

sound waves in medicine.

c4 Handle the radiotherapy techniques.



D3 d1 Work Effectively as a part of team

D9 d2 Acquire effective time management

4. Contents:

4.1. Lectures

No. Topic No. of Credit hours

1 Solid mechanics 2

2 Fluid mechanics 2

3 Heat 2

4 Temperature + (quiz 1) 2

5 Sound and ultrasound 2

6 Nuclear and radiation 2

7 Optics 2

8 Quiz 2

9 Electricity 2

10 Magnetism and MRI 2

11 Laser 2

12 Thermodynamics 2

13 Modern physics 2

14 Final exam

Total

2 credit hours 15

62 | P a g e

4.2.Practical:

No. Topic No. of

Credit hours

1 Fine measurements 1

2 determination of specific heat of solid 1

3 determination viscosity coefficient 1

4 Metric bridge 1

5 Drawing and calculations 1

6 problems solving 1

7 determination of lens power 1

8 Quiz 2

9 determination of mirror power 1

10 tangent galvanometer 1

11 determination of sound speed in air 1

12 drawing and calculation 1

13 Practical exam 1

14 Final exam

Total

1 credit hour 15


5.1. Lectures

5.2. Practical classes

5.3. e-learning (Moodle)



1. Written exam To assess knowledge, understanding, intellectual and professional

skills.








Assessment 3 Assignment/activity (posters.) all over the term



63 | P a g e


1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment/activity (poster) 10



Total 100%


No. Reference type

1 Physics in Biology and Medicine, 4th Edition. Paul Davidovits

(2017). Textbook

2 Physics for scientist and engineers 4th Ed. R.A Serway. 2017.

Cengage learning India private limited. Textbook

3 www.explorelearign.com Website


8.1. Lectures:

Study

week Course contents

ILOs

K&U IS P&PS G&TS

1 Solid mechanics a1 b3 c1 d1

2 Fluid mechanics a1 b3 c1 d1

3 Heat a4 b3 c1 d1

4 Temperature a4 b3 c1 d1

5 Sound and ultrasound a3 b1 c3 d3

6 Nuclear and radiation a2 b4 c4 d3

7 Optics a1 b2 c2 d1

9 Electricity a1 b3 c2 d3

10 Magnetism and MRI a2 b3, b4 c3 d3

11 Laser a1 b4 c4 d3

12 Thermodynamics a4 b3 c1 d1

13 Modern physics a2 b4 c4 d1

64 | P a g e

8.2.Practical:

Study


ILOs

K&U IS P&PS G&TS

1 Fine measurements a1 b3 c1 d1

2

determination of

specific heat of

solid

a1 b3 c1 d1

3 determination

viscosity coefficient a4 b3 c1 d1

4 Metric bridge a4 b3 c1 d1

5 Drawing and

calculations a3 b1 c3 d3

6 problems solving a2 b4 c4 d3

7 determination of

lens power a1 b3 c2 d3

9 determination of

mirror power a1 b3 c2 d3

10 tangent

galvanometer a2 b3, b4 c3 d3

11 determination of

sound speed in air a1 b4 c4 d3

12 drawing and

calculation a4 b3 c1 d1

Name Signature

Course Coordinator: Dr. Ehab Hegazy

Head of Department: Prof. Dalia Rashad

Approval Date 5-2-2018

65 | P a g e





Course Title: Mathematics

Course Code: PC 101


Department offering the course: Pharmaceutical chemistry

Academic year/ level: Fall Semester 2017/2018 Level one

Prerequisite: None


2. Course Aims:

This course aims at providing the students with the mathematical principles of functions

and graphs, exponential, logarithmic, and trigonometric functions as well as differential and

integral calculus.




A1 a1. Identify the principles of mathematics and its pharmaceutical applications.

A17

a2. Distinguish between the sets, sets operations, function types.

a3. Identify the concept of differentiation and integration and their

pharmaceutical applications.



B6

b1. Differentiate between the numbers’ sets and their operations to be used in

pharmaceutical calculations.

b2. Solve different mathematical problems by applying types of functions.

b3. Apply mathematical approaches for different pharmaceutical problems.



C11 c1. Conduct experimental studies, including: presentation, analysis and

interpretation of the results

C14 c2. Employ different quantitative mathematical operations for different chemical

and biological analysis.

66 | P a g e



D4 d1 Collect, evaluate and present data

D9 d2 Acquire effective time-management skills

4. Contents:

4.1.Lectures:

4.2.Practical: N/A


5.1. Lectures

5.2. Homework




skills.




Study

week Topics

No. of

Credit Hours

1. Sets and Sets Operations (1) 2

2. Sets and Sets Operations (2) 2

3. Advanced Operation on Sets 2

4. Exponentiation and Functions + Quiz 1 2

5. Functions Definition 2

6. Function Types (1) 2

7. Function Types (2) 2

8. Quiz 2

9. Exponential & Logarithmic Functions (1) 2

10. Exponential & Logarithmic Functions (2) 2

11. Trigonometric Functions (1) 2

12. Trigonometric Functions (2) 2

13. Differentiation and integration 2

14. Final Exam

Total: 2 credit

hours 15.

67 | P a g e







1. Course work:

- Quiz 1 10

- Quiz 2 10



Total 100%


No. Reference Type

1. Schaum's Mathematical Handbook of Formulas and Tables, 2000 textbook

2. Mathematics and Statistics for Use in Pharmacy, Biology, and

Chemistry, latest edition. textbook


8.1. Lectures:

Study


ILOs

K&U IS P&PS G&TS

1. Sets and Sets Operations (1) a1, a2 b1 c1,c2 -

2. Sets and Sets Operations (2) a2 b1 c1,c2 -

3. Advanced Operation on Sets a2 b1 c1,c2 d1

4. Exponentiation and Functions a2 b1 c1 d1

5. Functions Definition a2 b1 - d1

6. Function Types (1) a2 b1 c1 d1

7. Function Types (2) a2 b2 c1 d1

9. Exponential & Logarithmic Functions (1) a3 b2 c1 d1

10. Exponential & Logarithmic Functions (2) a3 b3 c1 d1

11. Trigonometric Functions (1) a3 b2 - d1

12. Trigonometric Functions (2) a3 b2 - d1

13. Differentiation and integration a3 b3 c1 d1

Name Signature

Course Coordinator: Dr. Noha El-Attar

Head of Department: Prof. Dr. Dalia Rashad


68 | P a g e

Other Courses Not Opened for Registration

at Academic Year (2017-2018)

Final Approval 2016-2017

69 | P a g e


Course title: Advanced instrumental analysis

Course code: PC 423


Department: Pharmaceutical chemistry

Academic level: Elective course

Prerequisite: None

Credit hours: Lecture :2 Practical: ---- Total: 2

2. Course Aims:

Giving the principle of quantitative chemical methods of analysis, Covers electro-analytical

methods of analysis, Provides basic concepts of spectroscopy and chromatography




A3 a1 Manage the different analytical techniques

A4 a2 Enumerate the theories of evaluation and standardization of chemicals and

pharmaceuticals



B3 b1 Determine suitable methods of analysis of drugs as raw materials and in dosage

forms

B5 b2 Design appropriate methods for identification and standardization of various

chemical and pharmaceutical compounds



C2 c1 Handle and dispose chemicals safely

C4 c2 Select appropriate methods for identification and standardization of active

substances from different origins

C8 c3 Manipulate pharmaceutical instruments and equipment safely and efficiently and

solve commonly encountered problems in pharmaceutical analysis.

C14 c4 Employ different quantitative chemical methods for assay of raw materials



D3 d1 Work effectively as a part of a team to perform the required tasks

D9 d2 Acquire effective time management skills

D10 d3 Implement writing and presentation skills

70 | P a g e

4. Contents:

4.1.Lectures:

Week

No. Topics

No. of

Credit

hours

1.

Spectrophotometry

Introduction:

Electromagnetic radiation (EMR).

Properties of light:

(a) as waves.

(b) as particles.

Chromophores.

Auxochromes.

2

2.

Components of spectrophotometer:

Light source.

Wavelength selector (monochromator):

Filters.

Prisms.

Gratings.

Sample compartment and cuvette.

Detector:

Phototube.

Photomultiplier.

Readout device

2

3.

Types of spectrophotometers:

(a) Single-beam spectrophotometer.

(b) Double-beam spectrophotometer.

Beer-Lambert law:

Definitions and equations.

Problems.

Deviations of Beer’s law

2

4.

Factors affecting absorption spectrum:

(1) Effect of pH:

Phenol.

Aniline.

(2) Effect of Dilution.

(3) Effect of Solvent.

(4) Effect of Temperature.

Applications:

(a) Qualitative applications.

(b) Quantitative applications:

Steps for a spectrophotometric determination.

2

71 | P a g e

5.

Electro chemistry: Introduction to electrochemistry:

Ionic pressure and Electrolytic solution pressure

Galvanic and electrolysis cells

Daniel cell

Liquid junction potential and role of salt bridge

2

6.

Potentiometry:

Reference electrodes:

Standard hydrogen electrode (diagram, half reaction,

potential,disadvantages)

Saturated calomel electrode (diagram, half reaction,

potential, disadvantages)

Indicator electrodes (glass electrode):

(diagram, composition, theory of operation, disadvantages)

Applications

Potentiometric titration curves (zero, first, second), location of EP

on curves.

2

7. Mid-Term exam

8.

Polarography:

*polarograph: parts, function of auxiliary electrode and

potentiostst).

*Polarogram, potential range

*Advantages and drawbacks of DME

*Role of supporting electrolyte

*Oxygen waves and their removal

2

9.

Conductometry:

*Specific, molar and equivalent conductance (definition, unit, effect

of dilution on each)

*Factors affecting conductance of a solution

*Conductometric titration of HCl# NaOH and HCl # NH4OH

2

10.

Chromatography

Parts of chromatograph

Difference between normal and reversed phase

chromatography

2

11.

Difference between adsorption and partition

chromatography

Difference between size exclusion and ion exchange

chromatography

Columns used in revered phase chromatography

2

12.

Difference between silica based and polymer based

columns

Difference between gel filtration and gel permeation

chromatography

2

13. Difference between isocratic and gradient elution

NTP,HETP,K' 2

14. Final Exam

2 credit

hours4 15.

72 | P a g e


5.1. Lectures

5.2. Homework and assignments


6.1. Assessment methods:

1. Written exam to assess knowledge, understanding, intellectual and professional skills

2. Class work to assess knowledge, understanding, intellectual skills, general skills and

confidence

3. Quizzes to assess knowledge, understanding and intellectual skills

6.2. Assessment schedule:

Assessment 1 Mid-term 7th week

Assessment 2 Quiz 11th week

Assessment 3 Written 14th &15th weeks


Mid-Term Exam & course work 25%

Final-Term Exam 75%

Total 100%


No. Reference type

1.

Fundamentals of Analytical Chemistry

Douglas A.; Skoog ;Donald M., West, F. James Holler, Stanely, R. Crouch

Edition thThomson, Australia , 6

Textbook

2. www.mediafire.com/download/tfw77m3ewhbte0s/Animation_Spectro_Photom

ultiplier.mp4 website


Study


ILOs

knowledge and

understanding

intellectual

skills

professional

and practical

skills

general and

transferable

skills

1.

Spectrophotometry

Introduction:

Electromagnetic radiation (EMR).

Properties of light:

(a) as waves.

(b) as particles.

Chromophores.

Auxochromes.

a1 b1 c3 d1

http://www.mediafire.com/download/tfw77m3ewhbte0s/Animation_Spectro_Photomultiplier.mp4

http://www.mediafire.com/download/tfw77m3ewhbte0s/Animation_Spectro_Photomultiplier.mp4

73 | P a g e

2.

Components of

spectrophotometer:

Light source.

Wavelength selector

(monochromator):

Filters.

Prisms.

Gratings.

Sample compartment and cuvette.

Detector:

Phototube.

Photomultiplier

Readout device

a1 b1 c3 d1

3.

Types of spectrophotometers:

(a) Single-beam

spectrophotometer.

(b) Double-beam

spectrophotometer.

Beer-Lambert law:

Definitions and equations.

Problems.

Deviations of Beer’s law

a1 b1 c3 d1

4.

Factors affecting absorption

spectrum:

(5) Effect of pH:

Phenol.

Aniline.

(6) Effect of Dilution.

(7) Effect of Solvent.

(8) Effect of Temperature.

Applications:

(c) Qualitative applications.

(d) Quantitative applications:

Steps for a spectrophotometric

determination.

a1 b1 c3, c4 d1,d2

5.

Electro chemistry

Introduction to electrochemistry:

Ionic pressure and Electrolytic

solution pressure

Galvanic and electrolysis cells

Daniel cell

Liquid junction potential and role

of salt bridge

a1,a2 b2 c1, c2 d3

74 | P a g e

6.

Potentiometry:

Reference electrodes:

Standard hydrogen electrode

(diagram, half reaction,

potential,disadvantages)

Saturated calomel electrode

(diagram, half reaction, potential,

disadvantages)

Indicator electrodes (glass

electrode):

(diagram, composition, theory of

operation, disadvantages)

Applications

Potentiometric titration curves (zero,

first, second), location of EP on

curves.

a1 b2 c3,c4 d1,d3

8.

Polarography:

*polarograph: parts, function of

auxiliary electrode and potentiostst).

*Polarogram, potential range

*Advantages and drawbacks of

DME

*Role of supporting electrolyte

*Oxygen waves and their removal

a1 b1 c3 d1

9.

Conductometry:

*Specific, molar and equivalent

conductance (definition, unit, effect

of dilution on each)

*Factors affecting conductance of a

solution

*Conductometric titration of HCl#

NaOH and HCl # NH4OH

a1,a2 b2 c3,c4 d1,d2

10.

Chromatography

Parts of chromatograph

Difference between normal and

reversed phase chromatography

a1,a2 b1 c3, c4 d1,d2,d3

11.

Difference between adsorption

and partition chromatography

Difference between size exclusion

and ion exchange

chromatography

Columns used in revered phase

chromatography

a1,a2 b1 c3, c4 d1,d2,d3

12.

Difference between silica based

and polymer based columns

Difference between gel filteration

and gel permeation

chromatography

a1,a2 b1 c3, c4 d1,d2,d3

75 | P a g e

13.

Difference between isocratic and

gradient elution

NTP, HETP, K'

a1,a2 b1 c3, c4 d1,d2,d3

Name Signature

Course Coordinator: Mary Wahba

Head of Department: Prof Fatma Goda


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