department of materials science, uop. nanotechnology takes aim at cancer – science 130 2005.1132...
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Department of Materials Science, UoP
MAGNETIC NANOASSEMBLIES IN MEDICINE
Department of Materials Science, UoP
Nanotechnology Takes Aim at Cancer – Science 130 2005.1132
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NANOMEDICINES IN THE MARKET
Department of Materials Science, UoP
NANOMEDICINES IN THE MARKET
Department of Materials Science, UoP
BIG PHARMA INCREASING INTEREST
Department of Materials Science, UoP
Department of Materials Science, UoP
• A. Jordan, et al. Presentation of a new magnetic field therapy system for the treatment of human solid tumors with magnetic fluid hyperthermia J. Magn. Magn. Mat. 225, 2001, 118.
• H. Bert, P. Wust, O. Ahlers, A. Dieing, G. Sreenivasa, T. Kerner, R. Felix, H. Riess. The cellular and molecular basis of hyperthermia Critical Reviews in Oncology/Hematology 43, 2002, 33.
TherapyMagnetic Hyperthermia
MagForce® NanoCancer Therapy
Department of Materials Science, UoP
• Some advantages:
– Targeting of the drug-carrier conjugate by physical routes
– Cancer cell necrosis or sensitization by physical routes: light or magnetically induced hyperthermia.
– Physical stimuli responsive drug release (light, AC)
– Simultaneous Imaging
TherapyDrug Nanocarriers
Department of Materials Science, UoP
• Some advantages:
– Targeting of the drug-carrier conjugate by physical routes
– Cancer cell necrosis or sensitization by physical routes: remotely (magnetically) induced hyperthermia.
– Physical stimuli responsive drug release (light, AC)
– Simultaneous Imaging
TherapyDrug Nanocarriers
Department of Materials Science, UoP
• Some advantages:
– Targeting of the drug-carrier conjugate by physical routes
– Cancer cell necrosis or sensitization by physical routes: light or magnetically induced hyperthermia.
– Physical stimuli responsive drug release (AC)
– Simultaneous Imaging
TherapyDrug Nanocarriers
Department of Materials Science, UoP
• Some advantages:
– Targeting of the drug-carrier conjugate by physical routes
– Cancer cell necrosis or sensitization by physical routes: light or magnetically induced hyperthermia.
– Physical stimuli responsive drug release (AC)
– Simultaneous Imaging/MRI
TherapyDrug Nanocarriers
ACS Nano 2012, 6, 8783
Department of Materials Science, UoP
1 10 500
20
40
60
80
% Release
Cum
ula
tive r
ele
ase (%
)
Time (hours)
PBSpH 7.4
% Release under AMF
PBSpH 7.4
30 40 50 60 70 80 90 100 110 1200.6
0.7
0.8
0.9
1.0
1.1MagAlg MagP(MAA-g-EGMA)
Time (min)
Absorb
ance c
m-1
Soft clustering
Condensed clustering
Structure-organization and properties
Magnetophoresis
Drug release experiments under AC magnetic field
Department of Materials Science, UoP
In-vivo Imaging
Passive targeting of cancerMagnetic targeting in vivo
Cancer
In vivo imaging through Multispectral Optoacoustic Tomography.
Our product passively targets the tumor area, after a tail vein administration to the mice (upper part).
The nanomedicines are also very effectively respond to external magnetic fields in vivo (bottom part).
Department of Materials Science, UoP
Therapeutic efficacy studies. FD: drug only, PD: nanomedicines, PDMF: with magnetic targeting.
With magnetic targeting the tumor growth has substantially decreased.
In addition, toxicity is particularly reduced as weight changes suggest.
Department of Materials Science, UoP
Y. Sarigiannis University of Pennsylvania, Pathology & Laboratory Medicine, Upen
E. Papadimitriou Pharmaceutical Dept., Univ. Patras, Greece
V. Zoubourlis National Hellenic Research Foundation, Athens
StudentsArgiris Kolokithas
Efi Voulgari
K. Avgoustakis Pharmaceutical Dept., Univ. Patras, Greece
V. Ntziachristos Institute for Biological and Medical Imaging at the Helmholtz Zentrum& N. Beziere Munich
Collaborators
Department of Materials Science, UoP
THANK YOU FOR YOUR ATTENTION!