department of chemical sciences and materials technologies · by developing an innovative...

National Research Council of Italy

Department of Chemical Sciences and Materials Technologies

Department of Chemical Sciences and Materials Technologies

Director: Dr. Maurizio Peruzzini

Human ResourcesPatents

Research Platforms

The needs of the modern society and the fast growth of several emerging economics that are characterized by continuous investments in research and development, are pushing the Europe and related Member States to define a research and development strategy to address grand societal challenges in the coming years. In this directions, Key Enabling Technologies (nanotechnology, micro-nanoelectronics, photonics, advanced materials, industrial biotechnology and advanced manufacturing systems) have been identified to strengthening Europe’s capacity for industrial innovation and the development of new products and services needed to deliver smart, sustainable and inclusive European growth. Moreover, excellence science are implemented of by the Future Emerging Technology (FET) programs. In Italy, the National Research Council, is one of the main institution promoting this strategy by

identifying the main objective: ....to produce values by the knowledge generate from research”. Based on this the Department of Chemical Science & Materials Technology has defined as own main missions the Chemical Manufacturing & Advanced Materials Technology. In this context, the Chemical and Material Science are crucial for the sustainable development based on integrate and dynamic innovation to respond to the social end technological challenges as defined by the demand pull of the modern society. In this directions, the department has defined and integrated the competences and knowledge to meet a research and innovation agenda in the following strategic area: Sustainable Chemistry, Advanced Materials and Enabling Technologies, Health Science.

Department

1% 10%

4%63%

8%

30%

32%

1%3%9%

13%

22%

Administrative staff

Green Chemistry

Advanced MaterialsChemistry for Cultural Heritage

Others

Computational Modeling

Chemistry and Energy

Chemistry for Life Sciences

Directors

Researchers

Technicians

Technologists

Director: Dr. MAURIZIO PERUZZINI

GREENCHEMISTRY

CHEMISTRY AND ENERGY

CHEMISTRY FOR LIFE SCIENCES

ADVANCED MATERIALS

14 institutes are within the department (ICB – Biomole-cular Chemistry; ICCOM – Chemistry of Organometallic Compounds; ICMATE - Institute of Condensed Matter Chemistry and Technologies for Energy; ICRM – Chemi-stry of Molecular Recognition; IC – Crystallography; IMC – Methodological Chemistry; IPCB – Institute of Polymers Composites and Biomaterials; IPCF – Institute for Chemi-cal and Physical Processes; ISTEC – Science and Techno-

logy for Ceramics; ISTM – Molecular Science and Techno-logy; ISOF – Organic Synthesis and Photoreactivity; ISMN – Nanostructured Materials; ISMAC – Macromolecular Studies; ITM – Membrane Technology). These institutes, spread all over the wole country, carry out advanced rese-arch activity and are distinguished for competences, expe-rimental facilities and the excellence of it’s researchers.

Institutes

Trieste

Bari

Arcavacata di Rende

Messina

Catania

Palermo

Sassari

Naples

Pozzuoli

Rome

Perugia

FaenzaBologna

Ferrara

Padua

Pisa

Florence

Genoa

BiellaMilan Lecco

Institute of CrystallographyDirector: Dr. MICHELE SAVIANO

The Institute of Crystallography (IC) has been officially active since 2002. It was born from the merg-er of the “Istituto di Ricerca per lo

Sviluppo di Metodologie Cristallografiche” in Bari and the “Istituto di Strutturistica Chimica Giordano Giacomello”(in-cluding the Basovizza section) in Monterotondo Scalo. The headquarters of the Institute are located in the CNR Re-search Area of Bari, secondary branches are located in the CNR Research Area of Rome 1, Montelibretti and in the Science Park Area of Basovizza, Trieste, and a research unit in Como in the Department of Science and Technology of the University of Insubria (To.Sca.Lab).The research and development activities of the IC have tak-en place in five mainly project area:1) development of new crystallographic methodologies for the structural characterization of inorganic and organic sys-tems with different complexity;2) development of nanomaterials and biomaterials;

3) molecular design of new drugs and di-agnostics;4) development of innovative biosensors;5) Anti Digital Divide for technology transfers and supports to public adminis-trations and private SME.IC has state-of-the-art instrumentations for diffraction data collection of microcrystalline powder and single crystal, and of SAXS, WAXS, GISAXS, GIWAXS and scanning SAXS microscopy techniques. The IC, through the Trieste unit, maintains the control of X-Ray Diffrac-tion 1 (XRD1) beamline at ELETTRA Sincrotrone Trieste, for macromolecular crystallography and material science. In addition, the IC has laboratories for the crystallization, expression and purification of biomolecules, and for their biochemical and biophysical characterization; laboratories for molecular biology; labs for synthesis of peptides and oligonucleotides; facilities for high performance computing systems and hardware development.

Bari

Trieste

Como

Montelibretti (RM)

Headquarter Institute

Research Unit

Third Parties Research Unit (URT)

Human Resources

38

22

1

Technologists Researchers

TechniciansAdministratives

10 20 30 40 50

3

What We Are Doing

Patents

The IC merges two souls of Crystallography: the methodological and the experimental ones. The devel-opment of innovative crystallographic methodologies for powder, single crystal and macromolecular X-ray diffraction data are implemented in software useful for molecules of industrial and bio-pharmaceutical interest, as well as chemistry and structural biology. Interdisciplinary studies are carried out on: struc-ture-based drug design; development of new biolog-ical and pharmacological compounds (antimicrobials, antibiotics, anticancer drugs, etc.); characterization of materials of technological interest, such as nanocrys-tals, quasi-crystals. In addition, new approaches are being developed for quantitative X-ray photograph of nano-structured materials and bone tissue engineered for preventive diagnostics in biomedicine; innovative scientific instrumentation for the international market; applications “Anti Digital Divide”; biosensors based on photosynthetic proteins suitable for many applications in biotechnology for health, for the environment and for the food industry.

IC distributes innovative crystallographic software for structural resolution to academic institutions and com-panies. IC has two know how non-exclusive license agreements with RIGAKU for commercialization of EXPO and SIR packages, with recognition to CNR of royalties. Actually, The licenses distributed around the world are above 6000.

From nano to bio-materials: research ac-tivities and state-of-the-art instrumenta-tion in material sciences.

From genes to drugs via crystallography: Experimental and computational tools for structural and functional investigations of biomolecules.

Development of methodologies and soft-ware (EXPO, SIR) for winning the chal-lenge of characterising crystalline com-pounds from minerals to biomolecules by means of X-ray diffraction techniques.

Our Projects

Excellence of the Institute

Project manager

Michele Saviano

Project manager

Rocco Caliandro

Project manager

Antonietta Guagliardi

This project aims to create a smart kit for celiac genetic diagnostics, based on microRNA and PNA, that exceeds the limitations of current kits available on the market both in terms of sensitivity and specificity. The added value of this achievement lies in the possibility of high sen-sitivity and specific epidemiological studies that are only possible when the nature of the biomarkers is genetic. The proposal is funded by Ital-ian Ministry of Economic Development.

This research project is funded under the call H2020 - FET OPEN-2014/2015, in the framework of Future and Emerging Technologies ac-tions. Its primary goal is to contribute in revolutionizing currently used downstream practices in biopharmaceutical productions mainly based on expensive and cumbersome multi-step batch chromatography platforms, by developing an innovative Continuous Template-Assisted Membrane Crystallization process as key-unit.

The main and promising research lines covers the following relevant scientific area:Crystallographic methods. IC is one of the world leader in the de-velopment of innovative crystallographic methods and their imple-mentation in software for structural resolution. SIR and EXPO are the most famous packages in the international scenario, used up to now by about 6000 laboratories.Structural Chemistry. More promising researches are in structural characterization by X-ray powder and single crystal diffraction of new ligands with application in medicinal chemistry, of cultural herit-age materials and of minerals.Material Sciences. Frontiers of research in engineering, science and

technology have been driven by developments in nano/bio/mate-rials, encompassing diverse disciplines. IC offers excellent scientific competences and state-of-the-art instrumentation to image struc-ture and morphology of smart materials at the nano and atomic scale. Biotechnology for agrifood field. A multidisciplinary team designs and develops biosensors to detect environmental pollutants, and address food quality and safety issues. Structural Biology. High impact researches are in progress on pro-teins or oligonucleotides and their complexes with biological mole-cules, with the aim to drive the design of new molecules with appli-cation in early diagnosis and in therapy.

HYPATIA (www.hypatiagro.it) is a multidisciplinary project aiming at integrating nanotechnology into fertilizers for sustainable Agriculture. Non-toxic, low-cost and industrially scalable nano-Apatites (nAp), containing P, will be engineered to incorporate NO3

- and NH4+ ions.

P and N, the macronutrients of plants, are slowly released thanks to pH-dependent dissolution processes. Advanced tools and suitable protocols will be developed for characterizing the E-nAp. Tests will be performed on wheat plants in growth chambers, greenhouses and in the field.

Study, Design and Development of an Innovative Kit for Early and non-Invasive Diagnosis of Celiac Disease by Genetic Markers

Revolutionizing Downstream Processing of Monoclonal Antibodies by Continuous Template–Assisted Membrane Crystallization (AMECRYS)

Romancing the Stone: Size-Controlled HYdroxyaPATItes for Sustainable Agriculture (HYPATIA)

Website: http://www.ic.cnr.itAddress: via Amendola, 122/O

70126 - Bari - ItalyTel: +39 080 5929142 - Fax: +39 080 5929170

http://www.ic.cnr.it

Institute of Biomolecular ChemistryDirector: Dr. BARBARA NICOLAUS

The mission of ICB consists of the chemical study of biological systems and processes to understand their function at the molecu-lar level and explore their new technological applications.

ICB personnel has expertise in fields ranging from basic chemistry to biology, for the development of molecules and processes of biological interest through multi- and inter-disciplinary approaches. Within the diversity of the methodologies employed by the personnel and of the ob-jectives pursued by the researchers, ICB research activity is centered on organic molecules and their biological proper-ties seen as pieces of a puzzle of growing complexity, from single metabolic steps to interactions between different or-ganisms, and tools to be used to obtain a desired biological

effect and to exploit metabolic process-es of biotechnological importance. ICB activities range from basic research on biomolecules and bioprocesses to their biotechnological applications in the fol-lowing sectors: 1) Health (development of new active principles, understanding of physiological and pathological mechanisms); 2) Energy (development of biofuels and other renewable bioenergetics resources); 3) Environment (understanding and counteraction of biolog-ical invasion phenomena, recycling of potentially polluting industrial waste products); 4) Agriculture and Food Indus-try (study and amelioration of species with nutritional val-ue, identification of active principles for the nutraceutic, cosmetic and veterinary use).

Pozzuoli

Padua

Catania

Sassari




Research Unit


Human Resources

10 20 30 40 50

69

29

12

2

What We Are Doing

Patents

ICB operates in the fields of bioorganic chemistry, chemical biology and fermentation chemistry, with expertise in the disciplines of spectroscopy, structural and synthetic chemistry, biochemistry, molecular mod-eling, microbiology, pharmacology, nutraceutics and bioenergetics. The synergic interactivity of the 4 “sec-tions” (branches) of ICB is ensured by 5 “Inter-Sec-tion Disciplinary Groups”: 1. Building the bricks for our home: synthesis of organic molecules; 2. When “small” meets “big”: molecular recognition and its bio-logical consequences; 3. Natural products: “tiny” mol-ecules with “great” applications; 4. (Biologic)al minds: the profilers of the biomolecules; 5. A factory of bio-logical systems and processes.

More than 50 patents are listed in the institution-al website of ICB, which, from its founding in 2002, has published more than 2600 papers on internation-al journals. Among the most recent patents, the in-vention of a macroporous material with heparin se-questering properties, which could be used for blood purification of excess heparin following anti-coagulant treatment; the use of non-psychotropic cannabinoids for the treatment of muscular dystrophies; and the use of anaerobic bacteria for CO2 capture.

Chromodoris quadricolor, a nudibranch mollusk wherefrom new defense mole-cules were isolated

Co-localization of proteins of the endocan-nabinoid system in hypothalamic neurons by means of confocal microscopy

Biofermenters for medium-high scale cul-ture of marine microalgae

Our Projects


Project managers

E. Manzo - M. Foti

Project managers

P. Peluso - R.M. Vitale

Project managers

E. Mollo - A. Cutignano

Synthesis, by applying also Green Chemistry principles and new meth-ods of asymmetric catalysis with organometallic catalysts and/or en-zymes (biocatalysis), of bioactive compounds with pharmaceutical and agrochemical potential, synthones and biofuels. Preparation of immunomodulatory glycolipids, antioxidant biphenylic compounds, an-titumorals, peptides and peptidomimetics, caspase inhibitors, tetrahy-droisochinolines, dihydropyridines, piperidines and calixarens. Selective oxidation of polyols and study of free radicals.

Study of the molecular bases of diseases through investigations of the structure-activity relationships of proteins and lipids, e.g. pharmacological chaperones, endocannabinoids, polyphenols, vanilloids. Chemical com-munication among bacteria. X-ray, EPR, HPLC and NMR methods for the study of chemical structures and their interactions. Ligand-protein com-plexes modeling and bioactive molecule design. 3D structures of non-pro-teic aminoacid-containing proteins. Pharmacological screening. Nanopar-ticles for the controlled release of biomolecules into biological systems.

Some of ICB research groups work on topics of great biotechno-logical relevance, whose excellence is internationally recognised. As an example, the groups working on the following subjects, often in a manner coordinated among the 4 ICB branches, must be remem-bered: 1) biochemistry and physiopathological role of the endo-cannabinoids and therapeutic use of phytocannabinoids and TRP channel ligands; 2) biochemistry and microbiology of extremophiles and biotechnological exploitation of agrifood wastes; 3) genetic bi-omarkers of melanoma and metabolic biomarkers of respiratory and metabolic diseases through the use of next generation DNA

sequencing and NMR techniques, respectively; 4) synthesis and bio-technological applications of calixarens; 5) chemical ecology of ma-rine mollusks; 6) polyoxydrylated phenols as potential phytodrugs, antioxidants and antitumorals; 7) development, optimization and uti-lization of bioprocesses for the production of biofuels; 8) methanol dehydrogenation for hydrogen production; 9) System biocatalysis for the development of artificial metabolic pathways for organic syn-thesis; 10) ceftriaxone mechanism of action; and 11) marine microal-gae as source of new therapeutic drugs and bioprocesses of interest for the energy and agrifood sectors.

Marine natural products as mediators of biological processes and eco-logical phenomena. Identification of molecules from marine and veg-etal sources of potential interest for the pharmaceutical, agrifood and cosmetic industry. Evaluation of the antioxidant activity of agrifood products. Use of polyfunctional platforms for the enhanced delivery of micronutrients. Stabilization of fruit-based products by means of functional natural substances. Study of polyhydroxylated phenols of industrial interest.

Synthesis of organic molecules

Molecular recognition and its biological consequences

Natural products

Website: http://www.icb.cnr.itAddress: Via Campi Flegrei, 34 80078 - Pozzuoli (NA) - Italy

Tel: +39 081 8675026 - Fax: +39 081 8041770

http://www.icb.cnr.it/it/

Institute of Chemistry of OrganoMetallic CompoundsDirector: Dr. FRANCESCO VIZZA

The Institute of Chemistry of Organometallic Compounds (ICCOM) was founded in 2001 joining former ISSECC (Insti-tute for the Study of Stereo-chemistry and Energetics of

Coordination Compounds), founded by Luigi Sacconi in Florence at the end of the 70’s, with three CNR Centers located in Florence (headquarters), Pisa and Bari, to create an important CNR chemistry center active in the fields of organometallic chemistry and its application in homogeneous and heterogeneous catalysis. Since 2006, ICCOM CNR manages the Center for Electronic Mi-croscopy (Ce.M.E.), located within the CNR Florence Research Area, a reference structure in the field of electronic microscopy available to CNR Researchers, Universities and the manufacturing and industrial world. Two Third Party Research Units (URT) are currently

affiliated to ICCOM. The first one, lo-cated at the Department of Chemistry at the University of Trieste, brings ex-pertise in nanotechnologies, heteroge-neous catalysis and new materials for use in the production of energy from renewable sources; the second one, at the School of Pharmacy at the University of Cameri-no, brings expertise in porous materials chemistry and coordination polymers and metallorganics. Personnel at ICCOM includes 77 staff units of whom 54 researchers. The Institute also involves a large number of University associates and over 30 young scientists for higher edu-cation (PhD students, postdocs, visiting scientists). Nu-merous collaborations involve Italian Universities (48), Research Institutes (30) and Foreign counterparts (78), industries and consortia, across 24 countries on four continents.

Trieste

Florence

Camerino

Bari

Pisa


Research Unit


6

14

54

Technologists

Researchers

Technicians

Administratives

10 20 30 40 50

1

Human Resources

What We Are Doing

Patents

The mission of the Institute is to develop fundamental and applied research together with advanced training in the following fields of molecular sciences:• New sustainable chemical processes with high efficiency and selectivity, optimisation of existing catalytic and stoi-chiometric processes;• Application of electrocatalysis and photocatalysis in the energy sector;• Photovoltaic solar cells: organic and organometallic compounds for new generation solar cells;• Hydrogen chemistry and technology: production, stor-age and use in fuel cells;• CO2 chemistry and technology: valorisation (CCU) and capture (CCS);• Organic, inorganic and hybrid polymeric materials with specific functional properties;• Organic chemistry and magnetic materials for pharma and medical applications;• Advanced analytical and spectroscopic techniques for the environment, health and for the conservation of the artistic and cultural heritage;• Theoretical and computational chemistry for the pre-dictive modeling.

• Method for preparing highly nitrogen-doped meso-porous carbon composites, European Patent No. EP 3 047 905 A1, 2016.• One-Pot process using heterogeneous catalyst, World Patent No. WO2016079036 A1, 2016.• Gas generator for producing gaseous hydrogen to fuel cells World Patent No. WO2014097334-A1, 2014.• Organic Thin film Transistor Comprising Thienyl Oli-gomers and Thier Use As Gaseous Phase Sensor, Europe-an Patent No. EP2121647, 2014.

Solar Fuels and Chemicals Production in the ENERGYLAB Project

SEM image of titania-palladium nano-tubes.

STEM Dual Beam instrumentation availa-ble a Ce.M.E.

Our Projects


Project managerMaurizo Peruzzini

Project managerFabrizio Santoro

Project managerCaterina Fusco

The PHOSFUN project (Phosphorene functionalization: a new platform for advanced multifunctional materials) studies the unexplored chemical reactivity of phosphorene, a 2D material made of a single ordered sheet of phosphorus atoms. The aims of the project include: setup of a scal-able and reproducible synthesis of mono- and multilayer phosphorene; functionalisation with organic and inorganic moieties; implanting phos-phorene derivatives into different device platforms for uses in material science, catalysis, microelectronics and optoelectronic devices.

MOSAICOS project (Eco-Sustainable Interactive Mosaics) aims at engag-ing the Advanced Materials (KET 5) and the Micro and Nanoelectronics (KET 1) for the development of environmentally sustainable interactive digital mosaics, developing i) polyurethanes from vegetable raw materi-als for the realization of mosaics, carried out by means of the innovative technology of Digital Mosaic, trademark of Pepe & Con, the project leader, and ii) digital interactive mosaics based on the hardware plat-forms and proprietary software, including embedded control systems.

The institute is a Center of Excellence in the fields of “Green Chem-istry and Sustainable Processes” and “Renewable Energy”. The Re-search activities cover all aspects of the hydrogen economy, from its production from renewable resources (e.g. biomass) to storage and utilisation. Innovative photovoltaic devices are being developed, not only for electrical energy production, but also for the produc-tion of “solar fuels” from the combination of solar energy, water and carbon dioxide. Catalytic, photo- and electrocatalytic process-es that convert carbon dioxide with high efficiency into fuels or chemical compounds are also studied. ICCOM is also carrying out

cutting-edge research in fields such as catalysis for green chemistry, environmental technology, the conservation of cultural heritage, ad-vanced polymers and the application of nanostructured materials in biomedical and energy applications. Of utmost importance to the institute is the presence of a highly qualified group of computation-al chemists, the most productive and important group within the DSCTM. Finally, ICCOM manages the Electron Microscopy Centre (Ce.M.E.) of the CNR Research Area of Florence, a highly special-ised laboratory capable of satisfying the scientific and technological needs of both public and private research sectors.

The main goal of the MSCA-ITN-2017 LightDyNAmics Project is to achieve a complete understanding of ultrafast dynamical processes at molecular scale, induced by UV light absorption in DNA, and to unveil the mechanisms leading to photodamage of the genetic code. LightDy-NAmics is an academia-industry research environment training 15 Early Stage Researchers (ESRs) by crossing the traditional border between theoretical and experimental expertise. The consortium, led by CNR-IBB and with CNR-ICCOM as Partner, brings together 10 top academic groups and 6 innovative companies.

PhosFun (ERC Advanced Grant)

MOSAICOS (Apulia Region)

LightDyNamics (MSCA-ITN-2017 )

Website: http://www.iccom.cnr.itAddress: Via Madonna del Piano, 10

Area di Ricerca di Firenze - 50019 Sesto Fiorentino (FI)Tel: +39 055 522 52 86 Fax: +39 055 522 52 03

http://www.iccom.cnr.it%0D

Institute of Condensed Matter Chemistry and Technologies for EnergyDirector: Dr. LIDIA ARMELAO

The Institute of Condensed Matter Chemistry and Technologies for Energy of the National Research Council of Italy (ICMATE - CNR) is

a highly interdisciplinary Institution, characterized by interdisciplinary expertise and consolidated know-how ranging from design and unconventional synthesis, to theoretical and experimental modelling, to prediction of relationships between structure, composition and properties of materials, interfaces and nanosystems. ICMATE has an important role in the development of innovative molecules, functional surfaces and inorganic materials, and advanced metallic components that provide relevant solutions for emerging technologies, energy efficiency and medicine, paying attention to critical issues related to raw materials and sustainability. Research efforts are directed towards the chemical processing of functional nanomaterials, interface chemistry, materials science and

engineering. Our strength originates from having multidisciplinary expertise and from being geographically spread. With four unit (Genova, Lecco, Milano, Padova) in different Italian regions (Lombardia, Veneto, Liguria), we are a distributed network of laboratories and competences, present also at the University of Padova. This allows us to work actively in the regional territories, able to increase competences, create synergies and promote smart specializations. ICMATE has a strong collaborative tradition with national industries and companies for the development of research and innovation programmes. This fosters consulting activities to public institutions and business, and transfer of knowledge to relevant stakeholders. We disseminate knowledge and give contribution to educational programmes.

Padua

Genoa

Milan

Lecco


Research Unit


13

30

78

Technologists

Researchers

Technicians

Administratives

10 20 30 40 50

6

Human Resources

What We Are Doing

Patents

Research activities are focused in the strategic areas of advanced manufacturing and emerging technologies, energy efficiency and sustainability, and nanomedicine. We design and perform non-conventional synthesis of innovative compounds and nanosystems, functional surfaces, and materials of inorganic and metallic nature. We combine advanced characterization techniques with theoretical and experimental competences to predict and correlate the compositional and structural characteristics of compounds, nanoscale systems and materials to their functional micro- and macro-properties, and performances. The activities include non conventional synthesis of inorganic and metallic nanocomposites and materials, control of their interfaces, new methods of analysis, development of prototype instruments, functional surfaces and coatings for innovative technologies of interest in cultural heritage, advanced manufacturing and biomaterials, synthesis of nanosystems and colloids, and nanomedicine (molecular systems and nanostructures). Along these lines we provide solution to territorial and state bodies, to public and private businesses.

Over the years, ICMATE researchers have deposited several patents ranging from advanced manufacturing to the study of surfaces and interfaces. Here are just a few examples: a methodology for the preparation of superhydrophobic treatments, a process for the determination of surface tension of liquid substances, the preparation of innovative alloys for various applications, and so on.

Examples of devices and materials for energetic applications.

Examples of materials and activities on advanced manufacturing and cultural her-itage.

Examples of activities in molecular sys-tems and nanomedicine.

Our Projects


Project managerSergio TAMBURINI

Project managerAdelaide NESPOLI

Project managerVincenzo BUSCAGLIA

Innovative pre-fabricated components including different Waste construction materials reducing building Energy and minimising Environmental impacts.InnoWEE will focus on the development and field tests of new high performance prefabricated geopolymeric panels made with a large content of recycled construction and demolition waste (CDW). The basic idea is to embed fragmented waste bricks, plaster or concrete, glasses, wood from pallets etc. in a geopolymer matrix to produce high added value prefabricated insulating and radiating panels to be used in energy efficient buildings.

The main objective of Polycom is to improve the dielectric properties and the energy density of polymeric composites containing inorganic inclusions (Ag, BaTiO3) with high dielectric constant. A homogeneous dispersion of the inorganic inclusions and a more effective distribution of the electric field inside the composite will be achieved by engineering the polymer/inorganic interfaces. Interface engineering will consist in (i) the surface functionalization of inorganic particles with suitable organic molecules and (ii) the coating of the particles with a thin shell of a binary oxide. The composite matrix will be a ferroelectric polymer with high dielectric constant. Web site: http://www.icmate.cnr.it/progetti/polycom

We operate in multiple fields of chemistry and materials science working on the design and development of high-value-added molecular systems and colloids, engineered surfaces and interfaces, multifunctional nanostructures, innovative materials, new architectures and devices, new methods of analysis and prediction of micro and macroscopic properties. We balance basic and applied research in collaboration with other disciplines, we aim at increasing knowledge and at employing these systems in fields of high technological impact and societal relevance. We provide innovative solutions to relevant technological issues which attract public and private, national and international fundings.

Our most effective groups have multidisciplinary competences and consolidated links with leading national and international research centres remaining at the forefront of their fields. This enables researchers to develop excellent science, including curiosity driven research. Scientists are active in national and international communities, e.g. as editors of international journals, presidents and appointed members of scientific societies, experts in international committees for standardization, CNR representatives in European initiatives (e.g. END, ERA). We lead and participate to international, national and local projects, and technological clusters.

The study of technological solutions to improve buildings performances is of great interest both for Energy efficiency and for Smart Grids. More stringent regulations, concerning the building performance requirements, have been introduced by the European Community (Directive 2010/31/UE). In particular it is strictly required the constructions of buildings according to the n-ZEB - near Zero Energy Buildings concept. In this context, this project, called I-ZEB, try to focus and develop technological solutions able to give an answer to all these needs as well as to ensure building and users safety.

InnoWEE

Polycom - Engineered Polymeric composites with high energy density

I-ZEB - Towards Intelligent Buildings Energy Zero for the smart city growth

Website: http://www.icmate.cnr.itAddress: Corso Stati Uniti, 4

Padua - 35127Tel: +39 04 98 295 850 Fax: +39 04 98 295 853

http://www.icmate.cnr.it/progetti/polycomhttp://www.icrm.cnr.it/

Chemistry Institute of Molecular RecognitionDirector: Dr. SERGIO RIVA

The unifying theme of ICRM activities is the chemistry of molecular recognition, which can be defined as a multidisciplinary area which studies the principles and strengths that regulate and determine biospecificity and biorecognition at the

molecular level. The area involves expertise in organic, bioorganic and computational chemistry, biochemistry and biotechnology. In order to have molecular recognition phenomena molecules must interact (establishing bonds between them) and exchange information (thanks to the selectivity of the formed bonds).Advances in understanding thus gained will help to discover innovative compounds, materials and

biotechnological methods in the pharmaceutical, diagnostic and food fields, as well as to develop knowledge in the areas of biocatalysis, bioseparation and bioregulation. All of these fields are and will be strategic to improve the quality of life. The mainquarter of the Institute is in Milano. Moreover, some of the ICRM scientists operate in two “Third Parties Research Units” (“Sedi Secondarie”), respectively, at the Department of Chemistry, Milano Politecnico ,in Milan and at “Policlinico Gemelli”, Catholic University, in Rome.

Milan

Rome


Research Unit


5

5

23

Technologists

Researchers

Technicians

Administratives

10 20 30 40 50

2

Human Resources

What We Are Doing

Patents

Presently, the Institute of Chemistry of Molecular Recognition (ICRM) carries out research, technological development and training activities in the following areas:

1. Biomolecules (natural bioactive substances and synthesis of compounds of biological interest);

2. Industrial biotechnologies (bioconversions, enzyme technology and analytical methodologies);

3. Mechanisms of bioregulation (molecular basis of biological regulation and experimental and theoretical studies of molecular recognition).

Key words are: Bioactive natural compounds; Peptides and proteins; Green Chemistry; Biocatalysis; Biorefineries; Computational chemistry; Biomolecular Simulations; Structural biochemistry; Analytical microsystems; Proteomics.

IP WO2013144931 A2, US2017204059 - De Rosa M.C., Ria F., Giardina B., Ferraccioli G., Pirolli D., Nicol C. - TCR/MHCII-Collagen interaction inhibitors useful for the treatment of rheumatoid arthritis.

EP 1 567 569 - Chiari M. - Method for Immobilizing Biologic Molecules on Solid Surfaces

US 8,809,071- Chiari M. - Method for Immobilizing Biologic Molecules on Solid Surfaces

PCT/US2016/053015 (pending) - Chiari M., Unlu S., Daaboul G. - Multiplexed phenotyping of nanovesicles

PCT/IB2015/002470 (pending) - Chiari M. - New clickable polymers and gels for microarray and other applications

MW-assisted fully automated peptide synthesizer.

Piezoelectric spotter for microarray produc-tion.

Capillary Electrophoresis microanalytical technique.

Our Projects


Project managerMarcella CHIARI

Project managerMarina CRETICH

Project managerGianluca

OTTOLINA

FOTO

Project INDEX (Funded by EU within H2020 FETOPEN) will isolate and characterize exosomes that are as small as 30nm in diameter from human plasma with high purity, and provide in-depth, multi-parameter characterization of the particles through digital counting, size determination, and biological phenotyping. Once completed, Project INDEX will demonstrate a new paradigm in cancer diagnostics.

The BIOCODE project (funded within the ERANET-LAC Framework) aims to produce high-value extraction compounds, cellulose and emicellulose products (nanocelluloses, soluble cellulosic macromolecules, etc.) and lignin based materials (biochar, soil additives, chemicals) based on main commercial grain crop residues (corn, rapeseed and wheat co-streams). The concept is envisioned to enable flexible and multi-feedstock processing in small-scale units which can be integrated with existing industries in the EU and Latin American regions.

The research excellence at ICRM can be summarized by the five ACTIVITIES in which our scientists are involved. Specifically:1. “SINTEX: Synthesis and characterization of peptides and bioactive molecules”. Organic synthesis and structural characterization of structurally complex molecules (ICRM headquarter and SS ICRM-Milano Politecnico).2. “PROMOL: PROteomic and MOLecular biology”. Activities related to health issues, specifically exploiting techniques of proteomics and molecular biology, with strong interactions with clinical doctors at Policlinico Gemelli – Roma (SS ICRM-Roma) 3. “ENZYMES: biocatalysis and biorefineries” Activities and

competences in the production, characterization and synthetic exploitation of enzymes for applications in organic synthesis and in the valorization of waste biomasses (ICRM headquarter and SS ICRM-Milano Politecnico).4. “MICRO: analytical microsystems” for the development of innovative biosensing platforms, particularly based on microarrays (ICRM headquarter).5. “MODEL: computational biochemistry and drug design”. Significant and widely recognized competences in computational chemistry and biochemistry (ICRM headquarter and SS ICRM-Roma).

Project READy, supported by Regione Lombardia, is intended to build a regional network of excellence for the rapid response against bioemergences, designing and developing novel bioreagents and analytical platforms for the prompt and rapid diagnosis of emerging tropical diseases. READy joins expertises from both the academia and the biotech industry, and combines skills ranging from the biomolecular area to the optomagnetic engineering.

INDEX

BIOCODE

READY

Website: http://www.icrm.cnr.it/Address: via Mario Bianco, 9

Milano - 20131Tel: +39 02 285 000 20 Fax: +39 02 289 012 39

http://www.icrm.cnr.it/

Institute of Polymers, Composites and Biomaterials Director: Dr. COSIMO CARFAGNA

The Institute for Polymers, Composites and Biomaterials (IPCB) was founded in March 2014 by merging the Institute of Chemistry and Technol-ogy of Polymers (ICTP) and

the Institute for Composite and Biomedical Materials (IMCB). The IPCB derives from the needs of coordinat-ing skills and knowledge on the chemistry and technolo-gy of polymeric materials, composites and biomaterials, with a vision oriented to European research develop-ments. The IPCB is located in Pozzuoli (NA), with sup-port units located in Napoli/Portici, Catania and Lecco. It is currently one of the most relevant Italian research

institutes on polymer based materials, with a staff of about 80 researchers, 35 technicians and administrative em-ployees, 30 post-doctoral fellows and 10 PhD students. Moreover, the IPCB guests foreign researchers and stu-dents in the frame of international co-operation programmes.

Catania

Naples

Lecco

Pozzuoli (Naples)


Research Unit


9

23

66

Technologists

Researchers

Technicians

Administratives

10 20 30 40 50

10

Human Resources

What We Are Doing

Patents

The research lines of IPCB represent the convergence of the skills coming from the original Institutes, with a vision projected on the research developments at European lev-el.Research activities are split into one of three main topics- Innovative materials- Health and nanomedicine- Sustainability

These activities, detailed below, are the result of the re-searchers’ skills, gained in almost 50 years of activities through national and international collaborations with in-dustries, and participation to European projects.

1. Polymer materials, composite materials and nanostruc-tures with programmed structural and functional proper-ties.2. Multiphase polymer materials for tissue engineering and regenerative medicine.3. Processing technology of synthetic and natural poly-mers, composites and nanostructures.4. Synthesis and chemical modification of polymers5. Structural characterization of natural macromolecules of natural origin and development of innovative methods for the investigation of advanced materials6. Technology transfer

4 Active Patents

Core (nanosilica)/Shell (hyperbranched) Nanoparticles mod-ified epoxy samples with a new dog bone configuration for Shock Loading Characterization Tests

Our Projects


Project managerMaurizio Avella

Project managerConcetto Puglisi

Project managerAnna Borriello

The washing of synthetic textiles have been lately identified as one of the sources of microplastic pollution in marine environment. Microfibres detach from the fabrics, can remain in the wastewater and reach marine ecosystem, representing a potential threat for flora and fauna. The Life+ project MERMAIDS - Mitigation of microplastics impact caused by tex-tile washing processes- coordinated by CNR (IPCB and ISMAC), evalu-ated the main factors involved in the microfiber release and developed innovative finishing treatments to reduce the environmental impact of such pollutants.

EXTREME project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 636549The aim of the EXTREME project is to develop novel material characterisation methods and in-situ measurement techniques, material models and simulation methods for the design and manufacture of aerospace composite structures under EXTREME dynamic loadings such as blade off events or foreign object damage (hail, runway debris, bird strike, etc.).EXTREME project, coordinated by Prof Michele Meo at the University of Bath, started on the 1st of September 2015 and will be running for four years.

New materials and technology developed at IPCB find applications

in several highly specialized sectors: aeronautic and aerospace,

automotive, construction, packaging and recycling, agro-food,

sensors, conservation of cultural heritage, biomedicine and tissue

regeneration. A clear indicator of the industrial interest to IPCB

research activities is the high number of projects financed by pri-

vate companies. These projects allow a fast transferring of tech-

nological results obtained at IPCB to end-users and contribute to

increase the self-financing ratio of IPCB, that in 2016 reached the

noticeable value of 63%.

The project, is oriented in the biomedical area to produce phthalate-free PVC plasticzer based on polyester/silicone hyper-branched copoly-mers. Block copolymers with controlled architecture, containing hydro-philic and hydrophobic segments able to release few micrograms of cor-tisone drugs for day, for several months. The determination of specific biomarkers by molecular characterization of glycoprotein/glycan con-tained in biological fluids (tears, spinal fluid, plasma) by innovative mass spectrometry techniques for monitoring the influence of drugs release kinetics on some deseases.

Mitigation of Microplastics Impact Caused by Textile Washing Processes

Dynamic Loading - Pushing the Boundaries of Aerospace Composite Material Structures

DIATEME

Website: http://www.ipcb.cnr.itAddress: Via Campi Flegrei, 34

80078 - Pozzuoli (Napoli)Tel: +39 081 8675327 Fax: +39 081 8675230

http://www.ipcb.cnr.it%0D

Institute of Chemical and Physical Processes Director: Dr. CIRINO SALVATORE VASI

At IPCF, the research activity is intrinsically inter-discipli-nary and focused on Chem-ical and Physical topics, as soft matter, disordered sys-

tems, interfaces, composites and nano-structured ma-terials, supra-molecular architecture and biophysics, complex f luids and colloids. Main interests concern with the investigation of phenomena as self-organ-ization, surface interactions, relaxation and trans-port properties, from nano- to meso-scale. IPCF is involved in the design and manufacturing of tailored materials, on theoretical models, on computational and analytical techniques and in the development of new devices and experimental methodologies. Some

of the activities are highly relevant for the society (energy, environment, health): development of dye sensi-tized solar cells, pollutant sensors and techniques for environmental clean-up, development of technolo-gies for industry and nanomedicine. The Institute is active, also as the coordinator, in many National and International (including EU) pro-jects. IPCF is involved in the design and construction of beam lines at neutron Large Scale facilities, includ-ing the European Spallation Source and the STFC Ru-therford Appleton Laboratory. At IPCF we are also deeply involved in the technological transfer of the obtained results.

Messina

Bari

Pisa


Research Unit


7

13

57

Technologists

Researchers

Technicians

Administratives

10 20 30 40 50

1

Human Resources

What We Are Doing

Patents

Different strongly connected soft matter research areas are covered, as -Life Science for isolation, reconstitution and investigation of biomaterials for energy transduction and molecular recognition;-Material science for synthesis of nanostructured materi-als and their mesoscale organizations for optoelectronic, biomedical and environmental applications -Interfaces and hybrid systems of photochemical interest, towards new generations of complex materials.-Computational modelling of free molecules and interfac-es for applications in medicine, bio-electronics and catal-ysis.

- U.S. PATENT N. US 9218914 B2 -Photoelectrochemi-cal solar cell comprising sensitizing anthocyanin dyes and method of preparing same - Calogero G, Di Marco G.- U.S. PATENT N. US 8748738 B2 - Process for obtaining stable extract of sensitizing betalaionic dye - Calogero G, Di Marco G.- U.S. PATENT N. US 9,575,029 B2 - Method to realize electronic field-effect transistor sensors. Torsi L, Palazzo G, Cioffi N, Angione MD, Magliulo M, Cotrone S, Scama-rcio G, Sabbatini L, Mallardi A. - EU PATENT N. 2385563 - Field effect transistors based on multilayers of self-assembled biological systems cov-ered by an organic semiconductor layer: processes for their realization and use as sensors. Torsi L, Palazzo G, Cioffi N, Angione MD, Magliulo M, Cotrone S, Scamarcio G, Sabbatini L, Mallardi A.- I.P. WO2012163426 A1 and EU Patent EP2715843 (A1) Electrode material for lithium and lithium ion batteries. E Paillard, D Bresser, M Winter, S Passerini, M Striccoli, E Binetti, R Comparelli, ML Curri

Design and synthesis of innovative (nano)materials for (photo)catalysis, automo-tive, energy conversion, nanomedicine, (bio)sensors.

From top: preparation of novel polymeric materials, smart drug delivery, characteri-zation of polymer bulk and interface prop-erties, modelling of cysteine molecules ad-sorbed on a gold surface and of asymmetric structures in plasma.

The research is characterized by a strong multidisciplinary research approach in the soft condensed matter.

Our Projects


Project managerRoberto Comparelli

Project managerFrancesco Aliotta

Project managerVincenzo Carravetta

NANOAPULIA aims at developing nanostructured visible-light-active metal oxides photocatalysts for application in building materials (innova-tive mortars and binders) and for abatement of pollutants from Diesel engines (automotive application). The innovative mortars and binders will be used as building materials aiming at exploiting UV and visible light to degrade gas-phase pollutants in outdoor (urban environment) and in-door applications. Nanophotocatalysts will be integrated in a prototype of photo-catalytic muffler to remove NOx from Diesel engine exhausts.

The main objective of the NanoDome project (www.nanodome.eu) is to de-velop a modelling and analysis computational tool for the detailed prediction of complex inorganic nanomaterial structures obtained by a single-step and industrially scalable Gas-Phase (plasma) synthesis process. The purposes are: optimization of existing industrial processes, shortening the development of new processes, increase the production rates for more accurate final product properties (e.g. particle size, surface area, structure, chemical composition, morphology and functionalization coatings).

- Fazio B.; Irrera A.; Pirotta S.; D’Andrea C.; Del Sorbo S.; Lo Faro MJ.; Gucciardi PG.; Iati MA.; Saija R.; Patrini M.; Musumeci P.; Vasi CS:; Wiersma DS.; Galli M.; Priolo F., Coherent backscattering of Raman light.NATURE PHOTONICS 11 (3) 170- (2017) ( IF 38.91) - Striccoli, Marinella, Photolithography based on nanocrystals. SCI-ENCE 357 (6349) 353-354 (2017) ( IF 38.06) - Calogero G.; Bartolotta A.; Di Marco G.; Di Carlo A.; Bonaccorso F., Vegetable-based dye-sensitized solar cells. CHEMICAL SOCIETY REVIEWS 44 (10) 3244-3294 (2015) (TC 71, IF 39.27)- Marago OM.; Jones PH.; Gucciardi PG.; Volpe G.; Ferrari AC., Op-tical trapping and manipulation of nanostructures. NATURE NANO-TECHNOLOGY 8 (11) 807-819 (2013). (TC 277, IF 44.323)

- A. Loiudice, A. Rizzo, G. Grancini, M. Biasiucci, M. R. Belviso, M. Corricelli, M. L. Curri, M. Striccoli, A. Agostiano, P. D. Cozzoli, A. M. Petrozza, G. Lanzani, G. Gigli Flexible all-inorganic nanocrystal solar cell by room-temperature processing. Energy & Environmental Sci-ence,6, 1565-1572 (2013) (TC 24, IF 24,78)- Micali N.; Engelkamp H.; van Rhee P. G.; Christianen P. C. M.; Sco-laro L. Monsu; Maan J. C., Selection of supramolecular chirality by application of rotational and magnetic forces. NATURE CHEMISTRY 4 (3) 201-207 (2012). (TC 90, IF 28,129)- Barcaro G.; Sementa L.; Negreiros FR.; Ferrando R.; Fortunelli A., Interface Effects on the Magnetism of CoPt-Supported Nanostruc-tures.NANO LETTERS 11 (12) 5542-5547 (2011) (TC 51, IF 14.298)

IMAT (Imaging and Materials Science & Engineering) is a neutron imaging and diffraction instrument for materials science, materials processing and engineering. The special features of the instrument will be energy-se-lective neutron imaging and the combination of neutron imaging and neutron diffraction. Currently IMAT is under engineering commissioning.

NANOAPULIA

NanoDome

NANOANTENNA

Website: http://www.ipcf.cnr.itAddress: Viale Ferdinando Stagno d’Alcontres, 37

98158 - MessinaTel: +39 090 39762 200 Fax: +39 090 39762 252

http://www.ipcf.cnr.it%0D

Institute of Macromolecular TechnologyDirector: Dr. Salvatore Iannace

The research activities of ISMAC are focused on the synthesis and ad-vanced characterization of synthetic

and biological macromolecules and their applications in plastic and rubber technologies, textiles, optoelectronics and life science. The activities are performed in the head-quarter of Milan and two distinct operative units located in Biella and GenoaISMAC possesses unique expertise in the field of mac-romolecular chemistry, physics and technology covering basic science, material design, prototyping and characteri-zation at the nano, micro and macroscale. Novel polymer-ic (nano)materials with specific functional and structural properties are designed for addressing current and future challenges in the field of advanced materials, renewable energy, green chemistry and human health.

The Institute has many links through its research programs with national and in-ternational research institutions on both fundamental and applied research ac-tivities. Along the development of new knowledge in the macromolecular field, the Institute is active in the organization of training stages and other dissemination initiatives for students and young researchers. Technology transfer and support to national and inter-national industries are provided by several instruments including the management of research project, basic or applied research agreements, technical analysis and trial (chemical, physical and biological), analysis and solution for industrial problems. Research activities have generated, in the last 10 years, more than 70 filed patents.

Milan

Genoa

Biella


Research Unit




10 20 30 40 50

Human Resources

34

15

1

7

What We Are Doing

Patents

- Synthesis and characterization of advanced polymeric materials with both plastic and elastomeric properties.- Synthesis of building blocks and polymers from renew-able sources.- Processing technologies of polymeric and composite materials.- Development of optoelectronic devices (organic light-emitting diodes, organic photovoltaics, sensors, lu-minescent solar concentrators, capacitors).. Novel technologies for textile applications (clothing, medical, filtration, composites).- Structural and dynamic characterisations of proteins to investigate structure/function relationships and for drug design.- Targeting bioactive molecules in foods, plant extracts and by-products; new functional food.

- WO2017109767 (A1): Process for the preparation of (co)polymers of conjugated dienes in the presence of a catalytic system comprising a vanadium bis-imine complex.

- WO2015068095 (A1): Stereoregular diblock polybuta-dienes having a 1,4-cis/syndiotactic 1,2 structure from stere-ospecific polymerization.

- Colori Iridescenti, Italian Patent N. 0001412471 (2012).

- Processo di lavorazione della lana, materiali di lana prodotti con detto processo e articoli comprendenti detti materiali di lana”. Italian Patent N. 0001410156 del 05/09/2014.

From catalysts to novel polymers and elastomers

Organic and hybrid materials for optoelec-tronics

Novel technologies for textile applications

Our Projects


Project manager

Laura Boggioni

Project manager

Salvatore Iannace

Project manager

Cristina D’Arrigo

APOLLO aims to develop innovative biorenewable polymers. Specifical-ly, two bio-based feedstock, namely CO2 and renewable non-food low-cost limonene oxide, LO, will be used to produce bio-based polycar-bonates and polyesters. The selection of the best processing conditions, the peculiar properties (thermal and mechanical), the biodegradability of the materials and the potential use of the novel bio-based polymeric ma-terials, including conditions for their recycling at the end of the life-cycle, represent the specific technical benefits of APOLLO.

FSONDE will develop innovative biomedical probes able to measure the local pressure in different districts of the human body. The project is funded by Regione Lombardia and it is aimed to increase the competitive-ness of industries by developing knowledge based innovative solutions. PFSONDE takles this challenge by integrating the experiences of the industrial partner and the ISMAC researchers on elastomeric materials, light-responsive optoelectronic device and advanced structural character-ization of macromolecules and metabolites.

Plastic and Rubber Technology: synthesis and characterization of novel organometallic complexes for the preparation of highly active, highly selective and more sustainable catalysts for the homo-and co-polymerization of olefins, cycloolefins and conjugated diolefins.Green Chemistry: Synthesis of biobased polymers from vegetable oils and limonene; polycarbonates using CO2 as co-monomer.Optoelectronic: preparation of novel conjugated polymeric materials with variable molecular weight to produce optoelectric devices and microsystems where the active layer is constituted by either organic or hybrid organic/inorganic materials.

NMR structural biology and metabolomics: characterization of protein interactions to investigate and target molecular mechanisms underly-ing neurodegenerative, metabolic and neoplastic diseases; biomarker discovery, metabolite profiling for nutrition and human well-being. Textile: development of sustainable materials and processes for con-ventional textile applications; therapeutic textiles, fibrous scaffolds; composites for transport and construction; functionalization of textile materials (antibacterial, antistatic, electrical conduction and water re-pellency properties); filtrationProcessing technology: chemical functionalization and compatibiliza-tion, extrusion, melt spinning, electrospinning.

BIMAP aims to develop new polyphenolic compounds for the preven-tion of Alzheimer’s Disease neurodegenerative disorder, starting from phenolic compounds, extracted from natural sources or waste. The con-sortium, composed of 1 academia and 2 research institutes, ensures the critical mass of scientific expertise and excellence in key areas (synthet-ic chemistry, molecular level characterization of the interactions of new compounds with amyloid toxic oligomers, in vivo test on mouse models) and grounds its strength on previous collaborative projects granted by Alzheimer Association.

APOLLO

PFSONDE

BIMAP (CARIPLO 2016-2018): From bio-inspired molecules to Alzheimer’s Disease prevention

Website: http://www.ismac.cnr.itAddress: via Alfonso Corti, 12

20133 - Milan - ItalyTel: +39 02 23699476 - Fax: +39 02 70636400

http://www.ismac.cnr.it

Institute of Nanostructured Materials Director: Dr. MICHELE MUCCINI

ISMN is a CNR research institute internationally re-nowned for its multidiscipli-nary activities in the f ield of

nanostructured materials and enabling processes and technologies. The Institute aims at generating state of the art knowledge in the f ield of Chemical Manufac-turing and Science and Technology of Materials, and at exploiting the research results through the rela-tionship with the industrial and business world.In a stimulating and dynamic environment, thanks to the presence of many young researchers and PhDs from various countries of the world, ISMN has a prestigious scientif ic track record and regularly per-forms industrial research programs focussed on spe-

cif ic applications.ISMN is present throughout the country with its four locations. The headquarter of the Institute is at the Research area of Montelibretti Roma 1, while the other locations are in Bo-logna, Palermo and at the University of Rome Sapienza. In order to reach its objectives, ISMN integrates transversal key enabling technolo-gies, which include advanced materials, photonics, nanotechnology, biotechnology, advanced chemical and manufacturing processes. These technologies are part of the ISMN assets thanks to its advanced research infrastrutures and state-of-the-art scientif ic and technological equipment.

Montelibretti(RM)

Palermo

Bologna

Rome


Research Unit


9

27

66

Technologists

Researchers

Technicians

Administratives

10 20 30 40 50

8

Human Resources

What We Are Doing

Patents

The research structure of ISMN has a high operation-al capability and is organized with the needed flexi-bility and critical mass to realize both research pro-grams aimed at generating new knowledge, as well as development and innovation projects. The strategic research lines of ISMN are:

• Nanomaterials and enabling processes forsustainable manufacturing

• Materialsandtechnologiesforthesustainableconservation and fruition of Cultural Heritage

• Flexibleandwearableorganicandhybridelec-tronics and photonics

• Materials and technologies for the environ-mental sustainability and energy eff iciency

• Nanostructured materials and bioelectronicdevices for the health and quality of life

• Magneticnanostructuredhybridmaterialsandsystems

ISMN has a significant patent portfolio formed by a num-ber of national and international patents in various techno-logical sectors, including chemistry and materials science, optoelectronics and photonics, lighting, environment and agrifood, biotechnologies, catalysis, green chemistry, re-newable energy. Batches of correlated patent families are transferred into start up initiatives to create value from the generated knowldge and the related technologies.

DNA GLASS LONG_EXPOSURE

Our Projects


Project managerMichele Muccini

Project managerG. Padeletti

Project managerA.V. Dediu

OLIMPIA focuses on research and development of innovative organic optoelectronic devices interfaced and integrated with living systems. The major objective of OLIMPIA is to establish an innovative training program aimed at enabling and supporting the development of a novel supradisciplinary field that combines the worlds of organic optoelec-tronics and of neuroscience. Novel tools based on organic optoelec-tronic devices are engineered.

MADIA aims at realizing a versatile and cheap diagnostic device based on magnetoresistive sensors, microfluidic device. Magnetic Nanoparticles and ad-vanced bio-chemical functionalization methods for the early and ultrasensitive in vitro detection of biomarkers associated with Alzheimer and Parkinson dis-ease. MADIA targets to achieve sensitivities at least three orders of magnitude higher than best state-of-the-art values.

Innovative Organic Optoelectronics based on advanced materials, architecture and new concept systems represents a distinguishing and broadly recognised experties of ISMN at international level. Over the last 20 years ISMN has pursued and consolidated the activity on low-consumption, wide area, flexible and integrated op-toelectronic devices and systems through numerous national and international projects. ISMN has invented the planar electrolumi-nescent transistor (OLET) that was at the basis of a start up worth 10 M euros investments.A worldwide excellence is represented by hybrid nanostructured magnetic materials, interfaces and devices for applications in the

field of micro-nano electronics (ICT), sensor for biomedical and environmental monitoring, tissue regeneration and other innova-tive applications in nanomedicine. ISMN has solid and recognised knowledge on advanced chemical, physical, morphological and structural characterization of Cultural Heritage artifacts. Inno-vative synthesis and validation of low toxic and environmental-ly-friendly materials are sussefully employed to develop and imple-ment sustainable conservation methods.

HERACLES main objective is to design, validate and promote responsive systems/solutions for effective resilience of CH against climate change effects, with an holistic and multidisciplinary approach through the in-volvement of different expertise .This will be pursued with the develop-ment of a system exploiting an ICT platform able to collect and integrate multisource information in order to provide complete and updated sit-uational awareness and support decision for innovative measurements improving CH resilience, including new solutions for maintenance and conservation.

OLIMPIA – Nuro Organic Optoelectronics

MADIA - Magnetic Diagnostic Assay for Neurodegenerative Diseases

HERACLES – Heritage Resilience Against CLimate Events on Site

Website: http://www.ismn.cnr.itAddress: Via Salaria Km 29,300

00015 - Monterotondo Stazione (Roma) - ItalyTel:+390690672484Fax:+390690672372

http://www.ismn.cnr.it

Institute of Organic Synthesis and PhotoreactivityDirector: Dr. ROBERTO ZAMBONI

The Institute of Organic Synthesis and Photoreactivity (ISOF) belongs to the Department of Chemical Sciences and Materials Technologies

(DSCTM) of the National Research Council of Italy (CNR), the largest public Research Institution in Italy.ISOF research activities are focused in the field of Key Enabling Technologies (advanced materials, photonics, nanotechnologies and chemical manufacturing) through an integrated and multidisciplinary approach, that allows developing novel technological solutions for healthcare, solar energy conversion and environmental

sustainability. ISOF research activities are supported by regional, national, European and international funding through projects of industrial relevance that address the societal challenges of the Europe 2020 strategy. The Institute is particularly committed to the transfer of technology to the productive world, which is accomplished both by establishing relevant industrial partnerships and by favoring the creation of start-up companies.

FerraraBologna


Research Unit


4

17

34

Technologists

Researchers

Technicians

Administratives

10 20 30 40 50

3

Human Resources

What We Are Doing

Patents

We assemble small molecules, polymers and other nanoscopic objects into innovative materials, to enable new applications in Energy production and storage, optoelectronics, environmental care, mechanics and biology.We exploit the tiny chemical and physical interactions acting between molecules at the atomic scale to assemble them into complex structures, obtaining in this way new properties for such materials and improved performance at the macroscopic scale.We use both top-down and bottom-up approaches, synthetic chemistry, supramolecular chemistry and nanotechnology to synthesize, characterize, process and use our materials, into working devices, taking advantage of the expertise of a skilled team of chemists, physicists and engineers. We have 40 running projects together with Graphen Flagship coordination role, KIC EIT Raw Materials action, and 3 running projects in the AFOSR Quantum Biology programme. WE are active in the education and learning in collaboration with european, national and regional scolastic system. We are a key Insitute of the technological tranfer in the CNR Technopole AMBIMAT in the Emilia Romagna Region. We generate spinoff : Mediteknology, APM and Lipinutragen togeher with new spinoff Kerline participated by CNR.

ISOF filed 10 patents in the last 5 years. ISOF set up the Smart Cities Living lab and we develop innovative technology solutions to make cities more sustainable from an environmental and energetic point of view.

Graphene-organic composites for elec-tronics: optical and electronic interactions in vacuum, liquids and thin solid films.

Mesenchymal stem cells as delivery ve-hicle of porphyrin loaded nanoparticles: effective photoinduced in vitro killing of osteosarcoma.

Optical sensing in Diagnostics.

Our Projects


Project managerV. PALERMO

Project managerN. ARMAROLI

Project managerG. VARCHI

The objective of the research theme ADVANCED MATERIALS is to assemble small molecules, polymers and other nanometric objects to create novel composite materials.We combine covalent and supramolecular chemistry with nanotechnology to produce a wide range of nano-composite materials based on polymers, graphene, organic semiconductors, metal nanoparticles and biomaterials such as keratin and silk.These materials are then used for applications in different industrial sectors such as energy production and storage, optoelectronics, mechanics, environmental protection and biomedical devices.

The ChemNanoCARE thematic platform aims at providing multidisciplinary advances in the field of (bio)medicine, healthcare, biomedical engineering and environment through a wide and synergistic integration of expertise in the field of organic, inorganic, material, analytical and physical organic chemistry, biochemistry, nanotechnology and cellular biology. ChemNanoCARE research activities are primarily focused on the development of small molecules, functional (nano)materials and biological-based solutions for biomedical and environmental applications.

The ISOF institute is one of the promoters and leaders of the GRAPHENE FLAGSHIP project, one of most ambitious research project ever launched by the European Commission, with a planned duration of ten years and a target budget of one billion euros. ISOF supports the activity of the flagship in the research on composites and flexible electronics, and coordinates the activity of the three CNR institutes involved in the project. ISOF collaborates on this topic with some of the most important industries at national and European level such as Airbus, BASF, FCA (former FIAT), Leonardo (former Finmeccanica) and Nokia. ISOF is internationally recognized for outstanding discoveries in the fields of free radical chemistry, biomimetic chemistry of stress conditions affecting biological molecules (lipids, DNA, proteins), membrane lipidomics and biomarker discovery. Exceptional breakthroughs have also been achieved in the

field of fibroin and keratin based functional (nano)materials, such as transparent organic transistors and drug delivery systems for cancer treatment. Historically, the Institute has excellent expertise in the field of drug discovery and medicinal chemistry.The ISOF PHEEL unit has outstanding scientists and fully equipped laboratories for steady-state and time-resolved photophysical characterization of materials both in solution and in the solid state. Forefront femtosecond laser transient techniques and advanced confocal microscopy are available, such as ultrafast luminescence determination, pump-and-probe transient absorbance and fluorescence lifetime imaging microscopy (FLIM). The CLAN Joint Lab, including the ERC advanced grant LEAPS, set up by ISOF together with the University of Bologna, is a centre of excellence of molecular machines nanoscience based on a chemical bottom up approach.

We are a team of chemists investigating the light-matter interaction at the molecular, supramolecular and macromolecular level.Our main research activities are:• Solar-to-electricity and solar-to-fuel energy conversion: fundamental processes and devices (e.g., DSSCs, LSCs)• Luminescent molecules, polymers and transition metal complexes for the fabrication of electroluminescent devices (e.g., OLEDs, LECs)• Supramolecular and nanostructured systems for sensing, imaging, diagnostics and drug delivery• Photochemical and photocatalytic systems for environmental remediation

ADVANCED MATERIALS and key enabling technologies.

CHEMISTRY AND NANOTECHNOLOGY FOR HEALTHCARE

PHOTONICS FOR HEALTH, ENERGY & ENVIRONMENT LAB

Website: https://www.isof.cnr.itAddress: CNR-ISOF, Area della Ricerca del CNR via P. Gobetti, 101

Bologna - 40129Tel: +39 051 639 9773 Fax: +39 051 639 9990

https://www.isof.cnr.it/

Institute of Science and Technology for CeramicsDirector: Dr. ANNA TAMPIERI

ISTEC is the Italian research institute with unique and renown international expertise for the study and development of function-al ceramics and hybrid materials for appli-

cations in extreme environments, aerospace, health, me-chatronics, energy and environmental protection, besides to traditional and ancient ceramics.ISTEC expertise covers basic science, materials design and prototyping, and full characterization from the nano to the macroscale: long-lasting experience in synthesis of inorganic materials, ceramic processing and consoli-dation methods (sintering), biomorphic transformation, biomineralization process for hybrids, functionalization techniques, as well as the aptitude to establish relationship between structural and functional properties at the mul-

ti-scale is an ISTEC prerogative. The institute has a long-lasting co-ordi-nation experience in major collaborative European projects (20 in the last decade with a total budget for ISTEC of 9 mil-lion Euro), which has enabled the imple-mentation of many existing and new research lines. The intense activity of research and development in the frame of industrial projects is another ISTEC priority with com-panies in various industrial sectors; moreover in the last 10 years ISTEC has generated several patents, many of them were licensed within technological transfer activities and generated innovative start-ups and spin-off companies, in-ternationally renowned.

istec

Faenza


Research Unit




10 20 30 40 50

Human Resources

37

7

4

6

What We Are Doing

Patents

The research in ISTEC: the main focus is to tailor the properties and performance of ceramic devices by con-trolling the process conditions and by engineering materi-als addressed to specific applications. Different solutions are also offered to impart new advanced features and performances to traditional products. ISTEC also fo-cusses on the development of new nature-inspired pro-cesses overcoming the limitations of the current process-ing methods in the generation of smart nanoceramics and hybrids. Besides, ISTEC is the first research center in Eu-rope designing and establishing new pilot plants to realize biomorphic transformations based on highly controlled heterogeneous reactions directly in the 3-D state, thus generating materials with multi-scale structural hierarchy, elective for frontier applications in regenerative medicine, catalysis and defense.

WO2017021894 (A1): Large 3D porous scaffolds made of active hydroxyapatite obtained by biomorphic transformation of natural structures and process for obtaining them (2016).WO 2012/063201 (A1): Implants for “load-bearing” bone substitutions having hierarchical organized architecture deriv-ing from transformation of vegetal structures (2011).WO2012014172: Intrinsically Magnetic Hydroxyapatite (2010).WO2013190587: Method for the treatment of metal surfac-es for bestowing thereon a high hydrophobicity and oleopho-bicity (2012).WO2012117386 A1: Method for the treatment of ceram-ic surfaces for bestowing thereon a high hydrophobicity and oleophobicity (2011).

Human mesenchymal stem cell seeded onto a biomimetic 3-D scaffold and ex-hibiting well spread morphology

Jagged dendritic-like pattern of geopolymer lamellae generated by ice-templating

Scheme of the mechanism for targeted delivery of micro-RNA functionalized na-noparticles to diseased cardiac tissue

Our Projects


Project manager

Michele Iafisco

Project manager

Diletta Sciti

Project manager

Anna Costa

Cupido aims to develop inhalable biocompatible and biodegradable nan-oparticles (NPs) that can deliver a therapy to the diseased heart. Exploit-ing such a tiny system as a route of administration can revolutionize the cardiovascular field, becoming the first non-invasive and heart-specific therapy. NPs, once inhaled, will first reach the lungs and later will translo-cate to the heart, where the drug will be released on the site of interest. The heart-specificity will be ensured thanks to chemical and magnetic guidance, reducing the chances of adverse side effects.

The main purpose of C3HARME is the design, development, manufactur-ing and testing of a new class of C fiber reinforced ultra-high temperature CMCs suitable for application in severe aerospace environments. The consortium is composed of 3 academia, 3 research centers, 3 large com-panies and 3 SMEs based in 6 different countries. The consortium ensures a critical mass of scientific expertise and excellence in key areas (materials science, engineering, process technology, material modelling, processing industrial scale up). The project will run for 4 years, 8M Euro total budget.

Hi-tech Ceramics for Severe Environments: Materials with superior mechanical properties (carbides, borides, nitrides), for applications in high temperature engineering, aerospace, energy and automotive. Bioceramics and Bio-hybrid Composites: Biomimetic, bioactive and bio-resorbable 3D structures and nanoparticles, able to exert thera-peutic or diagnostic functions. Nature-inspired approaches generate innovative materials capable of unpreceded performances. Implemen-tation with mechanisms of remote, on-demand, activation for smart personalized medicine. Determination of cell-biomaterial interaction. Nanotechnology and Nanosafety: Nano-products for application in clean technology, health and environment protection. Implementa-

tion of safety-by-product design to prevent and control potentially adverse effects generated by nano-objects handling.Smart Surfaces: Strategies and processes to enhance static and dy-namic repellence of various materials against water and oils, for appli-cations requiring anti-soiling, drag and friction reduction, anti-fouling, de-frost and anti-icing properties.Geopolymers: Environment-friendly net-shaped ceramics, by cold processes, for application as refractories, insulators and catalysts.Materials and Devices for Energy Production and Storage: New mate-rials and devices, able to shift the fossil fuel economy towards eco-sus-tainable energy sources: batteries, capacitors, solar cells, fuel cells.

BIORIMA aims to develop an Integrated Risk Management framework for nanobiomaterials (NBM) used in Advanced Therapy Medicinal Products or Medical Devices. The risk assessment and management of nanobioma-terials, materials born to specifically interact with living systems, is still a big challenge for research, industry, politics. BIORIMA tackles this challenge for the first time in Europe and built on a large database of materials and experience of researchers in Nanosafety and Nanomedicine present in ISTEC and in more than forty partners within and outside Europe.

Cupido (H2020-NMBP-10-2016-RIA–EU (2017-20)): Cardio Ultraefficient nanoParticles for Inhalation of Drug prOducts.

C3HARME (H2020-NMP-19-2015-RIA-685594 (2016-20)): Next generation ceramic comp

BIORIMA (NMBP-29-2017-760928, 2017-2021): Biomaterial Risk management

Website: http://www.istec.cnr.itAddress: Via Granarolo, 64

48018 - Faenza - ItalyTel: +39 0546 699 725 - Fax: +39 0546 46 381

http://www.istec.cnr.it

Director: Dr. RINALDO PSARO

The Institute of Molecular Sci-ence and Technologies (ISTM)is headquartered in Milano, with a branch in Perugia and

a total of 37 researchers, 2 technologists, 2 technicians and 4 clerks. The ISTM activity covers the most relevant fields of chemical sciences, by developing and exploiting new approaches to design and prepare molecules, supramo-lecules and nano-systems with tailored specific functions and properties. ISTM is involved in research, technology transfer and higher education in the following fields: the-oretical and experimental modeling of molecular systems and nano-systems; design, synthesis and characterization of precursors and functional molecules for photonics, dye sensitized solar cells and organic photovoltaic cells, nano-medicine; innovative catalysts for green chemistry, biore-finery and hydrogen production; spectroscopic and diag-nostic methodologies for the conservation and restoration

of cultural heritage. Scientific activity is mainly focused on innovative, basic re-search, aimed at improving knowledge above all. Significant partnerships with local companies, particularly in the areas of green chemistry, energy and cultural heritage. Consolidated collaborations with public and private institutions, national and interna-tional universities. ISTM coordinates FREECATS: Network of Infrastructures (NoI) financed by European Institute of Innovation and Technology Raw-Materials GmbH, and the outreach project BloW-UP: Balkans Waste to Products: transfer of NoI model to Balkan area. ISTM is one of the six international partners of the Center for Materials Crys-tallography (CMC), having its home base at the University of Aarhus (Denmark). The higher education is currently performed in cooperation with the host Universities of Milano, Perugia and CMC partners.

Institute of Molecular Science and Technologies

Perugia


Research Unit


4

2

37

Technologists

Researchers

Milan

Technicians

Administratives

10 20 30 40 50

2

Human Resources

What We Are Doing

Patents

Applications of heterogeneous metal catalysts in contin-uous-flow eco-sustainable catalytic processes directed to the synthesis of fine chemicals. Development of (photo)catalysts for hydrogen production and pollutants abate-ment. The development of solid catalysts as substitutes of traditional stoichiometric reagents for fine chemical synthesis and for the set-up of processes for biorefinery.Synthesis of molecular and supramolecular systems char-acterized by functional properties suitable for optoelec-tronics, light emission/absorption, light-to-electricity con-version, magnetic and molecular recognition. Deposition of thin films: by physical vapour system, screen ad ink-jet printing, spin coating, and their thickness and roughness measurements. Characterization of nanostructured met-al systems by electron microscopy (i.e. HRTEM, STEM, ESEM FEG) and spectroscopic techniques. Theoretical and computational materials and device modeling, de-sign and simulation; high-throughput materials discovery; insights on material properties from their geometrical/electronic/bonding structure. In-situ non-destructive measurements on artworks.

M. Saliba, M. K. Nazeeruddin, Mi. Graetzel, K. H. Dah-men, G. Pozzi, S. OrlandiFunctional hole transport materials for optoelectronic and/or electrochemical devicesWO2016/207775 A1G. Ricci, G. Leone, A. Sommazzi, A. Forni, F. MasiPhosphinic vanadium complex, catalytic system compris-ing said phosphinic vanadium complex and process for the (co) polymerization of conjugated dienesWO2016128812 (A1)_2016-08-18S. Brini, R. Psaro, F. Zaccheria, M. N. Ravasio Process or the synthesis of esters of fatty acidsWO 2014/006595 A1M. F. Starodub, M. V. Taran, M. Guidotti, C. BisioSorbents based on innovative saponites for deactivation of aflatoxin B1 UA114683U 2017

Green Chemistry and Biorefinery Nanostructured materials for solar fuels pro-duction

Modelling-driven search of optimal met-al-free electrodes for Li-ion batteries

Our Projects


Project managerNicoletta Ravasio

Project managerDavide Ceresoli

Project managerCostanza Miliani

The aim of the project is to upgrade the main wastes of the rice sup-ply chain, namely the straw, the husk and the bran, by creating a wide range of bio-products with different added value. In particular the straw is used to add mechanical strength to phono- and thermo-insulating materials produced by waste wool, while husk is added as filler in the formulation of composite materials with bio-polymers. The acidic oil ex-tracted from bran is used to produce monoglycerides (food emulsifier) or, after esterification with phytosterols present in the oil itself, for the synthesis of additives for functional food.

IPERION CH aims to establish a unique pan-European research infrastruc-ture in Heritage Science, the cross-disciplinary consortium of 23 partners provides access to instruments, methodologies and data for advancing knowl-edge and innovation in the conservation and restoration of cultural heritage. In this framework, CNR-ISTM leads MOLAB, which stands for “mobile lab-oratory”, an integrated platform of five national scientific facilities (CNR-It-aly, FORTH-Greece, NCU-Poland, RWTH-Germany, CNRS-France) which offers access to 19 state-of-the art non-invasive analytical methodologies and related competences to European Heritage Science researchers.

2014: 138 ISI Publications, 6 book chapters2015: 131 ISI Publications, 2 book chapters2016: 127 ISI Publications, 9 book chaptersThe SmartMatLab Center is an advanced research center at the academy/industry interface focused on prominent key enabling technologies such as nanotechnology, micro- and nanoelectronics, advanced materials, biotechnology and photonics, and optoelec-tronics. Two laboratories with up-to-date instrumentation testing, in pre-applicative device mode, the advanced and smart functional materials developed. The Nanotechnology lab is focused on the synthesis of nanostructured materials (i.e. metal vapor synthesis) and advanced characterization.

The Mobile laboratory (MOLAB) is a unique joint collection of portable equipment for non-destructive in situ measurements. MOLAB instruments are accessible to European researchers through a peer-review selection of proposals.The Computational Laboratory for Hybrid/Organic Photovoltaics (PVs) is worldwide recognized as an excellence in modeling mate-rials and processes for new generation PVs. As a representative work, a join experimental and computational study on the interface between organohalide perovskites and organic hole transporters was published in 2016 in Nature Energy (M. Saliba et al. Nature Energy 1, 15017, 2016) which gathered more than 200 citations in a few months and 17 news releases.

This project is aimed at improving the efficiency and life-time of OLED display, by studying the degradation processes of the most common lu-minescent molecules, emitting in the blue region. Our research consists in the simulation and study of transport and charge-separation in “exci-plexes” (i.e. excited molecular complexes), which are forefront in OLED active matrices. These systems, are purely organic, and without the need of heavy metal ions, are potentially advantageous in harvesting more charge carriers and increase amount of light emitted from the device.

RiceRes

IPERION CH

Efficient OLED design by theory and experiments

Website: http://www.istm.cnr.itAddress: Via C. Golgi. 19

20133 - Milan - ItalyTel: +39 02 503 14 190 Fax:

http://www.istm.cnr.it

Institute of Membrane TechnologyDirector: Dr. LIDIETTA GIORNO

Mission of the Institute for Membrane Technology (ITM) is the research and development in the field of science and engineering of membranes. The research activities aim to promote knowledge,

innovation and high-level training in the field of membranes and their application in water treatment, gas separation, bioartificial organs, biotechnology, food and agriculture. With more than 100 people (including 30 permanent staff, 37 research contracts, 4 associated professors, 8 PhD students, 39 foreing visiting scientists, 14 master students, 12 trainees), ITM is the major critical mass in the world specialized in membra

department of chemical sciences and materials technologies · by developing an innovative...

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