dentistry drug interactions
TRANSCRIPT
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In The Name Of GOD
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The simplest clinical classification scheme recognizes three basic types of drug interactions:
1- antagonism2- potentiation3- unexpected drug effect4- summation5- synergism
An example of this type of interaction is seen in antibiotic therapy , where the combined use of a drug that acts by inhibiting the synthesis bacterial cell walls .
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The increased neuromuscular blocking activity of succinylcholine occurring in patients receiving a pseudocholinesterase inhibitor .
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Disulfiram inhibits the intermediary metabolism of alcohol, resulting in the accumulation of acetaldehyde if alcohol is ingested by the patient .
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Examples of drugs that summate by acting at identical and at different sites include the opioid analgesics morphine and meperidine .
The combination of chemotherapeutic agents to treat certain infections (e.g., tuberculosis) and neoplastic diseases .
1- pharmaceutical interactions .
2- pharmacokinetic interactions .
3- pharmacodynamic interactions .
Most pharmaceutical interactions of importance to dentistry involve drugs that are given parenterally for intravenous sedation.
Pharmacodynamic interactions represent modifications in the pharmacologic effects of a drug independent of any change in the quantitative disposition of that drug. Such interactions may increase, diminish, or qualitatively alter the therapeutic effect.
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: PABA
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:1 3 G6PD
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COMT
HR (MAP)
HR (MAP) : 1
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(MOAIs) --
(TCA) ---
(SSRI) ---
MAOI :
TCA VC
SSRI VC
:Selective--Nonselective--
12 2 1
VC
VC : 200/115 6 CVA 6 CABG 6 CHF : :
OCP CCB BZD :
MAOI : NSAID
Tolerance: Dependance: Addiction:
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NO CO2 Diffusion Hypoxia: 5 100%
Smoking
: Co:
NSAID : COX
NSAID PG COX2
NSAID Cox1 PG COX1 PG PG GFR .PG
Cox2 PG
NSAID
NSAID ( PG) : ACE ( ) 7 8 . NSAID 4 : NSAID 4
NSAID Dry Socket ( diflunisal) ( Reye)
NSAID ( )
NSAID Nsaid COX A2
NSAID COX2: PG COX2 COX1
CELEXIB
PG
NSAID
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Turn Over
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nsaid
Latex Free
NSAID