Dental Research

Administration

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Message from Dean Thomas

Research, the organized quest for new information that ulti-mately benefits humankind, has been a fundamental component of life at Tufts University School of Dental Medicine (TUSDM) for most of its existence. Our advancement of knowledge is particu-larly relevant this year, our one hundred and fiftieth, as we look back at the excellence of our research heritage, its impact on the oral and general health of people, and plan for our future endeavors. As one example of our impact, consider one of our graduates from the Class of 1945, Michael G. Buonocore. His research

showing that adhesive bonds could be used to seal tooth enamel, thereby preventing tooth decay and the formation of cavities, earned him the moniker “Father of Adhe-sive Dentistry”. His further investigations, using ultraviolet light and weak acids to adhere plastic sealants to teeth, paved the way for future research in restorative and esthetic dentistry.

Current research opportunities at TUSDM are many and varied and in the past dec-ade have primarily focused on materials, public health and basic biological science research, with significant funding from both federal and corporate sources. More re-cently, we have broadened our portfolio by adding behavioral, outcomes, and peda-gogical research opportunities for our faculty and students alike. We are fortunate to have an outstanding, inquisitive student body and an exemplary faculty who devote their time to the students’ education. That we are housed in a student-centered re-search University that has a unique combination of Schools and promotes interdisci-plinary research, affords us an enviable opportunity for our next 150 years!

Huw F. Thomas, B.D.S., M.S., Ph.D. Dean and Professor of Pediatric Dentistry

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Dental Research Administration Dental Research Administration (DRA) at TUSDM can partner on any dental research study you are looking to perform. We are equipped with a clinical research center, a dedicated material re-search lab, an established Practice Based Network (PBRN), a simulation lab, and a student travel program where students travel to your facility to conduct a research study. The possibilities are endless!

Our experienced and highly trained staff will help you every step of the way. From proposal devel-opment, sample size calculation, budget creation, IRB submission, and contract negotiations. Once the study has been approved we have highly qualified research technicians, research coordi-nators, and faculty members to conduct the research.

The mission of DRA is to promote the research enterprise at TUSDM, reduce administrative bur-den and support research productivity and compliance.

We are here to support you from start to finish. Please look through this brochure for more infor-mation on what we can offer.

Table of Contents

Contact Information..............................................................................................................................................................1

Industry Collaborations......................................................................................................................................................2

TUSDM Research Clinic.......................................................................................................................................................3

Basic Science Research........................................................................................................................................................4

Dr. J. Murray Gavel Center...................................................................................................................................................5

PBRN (Practice Based Network).....................................................................................................................................6

Market Research and Product Evaluation...................................................................................................................7

Division of Biostatistics and Experimental Design..................................................................................................8

Student Fellowship Program.............................................................................................................................................9

Student Travel Program.............................................................................................................................................10-11

Letter from Dr. Gerard Kugel..........................................................................................................................................12

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Contact Information

Associate Dean for Dental Research & Professor of Comprehensive Care

Dr. Kugel has been conducting research at the Dental School for 25 years which has contributed to his expertise

in Clinical Research and Esthetic Dentistry. He is a reviewer and board member for many dental journals and is a

Fellow in the American and International Colleges of Dentistry, the Academy of General Dentistry, and the Acade-

my of Dental Materials. Dr. Kugel has published over 120 articles and over 200 abstracts in the field of restora-

tive materials and techniques. He was given over 300 lectures both nationally and internationally.

Gerard.Kugel@tufts.edu or 617 636-0870

Dr. Gerard Kugel

Director of Dental Research

As the Director of Dental Research Administration, Pam is responsible for overseeing financial and regulatory

compliance and all research operations at TUSDM. Pam acts as the main research liaison to federal, corporate

and foundation funding agencies and Tufts central Research Administration and budget center offices. The Direc-

tor is charged with providing education, training and support for departmental research coordinators and staff

throughout the Dental School as well as for faculty and students interested in research. She is responsible for

managing the TUSDM Shared Labs; and shaping the evolving research program at TUSDM.

Pamela.Corrado@tufts.edu or 617 636-0389

Pamela Corrado

Program Manager

Katie manages the administrative processes for the Dental Research department and Gavel Research Center. She

coordinates administrative process of the pre-doctoral Student Research Program, oversees the International

Research Program, coordinates travel for the AADR/IADR Annual Meeting and supervises the department Ad-

ministrative Assistant and the Gavel Center Sr. Research Tech. Katie also acts as liaison to other School and Uni-

versity offices, assists with research budget management/planning, and submitting grant applications.

Katie.Dunn@tufts.edu or 617 636-2745

Katie Dunn

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Industry Collaborations Tufts University School of Dental Medicine (TUSDM) wel-

comes the many valuable contributions corporations and

foundations make to its mission of extraordinary

education, research and community service. As the third

largest dental school in the nation, Tufts offers a variety of

opportunities for both community investment and

research with diverse populations. Researchers at Tufts

University School of Dental Medicine conduct research for

corporate sponsors in many areas, including:

• Bench studies in dental materials

• Clinical studies of dental devices, tooth whitening products, restorative materials, pharmaceuticals, and adhesive systems

• Basic science research in tissue engineering, wound healing, and dry-eye syndrome

The TUSDM research

community welcomes

inquires from potential

corporate partners. To learn

more about the wealth of

research resources available

at Tufts, please contact:

Research Administration

617.636.2745

Corporate & Foundation

Relations

617.636.2775

Opportunities abound for interdisciplinary and

collaborative research with the Tufts University Schools of

Bioengineering, Nutrition, Medicine, and

Veterinary Medicine.

TUSDM Major Areas of Research

Behavioral, Epidemiologic & Health Services

Cariology Research

Craniofacial Biology

Dental Materials: Adhesion, Ceramics, Polymers, Instruments, Equipment, Biocompatibility, Clinical Trials

Diagnostic Sciences

Education Research

Geriatric Oral Research

Implantology

Microbiology, Immunology & Infection Control

Mineralized Tissue

Neuroscience

Nutrition

Oral & Maxillofacial Surgery

Oral Health Research

Oral Medicine & Pathology : Oral Tumor Progression, Cellular Differentiation, & Wound Healing

Pediatric Dentistry

Periodontal Research

Pharmacology, Therapeutics & Toxicology

Pulp Biology & Regeneration

Prosthodontics Research

Salivary Research

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The TUSDM research community welcomes inquiries from potential corporate partners.

To learn more about the wealth of research resources available at TUSDM, please contact:

Dental Research Administration:

617-636-2745

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The TUSDM research community welcomes inquiries from potential corporate partners. To learn more about the wealth of research resources available at TUSDM, please contact:

Dental Research Administration: 617-636-2745

TUSDM Clinical Research Center Located on the 14th floor of the Tufts University School of

Dental Medicine, the TUSDM Research Clinic contains seven

fully equipped dental bays with air water syringes, dental lights

and peninsula sink cabinets. An adjacent 100 sq. ft. room is

fully equipped for private patient consultations and research

coordination.

Our staff is dedicated to protecting research participant safety

and confidentiality, and ensuring protocol compliance, in order

to provide our sponsors with high quality data.

Site Capabilities

6 full-time experienced research coordinators

Access to phlebotomists, research nurses, and physicians of all specialties (through affiliation with Tufts Medical Center)

Private consenting room

Private monitoring rooms

Double locked storage area for study documents

Capable of submitting to local and central IRBs

Experienced in a wide range of clinical trials

7 fully equipped dental bays

Double locked drug storage area with temperature monitor-ing

Full mouth x-ray capabilities

Temperature regulated 4°C refrigerator

Temperature regulated –20°C and –80°C freezers

Backup generator

Live broadcasting, intraoral Production VIEW HD camera console

4 overhanging HD Sony cameras

Weight calibrated equipment—saliva, weight, thermometers, blood pressure

Dispensary on the floor

Laboratory processing area

Facilities and Equipment

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Basic Science Research Our faculty are at the forefront of dental research using new technology, inventing innovate ap-

proaches and finding new ways to improve dental procedures and education. Please find a list

of the Divisions and Centers within Tufts University School of Dental Medicine.

Divisions and Centers

1 Kneeland Street, Boston, MA 02111

TEL: 617.636.2745 | FAX: 617.636.6511

Katie.Dunn@tufts.edu 4

Cancer Center Tissue Engineering Core Director: Addy Alt-Holland - 617 636-4072

Center for Integrated Tissue Engineering (CITE) Director: Jonathan Garlick - 617 636-2444

Dental Materials Lab-Gavel Center Director: Dr. Gerard Kugel - 617 636-2745

Division of Oral Biology Laboratory Director: Jake Jinkun Chen - 617 636-2729

Division of Craniofacial and Molecular Genetics Director: Pamela Yelick - 617 636-2430

Division of Biostatistics & Experimental Design Dr. Matthew Finkelman - 617 636-3449

Dry Eye Research Laboratory Director: Driss Zoukhri - 617 636-3914

Dry Mouth Clinic Director: Athena Papas - 617 636-3932

Facial Animation Laboratory Director: Carroll-Ann Trotman - 617 636-0347

The Craniofacial Pain Center Director: Shuchi Dhadwal - 617 636-0813

Tufts Dental Facilities – Vulnerable Populations Hogan Regional Center (Hathorne) 978-774-5000 x510 Northwoods Medical Center (Taunton) 508-823-7323 Pappas Rehab. Hospital for Children (Canton) 781-562-0349 Seven Hills Pediatric Center (Groton) 978-732-5400 West Springfield 413-363-1345 Worcester 508-796-1555 Wrentham Developmental Center 508-384-8987

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Dr. J. Murray Gavel Center For Restorative Dental Research Established in 1992, the Dr. J. Murray Gavel Center for

Restorative Dental Research has a long history of

performing high quality bench studies in the area of dental

materials research. The center is located at Tufts University

School of Dental Medicine in the heart of downtown Boston,

MA. The university welcomes the many valuable

contributions from agencies, corporations, foundations, and

individuals which makes its mission of extraordinary

education, research, and community service possible.

Compressive Strength Shear Bond Strength Tensile Strength Spectrophotometry Thermocycling Hydroxyapatite Formation Scanning Electron Microscopy (SEM)

Water Absorption & Solubility Microleakage Three-Point Bend Fluoride Release Influence of pH on Dental Materials Demineralization Vickers Hardness Testing

Common Testing Methods

Dental Cements Dental Base/Liners Dental Composites Dental Implants Adhesive Systems Tissue Management Materials Various Indirect Restorative Materials

Impression Materials Provisional Materials Glass Ionomers and RMGCIs Prosthetic Materials Endodontic Materials Orthodontic Materials

Commonly Tested Materials

Compression testing of dental cements occurring on the universal testing machine, Instron® 5566A.

Shear Bond testing occurring on the universal testing machine,

Instron® 5566A. pH readings are recorded on the Orion™ star

A214.

The TUSDM research community

welcomes inquires from potential

corporate partners. To learn more about

the wealth of research resources available

at TUSDM, please contact:

Dental Research Administration

617.636.2115

1 Kneeland Street, Boston, MA 02111

TEL: 617.636.2115 | FAX: 617.636.6511

Jeffrey.Daddona@tufts.edu 5

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Practice Based Research Network (PBRN)

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The TUSDM research community welcomes inquiries from potential corporate partners. To learn more about the wealth of research resources available at TUSDM, please contact:

Dental Research Administration: 617-636-2745

The Tufts University School of Dental Medicine

(TUSDM) PBRN is a network of TUSDM alumnus

private practitioners who conduct clinical studies

in the course of routine patient care. TUSDM PBRN

practitioners are located across the country and

have all completed training and preparation to

certify their practices for clinical research.

TUSDM is the administrative center for the projects

and provides training, research certifications,

quality control, administrative oversight as well as

fiscal and regulatory oversight. All projects are

approved via a Tufts IRB.

TUSDM PBRN studies originate with ideas submitted by corporate sponsors that seek to answer

questions of immediate interest to the dental profession. PBRN has access to a wide geographic range,

and diverse patient populations of varying ages, backgrounds and dental needs. The network is well

suited to handle a variety of research projects, particularly those centered on over-the-counter products

and consumer reaction.

Benefits to Sponsors

Benefits to Sites

PBRN Sites

“Patients see that you are not only doing general practice,

which we love, but you are taking the time to go above and

beyond, to influence the products of the future.

They appreciate that.”

Dr. Kistama Naidu, D02, DG04

Diversity of study participants

Expedited recruitment and high retention rates

One contract for all sites

Centralized, experienced research administration team

Highly skilled private practitioners trained in clinical research

Fresno, CA—Cosmetic and General Dentistry

Las Vegas, NV—General Dentistry

Worcester, MA—Periodontics

Chicago, IL—General and Cosmetic Dentistry

Pembroke Pines, FL—Orthodontics

Faculty appointment at TUSDM

Bring new products and treatments to your patients

Help advance the science of dentistry

Work with pre-market products

Per-patient payment

Possibility for publishing and presentations

Research experience for CV

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Market Research and Product Evaluation The only thing that is predicable about the dental industry is that it will change. A new product

will come out tomorrow that might affect your bottom line. Tufts University School of Dental Med-

icine now offers market research and product evaluations. These studies can help you determine

which of two potential formulas is preferred by practicing dentists, if your instructions for use are

effective, name recognition, handling properties, and many other possibilities. TUSDM is here to

help you solidify your place in the ever growing market.

Blind Handling Studies

Comparison Studies

Mixing Tips

Cements

Bonding Agents

Polishing Kits

Focus Groups

Packaging Evaluation

Survey Studies

1 Kneeland Street, Boston, MA 02111

TEL: 617.636.2745| FAX: 617.636.6511

Katie.Dunn@tufts.edu

Types of Studies Benefits to Sponsors Diversity of study participants

Expedited recruitment and high retention rates

One contract for all sites

Centralized, experienced research administration team

Quickly approved by Institutional Review Board (IRB)

Data can be published in peer reviewed journal

Certified Focus Group Leader on staff

Review by practicing and future dentists

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Division of Biostatistics and Experimental Design

The primary mission of the Division is to collaborate with investigators at TUSDM on novel re-search. We are also active in teaching, conducting independent research, and seeking external funding.

For additional information, contact:

Dr. Matthew Finkelman, Director of the Division of Biostatistics and Experimental Design, Matthew.Finkelman@tufts.edu, 617-636-3449. 8

Services

The Division is available for consultation on all

aspects of research, including:

Grant development

Protocol development

Study design

Sample size calculation

Randomization

Statistical analysis

Dissemination of results

Benefits to Sponsors

Helps develop study design and protocol

Achieve best value for investment, by only

testing the needed sample size

Control sources of variation and detect

outlier

Conduct rigorous data analysis to support

sound conclusions

Provide insightful interpretation of results

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Student Research Fellowship Program Each year a selected number of dental students are awarded the research fellowships on a com-petitive basis by our internal Research Committee. These fellowships are to support the stu-dent’s research project, under the supervision of TUSDM Faculty members. The School of Den-tal Medicine is committed to providing all interested students with opportunities to do re-search. Students are encouraged to get involved in research projects being conducted at the School.

Students are able to conduct research in a wide variety of disciplines and dental specialties. You can read the abstracts from past student and faculty research here (https://dental.tufts.edu/sites/default/files/pdf/research_BatesAndrewsAbstracts_2015-2016.pdf).

Application to the Student Research Fellowship Program involves the submission of a complete research proposal which includes enough description to allow for objective evaluation of the project.

TUSDM provides a stipend for students awarded the research fellowship. Acceptance of the award requires participation in the Bates-Andrews Student Research Day. Only one student will be funded per project. Students can also be funded by corporate sponsors. It is it with the sup-port of our corporate sponsors that this program has been able to be so successful.

Students participating in the program also attend a mini-course designed to enhance learning, broaden the students’ skills, scientific thinking, satisfaction in their research experience and promote camaraderie among the group.

For additional information, contact:

Eileen Doherty, Director of Predoctoral Student Research, Eileen.Doherty@tufts.edu, 617-636-6870

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Research Travel Program In recent years, TUSDM faculty and students travelled to Germany, California, Delaware and Australia to collaborate on den-tal research studies. Some of the projects involved research on glass ionomer restorative cements, bone grafting materials, antimicrobial agents, composite systems, impression and provisional materials, and tissue management devices. There are many opportunities to expand this program to other sites in concert with additional corporate sponsors.

Corporate research and development teams benefit greatly from the presence of talented student and faculty researchers in their labs. From sharing clinical perspectives and marketing ideas to collaborating on protocol design and execution, industry partners can find endless ways to utilize the skills of Tufts dental researchers during a week-long visit. The program creates lasting relationships and future partnerships in both research and clinical dentistry. It also offers the industry sponsor opportunities to educate and inform current and future opinion leaders. Projects and programs are customized to meet the business objectives of the corporate host.

Tufts students and faculty value opportunities to visit the headquarters of leading dental manufacturers and conduct research with industry scientists. Rarely do dentists and educators gain insight into the multi-faceted and interdisciplinary world of dental product manufacturing. The TUSDM Research Travel Program offers educators, researchers and clinicians unique access to the industrial partners upon whose success they depend for their own professional achievement. The experience fosters understanding and shared infor-mation which benefits the participants, their patients, the Tufts community and the profession at large.

Industrial Appeal Educational Appeal

Summer 2017

3M Oral Care - Seefeld, Germany

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Participating in the Research Travel Program at 3M Oral Care in Seefeld, Germany was one of the most memorable experiences I’ve had in dental school. I got to work in the impression ma-terials lab testing different types of materials, including a newly developed product by 3M. It was very exciting to be able to visit and conduct research at a company that produces so many of the materials we use in clinic everyday. I am very grateful to be able to work with a group of such wonderful mentors whom I learned so much from in just one short week. Throughout my time there, I not only received a great level of support on my research project, I also got many tips on living in Germany. We even received a fascinating tour of Munich and got to experience traditional Bavarian food together. When we were not at 3M, we spent our time exploring and experiencing the local culture on our own, everything from visiting famous castles to trying to find the best fitting traditional clothing! Sunny Gaudet, D18

Southern Dental Industries - Melbourne, Australia “The Research Travel Program provided the opportunity to travel to the SDI in Melbourne, Australia. It was a great experience that allowed us to learn more about the manufacturing of different dental materials and delivery systems as well as the massive amount of research that goes into developing these materi-als and getting them into the hands of clinicians. Everyone at SDI was very wel-coming and friendly, and we enjoyed getting to know each other while working together to provide critical data and research for the newest, cutting-edge den-tal materials and equipment. We were able to collect data, analyze it, and com-plete abstracts for multiple studies by working efficiently and effectively. When we weren’t working, we got to explore Melbourne and the surrounding areas, including the Yarra Valley and Phillip Island. It was one of the most rewarding opportunities of my career at TUSDM and I highly recommend it.” Aaron Lalonde , D18

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Summer 2016

Kerr Corporation - Anaheim, CA

“The Travel Research Fellowship has been one of the most rewarding aspects of my dental school

experience. During the summer of 2015, I traveled with a classmate to Seefeld, Germany to perform a

dental materials research project at 3M ESPE. In addition to completing a project evaluating the ease

of handling of glass ionomer restorative materials, I worked alongside brilliant scientists and

technicians and had the opportunity to explore the manufacturing and product development

departments at 3M ESPE, a company whose products we learn about and utilize at TUSDM. I had no

idea how much I was going to learn from this experience or how much I would be able to teach the

scientists at the company about what is important about a given material to dental professionals. After

work each day and on the weekends, my classmate and I traveled to the surrounding areas and

immersed ourselves in the Bavarian culture. I highly recommend this program to any adventurous den-

tal student with a passion for research, learning, and traveling. It is truly an unparalleled experience.”

Rachel Cohen, D’16

“I travelled to Kerr Corporation in Anaheim, CA with a fellow student, and it was one of the best

experiences of dental school. Looking back, I can see how fortunate I was to perform research on

the newest products and see first hand everything that goes into producing the materials we use

on a daily basis. While at Kerr, I learned how products were created starting from the raw

materials stage through the shipping stage. One gains a great appreciation for just how vast the

profession is. On off hours, we had the opportunity to try great restaurants, go to Disneyland,

drive to Los Angeles, and catch an Angels game. I highly recommend this experience to anyone

who is interested in gaining a greater appreciation for dental materials, while having a blast.”

William Brown, D’16

3M Oral Care - Seefeld, Germany

“The research travel program allowed me to experience the structure and methods of corporate

dental research that I had never been exposed to previously. While working at Dentsply, I was able to

interact with staff daily from multiple departments. I learned how ideas transformed into products

and the magnitude of these products in dental offices. It was amazing to see how highly valued the

dentists’ opinions were throughout the research process. Delaware also had beautiful sunsets and

beaches to explore in the evenings! Michelle Ta, D’17

Summer 2015

Dentsply - Milford, DE

The TUSDM research community welcomes inquiries from potential corporate partners. To learn more about the wealth of research resources available at Tufts, please contact Dental Research Administration: Katie.Dunn@tufts.edu or at 617.636.2745 11

Southern Dental Industries - Melbourne, Australia “I was fortunate enough to have the opportunity to travel with a fellow student to Southern Den-

tal Industries main headquarters in Melbourne, Australia through the Travel Program. Not really

knowing what to expect from the experience, I was amazed by the friendliness of those we worked

with at the facility, the level of research we were able to accomplish and the beauty of the country.

We gained invaluable insight into how dental materials (including the amalgam we use in the

clinic) are made and worked first hand in testing products recently released to the market. We

were on the cutting edge of a product that is just becoming popular in the United States and I

have had some fun teaching faculty about the material when I returned to Tufts. We also had a

great time exploring Melbourne, driving the Great Ocean Road and watching Australian Rules

Football. Overall the trip was an invaluable experience that will make me a better clinician going

forward and one that I will reminisce on for a long time.” Tim Reichheld D’18

3M Oral Care - Seefeld, Germany "I was delighted when I first found out that I would have the chance to work with 3M since we use

many of their products in the pre-clinical and clinical settings. It was wonderful to have a chance

to be able to participate in corporate research. I was pleased to see that many of the techniques

and equipment used at 3M are also used at Tufts. This experience was absolutely wonderful and

has increased my interest in dental materials.” Alisha Anand D’18

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Message From Dr. Gerard Kugel

The research mission of Tufts University School of Dental Medicine promotes

integration of innovative studies in basic science, clinical practice, and public

health. This brochure is evidence of the progress we have made and will con-

tinue to make at the Dental School.

TUSDM welcomes the valuable partnerships and contributions of corpora-

tions, foundations, the NIH, and the NIDCR’s tour mission. Working together,

we have the means to perform ethical, meaningful research in oral and gen-

eral healthcare that can be applied for the benefit of the scientific community

and the public at large.

Researchers at TUSDM conduct studies in many areas, including bench and

clinical studies in dental materials, devices, and pharmaceuticals. We are

presently pursuing groundbreaking techniques in tissue engineering, bone

remodeling, and Sjo gren’s syndrome. Tufts also provides a wealth of opportu-

nities for interdisciplinary research with our schools of nutrition, biomedical

sciences, veterinary medicine, and engineering.

The combination of disciplines and talent at Tufts University provides the

ideal environment for collaborative research and materials testing. Our rec-

ord of contributions to the sciences and our potential to influence the future

of dental medicine are extensive.

As we continue to promote oral health and improve the quality of life for the

general population, we remain aware that strategic partnerships are vital to

our efforts. We recognize the power of shared knowledge and are always

looking to share resources and ideas.

Gerard Kugel, D.M.D., M.S., Ph.D.

Professor and Associate Dean for Research

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Dental Research Administration

1 Kneeland St. DHS 1513

Boston, MA 02111

P: 617 636-2745

F: 617 636-6511