delivery of aerosolized drugs through continuous positive airway pressure (cpap) team patrick...
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DELIVERY OF AEROSOLIZED DRUGS THROUGH CONTINUOUS POSITIVE AIRWAY PRESSURE (CPAP) Team Patrick Kurkiewicz Annie Loevinger Joe Decker Steve Welch Client Dr. Mihai Teodorescu Advisor Professor John Webster Slide 2 Outline Problem Statement Background Information Client Specifications Design Options Design 1: Jet Nebulizer Design 2: Ultrasonic Nebulizer with One-Way Valve Design 3: Ultrasonic Nebulizer with Flow Sensor Final Design Future Work Questions Slide 3 Problem Statement A method is needed for automated delivery of bronchodilator drugs, like Albuterol, while using the CPAP device. Automated delivery should either be continuous or at timed intervals over a patients sleep cycle. Slide 4 Background Continuous Positive Airway Pressure (CPAP) Used for sleep apnea and asthma patients Provides positive pressure to assist breathing Image from Webster, J.G. 2009. Medical Instrumentation. Slide 5 Background Uses Pressurized Air Efficiency 39+/-3%** Uses ultrasonic waves Efficiency 86+/-5%** Jet NebulizerUltrasonic Nebulizer Image from www.mece.ualberta.ca/arla/tutorial.htmwww.mece.ualberta.ca/arla/tutorial.htm ** Gessler T; Schmehl T; Hoeper M M; Rose F; Ghofrani H A; Olschewski H; Grimminger F; Seeger W. 2001. Ultrasonic versus jet nebulization of iloprost in severe pulmonary hypertension. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2001;17(1):14-9. Image from www.sonozap.com/nebulizer.htmwww.sonozap.com/nebulizer.htm Nebulizer: transforms liquid medication into mist patient Slide 6 Client Specifications Compatible with CPAP Automatically deliver albuterol sulfate Cannot compromise quality of sleep Design for clinical trials Made for adults Prototype can be computer interface Slide 7 Design Options Slide 8 Design 1: Jet Nebulizer in-line with CPAP + Simple + Inexpensive - Loud - Requires separate flow generation Slide 9 Design 2: Ultrasonic Nebulizer with One-Way Valve Nebulizer gas collects in side chamber during exhale, taken up during inhale + Simple design - Collecting gas may re-condense Slide 10 Design 3: Ultrasonic Nebulizer with Flow Sensor Flow sensor detects breathing rate, turns nebulizer on/off based on inhalation cycle + More control - Complicated, requires more parts Slide 11 Design Matrix Efficacy (25) Safety (20) Compatibility /Feasibility (20) Patient Comfort (20) Ease of Use (10) Cost (5) Total (100) Jet Nebulizer 15201505570 Ultrasonic One-Way Valve 201520 10489 Ultrasonic Flow Sensor 2515122010385 Slide 12 Final Design Ultrasonic nebulizer with one-way valve control Existing CPAP and mask Added programmable controls Slide 13 Future Work Finish proof of concept testing Construct prototype nebulizer Prototype testing Drug delivery Control efficacy Integrate design with CPAP Slide 14 Questions?