ctn web seminar series: a forum to exchange research knowledge a forum to exchange research...
TRANSCRIPT
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CTN WEB SEMINAR SERIES: A FORUM TO EXCHANGE RESEARCH KNOWLEDGE
Produced by: CTN Training
This training has been funded in whole or in part with federal funds from the National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, under Contract No.HHSN271201000024C
PUBLICATIONS PLANNING AND PREPARATION
Presented by:
George Bigelow, PhDDikla Blumberg, PhD
January 28, 2015
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Learning Objectives
• Describe what a Publication Plan is, the importance of an effective strategy, and when and how to incorporate it into a clinical investigation plan.
• Identify the various types of papers to produce from CTN study data and introduce other resources for sharing network data that contributes to analyses and publications.
• Discuss the role of the CTN Publications Committee and the process and materials needed for review.
• Discuss suggestions, based on experience of the Publications Committee, regarding ways to enhance the quality of CTN reports.
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PLANNING AND PREPARATION
Dikla (Dee) BlumbergProtocol Specialist, Clinical Coordinating Center at EMMES
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Publication Planning
• Begins as early as the development of study concept.
• Proposed publications documented in an official plan.
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Publication Plan – What is it?
• A comprehensive list, often designed as a spreadsheet, that indicates all the planned papers the study team would like to pursue.
• Includes the general research question(s), data source, lead author, and proposed co-authors, target journal and more.
• The publication plan serves as a guide that allows for planning, assessing progress, and general organization of ideas.
Note: The Publication Plan serves as a prompt for the Lead Investigator to organize and track progress.
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Publication Plan - SampleEncourage co-authorship from the research site staff.
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Timing of Data Availability
•Data captured in AdvantageEDC
•Database lock
•Study data set (raw data)
•Publication
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Authorship/Co-Authorship
• Writing teams should involve Investigators, Lead Team, and research site staff who participated in the study. – The Lead Author has primary responsibility for timely
preparation of the manuscript.– To qualify as a co-author, individuals must have made
substantial contributions to study design, implementation, or data analysis as well as drafting of the article or revising it critically.
• Study participants outside the writing workgroup (e.g., research assistants, clinic directors, etc.) who do not meet qualifications for co-authorship should be acknowledged by name and role at the end of the article.
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Submitting the Publication Plan
• When should the plan be submitted?– The Lead Investigator (LI) will submit a publication
plan to the Publications Committee(PC) when 50% of the target sample is enrolled.
– Within six months after database lock, the LI will review and revise the publication plan and resubmit the plan to the PC.
– Thereafter, the publication plan will be reviewed and revised semi-annually.
(CTN Policies & Procedures, Section 9.0)
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TYPES OF MANUSCRIPTS AND DATA RESOURCES
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Types of Manuscripts
Baseline Papers
Primary Outcome
Secondary Outcome(s)
Ancillary/ Platform Studies
Methods Papers
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Types of Manuscripts
• Primary Outcome paper:– Main outcome variable for the study.
• Research hypothesis based on this measure.• Used to power study and determine statistical significance of
any treatment effect.
– Should be completed and submitted within six months of database lock.
– Consolidated Standards of Reporting Trials (CONSORT)
• Set of recommendations for reporting randomized trials• Website: http://www.consort-statement.org/
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CTN Dissemination Library
http://ctndisseminationlibrary.org
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CTN Dissemination Library
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Types of Manuscripts
• Secondary Outcome paper(s):– Papers summarizing any other (non-primary) outcome
measures.– Any other analyses, for example:
• Sensitivity analysis of primary outcome measure with respect to missing data.
• Subgroups by age, race, gender, ethnicity, disease severity, etc.• Pooling data across studies.
– All secondary papers listed in the plan should be submitted to appropriate journals within one year after submission of the primary outcome paper.
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NIDA Data Share
• Website: https://datashare.nida.nih.gov/• An electronic environment that allows data from
completed clinical trials to be distributed to investigators and the public:– Promotes new research.– Encourages further analyses.– Disseminates information to the community.
• Secondary analyses produced from data sharing multiply the scientific contribution of the original research.
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NIDA Data Share
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Assessments
Data
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Other Types of Manuscripts
• Methodology– Papers that describe experimental design, methods for
conducting particular tests or interventions, and statistical analyses.
• Example: – Achieving Cannabis Cessation -- Evaluating N-Acetylcysteine
Treatment (ACCENT): Design and Implementation of a Multi-Site, Randomized Controlled Study in the National Institute on Drug Abuse Clinical Trials Network.
– Contemporary Clinical Trials 2014;39(2):211-223. – Protocol CTN-0053, LI Dr. Kevin Gray
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Other Types of Manuscripts
• Baseline– Papers that describe characteristics at the beginning of a
study, such as population demographic, clinical, product, or other variables before an intervention has been administered.
• Example:– Clinically Relevant Characteristics Associated with Early
Treatment Drug Use Versus Abstinence.– Addiction Science & Clinical Practice 2014;9:6. – Protocol CTN-0044, LI Edward Nunes
Reference: http://www.consort-statement.org/resources/glossary#B
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Other Types of Manuscripts
• Ancillary– An ancillary study is a supplementary study to a larger CTN parent study.
• Usually has its own protocol.• Generally uses data or specimens obtained from participants already
enrolled in the parent study.• Typically supported with CTN funding.
– Example: • The Multi-Site Prescription Opioid Addiction Treatment Study: 18-
Month Outcomes.• Sharpe Potter et al. (2015)• Journal of Substance Abuse Treatment;48(1):62-69.
Reference: http://grants.nih.gov/grants/guide/notice-files/NOT-DA-11-014.html
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Other Types of Manuscripts
• Platform – Platform studies utilize the CTN’s infrastructure for
research facilitating practice improvement processes or development/refinement of research tools (e.g., measurement instruments)
• May be stand-alone projects or add-ons to existing studies
• Typically supported with external funding
Reference: http://grants.nih.gov/grants/guide/pa-files/PA-06-497.html
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Questions – Use Chat Feature
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PUBLICATIONS COMMITTEE (PC)
George BigelowChair, CTN Publications Committee
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Goal of PC Review
To improve clarity, accuracy, effective communication.
If reviewers don’t fully understand and appreciate the message, it can probably be
said better.
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Publications Committee Members
George BigelowJack Blaine
Genie BaileyDennis Donovan
Jeff KorteTiffany Kyle
John RollGeorge Woody
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Publication Opportunities
• CTN encourages multiple publications.• We want to learn as much as possible.• Large-n, diverse, multi-site studies.• Broad study teams with diverse interests.• Extensive investment in assessments.• Repeated assessments over time.• Assessment commonalities across studies.
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Review Process
• Please submit early to allow time for PC review.
• PC Reviews – 2-3 week turnaround.• Then keep the PC informed of the status of
manuscripts and of reviewers’ comments as manuscripts progress through journal review:
[email protected]@jhmi.edu
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What Does/Doesn’tNeed PC Review?
What Does:• Reports with new CTN data
or analyses• Posters and slide
presentations • Abstracts or proposals for
presentations• Ancillary studies• Single site studies
What Doesn’t:• Reports of previously
approved material• Reviews that cite or
summarize CTN publications• Reports without data • Descriptive reports of local
node activities
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PC Review Activity Past 7 months
Goal: Clarity, accuracy, relevance
• 24 manuscripts, about 3-4 per month
• 88% approved with comments & suggestions
• 12% request revision and re-review
• Plus abstracts, posters, oral/slide presentations
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Diverse Venues of CTN Reports
23 different journals for 29 publications
Most frequent (5): J Substance Abuse Treatment
Top tier:• JAMA Internal Medicine; Bogenschutz et al SMART-ED primary outcome report• Addiction; McPherson et al
Statistical handling of missing data
Presentations at 11 different meetings
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Diverse Publication
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Advice to Authors
• Representing the whole CTN program.• State directions and magnitudes of relationships.• Avoid overstating relationships & conclusions.• Avoid causality statements about correlations.• Acknowledge the limitations of
studies & findings.• Read, and have co-authors read,
the manuscript.
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Meeting Presentations
• Typically precede publication.
• Can serve as model and initial steps.
• PC reviews abstracts and final posters and slides.
• Plan ahead for timely review.
• Submit final version 1 month prior to meeting.
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Posters
• Avoid “wall of words.”• Use bullet points,
graphics, clear headings.
• Try to capture and engage attention.
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Size and Contrast Matter in Slides
Can you read this?
Can you read this?
Can you read this? Can you read this? Can you read this?Can you read this?Can you read this?
Can you read this? Can you read this? Can you read this? Can you read this? Can you read this? Can you read this? Can you read this?
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PC Review is Useful & Usually Appreciated
“Special thanks... a great edit … really makes it read better”
“Timely turnaround and helpful comments”
“Thank you! We will fix these ... I forgot …”
“Many thanks … helpful comments”
“Forward my thanks to the reviewers”
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Responding to Reviewer Suggestions
• Goal is to improve the paper or presentation.
• Use good judgment.
• Incorporate good suggestions.
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Conclusion
CTN is producing many good, important publications and presentations, and having
significant impact on field.
Everyone involved is contributing to the quality and the value of CTN reports.
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Open the Lines for Questions / Comments
Alternatively, questions can be directed to the presenter(s)by sending an email to [email protected].
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http://ctndisseminationlibrary.org
A copy of this presentation will be available electronically.
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Survey Reminder
The CTN Training encourages all to complete the survey issued to participants directly following this webinar session, as this is the primary collective tool for rating your experience
with this and other webinars, and for communicating the interests and needs of CTN members and associates.
Next topic…
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THANK YOU FOR YOUR PARTICIPATION