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Cover Page Special TopicSyn thesis

SYNTHESIS0 0 3 9 - 7 8 8 1 1 4 3 7 - 2 1 0 X© Georg Thieme Verlag Stuttgart · New York2017, 49, 3885–3886special topicen

Sandwiched between iron and nickel, cobalt has not always enjoyed the interest that has beenshowered on its more famous neighbors. Yet the last few years has seen a steady rise in inter-est in cobalt-catalyzed transformations. The fact that it is considered a base metal makes itparticularly attractive when it may replace rarer, more expensive metals. More importantly, itis increasingly credited with facilitating a wide range of modern transformations in syntheticchemistry. These include: the venerable Pauson–Khand annulation, substitution reactions,epoxide opening, Mannich additions, arene couplings, functionalization of quinolines, hydro-boration, and C–H functionalization. SYNTHESIS and Thieme are proud to provide in this SpecialTopic a curated collection of reports describing important advances in chemistry mediated bycobalt and its complexes. We trust the readers will enjoy the cutting edge chemistry found inthis issue and be inspired to innovate!

rohi

bite

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Erick M. Carreira Editor ETH Zürich, Switzerland

Published as part of the Special Topic Cobalt in OrganicSynthesis

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© Georg Thieme Verlag Stuttgart · New York — Synthesis 2017, 49, 3885–3886

Cobalt in Organic Synthesis

K. Xu S. Zhang

M. Petit

R2R1

R1

BpinBPin

R2

R1

BpinH

R2

B2Pin2

HCo(PMe3)4 5 mol%

HBPin

Take one get one

Take two get two

NH

O

AQ

H

+ Et3Al

Co(acac)3 (5 mol%)1,10-phen (5.5 mol%)

2,3-DCB (120 mol%)THF, 70 °C, 20 h

NH

O

AQ

Et

D. P. Furkert M. A. Brimble

3886

© Georg Thieme Verlag Stuttgart · New York — Synthesis 2017, 49, 3885–3886

Cover Page Special TopicSyn thesis

E. Balaraman

* Simple & Efficient* Practical condition* Broad substarte scope* Functional group tolerance

CoCl2.6H2O/PPh3NH2

R + R OH

HN

R

R

Readilyavailable

tBuOK+ H2O

J. A. Gladysz

NH2

Co

NH2

NH2

H2N

H2NH2N Ar

Ar

Ar

Ar

Ar

Ar

3+

B. Sundararaju

A. Cabré X. Verdaguer A. Riera

O

RNMO·H2O

O

OR

Co2(CO)6

CH2Cl2, RTHO

OH

P. Knochel

R1 NH

O

N

R3

F R2

J.-L. Niu M.-P. Song

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