clinical research management 512 leslie mcintosh [email protected] ) 314.747.7959 (office)

9
Clinical Research Management 512 Leslie McIntosh [email protected] 314.747.7959 (office)

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Page 1: Clinical Research Management 512 Leslie McIntosh lmcintosh@path.wustl.edu ) 314.747.7959 (office)

Clinical Research Management 512

Leslie [email protected]

314.747.7959 (office)

Page 2: Clinical Research Management 512 Leslie McIntosh lmcintosh@path.wustl.edu ) 314.747.7959 (office)

Agenda

Vocabulary

Levels of Measurement

Measures of Central Tendencies

Study design types (overview)

Page 3: Clinical Research Management 512 Leslie McIntosh lmcintosh@path.wustl.edu ) 314.747.7959 (office)

Vocabulary Statistics

Levels of Measurement Continuous Discrete

(aka: Categorical) Dichotomous Nominal Ordinal

Measures of Central Tendencies Mean Median Mode Range

Confidence Interval

p-Value

Page 4: Clinical Research Management 512 Leslie McIntosh lmcintosh@path.wustl.edu ) 314.747.7959 (office)

Statistics The study of inference – taking

information from a small amount of data (sample) and making generalizations to a larger setting (population)

Extrapolating from a sample to a population

Page 5: Clinical Research Management 512 Leslie McIntosh lmcintosh@path.wustl.edu ) 314.747.7959 (office)

Levels of Measurement (Variable Types)

Continuous – variables that can take on any value in a given range

Discrete (aka: Categorical) – variables that have a limited number of values Dichotomous – two values Nominal – multiple values where order does

not matter Ordinal – multiple values where order does

matter

Page 6: Clinical Research Management 512 Leslie McIntosh lmcintosh@path.wustl.edu ) 314.747.7959 (office)

Activity: Variable Types1. What is your gender?

2. What is your age?

3. What is the highest level of education you have completed?

4. What is your own yearly income?

5. What is your total household income, including all earners in your household?

6. What is your current marital status?

7. What is your religious affiliation?

8. What is your race?

Page 7: Clinical Research Management 512 Leslie McIntosh lmcintosh@path.wustl.edu ) 314.747.7959 (office)

Measures of Central Tendencies

Mean Sum of all numbers divided by the total numbers within the

distribution

Median Midpoint of a distribution

Mode Most frequent number in the distribution

Range The spread of the distribution The smallest number to the largest number

Page 8: Clinical Research Management 512 Leslie McIntosh lmcintosh@path.wustl.edu ) 314.747.7959 (office)

Activity: Central Tendencies

How much soda did you consume over the weekend?

Participant Amount Participant Amount

Page 9: Clinical Research Management 512 Leslie McIntosh lmcintosh@path.wustl.edu ) 314.747.7959 (office)

Study Designs Descriptive

Analytic – hypothesis testing

1. Case reports

2. Case series

3. Ecologic (aka: correlational)

4. Cross-sectional

5. Case-control

6. Follow-up/cohort

7. Clinical trials