Active Implants – Second Cicor Innovation Insights Symposium

December 2, 2015, CSEM SA, Neuchâtel/Switzerland

cicor.com

ContactCicor Management AGCorporate CommunicationsLeutschenbachstrasse 958050 Zurich I Switzerland

CSEM SAJaquet-Droz 12001 Neuchãtel / Switzerland

gastric and cardiac pacemakers, cochlear implants, implantable cardioverter defi-brillators, and deep brain, nerve, and bone stimulators being implanted in patients worldwide.

Meet with experts and opinion leaders and get insights about new materials, technologies, latest developments, trends and new innovations.

DateWednesday December 2, 201513:00 – approx. 18:00

Target groups/Attendees• Opinion leaders • Start-up companies• Investors• Consultants• Scientific institutions• Media

Program

Active Implants – Second Cicor Innovation Insights Symposium

Active Implants – Second Cicor Innovation Insights Symposium

The demands placed on medical applications are high: their reliability and functionality must be guaranteed at all times while designs keep becoming smaller, more flexible and more complex. Implantable electronic systems and devices have undergone a significant transformation, becoming a valuable bio-medical tool for monitoring, measuring and soliciting physiological responses using wireless communication.

The invention of these devices have relied heavily on the growing knowledge regarding various aspects of the human neuro-motor system, and the development of latest technologies and materials capable of inter-facing with living tissues and organs at micro- and nano-scale. Miniaturization and lower energy requirement of modern devices led to a multitude of miniature wireless electronic devices, such as sensors, intelligent

13:00 Arrival and registration

Moderation

Harry Heinzelmann, CTO, CSEM SA

13:30 Welcome

Cicor Group and CSEM SA

13:40 NeuroComm, advanced implanted neural interface John Donoghue, Director, Wyss Center for Bio- and Neuro-Engineering

14:00 Challenges and opportunities for further improving cochlear implants Konstantin Silberzahn, Sonova, Advanced Bionics

14:20 Development of a bi-directional wireless brain interface and its implantable components Dr. Martin Schüttler, Chief Technology Officer, CorTec GMBH

14:40 Deep brain stimulation – clinical aspects and perspectives Prof. Dr. Volker Sturm, Universitätsklinikum Würzburg, Neurosurgery

15:00 Podium discussion – the challenge of materials and technologies

John Donoghue, Campus Biotech, Wyss Center

Karl-Heinz Fritz, Cicor AMS Division

Dr. Martin Schüttler, CorTec GMBH

Dr. Stephan Mohrdiek, CSEM SA

Prof. Dr. Volker Sturm, Universitätsklinikum Würzburg, Neurosurgery

15:30 Break

16:00 The alfapump® System – a breakthrough technology in ascites management Dirk Fengels, Director of engineering and manufacturing, Sequana Medical AG

16:20 Key technology and design considerations for semiconductors used in implantable stimulators and sensors Jakob Nielsen, ON Semiconductor

16:40 Podium discussion – Market opportunities Claude Clément, Campus Biotech, Wyss Center

Dr. Matthias Krieger, CSEM SA

Jakob Nielsen, ON Semiconductor

Dirk Fengels, Sequana Medical AG

Konstantin Silberzahn, Sonova, Advanced Bionics

17:10 Closing

17:15 Networking and drinks reception

Harry Heinzelmann is a physicist with degrees from the University in Basel and complementary post-doc training at the IBM Research Laboratories in San José, California, and Rüschlikon, Switzerland. Additionally he holds a MAES degree from the University of Basel and completed an IEP training at INSEAD, France. He joined the Centre Suisse d’Electronique de Microtech-nique CSEM in Neuchâtel where he worked for many years as Division Head of Nanotechnology and Life Sciences. In June 2014 he became CSEM’s Chief Technology Officer. Harry Heinzelmann’s main technology background is in nanostructures and nanotools, nano-biotechnology and nanoscale optics, with long-dating experience in scanning probe microscopy techniques. His general interest is in nanoscale science and technology and their impact and applications in today’s innovation process, as well as societal issues of nanotechnology.

Professor of neuroscience and engineering at Brown University (Rhode Island, USA) and holder of the Henry Merritt Wriston chair, John P. Donoghue is one of the founding fathers of the merger between neuroscience and cybernetics, now called neuroprosthetics. John P. Donoghue is one of the most recognised researchers in the neuroengineering field. He has won numerous awards, such as the 2007 KJ Zülch Prize, the highest European distinction for neurological research. He skilfully combines the qualities of a scientist, engineer and manager, for example by coordinating the multidisciplinary team behind the groundbreaking prototype neural interface known as BrainGate. John has recently been appointed as a Faculty member at EPFL and UNIGE.

Konstantin Silberzahn (born 1987, Germany) joined the Sonova group company Advanced Bionics as Research Engineer in March 2013. Before joining the company, he received a Dipl.-Ing. degree in mechanical engineering from Technical University Munich, Germany, with stations in Denmark and California. At Advanced Bionics’ European Research Center Konstantin Silberzahn is focusing on novel electrode and actuator concepts and external research collaborations.

Martin Schüttler studied electrical engineering at the University of Braunschweig. His dissertation discussed nerve intersections processed using microsystems engineering. Since the completion of his PhD in 2002, and with more than 150 publications, he has earned an international reputation in the field of neuroprosthetics. After several research periods abroad, he became team leader at the Department of Microsystems Engineering, chaired by Prof. Dr. Thomas Stieglitz, and one of the leading scientists at the BMII in Freiburg. At CorTec he is responsible for the coordination of all developmental work.

Moderation

Harry Heinzelmann I CSEM SA

Speaker

John Donoghue I Wyss Center for Bio- and Neuro-Engineering

Speaker

Konstantin Silberzahn I Sonova, Advanced Bionics

Speaker

Dr. Martin Schüttler I CorTec GMBH

Since 2012 Volker Sturm has been a Senior Professor with a professorship in neurosur-gery at the University of Würzburg. After his residency, he specialized in stereotaxis and functional neurosurgery at the University of Saarland before further studying stereotaxis at the Karolinka Institute in Stockholm and Saint Anne’s Hospital in Paris for four years. From 1988 to 2012 he was director and held the chair of the clinic for stereotaxis and functional neurosurgery at the University of Cologne. Volker Sturm has received several awards, including the Meyenburg prize for outstanding achievements in cancer research and the Claudius Galenus prize for pharmacological research. In 2013 he won the Spiegel-Wycis award.

Speaker

Prof. Dr. Volker Sturm I Universitätsklinikum Würzburg

Dirk Fengels joined Sequana Medical AG early 2015 as Director of Engineering and Manufacturing. Prior to joining Sequana Medical, he worked at the Swiss Center for Electronics and Microtechnology (CSEM) for 10 years, where he held a leading position as Section Head for Sensors and Systems. His team specialized in developing innovative solutions to create unique selling propositions centered around sensors, mechatronic systems and fluid handling. Prior to CSEM, Mr. Fengels was responsible for the develop-ment of next generation products in two medical start-up companies, one in Switzerland and one in Silicon Valley, where both products reached market maturity. Mr. Fengels holds a Masters in Electrical Engineering from the Swiss Federal Institute of Technology, Zürich (ETH).

Claude Clément started in R&D for the watch industry (Swatch Group) as head of the transducers and actuators development group. He entered the world of medical technologies by heading the diversification activities of Swatch in the field of wearable programmable drug delivery pumps. Afterwards, he spent 23 years in the field of active implantable medical devices, as Director of Manufacturing Engineering at Inter-medics (now Boston Scientific), as Plant Manager of the Swiss operations of Medtronic and later as a consultant for major companies, mainly in the field of pacemakers and for various highly innovative start-ups. Starting in 1996, he put in place and ramped-up the highly automated factory of Medtronic in the Lake Geneva area. Until 2014, he was CEO of MyoPowers, a start-up company developing an electromechanical implant to treat severe incontinence. Beginning of 2015, he joined the Wyss Center for Bio- and NeuroEngineering, as CTO. He holds a Master in Electricity from the Swiss Federal Institute of Technology (EPFL) in Lausanne, and an MBA from HEC at the University of Lausanne (Switzerland).

Jakob Nielsen is a senior manager in the Consumer Health Product Line at ON Semicon-ductor where he creates and markets innovative semiconductor solutions for consumer and clinical medical applications. He began his career as a DSP engineer at Oticon A/S and later worked as a manager of hardware and systems for Dspfactory and a senior manager in DSP systems technologies for AMI Semiconductor. With more than 17 years of experience in R&D related to health care device innovation for disease management and treatment, Nielsen has a strong interest in applications that require combined ultra-low processing while achieving high precision sensing of analog body signals. He holds several patents in the field of audio processing for hearing aids and sensor interfacing for blood gas analyzers. Nielsen holds a M.Sc.EE in applied digital signal processing from Aalborg University in Denmark and an MBA from the University of Western Ontario – Richard Ivey School of Business.

Matthias Krieger is a physicist with master degree from the ETHZ and PhD from EPFL in experimental physics. He holds an additional degree in strategic marketing from HSG (University St. Gallen). After his PhD, he joined the semiconductor industry to hold several consecutive management positions in R&D Die Attach process technology. Further professional experience moved his career into strategic marketing and Business Development, ranging from precision optics at Satis Photonics AG over Key Account Management at Oerlikon Solar to Corporate Marketing & Business Development at CSEM after 2006. In this position, Matthias Krieger has provided background market intelligence on behalf of all corporate research divisions in numerous industrial sectors and gained insight into favourable business conditions for advanced technologies beyond state of the art. His main technology background remains semiconductor industry, industrial automation and robotics and more recently ICT-Agriculture and active medical implants.

Speaker

Dirk Fengels I Sequana Medical AG

Speaker

Claude Clément I Campus Biotech, Wyss Center

Speaker

Jakob Nielsen I ON Semiconductor

Speaker

Matthias Krieger I CSEM SA

Karl-Heinz Fritz (born 1971, Austria) joined the Cicor Group in March 2011. Karl-Heinz Fritz is vice president for technology and development in Cicors AMS division. He attended the College for Technische Chemie und Umwelttechnik in Vienna.Before joining Cicor, he held several operational and technical positions in electronics companies in Austria, Norway and Switzerland. He is technically responsible for PCB, thinfilm, thickfilm and microassembly business at Cicor.

Stefan Mohrdiek is heading the packaging & optics activities at CSEM. The main focus of his work is on supervising programs and establishing new research platforms in microelectronics, enabling/targeting innovative packaging solutions and aligning the research strategy with industry needs and the company‘s existing research areas. He received the master degree in electrical engineering with emphasis on communications engineering at the Technical University Darmstadt (Germany) in 1990. The PhD in Optoelectronics he obtained working at the Deutsche Telekom Technology and Research Center in Darmstadt in 1995 within the department of opto-electronic components as guest from the Technical University Hamburg-Harburg. The PhD was followed by a fellowship granted by the European Union at the Technical University Tampere in Finland in the semiconductor laboratories, working on multinational programs in semiconductor physics and technology. When moving to Switzerland in 1998 he joined the semiconductor industry, developing applications for packaged semiconductor lasers. After 15 years he started at CSEM in 2013 with an overall experience of more than 20 years in the field of optoelectronics and packaging, about 50 scientific publications and a number of patents.

Speaker

Karl-Heinz Fritz I Cicor Advanced Microelectronics and Substrates Division

Speaker

Stefan Mohrdiek I CSEM SA