chromacademy premier membership brochure
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CHROMacademy Premier Membership offers chemical analysts the opportunity to learn at their own pace or use our tutor supported training courses. Webcasts, Live-on-the-Web and Live @ Your Place offer live training in group settingsTRANSCRIPT
eLearning
eLabs
assessments
webcastsapplication notes
ask the expert
troubleshooting
industrynews
The Essential Guide
tutorialsThe Essential Guide
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Premier Membership
e-Learning for Analytical Chemists www.chromacademy.com
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e-Learning for analytical scientists
Used by over 35,000 chromatographers worldwide, CHROMacademy will help increase your knowledge, efficiency and productivity in the lab. With a vast library of high-quality animated and interactive e-learning topics, webcasts, tutorials and troubleshooting tools we can help you refresh your chromatography skills or learn something completely new.
CHROMacademy is simply the best training tool for analytical scientists - see for yourself!
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HPLC | GC | MS | Sample Preppowered by
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High Performance Liquid Chromatography
THE THEORY OF HPLC• IntroductiontoHPLC• ChromatographicParameters• BandBroadening• Columnchemistry• Reversephase(partition)chromatography• Ion-PairChromatography• Normalphase(absorption)chromatography• GradientHPLC• QuantitativeandQualitativeHPLC• FastHPLC• HILIC• SupercriticalFluidChromatography• IntroductiontoIonChromatography
INSTRUMENTATIONOFHPLC• MobilePhaseConsiderations• HPLCSolventPumpingSystems• Autosamplers• Detectors
e-Learning for Analytical Chemists www.chromacademy.com
Stator
Rotor Seal
IsolationSeal
Stator Face
It is necessary to divert the flow of mobile phase away from the sampling system (i.e. the syringe) when aspirating the sample and / or filling the sam-ple loop prior to injection. This is achieved using the injection valve containing a Rotor Seal.
The interface between the HPLC capillaries and the stator is known as the Stator Face...
InjectionValveAnatomyy
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Gas Chromatography
THEORYANDINSTRUMENTATIONOFGC
• IntroductiontoGC• ChromatographicParameters• BandBroadening• GasSupplyandPressureControl• SamplingTechniques• SampleIntroduction• GCColumns• GCTemperatureProgramming• GCDetectors• SupercriticalFluidChromatography
1. Aims&Objectives2. Introduction3. Supercritical Fluids 4. Modes of Chromatography5. SFCApplications6. SFCInstrumentation7. Packed&CapillarySFC8. The Mobile Phase9. Exhaust Gases10.OrganicModifiers11.PumpingIssues12. SFC Columns13.SFCStationaryPhases&ColumnSelection14.Detection15. Pressure Regulators16.AdvantagesandDisadvantagesofSFC
e-Learning for Analytical Chemists www.chromacademy.com
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Mass Spectrometry
FUNDAMENTALLC-MS
• Introduction• ElectroSprayIonizationTheory• ElectroSprayIonization–Instrumentation• MassAnalyzers• AtmosphericPressureChemicalIonization
(APCI)• AtmosphericPressurePhotoIonization(APPI)• Solvents,BuffersandAdditives• VacuumSystems• FlowRatesandFlowSplitting• OrbitrapMassAnalyzers
FUNDAMENTALGC-MS• Introduction• GCConsiderations• GC-MSInterfaces
MSINTERPRETATION• GeneralInterpretationStrategies• FundamentalsofMSProteomicsResearch
e-Learning for Analytical Chemists www.chromacademy.com
Corona Electrode Pin
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Non-Volatile Analyte is Charged in Solution
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Nebulising Gas
Sample Preparation
SOLIDPHASEEXTRACTION• MolecularProperties
1. LearningAims&Objectives2. Functional groups3. Molecular Properties4. Functional group interactions5. HydrophobicorNon-PolarGroups6. HydrophobicInteractions-Solubility7. HydrophobicInteractions-Sorbents8. Polar Groups9. PolarInteractions-Solubility10.PolarInteractions-Sorbents11.Ionicgroups12.Ionicgroups-pH|Ka|pKa|Ionicstrength13.IonicInteractions-Solubility|Sorbents14.IonicInteractions-ChelatingGroups15. Chelating Groups 16.ChelatingInteractions17. Solubility18. Sorbents19.ProteinBinding20.Assessment
• SPEOverview• SPEMechanisms• MethodDevelopment• PrimarySamplePreparationTechniques• Liquid/LiquidExtractionTechniques• ApproachestoAutomationforSPE
e-Learning for Analytical Chemists
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Select up to 3 Chromatographic Symptoms
Positive baseline drift Negative baseline drift Irregular baseline drift Cycling Baseline (Short Term) Cycling Baseline (Long Term) Erratic baseline Regular baseline noise Irregular baseline noise Baseline Spikes Not the Chromatogram I was expecting! Loss of resolution (some peaks)Loss of resolution (all peaks)No Peaks Additional peaks (ghost peaks) Negative peaks (One or more peaks) Peak broadening (Loss of Efficiency)Peak fronting (one or more peaks)Peak shouldering (one or more peaks)Peak splitting (one or more peaks)Peak tailing (one or more peaks)Rounded peaksChange in selectivityDecreasing retention timesIncreasing retention timesToo much retention
Selectupto2Instrument Symptoms
Low pressureHigh pressureContinuously decreasing pressure (no sample injection)Continuously decreasing pressure (after sample injection)Continuously increasing pressure (no sample injection)Continuously increasing pressure (after sample injection)Pressure fluctuationLeaks in the solvent reserviour connective tubingLeaks at the degasser / fittingsLeaks around the pump headLeaks around the check valves or fittingsLeaks in the autosampler or connective tubingLeaks around the sampling valveLeaks at the column fittingsLeaks from the detector fiitingsLeaks within the detectorPoor quantititive reproducibilityPoor linearity of response
Possible Causes
Solution
Resources
Mobile phase pH affects retention of ionisable analytes and the selectivity of separations in reversed phase HPLCSome methods require a very precise pH in order to remain robustLow pH tends to increase retention of acidic an-alytes and decrease retention of basic analytes
1. Incorrect/non-optimalmobilephasepH2. Incorrect column geometry / dimensions3. Buffer precipitation4. Incorrect buffer / non-optimal buffer concentration5. Analyte-stationary phase secondary interaction (e.g. silanol interactions)6. Incorrect mobile phase7. Incorrect mobile phase temperature
BuffersandpHMeterThis video explains how to prepare a buffer and use a pH meter.BufferpreparationThis useful tool will help you to prepare the cor-rect buffer for your HPLC analysisHow to calibrate pH meterThis video describes how to calibrate your pH
Normal
Problem
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SavingTime&Money
Scientist“A”needed to understand why her chromatogram contained baseline spikes combined with a loss of sensitivity. She turns to CHROMacademy’s HPLC Troubleshooter and in 2.3 seconds, CHROMacademy tells her there are 26 possible causes for this combination of symptoms. Each possible cause is ranked using our unique ‘expert system’ and includes a comprehensive explanation and suggested fixes backed by 100’s of resources from LCGC magazine, CHROMacademy and instrument vendors.
Without a CHROMacademy Premier Membership:Called her manufactures’ representative.36 hours before someone called backLost time of instrument use: 40 hoursLost $ = $2,000 (@$95K/annum)Contacted her Lab Manager2 hours lost before Lab Manager could be located
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SavingTime&Money
Scientist“B” needed to develop a sensitive GC-MS method for a chlorinated pesticide derivative present in potable water samples at very low levels. The derivative was new and therefore no applications existed in manufacturers literature.
Using a CHROMacademy Webcast and Tutorial he was able to develop a GC method from a generic screening method and realized that Chemical Ionization was the route to attain the required sensitivity. From the Sample Preparation Channel he noted that solid phase extraction could be used to selectively extract the target analyte and again was able to develop a method from a suggested generic starting procedure. He used the ‘ask the expert’ function to enquire of the CHROMacademy academic team how to create a sensitive MS acquisition method whilst checking for the presence of co-eluting interferences. Method was developed and was ready for validation within 1 week.
Without a CHROMacademy Premier Membership:He wished that the department GC-MS expert hadn’t been laid off…..Method development now begins using ‘guesstimates’
e-Learning for Analytical Chemists www.chromacademy.com
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