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Chemistry and the Origins of Life
Christopher ButchResearch ScientistBMSIS, ELSI, and Emory University
Organic Chemistry is the Chemistry of Life
Origins of Biomolecules
Natural experiments
The tar problemBiomolecules plus heat
and time
Open Questions• What molecules can be and are created without
life?
• How can these molecules be made to react in a life like manner?
• How can formation of wasteful byproducts like tars be prevented?
Suggested Readinghttps://en.wikipedia.org/wiki/List_of_interstellar_and_circum
stellar_molecules
https://www.scientificamerican.com/article/murchison-meteorite/
Lazcano, Antonio, and Jeffrey L. Bada. "The 1953 Stanley L. Miller experiment: fifty years of prebiotic organic chemistry." Origins of Life and Evolution of the Biosphere 33.3 (2003): 235-242.
ReferencesFerus, Martin, et al. "Formation of nucleobases in a Miller–
Urey reducing atmosphere." Proceedings of the National Academy of Sciences 114.17 (2017): 4306-4311
Miller, Stanley L. "A production of amino acids under possible primitive earth conditions." Science 117.3046 (1953): 528-529.
Benner, Steven A., Hyo-Joong Kim, and Matthew A. Carrigan. "Asphalt, water, and the prebiotic synthesis of ribose, ribonucleosides, and RNA." Accounts of chemical research 45.12 (2012): 2025-2034.