cheminform abstract: stereoselective transformation of phytosphinosine to safingol
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LipidsU 0750 Stereoselective Transformation of Phytosphinosine to Safingol. — A short and
stereoselective route is elaborated for the synthesis of the antineoplastic drug safingol (VI) from commercially available phytosphinosine (I). Key steps are the stereoselective one-pot transformation of diol (II) into epoxide (IV) under PTC conditions and its regioselective epoxide ring opening. — (KIM, N.; LEE, S. H.; NAMGOONG*, S. K.; Bull. Korean Chem. Soc. 30 (2009) 3, 695-699; Dep. Chem., Seoul Women's Univ., Seoul 139-774, S. Korea; Eng.) — R. Staver
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ChemInform 2009, 40, issue 32 © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim