1

CHEM 452(G)

Forensic Toxicology

Western Illinois University

Spring 2019 Semester

Instructor: Dr. Liguo Song

Tel: (309) 298-1656

E-mail: l-song@wiu.edu

Office: Currens 324B

Office Hours: M.W.F. 10:00 – 11:20 am

Teaching Assistant: Mr. James D. Leese and Ms. Tiwalola Ogunleye

Lecture (Section/001; STAR Number/44474): M.W.F./ 12:00 – 12:50am; Currens 206.

Lab (Section/021; STAR Number/44530): Th./02:00 -4:50 pm; Currens 419. The first hour will

be the case studies and pre-lab lectures in Currens 206.

Course prerequisites: CHEM 332 Organic Chemistry II, CHEM 341 Quantitative Analysis.

Course description: This course will survey the principal areas in analytical and forensic

toxicology. The first half of the course covers the main elements of forensic toxicology, including

introduction to forensic toxicology, pharmacokinetics and metabolism, drugs of abuse, workplace

drug testing, postmortem toxicology, drug abuse in sport, drug-facilitated sexual assault, and

driving under the influence of alcohol and drugs. The second half of the course is devoted to the

main elements of analytical toxicology, including sample preparation, spectroscopy, immunoassay,

mass spectrometry, introduction to analytical separations, gas chromatography, high-performance

liquid chromatography, capillary electrophoresis, and QA/QC (quality assurance and quality

control) in the toxicology laboratory.

Couse structure: This course is composed of lectures (including class discussion and video

supplements), laboratory experiments, case studies, homework assignments, quizzes, a research

paper, and examinations. We will meet face-to-face for lectures, laboratory experiments, case

studies, quizzes and examinations. We will also make extensive use of our Western Online course

website (http://westernonline.wiu.edu) for homework assignments and a research paper. If you

need technical assistance at any time during the course or to report a problem with Western Online

you can:

1. Call uTech support center 309-298-2704

2. Use Desire2Learn Help 10.1

Objectives: 1. Gain knowledge of how to perform meaningful interpretation of data from

analytical/forensic measurements.

2. Gain a fundamental understanding of the types of toxicological evidence and the correct

procedures for their collection, preservation, inventory and transportation.

3. Understand the principles, theories, and application of the appropriate analytical

technologies used for the analysis of toxicological specimens.

2

Materials:

1. Textbook:

1) Clarke’s Analytical Forensic Toxicology, 2nd edition. Editor: Adam Negrusz and

Gail Cooper. Print: ISBN-13 9780857110541. Publishers: Pharmaceutical Press.

2. Supplemental textbooks:

1) Criminalistics: an introduction to forensic science, 11th edition. Author: Richard

Saferstein. Print: ISBN-13 9780133858136. Publisher: Pearson Prentice Hall.

2) Forensic Chemistry, 2nd edition. Author: Suzanne Bell. Print: ISBN-13

9780321765758. Publishers: Pearson Prentice Hall.

3) Quantitative Chemical Analysis, 9th edition, Author: Daniel C. Harris. Print:

ISBN-13 9781464135385. Publisher: W.H. Freeman and Company. 3. Lab Manual: Handouts.

4. Case files: to be provided.

5. Peer-reviewed journals in the fields of chromatography, mass spectrometry, forensic

chemistry and forensic toxicology.

Supplies (required):

1. Protective eyewear (safety goggles) for use in the laboratory experiments

2. Scientific calculator without internet access capability

3. Official lab research notebook-50 pages from the WIU bookstore.

Grade determination

Component % Possible points

Laboratory experiments 18 180

Case studies 8 80

Homework assignments 12 120

Quizzes 12 120

Research paper/presentation 5 50

Three semester exams 30 297

Final exam 15 153

Total points 100 1000

1. Laboratory experiments (18%): A total of 10 laboratory experiments will be performed

during the semester. Labs are given as scheduled in the syllabus (or announced in class in

the unlikely case that it must be rescheduled). Students may work in lab groups of a few

people, but each student must complete his/her own lab reports. No credit will be given to

any student who did not physically complete the lab as instructed or turn in the lab report.

To accommodate absence only your 9 best labs will be counted toward your final grade.

Also, should you miss two labs due to a medically required absence, military commitment,

or other excused reason, and provide acceptable documentation, a make-up lab will be

given after all the labs are completed to replace the missed lab score. It is the instructor’s

decision as to whether an absence shall be excused. Should you miss more than two labs,

no further make-up lab will be given. Each lab will be worth 20 points. Your total

number of points possible from labs will be 180 points. You must score a minimum of

100 points in the laboratory experiments to pass this course. There is a penalty for

3

turning in a lab report late: 20% will be deducted for each day. Assignments of lab

reports over five days late will not be accepted and will receive zero point. There will

be also a final exam of case studies and labs, which will be worth a total of 30 points.

To participate in the laboratory experiments, students must pay $35 charge and sign

the Chemistry Laboratory Safety Agreement.

To prepare for the lab, students must read through each lab in advance and also attend the

pre-lab lecture.

Safety is the first concern in a chemistry laboratory experiment. Material Safety Data

Sheets (MSDS) information on all chemicals utilized in the laboratory can be found at the

following web site, http://hazard.com/msds/. Proper handling of chemicals is expected. The

following rules must be observed while working in the laboratory:

1) Appropriate safety goggles must be worn at all times – the use of contact lenses

is discouraged.

2) Proper dress is required - bare feet, sandals, or opened-toed shoes are not allowed

in the laboratory. It is best not to wear expensive clothing as stains and holes can

result from misplaced chemicals.

3) Behaving appropriately – you must be aware of others around you, so be careful

when carry chemicals and walk through the laboratory.

4) Know the location and operation of the safety equipment – this includes

eyewash facilities, fire extinguishers, fire showers, and fire blankets. In case of fire,

do not panic, clear out of the immediate area, and call your instructor for help.

5) Cleaning up – it is important that you clean your workstation upon completing

your laboratory exercise.

6) Food, drinks and smoking of any kind are not allowed in the laboratory – keep

all objects, such as glassware or plastic tubing, out of your mouth while in the lab.

7) No cell phone calls in the laboratory.

The lab reports are to be typewritten (Font-12 and Times New Roman is preferred,

margins 1 inch). Lab reports must include the cover page, the objective of the experiment,

theory/background relates to the experiment, materials for the lab, and the procedures (in

your own words), experimental results (including calculations), discussions and

conclusions, and reference(s). The report must be completed and submitted electronically

as a single “word file” to the Western Online class dropbox by 11:30 pm on the day of

the same week when the next lab starts on the next day (see schedule below). Lab

reports should represent the individual student's work. Discussion with your lab partner

and classmates on the report is fine, but you must not copy the content of the report from

your partner or any other sources. The format and the distribution of lab points per lab

report are listed below:

1) Cover page (5%): Must include the title of the experiment, course number, your

name (bold type), your lab partner’s name, instructor’s name, TA’s name, and date.

2) Objective (5%): State two to three sentences about the objectives of the

experiment.

4

3) Theory/Background information (15%): Require half to a page to summarize the

basics of how the objectives will be realized. This may include important reactions,

techniques or instrumental methods. It should not include procedures.

4) Materials (5%): List chemicals, reagents and their concentration, instruments

being used.

5) Procedures (15%): The details should be sufficient so that your fellow students

can read your report without any guessing. Any last minute change in procedures

or concentration during lab session must be recorded. Use your own words to write

up a lab procedure; do not directly copy the procedure from lab manual/handout.

You must use past tense and passive voice to write up your lab report (5% will

be deducted with the wrong format).

[Sample examples]

“I collect the samples from the crime scene, place them in the bag, seal it, and

have my signature and date on the bag.” The format is wrong because the

present tense is used.

“I collected the samples from the crime scene, placed them in the bag, sealed it,

and had my signature and date on the bag.” The format is wrong even though

the past tense is used because it is not a passive voice.

“Samples from the crime scene were collected, placed in the bag and sealed,

and signed and dated by me.” This is the right format.

[Note] Avoid placing Arabic numerals at the beginning of each sentence.

For instance, “0.6 g glycine was weighed out and put into a 100 mL volumetric

flask” is not a correct format.

“Point six gram of glycine was weighed out and put into a 100-mL volumetric

flask” or “Glycine (0.6 g) was weighed out and put into a 100-mL volumetric

flask,” which is the correct format.

6) Results (30%): The accuracy/quality of your data will be graded.

These should include tables, graphs and calculations, if any

Tables and graphs should have self-explanatory titles

Numbers should have appropriate units

X and Y axes should be labeled

All calculations should be included with appropriate units

7) Discussions and Conclusions (20%) You recorded data and did some analysis

during the lab session and did further analysis and wrote a lab report in a week after

the experiment(s). What have you learned from the experiment(s) and what is (are)

the conclusion(s)?

8) References (5%): List cited references.

If you take information from Chem 251 Western Online handouts, then

cite the URL address. For instance:

Song, Liguo (2015). Density of glass by flotation.

https://westernonline.wiu.edu/d2l/le/content/66439/viewContent/971288/

View?ou=66439

If you cite any journal article you have to follow this format:

Thogmartin, Jon R., Wilson, Christopher I., Palma, Noel A., Ignacio,

Susan S., Mark, J. Shuman., and Flannagan, Lisa M. (2011). Sickle Cell

5

Trait-Associated Deaths: A Case Series with a Review of the Literature.

Journal of Forensic Sciences, 56 (5): 1352–1360.

2. Case studies (8%): There will be approximately 10 case files to be presented before every

pre-lab lecture. The presentation of each case file will last approximately 20 minutes.

Students are required to answer specific questions about each case and submit the answers

in the dropbox on Western Online. In order to receive a grade of each case study, the

answers must be submitted electronically as a single “word file” in the Western

Online class dropbox by 11:30 pm on the day of the same week when the next lab

starts on the next day (see schedule below). Each case study will be worth 5 points.

There is a penalty for turning in answers of case studies late: 20% will be deducted

for each day. Answers of case studies over five days late will not be accepted and will

receive zero point. There will also be a final exam of case studies and labs, which will be

worth a total of 30 points. The case files can also be watched after class. To watch them,

please download this syllabus, open this syllabus in Microsoft Word, right click the

corresponding case file name which is listed in the table of tentative class schedule at the

end of this syllabus, copy the hyperlink, and then paste it on Google Chrome.

3. Homework assignments (12%): There will be approximately eight homework

assignments periodically during the semester. The homework assignments will appear in

the Western Online as online quizzes. Each homework assignment will consist of

approximately 20 questions. Each question will be worth 1 point. You will be allowed to

have two attempts with unlimited time to solve the questions. At the end of each attempt,

the questions answered incorrectly will be shown to you. After you finish, your highest

attempt will be automatically graded. In order to receive a grade of each homework,

you must do it within the available time window, which is usually a couple of days. In

order to accommodate absence only your six best homework assignments will be used to

determine your final grades. Your total number of points possible from the homework

assignments will be 120 points.

5. Quizzes (12%): There will be approximately eight online quizzes periodically during the

semester. A quiz usually follow a homework assignment. Each quiz will consist of

approximately 20 questions. Each question will be worth 1 points. You will have 30

minutes to complete each quiz which will be automatically graded. In order to receive a

grade of each quiz, you must do it within the available time window, which is usually

a couple of day. To accommodate absence only your six best quizzes will be used to

determine your final grades. Your total number of points possible from the quizzes will be

120 points.

6. Regular Semester Exams (30%): There will be four regular semester exams. Each exam

will consist of approximately 33 questions and each question will be worth 3 points. To

accommodate absences only your best three of four lecture exams will be counted for your

semester grade. Also, should you miss two exams due to a medically required absence,

military commitment, or other excused reason, and provide acceptable

documentation, a comprehensive make-up examination will be given near the end of

the semester to replace the missed exam score. The make-up exam will be

6

comprehensive over all materials. It is the instructor’s decision as to whether an absence

shall be excused. Your total number of points possible from the regular semester exams

will be 297 points. Exams should be given approximately at the date as scheduled in the

syllabus, but the exact date will be announced in class.

7. Final Exam (15%): The final exam is comprehensive. It will consist of approximately 51

questions and each question will be worth 3 points. The final exam will be worth 153 points.

No incomplete grade will be given to a student without documented evidence of an

emergency that requires that the student be away from the university or requires that

the student miss the final examination. Students shall notify the instructor of the

emergency as soon as possible and prior to the final examination.

8. Research paper/presentation (5%): While a research paper is required for students who

take this course as CHEM 452, a research presentation is required for students who take

this course as CHEM 452(G).

Your research paper/presentation will be based on a journal research article describing

the analysis of a drug/poison. A list of drug/poison will be shared with you. You are

required to put your signature by the drug/poison that you choose. The same drug/poison

is not allowed to be chosen twice or by two students. You have to make your choice by

11:30 pm on February 28. Copies of two pertinent journal research articles must be

submitted for the instructor’s approval to the Western Online class dropbox by 11:30 pm

on March 31. Students are required to use Science Citation Index Expanded (via Web of

Science) through the WIU library to choose the two pertinent journal articles. Students are

advised to browse the journal articles and make sure that you will be able to understand

them before your final selection. After the instructor has selected one of the two pertinent

journal articles for each student to read, the student must study the drug/poison and relevant

instrumental technique(s) thoroughly which are usually not the main focus of the selected

article, but are crucial to understand the results described by the journal article.

Your research paper should be about seven pages (Times New Roman Font-12 and double

spaced). The first page should be the cover page which include the title of the article, course

number, your name (bold type), instructor’s name, and date. The last page should be the

reference page. In the middle, there should be about five pages describing the research in

the journal article. There will be 20% deduction for every page off the mark. While you

can use tables and graphics during the description of the research in the journal article, the

total number of tables and graphics cannot exceed three; and the size of the tables and

graphics cannot be larger than the originals in the journal article. The description should

include five sections: introduction (including toxicology and/or pharmacokinetics, 10

points), sample preparation (5 points), analytical method (5 points), results (20 points) and

discussion (10 points). Your total number of points possible from the research paper will

be 50 points. The final version of the research paper must be completed and submitted to

the Western Online class dropbox by 11:30 pm on April 30.

The PowerPoint slides of your research presentation should include at least five parts:

introduction such as toxicology and/or pharmacokinetics (5 points), sample preparation

7

(2.5 points), analytical method (2.5 points), results (10 points) and discussion (5 points).

Your total number of points possible from your PowerPoint slides will be 25 points. The

final version of your PowerPoint slides must be completed and submitted to the Western

Online class dropbox by 11:30 pm the day before your presentation. Your research

presentation will be approximately 20 minutes. There will be 25% deduction for every

more than 5 minutes off the mark. Your total number of points possible from your research

presentation will be 25 points.

The research paper/presentation is meant to be the original work of the individual student;

plagiarism is not acceptable and will result in a score of zero. If the student is not familiar

with the concept of plagiarism they should contact the University Writing Center for

clarification. "The University Writing Center is available to assist you with general and

specific questions on writing assigned in any discipline and at any academic level. The

one-on-one assistance available at the Writing Center is valuable for generating ideas,

talking about global-level issues such as organization, and even working through

grammatical problems. The University Writing Center is located in the Malpass Library,

third floor, west side. Call for an appointment (298-2815) and be sure to bring a copy of

your assignment."

Grading scale for CHEM 452:

90.00% and above A

86.70 - 89.99% A-

83.40 - 86.69% B+

80.00 - 83.39% B

76.70 - 79.99% B-

73.40 - 76.69% C+

70.00 - 73.39% C

66.70 - 69.99% C-

63.40 - 66.69% D+

60.00 - 63.39% D

56.70 - 59.99% D-

56.66% and below F

Grading scale for CHEM 452(G):

90.00% and above A

80.00 - 89.99% B

70.00 - 79.99% C

60.00 - 69.99% D

59.99% and below F

Course polices - to earn a passing grade in this course the student must:

1. Keep up with textbook reading, including supplemental textbook reading when required.

2. Complete laboratory experiments, case studies, homework assignments, the research paper,

quizzes and exams as assigned.

3. Attend class regularly and punctually. You are responsible for all information and materials

in classes whether you are present or not. Students who are present for all the classes

8

and labs will receive 20 bonus points at the end of the course. While students who

have excused absences may still qualify for 20 bonus points, students who receive

more than five excused absences do not qualify. In order to qualify for excused absence,

you have to hand in necessary paperwork. In addition, please make an official request

through the WIU online absence reporting system (OARS). While student are also

allowed to have unexcused absences, after a maximum of five unexcused absences

students will receive 50 point deduction for every additional unexcused absence. Any

student arriving more than ten minutes late for any exam, lecture or lab may not be allowed

to take or complete the exam, lecture or lab at the instructor’s discretion. Leaving the

classroom prior to completion of an exam is prohibited. When a student leaves the

classroom, the exam is complete. If the student leaves the classroom with an exam without

submitting the exam for grading, the value of the exam is zero.

4. Participate in a professional manner. Listen (do not have conversations) while the

instructor is speaking. If you have questions, raise your hand and/or politely say “excuse

me” to get the instructor’s attention. Phrase your questions using professional, respectful

words and tone of voice. Turn your cellphone ringer off, and put it away. Your instructor

should not be able to see your cell phone at any time during class. Laptops and tablets may

only be used with special permission. Use the restroom before class. Leaving the classroom

during class should only happen in very rare circumstances of dire emergency. Failure to

follow these rules may result in being required to leave the classroom for the remainder of

the class period.

5. Email correspondence must also be professional. This means that messages should be

written clearly, using proper spelling, punctuation, and grammar. Address the instructor

using the appropriate title (i.e., Dr. or Professor). Before sending an email, check to see

whether the answer to your question is in the syllabus or other document on Western Online.

Unprofessional messages may not receive a response from the instructor.

6. Study regularly for the exams—do not wait until just before. For best results, read the

material according to the schedule in advance, and then review the material and your notes

after lecture and lab the same week.

7. Check Western Online to stay apprised of any changes--the student is responsible for

keeping up with class. WIU policy on student rights and responsibilities can be found at

http://www.wiu.edu/provost/students.php.

8. Each student must complete their own individual course assignments and take their own

exams. All exams and the assignments are the responsibility of the individual student. If it

can be demonstrated that two students have collaborated in an assignment, they will both

lose the opportunity to earn a grade for that assignment. (This does not exclude students

from group study). Academic dishonesty in any form, including cheating and

plagiarism, will not be tolerated. Potential penalties will be decided on an individual case

basis. Please see the WIU Academic Policy for Undergraduate Students for further

information: http://www.wiu.edu/policies/acintegrity.php.

9. In accordance with University values and disability law, students with disabilities may

request academic accommodations where there are aspects of a course that result in

barriers to inclusion or accurate assessment of achievement. To file an official request for

disability-related accommodations, please contact the Disability Resource Center at 309-

298-2512, disability@wiu.edu or in 143 Memorial Hall. Please notify the instructor as

soon as possible to ensure that this course is accessible to you in a timely manner.

9

10. University values, Title IX, and other federal and state laws prohibit sex discrimination,

including sexual assault/misconduct, dating/domestic violence, and stalking. If you, or

someone you know, has been the victim of any of these offenses, we encourage you to report

this to the Title IX Coordinator at 309-298-1977 or anonymously online at:

http://www.wiu.edu/equal_opportunity_and_access/request_form/index.php. If you

disclose an incident to a faculty member, the faculty member must notify the Title IX

Coordinator. The complete Title IX policy is available

at: http://www.wiu.edu/vpas/policies/titleIX.php.

11. The WIU Office of Risk Management and Emergency Preparedness provides resources

on how to respond to emergency situations. Please view the video resources at

www.wiu.edu/rmep (click “Resources” on the right side of the page). If the fire alarms

sound and/or students are asked to evacuate the building all students should proceed

immediately to the nearest exit and gather at the southwest corner of the Higgins parking

lot (near the fence) until the “all clear” is given. 12. Web address for student rights and responsibilities: http://www.wiu.edu/provost/students.php.

Tentative class schedule*:

Week Date Chap/Lab Title

1 Monday, January 14, 2019 Chap 1 Syllabus, Introduction to forensic

toxicology

1 Wednesday, January 16, 2019 Chap 1 Introduction to forensic toxicology

1 Thursday, January 17, 2019 Chap 1 Introduction to forensic toxicology

1 Friday, January 18, 2019 Chap 3 Forensic drug analysis: selected

drug classes

2 Monday, January 21, 2019 Dr. Martin Luther King Day

2 Wednesday, January 23, 2019 Chap 3 Forensic drug analysis: selected

drug classes

2 Thursday, January 24, 2019 Chap 13 Sampling, storage and stability

2 Friday, January 25, 2019 Chap 13 Sampling, storage and stability

3 Monday, January 28, 2019 Chap 7 Postmortem toxicology

3 Wednesday, January 30, 2019 Chap 7 Postmortem toxicology

3 Thursday, January 31, 2019 Case Study 1 Writer’s block

3 Thursday, January 31, 2019 Lab 1 1a. Excel laboratory; 1b. Separation

of drugs using TLC

3 Friday, February 1, 2019 Chap 7 Postmortem toxicology

4 Monday, February 4, 2019 Chap 2 Pharmacokinetics and metabolism

4 Wednesday, February 6, 2019 Chap 2 Pharmacokinetics and metabolism

4 Thursday, February 7, 2019 Case Study 2 Sunday’s wake

4 Thursday, February 7, 2019 Lab 2 Discovery of internal standard for

GC analysis

4 Friday, February 8, 2019 Chap 2 Pharmacokinetics and metabolism

5 Monday, February 11, 2019 Exam 1 (Chapters 1, 3, 13 & 7)

5 Wednesday, February 13, 2019 Chap 2 Pharmacokinetics and metabolism

10

5 Thursday, February 14, 2019 Case Study 3 Bitter potion

5 Thursday, February 14, 2019 Lab 3

External versus internal standard

calibration in GC analysis (Part 1

sample preparation)

5 Friday, February 15, 2019 Chap 10 Drug-facilitated sexual assault

6 Monday, February 18, 2019 Chap 5 Work place drug testing

6 Wednesday, February 20, 2019 Chap 5 Work place drug testing

6 Thursday, February 21, 2019 Case Study 4 Something’s Fishy

6 Thursday, February 21, 2019 Lab 4

External versus internal standard

calibration in GC analysis (Part 2

GC analysis)

6 Friday, February 22, 2019 Chap 9 Drug abuse in sport

7 Monday, February 25, 2019 Chap 9 Drug abuse in sport

7 Wednesday, February 27, 2019 Chap 9 Drug abuse in sport

7 Thursday, February 28, 2019 Case Study 5 Cold hearted

7 Thursday, February 28, 2019 Lab 5

Salicylates in blood by visible

spectroscopy with external standard

calibration

7 Friday, March 1, 2019 Chap 11 Alcohol, drugs and driving

8 Monday, March 4, 2019 Chap 11 Alcohol, drugs and driving

8 Wednesday, March 6, 2019 Exam 2 (Chapters 2, 10, 5 & 9)

8 Thursday, March 7, 2019 Chap 11 Alcohol, drugs and driving

8 Friday, March 8, 2019 Chap 16 Immunoassays

9 Monday, March 11, 2019 Spring Break

9 Wednesday, March 13, 2019 Spring Break

9 Thursday, March 14, 2019 Spring Break

9 Friday, March 15, 2019 Spring Break

10 Monday, March 18, 2019 Chap 16 Immunoassays

10 Wednesday, March 20, 2019 Chap 17 Introduction to analytical

separations

10 Thursday, March 21, 2019 Case Study 6 Without a trace

10 Thursday, March 21, 2019 Lab 6 Salicylates in blood by visible

spectroscopy with standard addition

10 Friday, March 22, 2019 Chap 17 Introduction to analytical

separations

11 Monday, March 25, 2019 Chap 18 Gas chromatography

11 Wednesday, March 27, 2019 Chap 18 Gas chromatography

11 Thursday, March 28, 2019 Case Study 7 Political thriller

11 Thursday, March 28, 2019 Lab 7

Presumptive test of urine

adulteration, abused drugs in urine

and alcohol in saliva

11 Friday, March 29, 2019 Chap 18 Gas chromatography

11

12 Monday, April 1, 2019 Chap 19 High-performance liquid

chromatography

12 Wednesday, April 3, 2019 Chap 19 High-performance liquid

chromatography

12 Thursday, April 4, 2019 Case Study 8 Desert served cold

12 Thursday, April 4, 2019 Lab 8 Optimization of the separation of

NSAIDs by HPLC

12 Friday, April 5, 2019 Chap 19 High-performance liquid

chromatography

13 Monday, April 8, 2019 Exam 3 (Chapters 11, 16, 17 & 18)

13 Wednesday, April 10, 2019 Chap 20 Chromatographic methods and

capillary electrophoresis

13 Thursday, April 11, 2019 Case Study 9 Deadly formula

13 Thursday, April 11, 2019 Lab 9 SFE of phenylbutazone and internal

standard from equine plasma

13 Friday, April 12, 2019 Chap 20 Chromatographic methods and

capillary electrophoresis

14 Monday, April 15, 2019 Chap 21 Mass spectrometry

14 Wednesday, April 17, 2019 Undergraduate Research Day

14 Thursday, April 18, 2019 Case Study 10 Ultimate betrayal

14 Thursday, April 18, 2019 Lab 10

Phenylbutazone in equine plasma

by HPLC using internal standard

calibration

14 Friday, April 19, 2019 Chap 21 Mass spectrometry

15 Monday, April 22, 2019 Chap 21 Mass spectrometry

15 Wednesday, April 24, 2019 Chap 22 Quality assurance and control in the

toxicology laboratory

15 Thursday, April 25, 2019 Final exam of case studies and labs

15 Thursday, April 25, 2019 Make-up lab BAC by UV spectroscopy using an

enzymatic assay

15 Friday, April 26, 2019 Chap 22 Quality assurance and control in the

toxicology laboratory

16 Monday, April 29, 2019 Make-up exam (comprehensive)

16 Wednesday, May 1, 2019 Exam 4 (Chapters 19, 20, 21 & 22)

16 Thursday, May 2, 2019 Review

16 Friday, May 3, 2019 Review

17 Monday, May 6, 2019 Final Exam (1 pm)

*This table may not accurately represent the start and end points of each lecture.

Summary of homework assignments, quizzes and exams (not including the final exam):

1/4 1/8 Chap Title

Exam 1 Homework 1;

Quiz 1. 1 Introduction to forensic toxicology

3 Forensic drug analysis: selected drug classes

12

Homework 2;

Quiz 2. 13 Sampling, storage and stability

7 Postmortem toxicology

Exam 2 Homework 3;

Quiz 3. 2 Pharmacokinetics and metabolism

10 Drug-facilitated sexual assault

Homework 4;

Quiz 4. 5 Work place drug testing

9 Drug abuse in sport

Exam 3 Homework 5;

Quiz 5. 11 Alcohol, drugs and driving

16 Immunoassays

Homework 6;

Quiz 6. 17 Introduction to analytical separations

18 Gas chromatography

Exam 4 Homework 7;

Quiz 7. 19 High-performance liquid chromatography

20

Chromatographic methods and capillary

electrophoresis

Homework 8;

Quiz 8. 21 Mass Spectrometry

22

Quality assurance and control in the toxicology

laboratory

Note: This syllabus reflects the course policies and planned schedule, and may be amended at the

instructor’s discretion at any time. Any revisions will be announced in class. The most current

version of the syllabus will always be available via the class website on Western Online.