check your knowledge in… bhp/luts. 5-alpha-reductase inhibitors in the treatment of bph 00 1 -...

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Check your knowledge in… BHP/LUTS

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Page 1: Check your knowledge in… BHP/LUTS. 5-alpha-reductase inhibitors in the treatment of BPH 00 1 - Induce a significant decrease of libido 2 - Increase maximum

Check your knowledge in…

BHP/LUTS

Page 2: Check your knowledge in… BHP/LUTS. 5-alpha-reductase inhibitors in the treatment of BPH 00 1 - Induce a significant decrease of libido 2 - Increase maximum

5-alpha-reductase inhibitors in the treatment of BPH 00

1 - Induce a significant decrease of libido

2 - Increase maximum flow rates by about 5-10 mL/sec

3 - Cause a reduction of the volume of the prostatic gland of approximately 50%.

4 - Show a clinical response only several weeks or months after start of treatment

Page 3: Check your knowledge in… BHP/LUTS. 5-alpha-reductase inhibitors in the treatment of BPH 00 1 - Induce a significant decrease of libido 2 - Increase maximum

5-alpha-reductase inhibitors in the treatment of BPH

1 - Induce a significant decrease of libido

2 - Increase maximum flow rates by about 5-10 mL/sec

3 - Cause a reduction of the volume of the prostatic gland of approximately 50%

4 - Show a clinical response only several weeks or months after start of treatment

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Page 4: Check your knowledge in… BHP/LUTS. 5-alpha-reductase inhibitors in the treatment of BPH 00 1 - Induce a significant decrease of libido 2 - Increase maximum

Plant extracts for elderly men with LUTS 00

1 - Are recommended by all major BPH-guidelines

2 - Lead to a reduction of prostate volume by 30%.

3 - Have no effect on serum PSA.

4 - Can alter the natural history of the disease, i.e. reduce the risk of acute urinary retention.

Page 5: Check your knowledge in… BHP/LUTS. 5-alpha-reductase inhibitors in the treatment of BPH 00 1 - Induce a significant decrease of libido 2 - Increase maximum

Plant extracts for elderly men with LUTS

1 - Are recommended by all major BPH-guidelines

2 - Lead to a reduction of prostate volume by 30%.

3 - Have no effect on serum PSA.

4 - Can alter the natural history of the disease, i.e. reduce the risk of acute urinary retention.

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Page 6: Check your knowledge in… BHP/LUTS. 5-alpha-reductase inhibitors in the treatment of BPH 00 1 - Induce a significant decrease of libido 2 - Increase maximum

The efficacy of alpha-blockers in a patient with symptomatic BPH with moderate

obstruction is most with:

1. A prostate < 30 mL.2. A prostate of 30-50 mL.3. A prostate > 60 mL.4. Independent of prostatic size.

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Page 7: Check your knowledge in… BHP/LUTS. 5-alpha-reductase inhibitors in the treatment of BPH 00 1 - Induce a significant decrease of libido 2 - Increase maximum

The efficacy of alpha-blockers in a patient with symptomatic BPH with moderate

obstruction is most with:

1. A prostate < 30 mL.

2. A prostate of 30-50 mL.

3. A prostate > 60 mL.

4. Independent of prostatic size.

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Page 8: Check your knowledge in… BHP/LUTS. 5-alpha-reductase inhibitors in the treatment of BPH 00 1 - Induce a significant decrease of libido 2 - Increase maximum

Which statement regarding alpha-1-blockers for BPH is correct?

1. Tamsulosin has no effect on ejaculation.2. There are marked differences regarding clinical

efficacy of various alpha-1-blockers.3. Alpha-1-blockers have no effect on serum PSA-

levels.4. Alpha-1-blockers are more effective in men with

prostate volume > 40 mL.

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Page 9: Check your knowledge in… BHP/LUTS. 5-alpha-reductase inhibitors in the treatment of BPH 00 1 - Induce a significant decrease of libido 2 - Increase maximum

Which statement regarding alpha-1-blockers for BPH is correct?

1. Tamsulosin has no effect on ejaculation.

2. There are marked differences regarding clinical efficacy of various alpha-1-blockers.

3. Alpha-1-blockers have no effect on serum PSA-levels.

4. Alpha-1-blockers are more effective in men with prostate volume > 40 mL.

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Page 10: Check your knowledge in… BHP/LUTS. 5-alpha-reductase inhibitors in the treatment of BPH 00 1 - Induce a significant decrease of libido 2 - Increase maximum

For the medical management of BPH, Finasteride appears to lower:

1. Total PSA but not free PSA.2. Total PSA more than free PSA.3. Both free and total PSA without changing the ratio

of free to total PSA4. Both free and total PSA in different degree, thus

changing the ratio of free to total PSA.

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Page 11: Check your knowledge in… BHP/LUTS. 5-alpha-reductase inhibitors in the treatment of BPH 00 1 - Induce a significant decrease of libido 2 - Increase maximum

For the medical management of BPH, Finasteride appears to lower:

1. Total PSA but not free PSA.

2. Total PSA more than free PSA.

3. Both free and total PSA without changing the ratio of free to total PSA

4. Both free and total PSA in different degree, thus changing the ratio of free to total PSA.

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Page 12: Check your knowledge in… BHP/LUTS. 5-alpha-reductase inhibitors in the treatment of BPH 00 1 - Induce a significant decrease of libido 2 - Increase maximum

Which answer describes one of the actions of a 5-alpha-reductase inhibitor?

1. Serum PSA levels are unaffected.2. Sexual dysfunction is seen in more than 1%.3. An increase of serum PSA levels is observed

typically.4. Prostate volume is reduced by 50% within a period

of six months.

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Page 13: Check your knowledge in… BHP/LUTS. 5-alpha-reductase inhibitors in the treatment of BPH 00 1 - Induce a significant decrease of libido 2 - Increase maximum

Which answer describes one of the actions of a 5-alpha-reductase inhibitor?

1. Serum PSA levels are unaffected.

2. Sexual dysfunction is seen in more than 1%.

3. An increase of serum PSA levels is observed typically.

4. Prostate volume is reduced by 50% within a period of six months.

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Page 14: Check your knowledge in… BHP/LUTS. 5-alpha-reductase inhibitors in the treatment of BPH 00 1 - Induce a significant decrease of libido 2 - Increase maximum

The ‘TUR-syndrome’ is seen after transurethral surgery when using:

1. Low bladder pressure.2. High bladder pressure.3. Sterile water solution.4. Glycine as irrigating solution.

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Page 15: Check your knowledge in… BHP/LUTS. 5-alpha-reductase inhibitors in the treatment of BPH 00 1 - Induce a significant decrease of libido 2 - Increase maximum

The ‘TUR-syndrome’ is seen after transurethral surgery when using:

1. Low bladder pressure.

2. High bladder pressure.

3. Sterile water solution.

4. Glycine as irrigating solution.

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Page 16: Check your knowledge in… BHP/LUTS. 5-alpha-reductase inhibitors in the treatment of BPH 00 1 - Induce a significant decrease of libido 2 - Increase maximum

The urinary bladder responds to increased outlet resistance by:

1. Smooth muscle relaxation.2. Isotonic bladder wall contraction.3. Isometric smooth muscle contraction.4. Hypertrophy of the detrusor smooth muscle.

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Page 17: Check your knowledge in… BHP/LUTS. 5-alpha-reductase inhibitors in the treatment of BPH 00 1 - Induce a significant decrease of libido 2 - Increase maximum

The urinary bladder responds to increased outlet resistance by:

1. Smooth muscle relaxation.

2. Isotonic bladder wall contraction.

3. Isometric smooth muscle contraction.

4. Hypertrophy of the detrusor smooth muscle.

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Page 18: Check your knowledge in… BHP/LUTS. 5-alpha-reductase inhibitors in the treatment of BPH 00 1 - Induce a significant decrease of libido 2 - Increase maximum

The alpha-1-adrenoceptors are widely distributed throughout the body. Which

are the a1-receptors that predominate in the prostate?

1. 1A2. 1B3. 1D4. 1L

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Page 19: Check your knowledge in… BHP/LUTS. 5-alpha-reductase inhibitors in the treatment of BPH 00 1 - Induce a significant decrease of libido 2 - Increase maximum

The -1-adrenoceptors are widely distributed throughout the body. Which

are the 1-receptors that predominate in the prostate?

1. 1A

2. 1B

3. 1D

4. 1L

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Page 20: Check your knowledge in… BHP/LUTS. 5-alpha-reductase inhibitors in the treatment of BPH 00 1 - Induce a significant decrease of libido 2 - Increase maximum

A 72-year old man presents with chills and fever and slight pain in the right flank. Microscopic examination of urine shows 20

erythrocytes, 70 leukocytes and some bacteria (per high power field). Ultrasonography: residual urine 260 mL, prostatic size 55g,

dilation of both kidneys. The best therapy would be:

1. Hospitalization and antibiotics.2. Intermittent catherization, antibiotics, send patient home.3. Percutaneous puncture of kidney, hospitalization,

antibiotics.4. Hospitalization, catherization, resection of the prostate after

therapy of UTI

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Page 21: Check your knowledge in… BHP/LUTS. 5-alpha-reductase inhibitors in the treatment of BPH 00 1 - Induce a significant decrease of libido 2 - Increase maximum

A 72-year old man presents with chills and fever and slight pain in the right flank. Microscopic examination of urine shows 20

erythrocytes, 70 leukocytes and some bacteria (per high power field). Ultrasonography: residual urine 260 mL, prostatic size 55g,

dilation of both kidneys. The best therapy would be:

1. Hospitalization and antibiotics.

2. Intermittent catherization, antibiotics, send patient home.

3. Percutaneous puncture of kidney, hospitalization, antibiotics.

4. Hospitalization, catherization, resection of the prostate after therapy of UTI

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