chapter 23, part b
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Chapter 23, part B. Microbial Diseases of the Cardiovascular and Lymphatic Systems. Biological Weapons. 1346Plague-ridden bodies used by Tartar army against Kaffa 1925Plaque-carrying flea bombs used in the Sino-Japanese War - PowerPoint PPT PresentationTRANSCRIPT
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PowerPoint® Lecture Slide Presentation prepared by Christine L. Case
MicrobiologyB.E Pruitt & Jane J. Stein
AN INTRODUCTIONEIGHTH EDITION
TORTORA • FUNKE • CASE
Chapter 23, part BMicrobial Diseases of the Cardiovascular and
Lymphatic Systems
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• 1346 Plague-ridden bodies used by Tartar army against Kaffa
• 1925 Plaque-carrying flea bombs used in the Sino-Japanese War
• 1950sU.S. Army spraying of S. marcescens to test weapons dispersal
• 1972 International agreement to not possess biological weapons
• 1979 B. anthracis weapons plant explosion in the Soviet Union
• 1984 S. enterica used against the people of The Dalles
• 2001 B. anthracis distributed in the U.S.
Biological Weapons
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Biological Weapons
Bacteria VirusesBacillus anthracis “Eradicated” polio and measlesBrucella spp. Encephalitis viruses
Chlamydia psittaci Hermorrhagic fever viruses
Clostridium botulinum toxin Influenza A (1918 strain)Coxiella burnetti Monkeypox
Francisella tularensis Nipah virusRickettsia prowazekii Small pox
Shigella spp. Yellow fever
Vibrio choleraeYersinia pestis
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• Ischemia• Loss of blood supply to tissue
• Necrosis• Death of tissue
• Gangrene• Death of soft tissue
• Gas gangrene• Clostridium perfringens, gram-positive, endospore-
forming anaerobic rod, grows in necrotic tissue• Treatment includes surgical removal of necrotic
tissue and/or hyperbaric chamber
Gangrene
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• Pasteurella multocida• Clostridium• Bacteroides• Fusobacterium• Bartonella hensellae
• Cat-scratch disease
Animal bites and scratches
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• Yersinia pestis, gram-negative rod• Reservoir
• Rats, ground squirrels, prairie dogs• Vector
• Xenopsylla cheopsis• Bubonic plague
• Bacterial growth in blood and lymph• Septicemia plague
• Septic shock• Pneumonic plague
• Bacteria in the lungs
Plague
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Plague
Figure 23.10, 11
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• Borrelia spp., spirochete• Reservoir
• Rodents• Vector
• Ticks• Successive relapses are less severe
Relapsing Fever
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• Borrelia burgdorferi• Reservoir
• Deer• Vector
• Ticks
Lyme Disease
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Lyme Disease
Figure 23.13a
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Lyme Disease
Figure 23.13b, c
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• First symptom• bull's eye rash
• Second phase• Irregular
heartbeat, encephalitis
• Third phase• Arthritis
Lyme Disease
Figure 23.14
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• Ehrlichia, gram-negative, obligately intracellular (in white blood cells)
• Reservoir• Deer,
rodents• Vector
• Ticks
Ehrlichiosis
Figure 23.15
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• Epidemic typhus• Rickettsia prowazekii• Reservoir
• Rodents• Vector
• Pediculus humanus corporis• Transmitted when louse feces rubbed into bite
wound
Typhus
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• Epidemic murine typhus• Rickettsia typhi• Reservoir
• Rodents• Vector
• Xenopsylla cheopsis
Typhus
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• Rickettsia rickettsii• Measles-like rash
except that the rash appears on palms and soles too
Spotted Fevers (Rocky Mountain spotted fever)
Figure 23.18
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Spotted Fevers (Rocky Mountain spotted fever)
Figure 23.16
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Tick Life Cycle
Figure 23.17