Creating strong bonds through a range of leading vaccines.

1. Gray A et al (2003) Nobivac® DHPPi offers protection against infection with CDV and CPV within 7 days of vaccination. Proceedings 46th BSAVA Annual Congress, Birmingham, UK, 3-6 April 2003: p. 559.

2. Helps J et al (2007) An injectable modified live vaccine protects young puppies against challenge with either canine adenovirus-1 or canine adenovirus-2 seven days after a single vaccination. Proceedings 40th Voorjaarsdagen congress, 27th-29th April 2007, Amsterdam, NL: p. 193.

3. Hoskins JD et al (1995) Challenge Trial of a New Attenuated Canine Parvovirus Vaccine. Journal of Veterinary Internal Medicine 9:197.

4. Greenwood NM et al (1995) Comparison of isolates of canine parvovirus by restriction enzyme analysis, and vaccine efficacy against field strains. Veterinary Record 136: 63-67.

5. Horspool LJI et al (2005) A MLV vaccine pre-vents clinical signs and shedding of CPV type 2a and 2b after challenge at 36 months after vaccination. Proceedings 48th BSAVA Annual

References

Dis

tem

per (

MLV

)

Parv

oviru

s (M

LV)

Ade

novi

rus

type

2 (M

LV)

Para

influ

enza

(MLV

)

Bordetella

(Mod

ified

-live

)

Para

influ

enza

(Ina

ctiv

ated

)

Bordetella

(Ina

ctiv

ated

)

Vaccine Presentation

Nobivac DHP • • • 10 or 20 doses

Nobivac DHPPi • • • • 10 doses

Nobivac KC (Intranasal) • • 5 or 10 doses (with diluents)

Nobivac Bb/Pi • • 20 doses

Nobivac Puppy Pack 20 doses Nobivac DHP + 10 doses (with diluents) Nobivac KC

Nobivac C5 Pack 20 doses Nobivac DHP + 20 doses Nobivac Bb/Pi

The Nobivac Canine Vaccine range

comprises vaccines and services that reflect

MSD Animal Health’s long experience

and leadership in small animal vaccine

development.

A strong research commitment to small animal vaccines

ensures that the Nobivac vaccines are of the highest

quality, trusted for their efficacy and safety.

The Nobivac range is manufactured locally in Bendigo,

Victoria, and is supplied in recyclable packaging.

Canine Vaccines

SO93

6

congress, 7th-10th April 2005, Birmingham, UK: pp. 548.

6. Spibey N et al (2007) Canine parvovirus type 2 vaccine protects against virulent challenge with type 2c virus. Veterinary Microbiology 128: 48-55.

7. Bergman JGJE et al (2005) A MLV vac-cine has a duration of immunity of at least 36 months against CDV, CAV2 and CPV. Proceedings 48th BSAVA Annual congress, 7th-10th April 2005, Birmingham, UK: pp. 54.

8. Gore T et al (2005) Three-Year Duration of Immunity in dogs following vaccination against Canine Adenovirus Type-1, Canine Parvovirus, and Canine Distemper Virus. Veterinary Therapeutics Vol.6, No.1, Spring 2005: 5-14.

9. Gore T et al (2005) Intranasal kennel cough vaccine protecting dogs from experimental Bordetella bronchiseptica challenge within 72 hours. Veterinary Record 156:482-483.

10. Jacobs AA et al (2005) Protection of dogs for

13 months against Bordetella bronchiseptica and canine parainfluenza virus with a modified live vaccine. Veterinary Record 157:19-23.

11. Edinboro CH et al (2004) A placebo-controlled trial of two intranasal vaccines to prevent tra-cheobronchitis (kennel cough) in dogs entering a human shelter. Preventive Veterinary Medicine 62: 89-99.

12. Jacobs AAC et al (2006) An intranasal kennel cough vaccine administered at 3 weeks of age is able to stimulate protective immunity despite the presence of passive antibody. Proceedings 31st WSAVA Congress 11th - 14th October 2006, Prague: p. 850.

13. Data on file: Antibody, challenge and safety studies (Registration dossier, Part III, pages 22-83).

14. Bergman JGHE et al (2006) Comparative trial of the canine parvovirus, canine distemper virus and canine adenovirus type 2 fractions of two commercially available modified live vaccines. Veterinary Record 159: 733-736.

MSD Animal Health 91-105 Harpin Street, Bendigo East VIC 3550

Free Call: 1800 033 461www.msd-animal-health.com.au

Nobivac DHPNobivac DHPPiModified-live virus (MLV) vaccine• CanineDistempervirus(CDV)• CanineAdenovirustype2(CAV-2)• CanineParvovirus(CPV)• +/–CanineParainfluenzavirus(CPi)

Earlier socialisation of puppies • 10weekfinishpossibleinpuppies*• 7daysonsetofimmunity*1,2

Premium parvovirus protection• PatentedCPVstrain–C-154• BreaksthroughMDAearlierpermittinga

10weekfinishinpuppies• Provenclinicalprotectionandprevention of

viral sheddingforALLknownCPVfieldstrains(2, 2a, 2b and 2c)3,4,5,6

• Protectsagainstclinicaldiseaseandsheddingfor at least 3 years for CPV-2, 2a and 2b5,7,8

3 years duration of immunity* • Providescustomisedapproachtovaccination

supported by registered label claims• Consistentwithcurrentinternational(WSAVA)

and national (AVA) vaccination guidelines• Respondstopetownerconcernsabout

over-vaccination

Substantial peer-reviewed published laboratory and field data

DHP compatible for concurrent use with intranasal Nobivac KC

DHP can be reconstituted with Nobivac Bb/Pi to administer a single injectable ‘C5’

*ForDistemper,HepatitisandParvoviruscomponents

Modified-live vaccine • Bordetella bronchiseptica (Bb)• CanineParainfluenzavirus(CPi)

Premium canine cough protection• Rapidonsetoflocalimmunity–72hoursfor

the Bordetella component9• Atleast12monthsdurationofimmunity10

• Significantlyreducesorganismshedding10

• Intranasalvaccinespreventinfectionanddecrease signs of disease compared with parenteral vaccines that do not act locally to prevent pathogen entry11

Simple intranasal administration • Lowdose0.4mL• ONEnostrilonly

Earlier socialisation of puppies• Usefrom4weeksofage• Stimulatesprotectiveimmunityeveninthe

presence of MDA12

Annual revaccination

Registered for use in pregnant bitches

Compatible for concurrent use with Nobivac DHP

Inactivated vaccine• Bordetella bronchiseptica (Bb)• CanineParainfluenzavirus(CPi)

Use from 6 weeks of age

Annual revaccination

Provides convenience of administration for fractious dogs

Challenge trial demonstrated significant protection against Bb and CPi13

Can be used as a diluent to reconstitute Nobivac DHP to permit administration of a single ‘C5’ vaccination

Technical ServicesExperienced veterinarians are available to provide technical support for your practice for Intervet/Schering-Plough’s extensive product range.

✆ 1800 033 461Call to speak to one of our Technical Services Veterinarians

Services and advice include:• Vaccinationprotocols• Questionsrelabelclaims• Monitoringofpost-registrationproductperformance• Productcomplaintinvestigations

PREMIUMParvo

Protection

Nobivac KC Nobivac Bb/Pi

INTRANASALCanine Cough VACCINE

INJECTABLECanine Cough Vaccine

VACCINATIoN PRogRAM foR NoBIVAC KC

Primary vaccination in dogs A single dose of Nobivac KC administered to dogs ≥ 4 weeks of age

Annual revaccination is recommended

VACCINATIoN PRogRAM foR NoBIVAC Bb/Pi

Primary vaccination in dogs 2 doses of Nobivac Bb/Pi at an interval of one month to dogs ≥ 6 weeks of age

Annual revaccination is recommended

Cross-protection: Clinical signs following CPV-2, CPV-2a and CPV-2b challenge3

100%

80%

60%

40%

20%

0%

Contr

ol

Vacci

nates

3 years duration of immunity: Clinical signs following CDV, CAV-1 and CPV challenge 3 years after vaccination with Nobivac DHP8

100%

80%

60%

40%

20%

0%

CDV

Vacci

nates

CAV-1

Vacci

nates

CPV

Vacci

nates

Contr

ol

Contr

ol

Contr

ol

Duration of immunity: Mean clinical scores after combined challenge with Bordetella bronchiseptica and canine parainfluenza virus carried out 56 weeks after vaccination10

10

5

0

15

Vacci

nates

Cont

rol

Onset of immunity: Mean clinical scores after Bordetella bronchiseptica challenge, carried out 72 hours after vaccination9

10

8

6

4

2

0

12

14

16

18

Vacci

nates

Cont

rol

10 week finish: Serological response to vaccination14

6 week vaccination

100%

80%

60%

40%

20%

0%10 week vaccination

n CDV n CAV-2 n CPV

VACCINATIoN PRogRAM foR NoBIVAC DHP/DHPPi

Puppies Where vaccination commences at 6 - 8 weeks of age: 1st dose 6 - 8 weeks: Nobivac DHP (or DHPPi)2nd dose 10 weeks: Nobivac DHP (or DHPPi)Where vaccination commences at ≥ 10 weeks of age: Single dose of Nobivac DHP (or DHPPi)

1st booster: 12 months after primary vaccinationSubsequent boosters: Every 3 years for distemper, hepatitis and parvovirus

Adult Dogs A single vaccination with Nobivac DHP or DHPPi will provide at least 3 years protection against distemper, hepatitis and parvovirus

Booster vaccination: Every 3 years for distemper, hepatitis and parvovirus