CanœrResearchVOLUME 50 •NUMBER 18 •CNREA8 •PP 5709-6117

CONTENTS§

Asterisks * preceding page numbers refer to studies using human-derived material.

Editorial

5709 Advances in Brief. Carlo M. Croce. Editor-in-Chief.

Review

5710 Analysis of Dietary Fat, Calories, Body Weight, and the Development of Mammary Tumors in Rats and Mice: A Review.Laurence S. Freedman. Carolvn Clifford, and Mark Messina.

5720 Mechanisms of Cyclophosphamide Action on Hepatic P-450 Ex

pression. Gerald A. LeBlanc and David J. Waxman.

*5727 Differential Growth-inhibitory Effects of Gallium on B-Lympho-

cyte Lines in High versus Low Iron Concentrations. Jan Kovar.Paul Seligman. and Erwin W. Gclfand.

5731 Inhibition of Growth of Established A'-Methyl-A'-nitrosourea-in-

duced Mammary Cancer in Rats by Retinole Acid and Ovariec-

tomy. AndréLacroix. Carol Doskas. and Pángala V. Bhat.

* 5735 Interaction of Fluorouracil and Interferon in Human Colon Can

cer Cell Lines: Cytotoxic and Cytokinetic Effects. Scott Wadler.Robert Wersto. Vivian Weinberg, Deborah Thompson, andEdward L. Schwartz.

5740 Differential Down-Regulation of Epidermal Protein Kinase C by12-0-Tetradecanoylphorbol-13-acetate and Diacylglycerol: Asso

ciation with Epidermal Hyperplasia and Tumor Promotion. Laura A.Hansen. Nancy A. Monteiro-Riviere. and Robert C. Smart.

* 5746 Diverse Effects of Camptothecin, an Inhibitor of Topoisomerase

I, on the Cell Cycle of Lymphocytic (L1210, MOLT-4) and My-elogenous (HL-60, KG1) Leukemic Cells. Giacinta Del Bino.

Janusz S. Skierski, and Zbigniew Darzynkiewicz.

^5751 Clearance and Tissue Distribution of Recombinant Human Inter-

Icukin \ßin Rats. Shoji Kudo. Keiko Mizuno. Yoshikatsu Hirai.and Takefumi Shimizu.

5756 Potentiation of Carcinogen-induced Methotrexate Resistance and

Dihydrofolate Reducíase Gene Amplification by Inhibitors ofPoly(adenosine diphosphate-ribose) Polymerase. Alexander

Bürkle.Regine Heilbronn, and Harald zur Hausen.

5761 Effect of Different Levels of Calorie Restriction on Azoxy-methane-induced Colon Carcinogenesis in Male E344 Rats. Siva

P. Kumar. Samuel J. Roy. Kenji Tokumo. and Bandaru S.Reddy.

*5767 Two Distinct Mechanisms of Antitumor Activity Mediated by the

Combination of Interlcukin 2 and Monoclonal Antibodies. WimM. J. Vuist. Frank v. Buitenen. Annemarie Hekman. andCornells J. M. Melief.

*5773 Uveal Melanoma in Relation to Ultraviolet Light Exposure andHost Factors. Elizabeth A. Holly. Diana A. Aston. Devron H.Char. Jennifer J. Kristiansen. and David K. Ahn.

5778 DNA Double-Strand Break Repair Pathways and Cellular Tolerance to Inhibitors of Topoisomerase II. Keith Caldecott. GeoffreyBanks, and Penny Jeggo.

*5784 Allelotype of Human Malignant Astrocytoma. Dan Fulls.Carolyn A. Pedone. Gregory A. Thomas, and Ray White.

*5790 Early Postoperative Intraperitoncal Chemotherapy as an Adjuvant Therapy to Surgery for Peritoneal Carcinomatosis fromGastrointestinal Cancer: Pharmacological Studies. Paul H.Sugarbaker. T. Graves, E. A. DcBruijn. W. J. Cunliffe. R. E.Mullins. W. E. Hull. L. Oliff. and P. Schlag.

*5795 Adoptive Immunotherapy of Human Cancer: The Cytokinc Cas

cade and Monocyte Activation following High-Dose Interleukin 2Bolus Treatment. G. Boccoli. R. Masciulli. E. M. Ruggeri.P. Carlini. G. Giannella. E. Montesoro. G. Mastroberardino.G. Isacchi. U. Testa. F. Calabresi, and C. Peschle.

*580I Constitutive and Induced Expression of Growth Factors in Normal and Chronic Phase Chronic Myelogenous Leukemia I'll1

Bone Marrow Stroma. Meir Wctzler. Razelle Kurzrock. KerryTaylor. Gary Spitzer. Hagop Kantarjian. Gabriella Baiocchi.Stella Ku. Jordan U. Gutterman. and Moshe Talpaz.

5806 Ability of the Ca2* lonophores A23187 and lonomycin to Mimic

Some of the Effects of the Tumor Promoter 12-O-Tetra-decanoylphorbol-13-acetate on Hydroperoxide Production, Or

nithine Decarboxylase Activity, and DNA Synthesis in MouseEpidermis in y ivo. Elisabeth M. Perchellet. Denalda Jones, andJean-Pierre Perchellet.

*5813 Long-Term Inhibition of DNA Synthesis and the Persistence ofTrapped Topoisomerase II Complexes in Determining the Tox-icity of the Antitumor DNA Intercalators mAMSA and Mitox-

antrone. Mary E. Fox and Paul J. Smith.

*5819 Reduction of Drug Accumulation and DNA Topoisomerase II Activity in Acquired Teniposide-resistant Human Cancer KB CellLines. Ken-ichi Matsuo. Kimitoshi Kohno. Hiroshi Takano.Shin-ichi Sato. Akira Kiue. and Michihiko Kuwano.

*5825 Noncoordinated Expression of S6, SII, and S14 Ribosomal Protein Genes in Leukemic Blast Cells. Sergio Ferrari. RossellaManfredini. Enrico Tagliafico. Elena Rossi, Amedea Donelli.Giuseppe Torelli, and Umberto Torelli.

5829 Lorglumide and Loxiglumide Inhibit Gastrin-stimulated DNA

Synthesis in a Rat Tumoral Acinar Pancreatic Cell Line (AR42J).Catherine Seva. Jean Luc Scemama. Marie JoséBastie. LucienPradayrol. and Nicole Vaysse.

*5834 Interaction of 7 Interferon and 5-Fluorouracil in the H630 Hu

man Colon Carcinoma Cell Line. Edward Chu. Sydelle Zinn.Donna Boarman. and Carmen J. Allegra.

5841 Induction of Mammalian DNA Topoisomerase II DependentDNA Cleavage by Antitumor Antibiotic Streptonigrin. YoshinoriYamashita. Sho-zou Kawada. Noboru Fujii. and Hirofumi

Nakano.*5845 Opposite Effects of Tamoxifen on in Vitro Protein Kinase C Ac

tivity and Endogenous Protein Phosphorylation in Intact MCF-7

Cells. M. Issandou. C. Faucher. F. Bayard, and J. M. Darbon.

*5851 Decreased Serum Concentrations of Tamoxifen and Its Metabo

lites Induced by Aminoglutethimide. Ernst A. Lien. Gun Anker.Per Eystein Lcnning. Einar Solheim. and Per M. Ueland.

§The CONTENTS arranged by Subject Category can be found immediately following these CONTENTS.

on May 1, 2018. © 1990 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from

5X58 Kopulation of Succinyl C'ocn/yme A:Acetoacetyl C'ocn/ymc A

Transferase in Rat Hcpatoma Celi Lines. Wei-Wei Zhang.Ronald Lindahl. and Perry Churchill.

*5863 Molecular Genetic Analysis of Chromosome 22 in HI Cases of

Mcningioma. Jan P. Dumanski. Guy A. Rouleau. MagnusNordenskjold. and V. Peter Collins.

'•:5868Cellular and Molecular Kvents in Loss of Estrogen Sensitivity in/R-75-1 and 1-47-1) Human Breast Cancer Cells. R. J. Daly andPhilippa D. Darhre.

*5876 Antitumor Kfficacy of lnterleukin-2 Alone and in Combination

"iih Adriamycin and Dacarba/.inc in Murine Solid Tumor Systems. Patricia Mucci LoRusso. Sharon Lea Aukerman. LisaPolin. Bruce G. Redman. Manuel Valdivieso. Laura Biernat. andThomas H. Corbett.

* 5883 Seasonal Change in the Concentration of Progesterone Receptorin Breast Cancer. Ian M. Holdaway. Barbara H. Mason. Roger J.Marshall. Lorraine M. Neave. and Ronald G. Kay.

^SSK? Ascorbate Free Radical Stimulates the Growth of a HumanPromyelocytic Leukemia Cell Line. Francisco J. Alcaín.M. IsabelBurón.Juan Carlos Rodrigucz-Aguilera. JoséM. Villalba. andPlácidoNavas.

5892 Direct Inhibiting F.ffects of [l)-Trp6|Gonadotropin-releasing Hormone on the Kstrogen-sensitive Progression of Polyoma Virus-induced Mammary Tumors in Athymic Mice. Christian Néri.Daniel Blangy. Bernard Schatz. Katy Drieu. Monique Berebbi.and Pierre-Marie Martin.

*5898 DN'A Damage Induced by a New 2-Chloroethyl Nitrosourea on

Malignant Melanoma Cells. Denise Godeneche. Manse Rapp.Alain Thierry1. Françoise Laval. Jean-Claude Madelmont.

Philippe Chollet. and Annie Veyre.

*590-4 Serum Iunior Marker Half-Life during Chemotherapy AllowsF.arly Prediction of Cúmplete Response and Survival in Non-seminomatous Germ Cell Tumors. Guy C. Toner. Nancy L.Geller. Claire Tan. Jerome Nisselbaum. and George J. Bosl.

*5911 Analysis of the ini-1, ¡nt-2,K-myc,and neu Oncogenes in HumanBreast Carcinomas. Shari L. Meyers. Michael T. O'Brien. Tern

Smith, and Jaquelin P. Dudley.

*5919 F.stablishmcnt of a Camptothedn Analogue (CPT-II(-resistantC'ell Line of Human Non-Small Cell Lung Cancer: Characteriza

tion and Mechanism of Resistance. Fumihiko Kanzawa.Yoshikazu Sugimoto. Koichi Minato. Kazuo Kasahara. MasamiBungo. Kazuhiko Nakagawa. Yasuhiro Fujiwara. Leroy F. Liu.and Nagahiro Saijo.

*5925 Cloning and Sequencing ufa Complementary DNA Kncoding aI/, 70,000 Human Breast Kpithelial Mucin-associatcd Antigen.David Larocca, Jerry A. Peterson. Gary Walkup. Ramon Urrea.and Roberto L. Ceriani.

*593I Human Tumor Cell Line Resistance to Chemotherapeutic AgentsDoes Not Predict Resistance to Natural Killer or Lymphokine-activated Killer Cell-mediated Cytolysis. W. Graydon Harker.Corrynne Tom. John R. McGregor. Lynn Slade. and Wolfram E.Samlowski.

*5937 Suramin Inhibits I.aminin- and Thrombospondin-mediatedMelanoma C'ell Adhesion and Migration and Binding of 'These

Adhesive Proteins to Sulfatide. Vivian S. Zabrenetzky. Elise C.Kohn. and David D. Roberts.

*5943 Growth of Human Cell Lines in BALB/c Mice. Barney S.Graham and Neal T. Wetherall.

;':->'M~" Immortali/ation of Human Keratinocytes by Simian Virus 40

Large T-Antigen Alters Keratin Gene Response to Retinoids.Chapla Aganval and Richard L. Eckert.

*5954 Pharmacokinetics, Biodistribution, and Gamma Camera Imagingof '"In-KC-4G3 Murine Monoclonal Antibody in Athymic Nude

Mice with or without Human Tumor Xenografts. CliffordLongley. Philip Furmanski. David G. Dienhart. James Lear,Duane Bloedow. Ravindra Kasliwal. and Paul A. Bunn. Jr.

*5962 Isolation of a Human Melanoma Adapted Newcastle Disease Virus Mutant with Highly Selective Replication Patterns. T. Ahlcrtand V. Schirrmacher.

*'C5969 Detection of Somatostatin Receptors in Surgical and Per

cutaneous Needle Biopsy Samples of Carcinoids and Islet CellCarcinomas. J. C. Reubi. L. K. Kvols. B. Waser. D. M. Nagorney.P. U. Heitz. J. W. Charboneau. C. C. Reading, and C. Moertel.

5978 Hepatic Neoplasms in the Mummichog Fúndalas heteroclitusfrom a Creosote-contaminated Site. Wolfgang K. Vogelbein. JohnW. Fournie. Peter A. Van Veld, and Robert J. Huggett.

*5987 Short Exposure to Actinomycin D Induces "Reversible" Trans-location of Protein B23 as Well as "Reversible" Inhibition of Cell

Growth and RNA Synthesis in HeLa Cells. Benjamin Yat-MingYung. Amy Meei-Shuu Bor. and Pui-Kwong Chan.

*5992 Selective Klimination of Breast Cancer Cells from Human BoneMarrow L sing an \ntH>t>d\-Pseudomonas Exotoxin A Conjugate.Michael J. Björn.Ronald Manger. Gowsala Sivam. Alton C.Morgan. Jr.. and Beverly Torok-Storb.

:i:5997 Basement Membrane Type IV Collagen Degradation: Evidencefor the Involvement of a Proteolytic Cascade Independent of Met-alloproteinases. A. R. Mackay. R. H. Corbitt. J. L. Hartzler. andU. P. Thorgeirsson.

*6002 Morphological and Molecular Characterization of SpontaneousMjogenic Differentiation in a Human Rhabdomyosarcoma CellLine. David N. Shapiro. Peter J. Houghton. Bonnie J. Hazelton.Glen S. Germain. Kuruganti G. Murti. Atiqur Rahman, andJanet A. Houghton.

6010 Transaction of Activated Ila-ras Protooncogenes Causes MouseMammary Hyperplasia. Shigeki Miyamoto. Raphael C. Guzman.Robert A. Shiurba. Gary L. Firestone, and Satyabrata Nandi.

*60I5 A Novel Ribonucleoprotein C'omplex Defined by Monoclonal An

tibodies to NTH 3T3 Cells Transfected with Human PancreaticAdenocarcinoma DNA. Michael A. Hollingsworth. Michael J.Borowitz. Man Lou Everett, and Richard S. Metzgar.

* 61)23 Mow and Image Cytometric DNA Analysis in Rhabdomyosarcoma. Areta Kowal-Vern. Frank Gonzalez-Crussi, Joyce Turner.Yolanda P. Trujillo. Pauline Chou. Chester Herman. MelanieCastelli, and Jami Walloch.

6028 Effect of Tumor Necrosis Factor on the Antitumor Efficacy andToxicity of Aminopterin-Monoclonal Antibody Conjugates: Parameters for Optimization of Therapy. S. M. Russell. K.. G.krauer. I. F. C. McKenzie. and G. A. Pietersz.

6034 Antibody-mediated Redirected Cytolysis against MurineMelanoma Cells in Vìvo.Osamu Usuba. Masafumi Ito.Constantin A. Bona, and Thomas M. Moran.

*6039 Effect of Epidermal Growth Factor on Glioma Cell Growth, Migration, and Invasion in Vitro. Morten Lund-Johansen. RolfBjerkvig. Peter A. Humphrey. Sandra H. Bigner. Darell D.Bigner, and Ole-Didrik Laerum.

*6045 Cathepsin D in Breast Cancer Cells Can Digest ExtracellularMatrix in Large Acidic Vesicles. Philippe Montcourricr. Paul H.Mangeât.Guillermo Salazar. Muriel Morisse!. Alain Sahuquet.and Henri Rochefort.

*6055 Neuropeptide Y Expression in the Developing Adrenal Gland andin Childhood Neuroblastoma 'Tumors. Pamela S. Cohen. Mark J.

Cooper. Lee J. Helman. Carol J. Thiele. Robert C. Secger. andMark A. Israel.

on May 1, 2018. © 1990 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from

6062 Production of Hydrogen Peroxide by Murine Kpidermal Ker-atinocyles folio»insTreatment with the Tumor Promoter \1-O-Tetradecanoylphorbol-13-acetate. Fredika M. Robertson.Andrew J. Beavis. Tatiana M. Oberyszyn. Sean M. O'Connell.

Anlhea Dokidos. Debra L. Laskin. Jeffrey D. Laskin. and John J.Reiners. Jr.

*6068 A Comparison of Synaptophysin, Chromogranin, and i.-Dopa De-

carboxylase as Markers for Neuroendocrinc Differentiation inLung Cancer C'ell Lines. Sandra M. Jensen. Adi F. Gazdar. Frank

Cuttitta. Edward K. Russell, and R. Ilona Linnoila.

*6075 Isolation and Characterization of a Spontaneously ImmortalizedHuman Breast Kpithelial Cell Line. MCF-IO. Herbert D. Soule.Terry M. Maloney. Sandra R. Wolman. Ward D. Peterson. Jr..Richard Bren/. Charles M. McGrath. Jose Russo. Robert J.Pauley. Richard F. Jones, and S. C. Brooks.

•'•(»(IS"I Itrast ruciuia I and Immunocytochcmical Characterization of an

Immortalized Human Breast Kpithelial Cell Line, MCF-IO. LarryTait. Herbert D. Soule. and Jose Russo.

*6095 The Distinction of Small Cell and Non-Small Cell Lung Cancerby Growth in Native-State Histoculture. R. A. Vescio. K. M.Connors. G. M. Bordin. J. A. Robb. T. Youngkin. J. N. Umbreit,and R. M. Hoffman.

*6IOO Membrane Vesicle Formation Due to Acquired Mitoxantrone Resistance in Human Gastric Carcinoma Cell Line FPG85-257.Manfred Dietel. Hartmut Arps. Hermann Lage, and AxelNiendorf.

*6107 Integrin (ajß4)F.xpression in Human Lung Cancer as Monitoredby Specific Monoclonal Antibodies. Renato Mariani Costantini.Rita Falcioni. Pasquale Battista. Gabriella Zupi. Stephen J.Kennel. Antondla Colasante. Irene Venturo. Corrado GalloCurdo, and Ada Sacelli.

6113 AnnouncementsEighty-second Annual Meeting of the AACRC'ali for Nominations for the Scientific Awards of the AACR

AACR Special Conferences in Cancer ResearchFuture Annual Meetings of the AACRRecent DeathCalendar of Events

6115 FrrataE. A. Mueller and F. A. Anderer. 50: 3646-3651. 1990.J-M. Le Doussal el a/., 50: 3445-3452, 1990.August 15. 1990 ( 'ancer Research cover legend.

6116 Author Index

NOTE: AACR forms available in the back of this issue—•Application for Active and Corresponding Membership•Application for Associate Membership

on May 1, 2018. © 1990 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from

Cancer Research

VOLUME 50 •NUMBER 18

CONTENTS Arranged by Subject Category

Editorial

5709 Advances in Brief. Carlo M. Croce. Editor-in-Chief.

Review

5710 Analysis of Dietary Fat, Calories, Body Weight, and the Development of Mammary Tumors in Rats and Mice: A Review.Laurence S. Freedman. Carolvn Clifford, and Mark Messina.

BASIC SCIENCES

Biochemistry and Biophysics

5720 Mechanisms of Cyclophosphamide Action on Hepatic P-450 Expression. Gerald A. LeBlanc and David J. Waxman.

*5813 Long-Term Inhibition of DNA Synthesis and the Persistence ofTrapped Topoisomerase II Complexes in Determining the Tox-icity of the Antitumor DNA Intercalators mAMSA and Mitox-antrone. Mary E. Fox and Paul J. Smith.

5829 Lorglumide and Loxiglumide Inhibit Gastrin-stimulated DNASynthesis in a Rat Tumoral Acinar Pancreatic Cell Line (AR42J).Catherine Seva. Jean Luc Scemama. Marie JoséBastie. LucienPradayrol. and Nicole Vaysse.

5841 Induction of Mammalian DNA Topoisomerase II DependentDNA Cleavage by Antitumor Antibiotic Streptonigrin. YoshinoriYamashita. Sho-zou Kawada. Noboru Fujii. and HirofumiNakano.

* 5845 Opposite Effects of Tamoxifcn on in Vitro Protein kinase C Activity and Endogenous Protein Phosphorylation in Intact MCF-7Cells. M. Issandou. C. Faucher. F. Bayard, and J. M. Darbon.

5858 Regulation of Succinyl Coenzyme A:Acetoacetyl Coenzyme ATransferase in Rat Hepatoma Cell Lines. Wei-Wei Zhang.Ronald Lindahl. and Perry Churchill.

*5887 Ascorbate Free Radical Stimulates the Growth of a HumanPromyelocytic Leukemia Cell Line. Francisco J. Alcain. M. IsabelBurón. Juan Carlos Rodriguez-Aguilera. JoséM. Villalba. andPlácidoNavas.

*5898 DNA Damage Induced by a New 2-Chloroethyl Nitrosourea onMalignant Melanoma Cells. Denise Godeneche. Maryse Rapp.Alain Thierry. Françoise Laval. Jean-Claude Madelmont.Philippe Chollet. and Annie Veyre.

*5937 Suramin Inhibits Laminin- and Thrombospondin-mediatedMelanoma Cell Adhesion and Migration and Binding of TheseAdhesive Proteins to Sulfatide. Vivian S. Zabrenetzky, Elise C.Kohn, and David D. Roberts.

*5997 Basement Membrane Type IV Collagen Degradation: Evidencefor the Involvement of a Proteolytic Cascade Independent of Met-alloproteinases. A. R. Mackay. R. H. Corbitt. J. L. Hartzier, andU. P. Thorgeirsson.

5756 Potentiation of Carcinogen-induced Methotrexate Resistance andDihydrofolate Redactase Gene Amplification by Inhibitors ofPoly(adenosine diphosphate-ribose) Polymerase. AlexanderBürkle.Regine Heilbronn, and Harald zur Hausen.

5761 Effect of Different Levels of Calorie Restriction on Azoxy-methane-induced Colon Carcinogenesis in Male F344 Rats. SivaP. Kumar. Samuel J. Roy. Kenji Tokumo, and Bandaru S.Reddy.

5778 DNA Double-Strand Break Repair Pathways and Cellular Tolerance to Inhibitors of Topoisomerase II. Keith Caldecott. GeoffreyBanks, and Penny Jeggo.

5806 Ability of the Ca2+lonophores A23187 and lonomycin to MimicSome of the Effects of the Tumor Promoter 12-0-Tetra-decanoylphorbol-13-acetate on Hydroperoxide Production, Or-nithine Decarboxylase Activity, and DNA Synthesis in MouseEpidermis in Vivo. Elisabeth M. Perchellet. Denalda Jones, andJean-Pierre Perchellet.

*5947 Immortalization of Human Keratinocytes by Simian Virus 40Large T-Antigen Alters Keratin Gene Response to Retinoids.Chapla Agarwal and Richard L. Eckert.

*5962 Isolation of a Human Melanoma Adapted Newcastle Disease Virus Mutant with Highly Selective Replication Patterns. T. Ahlertand V. Schirrmacher.

5978 Hepatic Neoplasms in the Mummichog luminili* heteroclitusfrom a Creosote-contaminated Site. Wolfgang K. Vogelbein, JohnW. Fournie. Peter A. Van Veld, and Roben J. Huggett.

6010 Transfection of Activated Ha-ras Protooncogenes Causes MouseMammary Hyperplasia. Shigeki Miyamoto. Raphael C. Guzman.Robert A. Shiurba. Gary L. Firestone, and Satyabrata Nandi.

*6023 Flow and Image Cytometric DNA Analysis in Rhabdomyosar-coma. Areta Kowal-Vern. Frank Gonzalez-Crussi. Joyce Turner.Yolanda P. Trujillo. Pauline Chou. Chester Herman. MelanieCastelli, and Jami Walloch.

6062 Production of Hydrogen Peroxide by Murine Epidermal Keratinocytes following Treatment with the Tumor Promoter 12-0-Tetradecanoylphorbol-13-acetate. Fredika M. Robertson,Andrew J. Beavis. Tatiana M. Oberyszyn. Sean M. O'Connell.

Anthea Dokidos. Debra L. Laskin. Jeffrey D. Laskin. and John J.Reiners. Jr.

Endocrinology*5868 Cellular and Molecular Events in Loss of Estrogen Sensitivity in

ZR-75-1 and I-47-D Human Breast Cancer Cells. R. J. Daly andPhilippa D. Darbre.

*5969 Detection of Somatostatin Receptors in Surgical and Per

cutaneous Needle Biopsy Samples of Carcinoids and Islet CellCarcinomas. J. C. Reubi. L. K. Kvols. B. Waser. D. M. Nagorney.P. U. Heitz. J. W. Charboneau. C. C. Reading, and C. Moertel.

Carcinogenesis

5740 Differential Down-Regulation of Epidermal Protein Kinase C by12-0-Tetradecanoylphorbol-13-acetate and Diacylglycerol: Association with Epidermal Hyperplasia and Tumor Promotion. LauraA. Hansen. Nancy A. Monteiro-Riviere. and Robert C. Smart.

* Indicates studies using human-derived material.

Immunology* 5727 Differential Growth-inhibitory Effects of Gallium on B-Lympho-

cyte Lines in High versus Low Iron Concentrations. Jan Kovar.Paul Seligman. and Erwin W. Gelfand.

on May 1, 2018. © 1990 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from

* 5767 Two Distinct Mechanisms of Antitumor Activity Mediated by theCombination of Interleukin 2 and Monoclonal Antibodies. WimM. J. Vuist, Frank v. Buitenen. Annemarie Hekman, andCornells J. M. Melief.

*5795 Adoptive Immunotherapy of Human Cancer: The Cytokine Cascade and Monocyte Activation following High-Dose Interleukin 2Bolus Treatment. G. Boccoli, R. Masciulli. E. M. Ruggeri.P. Carlini. G. Giannella. E. Montesoro. G. Mastroberardino.G. Isacchi. U. Testa. F. Calabresi, and C. Pésenle.

*5943 Growth of Human Cell Lines in BALB/c Mice. Barney S.Graham and Neal T. Wetherall.

*5992 Selective Klimination of Breast Cancer Cells from Human BoneMarrow Using an \nlVaoA\-Pseudomonas Exotoxin A Conjugate.Michael J. Björn.Ronald Manger. Gowsala Sivam. Alton C.Morgan. Jr.. and Beverly Torok-Storb.

6034 Antibody-mediated Redirected Cytolysis against MurineMelanoma Cells in Vivo. Osamu Usuba. Masafumi Ito.Constantin A. Bona, and Thomas M. Moran.

Molecular Biology and Genetics

*5784 Allelotype of Human Malignant Astrocytoma. DanCarolyn A. Pedone. Gregory- A. Thomas, and Ray White.

5825 Noncoordinated Expression of S6, SII, and S14 Ribosomal Protein Genes in Leukemic Blast Cells. Sergio Ferrari. RossellaManfredini. Enrico Tagliafico. Elena Rossi. Amedea Donelli.Giuseppe Torelli, and Umberto Torelli.

*5863 Molecular Genetic Analysis of Chromosome 22 in 81 Cases ofMeningioma. Jan P. Durnanski. Guy A. Rouleau. MagnusNordenskjöld.and V. Peter Collins.

*5911 Analysis of the int-1, int-2, c-myc, and neu Oncogenes in HumanBreast Carcinomas. Shari L. Meyers. Michael T. O'Brien. Terry

Smith, and Jaquelin P. Dudley.

*5925 Cloning and Sequencing of a Complementary DNA Encoding aM, 70,000 Human Breast Epithelial Mucin-associated Antigen.David Larocca, Jerry A. Peterson, Gary Walkup. Ramon Urrea.and Roberto L. Ceriani.

Preclinica! Pharmacology and Experimental Therapeutics

*5731 Inhibition of Growth of Established /V-Methyl-/V-nitrosourea-in-duced Mammary Cancer in Rats by Retinoic Acid and Ovariec-tomy. AndréLacroix. Carol Doskas. and PángalaV. Bhat.

*5735 Interaction of Fluorouracil and Interferon in Human Colon Cancer Cell Lines: Cytotoxic and Cytokinetic Effects. Scott Wadler.Robert Wersto. Vivian Weinberg. Deborah Thompson, andEdward L. Schwartz.

* 5746 Diverse Effects of Camptothecin, an Inhibitor of TopoisomeraseI, on the Cell Cycle of Lymphocytic (LI 210, MOLT-4) and My-elogenous (HL-60, KG1) Leukemic Cells. Giacinta Del Bino.Janusz S. Skierski, and Zbigniew Darzynkiewicz.

*5751 Clearance and Tissue Distribution of Recombinant Human Interleukin 10 in Rats. Shoji Kudo. Keiko Mizuno. Yoshikatsu Hirai.and Taket'umi Shimizu.

*5819 Reduction of Drug Accumulation and DNA Topoisomerase II Ac

tivity in Acquired Teniposide-resistant Human Cancer KB CellLines. Ken-ichi Matsuo. Kimitoshi Kohno. Hiroshi Takano,Shin-ichi Sato. Akira Kiue. and Michihiko Kuwano.

*5834 Interaction of 7 Interferon and 5-Fluorouracil in the H630 Human Colon Carcinoma Cell Line. Edward Chu. Sydelle Zinn.Donna Boarman. and Carmen J. Allegra.

*5876 Antitumor Efficacy of Interleukin-2 Alone and in Combinationwith Adriamycin and Dacarbazine in Murine Solid Tumor Systems. Patricia Mucci LoRusso. Sharon Lea Aukerman. LisaPolin. Bruce G. Redman, Manuel Valdivieso. Laura Biernat. andThomas H. Corbett.

*5919 Establishment of a Camptothecin Analogue (CFr-ll)-resistantCell Line of I luman Non-Small Cell Lung Cancer: Characterization and Mechanism of Resistance. Fumihiko Kanzawa,Yoshikazu Sugimoto, Koichi Minato. Kazuo Kasahara. MasamiBungo. Kazuhiko Nakagawa. Yasuhiro Fujiwara. Leroy F. Liu.and Nagahiro Saijo.

* 5931 Human Tumor Cell Line Resistance to Chemotherapeutic AgentsDoes Not Predict Resistance to Natural Killer or Lymphokine-activated Killer Cell-mediated Cytolysis. W. Graydon Harker,Corrynne Tom. John R. McGregor. Lynn Slade. and Wolfram E.Samlowski.

*5954 Pharmacokinetics, Biodistribution, and Gamma Camera Imagingof '"In-KC-4G3 Murine Monoclonal Antibody in Athymic Nude

Mice with or without Human Tumor Xenografts. CliffordLongley. Philip Furmanski. David G. Dienhart. James Lear,Duane Bloedow. Ravindra Kasliwal, and Paul A. Bunn, Jr.

*5987 Short Exposure to Actinomycin D Induces "Reversible" Trans-Fults. location of Protein B23 as Well as "Reversible" Inhibition of Cell

Growth and RNA Synthesis in HeLa Cells. Benjamin Yat-MingYung, Amy Meei-Shuu Bor. and Pui-Kwong Chan.

6028 Effect of Tumor Necrosis Factor on the Antitumor Efficacy andToxicity of Aminopterin-Monoclonal Antibody Conjugates: Parameters for Optimization of Therapy. S. M. Russell. K. G.Krauer. I. F. C. McKenzie. and G. A. Pietersz.

Tumor Biology

Constitutive and Induced Expression of Growth Factors in Normal and Chronic Phase Chronic Myelogenous Leukemia Ph1Bone Marrow Stroma. Meir Wetzler. Razelle Kurzrock, KerryTaylor. Gary Spitzer. Hagop Kantarjian. Gabriella Baiocchi.Stella Ku. Jordan U. Gutterman. and Moshe Talpaz.

5892 Direct Inhibiting Effects of |D-Trp6|Gonadotropin-releasing Hormone on the Estrogen-sensitive Progression of Polyoma Virus-induced Mammary Tumors in Athymic Mice. Christian Néri.Daniel Blangy, Bernard Schatz. Katy Drieu. Monique Berebbi.and Pierre-Marie Martin.

*6002 Morphological and Molecular Characterization of Spontaneous

Myogenic Differentiation in a Human Rhabdomyosarcoma CellLine. David N. Shapiro. Peter J. Houghton. Bonnie J. Hazelton.Glen S. Germain. Kuruganti G. Murti. Atiqur Rahman, andJanet A. Houghton.

*60I5

*6039

*6045

A Novel Ribonucleoprotein Complex Defined by Monoclonal Antibodies to NIH 3T3 Cells Transfected with Human PancreaticAdenocarcinoma DNA. Michael A. Hollingsworth. Michael J.Borowitz. Mary Lou Everett, and Richard S. Metzgar.

Effect of Epidermal Growth Factor on Glioma Cell Growth, Migration, and Invasion in Vitro. Morten Lund-Johansen. RolfBjerkvig. Peter A. Humphrey. Sandra H. Bigner. Darei! D.Bigncr. and Ole-Didrik Laerum.

Cathepsin D in Breast Cancer Cells Can Digest ExtracellularMatrix in Large Acidic Vesicles. Philippe Montcourrier. Paul H.Mangeât.Guillermo Salazar. Muriel Morisse!. Alain Sahuquet.and Henri Rochefort.

Neuropeptide Y Expression in the Developing Adrenal Gland andin Childhood Neuroblastoma Tumors. Pamela S. Cohen. Mark J.Cooper. Lee J. Helman. Carol J. Thiele. Robert C. Seeger. andMark A. Israel.

on May 1, 2018. © 1990 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from

* 6068 A Comparison of Synaptophysin, Chromogranin, and l.-Dopa De-carboxylase as Markers for Neuroendocrine Differentiation inLung Cancer Cell Lines. Sandra M. Jensen, Adi F. Gazdar. FrankC'uttitta. Edward K. Russell, and R. Ilona Linnoila.

Isolation and Characteri/ation of a Spontaneously ImmortalizedHuman Breast Kpithelial Cell Line, MCK-10. Herben D. Soûle.Terry M. Maloney. Sandra R. Wolman. Ward D. Peterson. Jr..Richard Bren/. Charles M. McGrath. Jose Russo. Robert J.Pauley. Richard F. Jones, and S. C. Brooks.

*6087 I'llrastructural and Immunocytochemical Characteri/ation of anlimnortali/ed Human Breast Kpithelial Cell Line, MCK-10. LarryTail. Herbert D. Soule. and Jose Russo.

*6095 The Distinction of Small Cell and Non-Small Cell Lung Cancerby Growth in Native-State Histoculture. R. A. Vescio. K. M.Connors. G. M. Bordin. J. A. Robb. T. Youngkin. J. N. Umbreit,and R. M. Hoffman.

*6IOO Membrane Vesicle Formation Due to Acquired Mitoxantrone Resistance in Human Gastric Carcinoma Cell Line KPG85-257.Manfred Dietel. Hartmut Arps. Hermann Lage, and AxelNiendorf.

*6107 Integrin (ab/ß4)Kxpression in Human Lung Cancer as Monitoredby Specific Monoclonal Antibodies. Renato Mariani Costantini.Rita Falcioni. Pasquale Battista. Gabriella Zupi. Stephen J.Kennel. Antonella Colasante. Irene Venturo. Corrado GalloCurcio. and Ada Sacelli.

CLINICAL AND EPIDEMIOLOGICALINVESTIGATIONS

Clinical5790 Karly Postoperative Intraperitoneal Chemotherapy as an Adju

vant Therapy to Surgery for Peritoneal Carcinomatosis fromGastrointestinal Cancer: Pharmacological Studies. Paul H.Sugarbaker. T. Graves. E. A. DeBruijn. W. J. Cunliffe. R. E.Mullins. W. E. Hull. L. Oliti and P. Schlag.

5851 Decreased Serum Concentrations of Tamoxifen and Its Metabolites Induced by Aminoglutethimide. Ernst A. Lien. Gun Anker.Per Eystein Lonning. Einar Solheim. and Per M. Ueland.

5883 Seasonal Change in the Concentration of Progesterone Receptorin Breast Cancer. Ian M. Holdaway. Barbara H. Mason, Roger J.Marshall. Lorraine M. Neave. and Ronald G. Kay.

5904 Serum Tumor Marker Half-Life during Chemotherapy AllowsKarly Prediction of Complete Response and Survival in Non-seminomatous Germ Cell Tumors. Guy C. Toner, Nancy L.Geller. Claire Tan. Jerome Nisselbaum. and George J. Bosl.

Epidemiológica/

5773 L'veal Melanoma in Relation to Ultraviolet Light Exposure andHost Factors. Elizabeth A. Holly. Diana A. Aston. Devron H.Char. Jennifer J. Kristiansen. and David K. Ahn.

6113 AnnouncementsEighty-second Annual Meeting of the AACRCall for Nominations for the Scientific Awards of the AACRAACR Special Conferences in Cancer ResearchFuture Annual Meetings of the AACRRecent DeathCalendar of Events

6115 ErrataE. A. Mueller and F. A. Anderer, 50. 3646-3651. 1990.J-M. Le Doussal el al.. 50: 3445-3452. 1990.August 15. 1990 C'ancer Research cover legend.

6116 Author Index

NOTE: AACR forms available in the back of this issue—•Application for Active and Corresponding Membership•Application for Associate Membership

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