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Biographical Sketch – Alejandro M.S. Mayer, Ph.D., M.S.Ed. (September 2018)

Alejandro M.S. Mayer, Ph.D., is Professor in the Department of Pharmacology, Chicago College of Graduate Studies, Midwestern University. He received his Ph.D. in 1979 from the University of Buenos Aires, Argentina, and from 1985-1988 completed a three-year postdoctoral fellowship in marine immunopharmacology in the laboratory of Dr. Robert S. Jacobs, University of California at Santa Barbara. From 1990-1993, he became Assistant Professor, in the Physiology Department, Louisiana State University Medical Center in New Orleans, LA. In 1993, he moved to the Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, where he rose from Assistant to Full Professor of Pharmacology in 2000. Dr. Mayer teaches pharmacology to medical, pharmacy, dental, optometry and health sciences students, and continues to research the immunopharmacology of marine natural products, and the immunotoxicology of marine cyanobacterial lipopolysaccharides. He is the author of 74 peer-reviewed publications, which include a series of 16 marine preclinical pharmaceutical pipeline reviews covering the period 1998-2013, which he has co-authored with Drs. Gustafson, Hamann, Berlinck, Rodríguez, Fusetani and Taglialatela-Scafati. His 2010 review on the global clinical pharmaceutical pipeline which he co-authored with Drs. Glaser, Cuevas, Jacobs, Kem, Little, McIntosh, Newman, Potts and Shuster Trends in Pharmacological Sciences 31(6): 255-265, 2010, has been referenced over 479 times (Google Scholar Citations). In 2005 Dr. Mayer created a marine clinical pharmaceutical pipeline website, as a contribution to both the general public and the global research community at large interested in both preclinical and clinical pharmaceutical research with marine natural products. The marine pharmacology website remains # 1 in Google and is being updated monthly by Dr. Mayer, his colleagues, and Chicago College of Pharmacy students.

Dr. Mayer has been awarded 2 patents and has been funded by the Department of Commerce, NOAA, Sea Grant College Program, and NIH, and is a member of AAAS, American Society of Pharmacology and Experimental Therapeutics, and the Society for Toxicology. From January 1, 2014 to July 31, 2018, Dr. Mayer has served as Editor-in-Chief of the MARINE DRUGS, an open access journal on the research, development, and production of drugs from the sea.

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Marine pharmacology and toxicology research in A.M.S. Mayer’s laboratory: articles, abstracts, patents and seminars .

(a) Peer-reviewed articles ( From a total of 74 peer-reviewed articles)

Mayer, A.M.S. and K. R. Gustafson Marine Pharmacology in 2001-2: Antitumor and Cytotoxic Compounds. European Journal of Cancer 40(18) 2676-2704, 2004.

Mayer, A.M.S, Hall, M.L, Lynch, S. M, Gunasekera, S.P, Sennett, S.H. and Pomponi, S.A. Differential modulation of microglia superoxide anion and thromboxane B2 generation by the marine manzamines. BioMedCentral Pharmacology 5(1)6, 2005.

Mayer, A.M.S. and M. T. Hamann. Marine pharmacology in 2001-2: Marine Compounds with Antibacterial, Anticoagulant, Antifungal, Anthelmithic, Anti-inflammatory, Antiplatelet, Antiprotozoal, and Antiviral Activities; affecting the Cardiovascular, Endocrine, Immune and Nervous Systems and other Miscellaneous Mechanisms of Action. Comparative Biochemistry and Physiology Part C 140(3-4):265-286, 2005.

C. A. Ospina, A. D. Rodrıguez, J. A. Sanchez, E. Ortega-Barria, T.L. Capson, and A.M.S. Mayer. Caucanolides A-F, Unusual Antiplasmodial Constituents from a Colombian Collection of the Gorgonian Coral Pseudopterogorgia bipinnata. Journal of Natural Products 68(10):1519-1526, 2005.

S. S. Sawant, D.T.A. Youssef, A. M. S. Mayer, P. W. Sylvester, V. Wali, M. E. Arant and K. A. El Sayed. Anticancer and Anti-inflammatory Sulfur-Containing Semisynthetic Derivatives of Sarcophine. Chemical and Pharmaceutical Bulletin (Japan) 54(8): 1119-1123, 2006.

Mayer, A.M.S. and K. R. Gustafson. Marine Pharmacology in 2003-4: Antitumor and Cytotoxic Compounds. European Journal of Cancer , 43: 2241-2270, 2006.

Mayer, A.M.S., A.D. Rodriguez, R. Berlinck and M.T. Hamann. Marine pharmacology in 2003-4: Marine Compounds with Antibacterial, Anticoagulant, Antifungal, Anthelmitic, Anti-inflammatory, Antiplatelet, Antiprotozoal, and Antiviral Activities; affecting the Cardiovascular, Endocrine, Immune and Nervous Systems and other Miscellaneous Mechanisms of Action. Comparative Biochemistry and Physiology Part C 145: 553-581, 2007.

Mayer, A.M.S., Guzman, M., Peksa, R., Hall, M., Fay, M.J., Jacobson, P.B., Romanic, A.M. and Gunasekera, S.P. Differential effects of domoic acid and E. Coli Lipopolysaccharide on tumor necrosis factor , transforming growth factor β1 and matrix metalloproteinase-9 release by rat neonatal microglia: evaluation of the direct activation hypothesis. Marine Drugs 5: 113-135, 2007.

M. H. Kossuga, A. M. Nascimento, J. Q. Reimão, A. G. Tempone, N. N. Taniwaki, K. Veloso, A. G. Ferreira, B. C. Cavalcanti, C. Pessoa, M. O. Moraes, A. M. S. Mayer, E. Hajdu and R. G. S. Berlinck, Antiparasitic, antineuroinflammatory and cytotoxic polyketides from the marine sponge Plakortis angulospiculatus from Brazil. Journal of Natural Products 71:334-339, 2008.

K. A. El Sayed, A. A. Khalil, M. Yousaf, G. Labadie, M. K. Gundluru, S. G. Franzblau, A.M.S. Mayer, M. A. Avery, and M. T. Hamann. Semisynthetic Studies of the Manzamine Alkaloids. Journal of Natural Products  71:300-308, 2008.

Mayer, A.M.S. and K. R. Gustafson. Marine Pharmacology in 2005-6: Antitumor and Cytotoxic Compounds. European Journal of Cancer 44:2357-2387, 2008.

Y-P Shi, X. Wei, I.I. Rodríguez, A.D. Rodríguez, and A.M.S. Mayer. New Terpenoid Constituents of the Southwestern Caribbean Sea Whip Pseudopterogorgia elisabethae

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(Bayer), including a Unique Pentanorditerpene. European Journal of Organic Chemistry, 493-502, 2009.

Mayer, A.M.S., A.D. Rodriguez, R. Berlinck and M.T. Hamann. Marine pharmacology in 2005-6: Marine Compounds with Antibacterial, Anticoagulant, Antifungal, Anthelmitic, Anti-inflammatory, Antiprotozoal, and Antiviral Activities; affecting the Cardiovascular, Endocrine, Immune and Nervous Systems and other Miscellaneous Mechanisms of Action. Biochimica et Biophysica Acta, General Subjects 1790: 283-308, 2009.

A.K. Ibrahim, S.I. Khalifa, M.K. Mesbah, A.M.S. Mayer, R.W.M. Van Soest, and D.T.A. Youssef. New anti-inflammatory sterols from the Red Sea sponges Scalarispongia and Callyspongia species. Natural Product Communications, 5(1): 27-31, 2010.

J. Peng, S. Kudrimoti, S. Prasanna, S. Odde, R. J. Doerksen, H. K Pennaka, Y-M. Choo,

K.V. Rao, B. L. Tekwani, V. Madgula, S. I. Khan, B. Wang, A. M. S. Mayer, M. R. Jacob,

L.C.Tu, J. Gertsch, and M. T. Hamann. Structure Activity Relationship and Mechanism of Action Studies of Manzamine Analogues for the Control of Neuroinflammation and Cerebral Infections. Journal of Medicinal Chemistry, 53: 61-76, 2010.

A.M.S. Mayer, K.B. Glaser, C. Cuevas, R. S. Jacobs, W. Kem, R. D. Little, J. M. McIntosh, D. Newman, B. C. Potts and D. E. Shuster. The Marine Pharmaceuticals Pipeline in 2010 . Trends in Pharmacological Sciences, 31(6): 255-265, 2010, 2010.

Mayer, A.M.S., A.D. Rodriguez, R. Berlinck and N. Fusetani. Marine pharmacology in 2007-8: Marine Compounds with Antibacterial, Anticoagulant, Antifungal, Anti-inflammatory, Antiprotozoal, and Antiviral Activities; affecting the Immune and Nervous Systems and other Miscellaneous Mechanisms of Action. Comparative Biochemistry and Physiology Part C, Comparative Biochemistry and Physiology Part C, 153: 191-222, 2011.

Mayer, A.M.S., J. Clifford, M. Aldulescu, J. Frenkel, M. L. Hall, K. B. Glaser, and J. Berry. Cyanobacterial Microcystis aeruginosa lipopolysaccharide elicits release of superoxide anion, thromboxane B2, cytokines, chemokines, and matrix metalloproteinase-9 by rat microglia. Toxicological Sciences, 121(1): 63-72, 2011.

Mayer, A. M. S., E. Avilés and A. D. Rodríguez. Marine sponge Hymeniacidon sp. amphilectane metabolites potently inhibit rat brain microglia thromboxane B2 generation. Biorganic and Medicinal Chemistry 20: 279 – 282, 2012.

Mayer, A.M.S., A.D. Rodríguez, O.Taglialatela-Scafati and N. Fusetani. Marine pharmacology in 2009-11: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; affecting the Immune and Nervous Systems, and other Miscellaneous Mechanisms of Action. Marine Drugs 11: 2510-2573, 2013.

K. A. El Sayed, A.I. Foudah, A.M.S. Mayer, A. M. Crider and D. Song. Synthesis, microbial transformation, and pharmacological evaluation of 4,5-dihydronaphtho[2,1-b]furna-2-ones and related analogues. Medicinal Chemistry Communication (Wiley) 4: 1231-1238, 2013.

C. Jiménez-Romero, A.M.S. Mayer and A.D. Rodríguez. Dactyloditerpenol acetate, a new prenylbisabolane-type diterpene from Aplysia dactylomela with strong anti-neuroinflammatory activity. Bioorganic & Medicinal Chemistry Letters 24: 344-348, 2014.

Mayer, A.M.S., M. L. Hall, M. Holland, C. De Castro, A. Molinaro, M. Aldulescu, J. Frenkel, L. Ottenhoff, D. Rowley and J. Powell. Vibrio vulnificus M06-24/O lipopolysaccharide stimulates superoxide anion, thromboxane B2, matrix metalloproteinase-9, cytokine and chemokine release by rat microglia in vitro. Marine Drugs 12:1732-1756, 2014.

Avilés, E, Prudhomme, J., Le Roch, K.G., Franzblau, S.G., Chandrasena, K., Mayer, A.M.S., and A.D. Rodríguez. Synthesis and preliminary biological evaluation of a small library of hybrid compounds based no Ugi isocyanide multicomponent reactions with a

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marine natural product scaffold. Bioorganic & Medicinal Chemistry Letters 25(22):5339-43, 2015. doi: 10.1016/j.bmcl.2015.09.033. PMID: 26421992

Mayer, A. M. S., J. Murphy, D. MacAdam, C. Osterbauer, I. Baseer, M. L. Hall, D. Feher and P. Williams. Classical and alternative activation of cyanobacterium Oscillatoria sp. lipopolysaccharide-treated rat microglia in vitro. Toxicological Sciences 149(2):484-95, 2016.

M. Swanson-Mungerson, R. Incrocci, V. Subramaniam, P. Williams, M. L. Hall, and A.M.S. Mayer. Effects of cyanobacteria Oscillatoria sp. lipopolysaccharide on B cell activation and Toll-like receptor 4 signaling. Toxicology Letters 275: 101-107, 2017. PMID: 28499610

Mayer, A.M.S., A. D. Rodríguez, O. Taglialatela-Scafati and N. Fusetani. Marine Pharmacology in 2012–2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and other Miscellaneous Mechanisms of Action. Marine Drugs 15 (9): 273, 2017. PMID: 28850074

L. C. Klemm, E. Czerwonka, M. L. Hall, P. Williams, and A.M.S. Mayer. Cyanobacteria Scytonema javanicum and Scytonema ocellatum lipopolysaccharides elicit release of superoxide anion, matrix-metalloproteinase-9, cytokines and chemokines by rat microglia in vitro. TOXINS 10: 130, 2018. PMID: 29561785

[b] PUBLISHED EDITORIALS, COMMENTARIES

Mayer, A.M.S. Current marine pharmacology contributions to new drug development in the biopharmaceutical industry. Pharmaceutical News 9: 479-482, 2002

Mayer, A.M.S. Special Issue on Marine Toxins. Marine Drugs 2009, 7(1), 19-23, 2009. K.B. Glaser and Mayer, A.M.S. A Renaissance in Marine Pharmacology: From

Preclinical Curiosity to Clinical Reality. Biochemical Pharmacology, 1790: 283-308, 2009.

Mayer, A.M.S. Special Issue on Marine Toxins. Marine Drugs 7: 19-23, 2009. Mayer, A.M.S. Marine Drugs best paper award 2014. Marine Drugs 12: 1157-1159,

2014 Mayer, A.M.S. Marine Drugs best paper award 2015. Marine Drugs 13: 1068-1070,

2015

[c] PATENTS

A. Mayer, S.P. Gunasekera, S.A. Pomponi and S.H. Sennett. Anti-inflammatory uses of the Manzamines. United States Patent No.: US 6,387,916, issued May 14, 2002.

A. Mayer, S.P. Gunasekera, S.A. Pomponi and S.H. Sennett. Anti-inflammatory uses of the Manzamines. United States Patent No.: US 6,602,881 issued Aug. 5, 2003.

[d] ABSTRACTS

A.M.S. Mayer, M. Guzman, R. Peksa, M.L. Hall and M. J. Fay. Cytokine gene expression in rat microglia exposed to the marine toxin domoic acid. The Toxicologist 84 (S-1): 293, 2005.

Peksa, R., Hall, M.L., P. B. Jacobson, and A.M.S. Mayer. Differential TNF- and TGF-β1 generation by rat microglia exposed to E. coli lipopolysaccharide and the

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marine toxin domoic acid. JAOA 105(7): 336, 2005. A.M.S. Mayer, M. Hall and M.T. Hamann. Structure-activity relationship study with

marine and synthetic Manzamines: novel inhibitors of microglia thromboxane B2 and superoxide anion generation. The Pharmacologist 47(3): 121, 2005.

R. L. Peksa, M. L. Hall, P.B. Jacobson and A.M.S. Mayer. Differential TNF-alpha and TGF beta 1 generation by rat microglia exposed to E. Coli lipopolysaccharide and the marine toxin domoic acid. The Pharmacologist 47(3): 122, 2005.

A.M.S. Mayer, R. L. Peksa, M. L. Hall and P.B. Jacobson. Differential release of TNF-alpha and TGF beta 1 by rat microglia exposed to E. Coli lipopolysaccharide and the marine toxin domoic acid. The Toxicologist 90(1): 285, 2006.

A.M.S. Mayer, Carlson, L.A., Braddock, M.T., McCulloch, P.F. Hippocampal C-Fos expression and microglia accumulation in rats exposed to the marine toxin domoic acid. The Toxicologist 96(1): 364, 2007.

A.M.S. Mayer, Mary L. Hall, P. B. Jacobson and Jan L. Powell. Differential effect of Vibrio vulnificus and Escherichia coli LPS on rat brain neonatal microglia release of thromboxane B2 and tumor necrosis factor . The Faseb Journal 21(5): A 404, 2007.

M.T. Braddock, L.A. Carlson, M.L. Hall, P. F. McCulloch, A.M.S. Mayer. The effect of the marine toxin domoic acid on hippocampal c-FOS expression and microglia accumulation in rats. JAOA 107(8):347, 2007.

A.M.S. Mayer, M. A. Holland, M. L. Hall, P. B. Jacobson and J. P. Berry.Effect of Microcystis aeruginosa Lipopolysaccharide (LPS) on Neonatal Rat Brain Microglia Release of Superoxide Anion, Thromboxane B2, Tumor Necrosis Factor and Matrix Metalloproteases. The Toxicologist 102(1):254, 2008.

A.M.S. Mayer, M.H. Kossuga, K.Veloso, A.G. Ferreira, E. Hajdu and R.G.S. Berlinck. Antineuroinflammatory polyketide plakortide N from the Brazilian marine sponge Plakortis angulospiculatus. The Faseb Journal, 22:1139.3, 2008.

J. Frenkel, M. Aldulescu, M. Hall, J.L. Powell, K.B. Glaser and A.M.S. Mayer. Effect of the marine Vibrio vulnificus Lipopolysaccharide on rat brain microglia cytokine and chemokine release. The Toxicologist CD — An official Journal of the Society of Toxicology, Volume 108, Number S1: 12, 2009.

M. Aldulescu, J. Frenkel, M. Hall, J.L. Powell, K.B. Glaser and A.M.S. Mayer. Effect of Microcystis aeruginosa Lipopolysaccharide on neonatal rat brain microglia cytokine and chemokine release. Faseb Journal 23, 755.1, 2009.

M.J. Fay, G.K. Tan, S.S. Baxter, M.L. Hall, A.M.S. Mayer and L.A. Carlson. Differential expression of full-length and truncated cullin-5 is associated with granulocytic differentiation of HL-60 leukemia cells. In Vitro Cellular & Developmental Biology, 45: S42, 2009.

A.M.S. Mayer and M.L. Hall. Differential effect of the antineuroinflammatory marine β-carboline alkaloid manzamine A on p90 ribosomal S6 kinase 1 and 2. Program No. 545.5. 2009 Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience, 2009. Online.

N. Patel, J. Clifford, M. L. Hall, K. B. Glaser, P. Jacobson, J. Berry, and A. M.S. Mayer. Effect of Microcystis aeruginosa Lipopolysaccharide (LPS) on Neonatal Rat Brain Microglia: Cytokine Expression Profiling by Antibody Array Technology. The Toxicologist CD — An official Journal of the Society of Toxicology, 114 (1): 161, 2010.

S. Chaudhri, M. L. Hall, E. Áviles , A. D. Rodríguez and A. M.S. Mayer. Marine sponge Hymeniacidon sp. amphilectane metabolites potently inhibit rat brain microglia thromboxane B2 generation. Faseb Journal 24: 966.1, 2010.

S. Chaudhry, M. L. Hall, E. Áviles, A. D. Rodríguez and A.M.S. Mayer. Inhibition of activated rat microglia thromboxane B2 release by the marine sponge Hymeniacidon

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sp metabolites. JAOA 110(8):462, 2010. J. A. Clifford, N. Patel, M. L. Hall, K. B. Glaser, P. B. Jacobson, J. P. Berry, and A.

M. S. Mayer. The effect of Microcystis Aeruginosa lipopolysaccharide (LPS) on neonatal rat brain microglia cytokine and chemokine generation. JAOA 110(8):478, 2010.

L.D. Ottenhoff, N. Patel, M. L. Hall, K. B. Glaser, P. Jacobson, D. Rowley, C. De Castro, A. Molinaro and A. M.S. Mayer. Effect of Vibrio vulnificus lipopolysaccharide (LPS) on rat brain microglia: cytokine and chemokine expression profiling by antibody array technology. [Abstract 688], The Toxicologist CD—An official Journal of the Society of Toxicology, 120, S-2, March 2011.

A.M.S. Mayer and K.B. Glaser. Marine pharmacology and the 2011 pharmaceuticals pipeline. Faseb Journal 25: 623.1, 2011.

J. Murphy, M. L. Hall, D. Feher, P. Williams and A. M. S. Mayer. Cyanobacterial Lipopolysaccharides (LPS) elicit release of superoxide Anion, thromboxane B2, and cytokines from rat brain microglia. [Abstract 714], The Toxicologist CD—An official Journal of the Society of Toxicology, Volume126, Number S-1, March 2012.

J. A. Clifford, J. Lach, M. L. Hall, and A. M. S. Mayer. The mechanism of the marine thromboxane B2 inhibitor Manzamine A: possible involvement of rat brain microglia p90 ribosomal S6 kinase1. Faseb Journal 26: 1124.1, 2012.

Macadam, D., Hall, Mary L., Fehrer, D., Williams, P., and A.M.S. Mayer. Cyanobacterium Anabaena sp. Lipopolysaccharide (LPS) Elicits Release Of MIP-α, Interleukin 6, and Matrix Metalloproteinase-9 from Rat Brain Microglia in vitro. The Toxicologist CD—An official Journal of the Society of Toxicology, Volume132, Issue 1, Abstract 247, March 2013.

A.M.S. Mayer and K.B. Glaser. Marine pharmacology and the marine pharmaceuticals pipeline. Faseb Journal 27: 1167.7, 2013.

K. Chandrasena, M. L. Hall and A. M. S. Mayer. The mechanism of the marine β-carboline thromboxane B2 inhibitor Manzamine A: possible involvement of rat brain microglia p90 ribosomal S6 kinase 1. Faseb Journal 27: 888.1, 2013.

D. Macadam, M.L. Hall, D. Feher, P. Williams and A.M.S. Mayer. Differential effect of cyanobacterium Anabaena LPS on rat brain microglia-derived proinflammatory and anti-inflammatory cytokine and chemokine generation. Toxicology Letters 221, S135, 2013.

C. Osterbauer, D. Macadam, M.L. Hall, D. Feher, P. Williams and A.M.S. Mayer. Classical and Alternative Activation of cyanobacterium Anabaena LPS-treated rat brain microglia., The Toxicologist CD—An official Journal of the Society of Toxicology, Volume138, Issue 1, Abstract 995, March 2014.

A.M.S. Mayer and K.B. Glaser. Marine pharmacology and the marine pharmaceuticals pipeline in 2013. Faseb Journal 28 (1) Supplement): 657.17, April 2014.

I. Baseer, M. Luce, M.L. Hall, P. Williams and A.M.S. Mayer. Temporal Dynamics of Classical and Alternative Activation of Cyanobacterium Oscillatoria sp. LPS-treated rat brain microglia. The Toxicologist CD—An official Journal of the Society of Toxicology, Volume 144, Issue 1, Abstract 137, March 2015.

A.M.S. Mayer, M. Hall, J. Lach, J. Clifford, K. Chandrasena, C. Caton and M. Kontoyianni. Preferential Binding of the Marine β-carboline Manzamine A to the NTDK Domain of RSK1. Faseb Journal 29 (1) Supplement: 936.4, April 2015.

A.M.S. Mayer, D. Nguyen and K.B. Glaser. Marine pharmacology and pharmaceuticals pipeline in 2014. Faseb Journal 29 (1) Supplement: 936.3, April 2015.

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L. C. Klemm, M. L. Hall, P. Williams, and A. M.S. Mayer. Classical and Alternative Activation of Cyanobacteria Scytonema javanicum and Scytonema ocellatum Lipopolysaccharide-treated Rat Brain Microglia. The Toxicologist, Supplement to Toxicological Sciences, Volume 150, Issue 1, Abstract # 1924, March 2016.

A.M.S. Mayer, M. Nguyen, D.J. Newman and K.B. Glaser. The Marine pharmacology and Pharmaceuticals pipeline in 2015. Faseb Journal 30 (1) Supplement: 932.7, April 2016.

J. Mayer, M. Luce, L. C. Klemm, M. L. Hall, and A. M.S. Mayer. The effect of Porphyromonas gingivalis Lipopolysaccharide on Rat Brain Microglia classical and alternative Activation. The Toxicologist, Supplement to Toxicological Sciences, Volume 150 (1), Abstract # 2974, March 2017.

M. Swanson-Mungerson, R. Incrocci, V. Subramaniam, M. L. Hall, P. Williams, and A. M.S. Mayer. Effect of Oscillatoria sp. Lipopolysaccharide on B cell Activation and Toll-like Receptor 4 Signaling. The Toxicologist, Supplement to Toxicological Sciences, Volume 150(1), Abstract # 1981, March 2017.

A.M.S. Mayer, M. Nguyen, P. Kalwajtys, H. Kerns, D.J. Newman and K.B. Glaser. The Marine Pharmacology and Pharmaceuticals pipeline in 2016. Faseb Journal 31 Supplement 1: 818.6, April 2017.

E. Czerwonka, Z. Memedovski, J. Han, J. Mayer, L. C. Klemm, M. L. Hall, and A. M. S. Mayer. The effect of Porphyromonas gingivalis Lipopolysaccharide on Rat Brain Microglia classical and alternative Activation: MMP-9 generation. Faseb Journal 32.1 Supplement: 702.2, 2018.

J. Trieu, D.J. Newman, K.B. Glaser and A. M. S. Mayer. The Marine Pharmacology and Pharmaceuticals pipeline in 2017. Faseb Journal 32.1 Supplement: 823.1, 2018.

[e] INVITED SEMINARS AND LECTURES

Dr. Mayer has been delivering a marine pharmaceuticals lecture presentation that covers: (1) FDA-approved marine pharmaceuticals, (2) the clinical pipeline; and, (3) the preclinical pipeline (marine natural products with antitumor and cytotoxic activity, as well as other pharmacological activities) at several scientific meetings and universities in the USA, Argentina, Brasil, Canada, France, Germany, Italy, Mexico and South Africa, as shown below.

2018 Mayer, A.M.S. The Marine Pharmaceutical Pipeline in 2018. School of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology & Scripps Institution of Oceanography, University of California at San Diego, CA. April 26.

2017 Mayer, A.M.S. The Marine Pharmaceutical Pipeline in 2017. 10th European Marine Natural Products Meeting, Kolymbari, Crete, Greece. September 7.

2016 Mayer, A.M.S. The Marine Pharmaceutical Pipeline in 2016.Technische Universität Bergakademie Freiberg, Freiberg, Germany. May 18.

2016 Mayer, A.M.S. Biotechnology and the Marine Pharmaceutical Pipeline in 2016. Fundación Farmecal, A.C., La Paz, Baja California Sur, Mexico. April 20-23.

2015 Mayer, A.M.S. Biotechnology and the Marine Pharmaceutical Pipeline in 2015. National Academy of Medicine, Buenos Aires, Argentina. June 12.

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2014 Mayer, A.M.S. The global marine clinical and preclinical pipeline. 17th World Congress of Basic and Clinical Pharmacology, IUPHAR Natural Products Section Symposium, Cape Town, South Africa. July 13-18.

2013 Mayer, A.M.S. The global marine pharmaceutical pipeline. Department of Pharmaceutical Sciences, Southern Illinois University Edwardsville, Illinois. November 14.

2013 Mayer, A.M.S. The global marine pharmaceutical pipeline. Department of Molecular Therapeutics and Pharmacology, Loyola University Medical Center, Maywood, Illinois. February 20.

2012 Mayer, A.M.S. The global marine pharmaceutical pipeline. Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois. August 22.

2012 Mayer, A.M.S. The global marine pharmaceutical pipeline. OECD Global Forum on Biotechnology: Marine Biotechnology - Enabling Solutions for Ocean Productivity and Sustainability. Sponsored by Organization for Economic Co-operation and Development (OECD). Wosk Centre for Dialogue, Vancouver, Canada. May 30-31.

2012 Mayer, A.M.S. The global marine pharmacology preclinical pipeline. ASPET Symposium: “ Clinical Pipeline of Marine Pharmaceuticals: The Odyssey Continues” sponsored by The Division for Drug Discovery, Development and Regulatory affairs from the American Society of Pharmacology and Experimental Therapeutics, Experimental Biology 2012, San Diego, California. April 25.

2012 Mayer, A.M.S. Marine pharmacology and the global pharmaceutical pipeline. Associated Colleges of the Chicago Area Spring Seminar Series. Benedictine University, Illinois. March 13.

2011 Mayer, A.M.S. The global marine pharmaceutical pipeline. Station Biologique de Roscoff, CNRS, Roscoff, France. September 1.

2011 Mayer, A.M.S. The global marine pharmaceutical pipeline. Annual Workshop on Marine Biotechnology. Station de Biologie Marine, Museum National D’Histoire. Roscoff, France. September 1. Concarneau, France. August 31.

2011 Mayer, A.M.S. The global marine pharmaceutical pipeline. Department of Chemistry, U University of Louisiana, Monroe, Louisiana. February.

2010 Mayer, A.M.S. Marine Biodiversity and Drug Development from Marine Sources. Instituto Nacional de Tecnologia Industrial, Buenos Aires, Argentina. November 12.

2010 Mayer, A.M.S. The global marine pharmaceutical pipeline. Department of Biological Sciences, Benedictine University, Lisle, Illinois. October 13.

2010 Mayer, A.M.S. The global marine pharmaceutical pipeline. Dipartimento di Chimica delle Sostanzi Naturali, Universita Degli Studi Di Napoli Federico II, Naples, Italy.  May 21.

2010 Mayer, A.M.S. The global marine pharmaceutical pipeline. Department of Biopharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois. March 17.

2009 Mayer, A.M.S. The global marine pharmacology pipeline. Chemistry Institute of São Carlos, University of São Paulo at São Carlos, Brasil. November 23.

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2009 Mayer, A.M.S. The global marine pharmacology pipeline. Experimental Biology 2009. American Society of Experimental Pharmacology and Therapeutics (ASPET) Symposium: A Renaissance in Marine Pharmacology: Preclinical Curiosity to Clinical Reality. New Orleans, Louisiana. April 19.

2009 Mayer, A.M.S.  Marine Pharmacology: FDA-approved marine drugs, and the marine clinical and preclinical pipeline. Florida International University, Graduate School and Marine Sciences Program. Miami, Florida. January 30.

2008 Mayer, A.M.S.  Marine Pharmacology: A Critique of the Preclinical and Clinical Literature. University of Puerto Rico, Rio Piedras Campus, Department of Chemistry, San Juan, Puerto Rico. January 28.