CURRICULUM VITAE

Mr. Christopher John Peters

BSc (Hons), MBChB, FRCS (Gen Surg), PhD

5th January 2017

CURRICULUM VITAE

Name: Mr. Christopher John Peters GMC Number: 6050491

School: Watford Grammar School for Boys, Watford, Herts. (1989-1996)

GCSEs 3 A*'s, 6 A's A-Levels 3 A's S-Level Physics Distinction University: University of Leeds Medical School (1996-2002) BSc (Hons) Clinical Sciences- First Class (1999) Bachelor of Medicine and Bachelor of Surgery (2002) University of Cambridge (2006-2010) PhD awarded 2011.

Memberships: Fellow of the Royal College of Surgeons (England) Medical Defence Union

British Medical Association Prizes / Awards: Littlewood Prize for Anatomy, University of Leeds (1997) Yorkshire Cancer Research Scholarship (1998) Thorp Award for Elective Research (2001) Finalist for the British Transplant Society Medwar Medal (2006) Finalist in British Journal of Surgery Prize at AUGIS (2007) Poster of Distinction at AUGIS (2007)

Winner of Best Poster Hutchison-MRC Retreat (2007) Barrett’s Oesophagus Foundation Lay Presentation Award (2008) Plenary Poster at BSG (2009) Academy of Medical Sciences / Medical Research Soc Prize (2009)

Winner Gut Club Prize, Regional Digestive Disease Day (2009) Winner British Journal of Surgery Prize at AUGIS (2009) First place in Oesophageal section at BSG (2010) Plenary Abstract of Distinction Digestive Diseases Week (2010) Winner British Journal of Surgery Prize at BASO (2015) Winner Best Poster ERAS (2015)

Courses: Trauma Team Leader (June 2015)

Advanced Trauma Life Support (ATLS) (March 2014) Training the Trainers (February 2014) SpR Leadership and Management Course (December 2013)

Care of the Critically ill Surgical Patient (CCrISP) (May 2005) Basic Surgical Skills (September 2004)

Immediate Life Support (ILS) (August 2004)

Employment History:

• September 2016- Present Clinical Senior Lecturer, Imperial College London.

• September 2016- Present Honorary Consultant Upper GI Surgeon, St Mary’s Hospital, London.

• April 2016- September 2016 ST9 in Upper GI Surgery (Malignant & Benign), St Mary’s Hospital, London. Consultants- Professor Hanna and Mr Moorthy.

• April 2015- April 2016 ST8 in Upper GI Surgery (Malignant), Royal Marsden Hospital, London. Consultants- Mr Allum, Mr Thompson, and Mr Chaudry

• April 2014- September 2016 Honorary Clinical Lecturer, Imperial College London. Consultants- Professor Hanna

• April 2014- April 2015 ST7 in Upper GI Surgery (Malignant & Benign), St Mary’s Hospital, London. Consultants- Professor Hanna, Professor Zaninotto, Mr Moorthy, and Mr Purkayastha.

• April 2013- April 2014 ST6 in Upper GI Surgery (Benign & Bariatric), Chelsea & Westminster Hospital, London. Consultants- Mr Thompson, Mr Efthimiou and Mr Bonanomi

• October 2012- April 2013 ST5 in Colorectal Surgery, Watford General Hospital, Herts Consultants Mr Arbuckle and Mr Cheetham

• October 2011- October 2012 ST4 / ST5 in Upper GI Surgery (Malignant & Benign), St Thomas Hospital, London. Consultants- Professor Mason, Mr Gossage, Mr Atkinson & Mr Botha.

• April 2010- October 2011 ST3 / ST4 in General Surgery, Northwick Park Hospital, London Consultants- Professor Chadwick, Mr Gould, Mr Isla & Mr McDonald.

• August 2006- April 2010 Clinical Research Fellow, Cambridge University / Addenbrooke’s Hospital. MRC Clinician Scientist / Career Development Fellow- studying for PhD. Supervisors- Professor Rebecca Fitzgerald and Mr Richard Hardwick

• February 2006- August 2006. Clinical Fellow in Laparoscopic and HPB Surgery, Kings College Hospital, London. Consultant- Mr Ameet Patel.

• August 2005- February 2006. SHO in General Surgery (Breast and Endocrine), St James’ University Hospital, Leeds. Consultants- Mr Turton and Mr Lansdown.

• February 2005- August 2005. SHO in Intensive Care, St James’ University Hospital, Leeds. Consultants- Professor Bellamy, Dr Snook, Dr Dean, and Dr Murdoch.

• August 2004- February 2005. SHO in Transplantation Surgery, St James University Hospital, Leeds. Consultants- Professor Lodge, Mr Pollard, Mr Prasad, and Mr Toogood.

• February 2004- August 2004. SHO in General Surgery (Colorectal), Huddersfield Royal Infirmary, Huddersfield. Consultants- Mr Holdsworth and Mrs Salaman.

• August 2003- February 2004. SHO in Accident and Emergency, Calderdale Royal Infirmary, Halifax.

Consultants- Dr Lockey and Mr Mohammed.

• February 2003- August 2003. PRHO in Medicine, Leeds General Infirmary, Leeds. Consultants- Dr Reynolds, Dr Corrado, Dr Baig, and Dr Dickinson.

• November 2002- February 2003. PRHO for the Academic Unit of Orthopaedic Surgery, St James University Hospital, Leeds. Consultants- Professor Dickson, Mr Millner, Mr Rao and Mr Dunsmuir.

• Aug 2002- Nov 2002. PRHO for the Professorial Surgical Unit, St James University Hospital, Leeds. Consultants- Professor Guillou and Mr Menon.

Surgical Experience:

• My registrar rotation was heavily tailored towards oesophago-gastric cancer. I spent three of the six years in resectional centres resulting in my having performed an above average 40 subtotal / total gastrectomies (assisting in a further 10) and 22 oesophagectomies (assisting in another 20) as of February 2016. I have performed the full breadth of OG resectional procedures including transhiatal, 2-stage, 3-stage and left thoracoabdominal approaches to the oesophagus, and have participated in colonic interpositions in both St Mary’s and St Thomas’s. I have been trained in St Mary’s to perform radical lymphadenectomies. These posts have also greatly developed my decision-making and postoperative management skills.

• Separate to oesophago-gastric malignancy I have been fortunate to have been exposed to

other complex Upper GI operations including- HPB resections, liver transplantation, bariatric surgery, complex redo fundoplications and fundoplications in lung transplant patients. During my higher surgical training I have logged over 1650 operations and approximately 75% in the last four years have been performed by me (supervised, unsupervised or training a junior).

• My clinical decision-making and management of sick patients has been developed by working

in busy acute hospitals such as Northwick Park where there are over 30 new referrals per day and I was fortunate to carry out a 6 month placement in the ITU in St James Hospital, Leeds. I have worked in the St Mary’s Major Trauma Centre, which honed my handling of complex trauma, including trauma laparoscopies and laparotomies, which I performed unsupervised. I have also attended the Trauma Team Leader course. During my PhD I carried out aeromedical repatriations which involved caring for sick patients in an isolated environment with limited medical equipment.

• I have now performed over 150 upper gastrointestinal endoscopies, a third of which of have

been interventional (dilatations and intra-gastric balloon insertion, removal or exchange).

Research:

• Intercalated BSc (Hons) in Clinical Sciences- First Class. University of Leeds.

As part of my intercalated BSc I studied photodynamic therapy and designed a system to measure photosensitiser concentration in a blood sample using Raman spectroscopy. I successfully obtained a Yorkshire Cancer Research scholarship for this project.

• PhD- University of Cambridge.

For my PhD I generated and validated a clinical and molecular staging system for oesophageal and junctional adenocarcinoma. This involved the creation of a multicentre collaboration, called the Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group, representing 18 tertiary centres for Upper GI Cancer spread throughout the UK.

This PhD has been published in two papers (British Journal of Surgery and Gastroenterology) and I have been lucky enough to have won a number of national and international prizes including the British Journal of Surgery prize (2009), best paper in the oesophageal section at

the BSG (2010), posters of distinction at BSG (2009) and AUGIS (2007), and a plenary abstract of distinction with a high profile oral presentation at DDW in 2010. It has also led to me being invited to talk at a number of high profile National and International conferences.

• Ongoing research

Spin offs from my PhD include the ongoing validation of the molecular signature including the possible development of novel targets for therapeutics. The OCCAMS study group was also chosen by CRUK to run a UK oesophageal adenocarcinoma arm of the International Cancer Genome Consortium (ICGC) Project. This project aims to whole genome sequence 500 oesophageal adenocarcinomas and matched normal tissue to determine the underlying molecular basis of the disease. Due to the strength of the OCCAMS group over 1800 patients have already been recruited for this study with nearly 300 genomes sequenced to date. The first papers representing the preliminary findings have now been published.

I have now started a research project that will create a prognostic scoring system able to predict survival on a patient-by-patient basis- based on both pathological and molecular features of the tumour. Work is underway to retrospectively validate this in UK, Northern Ireland and European cohorts and subsequently it will be prospectively validated using the OCCAMS collaboration.

I have actively supported junior members of my team to prepare and publish interesting case studies, to help them develop a track record of publications. In the Royal Marsden I worked with a Physiotherapist to develop a project assessing shuttle walk tests in preoperative fitness assessment- this project went on to win the BJS prize at BASO 2015.

• Research leadership

I was responsible for creating the OCCAMS collaboration during my PhD as a framework to collect the tissue and data required for my original PhD. This involved detailed negotiations with centres to gain their agreements to participate and then organisation of the multicentre ethics and tissue transfer agreements. Once set up the collaboration required very careful management to ensure everyone involved was happy and contributing. I jointly led the original competitive application to use OCCAMS to collect the data and tissue for the ICGC project that ultimately led to the successful multimillion-pound grant. The OCCAMS collaboration has been a hugely successful group, now numbering 18 centres, with large numbers of high impact publications.

Since becoming a Clinical Senior Lecturer I have created a new European Biomarker consortium (Predicting Outcome in Esophageal Maligancy, POEM) consisting of London, Belfast, Dublin and Rotterdam. This group has the aim of improving our validation of oesophageal biomarkers and to help translate them into clinical settings.

I have reviewed and scored both grant applications and academic papers (BMJ, Gastroenterology, Disease of the Esophagus, and BJS) and have helped colleagues build their own grant applications using the experience I have gained during my early academic career. I have also independently advised early PhD students about their projects, helping them decide which direction to take for the subsequent years.

Grants:

• I was listed as a co-applicant in the CRUK grants for the ICGC study described above and currently sit on the OCCAMS/ICGC steering committee. The pilot study for this project was awarded £500K of funding and the full project, currently underway, was awarded a £5.9 million pound grant to cover the costs to collect and process tissue through the OCCAMS centres, whole genome sequence the samples, and then carry out the extensive downstream data analysis. Due to its success, CRUK have recently agreed to continue to fund the OCCAMS collaboration for another 5 years. In addition a number of other research projects and PhDs have spun off from my research and have successfully achieved funding.

• I am the principle investigator on a CRUK Biomarkers grant (£143 000 over two years), which

is a collaboration with Professors George Hanna and Rebecca Fitzgerald and utilises the

OCCAMS collaboration for tissue and data. Whilst the grant narrowly missed being funded we have subsequently been asked by the committee to resubmit with some minor alterations for the next funding round starting early 2017.

Publications, Presentations and Invited Talks:

• Full papers (13), Reviews (2) and Comment pieces (2)

Peters CJ. Telling it how it is, BMA News, January 26, 2002.

Peters CJ, Botterill I, Ambrose NS, Hick D, Casey J, & Jayne DJ. LigasureTM vs conventional diathermy haemorrhoidectomy: long term follow up of a randomised clinical trial. Colorectal disease 2005; 7(4): 350-355. Young AL, Peters CJ, Toogood GJ, Davies MH, Millson CE, Lodge JPA, Pollard SG, Prasad KR. A combined liver-pancreas en-bloc transplant in a patient with cystic fibrosis. Transplantation 2005; 80(5): 605-7. Young AL, Rajasundurum R, Asthana S, Peters CJ, Toogood GJ, Davies MH, Millson CE, Lodge PA, Pollard SG and Prasad KR. The value of MELD and sodium in assessing potential liver transplant recipients in the United Kingdom. Transplant International 2007; 20(4): 331-7. Peters CJ, Fitzgerald RC. Review Article: The Molecular Pathogenesis and Chemoprevention of Oesophageal Adenocarcinoma. Alimentary Pharmacology and Therapeutics 2007; 25(11): 1253-69. Huang Y, Peters CJ, Fitzgerald RC, Gjerset RA. Progressive silencing of p14ARF in oesophageal adenocarcinoma. J Cell Mol Med. 2008; 13(2): 398-409. DiPietro M, Peters CJ, Fitzgerald RC, Clinical puzzle: Barrett’s Oesophagus. Disease Models and Mechanisms 2008 Jul; 1(1): 26-31. Peters CJ, Hardwick RH, Vowler SL, Fitzgerald RC on behalf of the OCCAMS Study Group. Generation and Validation of a Revised Classification for Oesophageal and Junctional Adenocarcinoma. British Journal of Surgery 2009; 96(7): 724-733. Young AL, Peters CJ, Pocock PV, Millson CE, Prasad KR. Do smaller adults wait longer for liver transplantation? -A comparison of UK and US data. Clinical Transplantation 2010; 24(2): 181-7. Peters CJ, Rees JRE, Hardwick RH, Hardwick JS, Vowler SL. Ong C-A.J, Zhang C, Save V, O'Donovan M, Rassl D, Alderson D, Caldas C, Fitzgerald RC, on behalf of the OCCAMS Study Group. A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardia. Gastroenterology 2010; 139(6): 1995-2004. Peters CJ, Chadwick SJD, Clinical services should do their bit for efficiency, as well as productivity. Health Services Journal; 16th June 2011. Rollins KE, Peters CJ, Safranek PM, Ford H, Baglin TP, Hardwick RH. Venous thromboembolism in oesophago-gastric carcinoma: Incidence of symptomatic and asymptomatic events following chemotherapy and surgery. European Journal Surgical Oncology 2011; 37(12): 1072-7. Ujam. A, Peters CJ, Tadrous PJ, Webster.J, Steer.K, Martinez-Isla. A, Adrenal Pseudocyst: Diagnosis and Laparoscopic Management – A Case report, International Journal of Surgical Case Reports; 2011; 2(8): 306-8.

King A, Peters CJ, Shorvon P. Acute pancreatitis with pancreatic abscess secondary to sealed jejunal diverticular perforation. BMJ Case Rep. 2012 Feb 25; pii: bcr1120115255. Paterson, A., Shannon N., Lao-Sirieix, P, Ong, C-A., Peters CJ, O’Donovan, M, Fitzgerald, RC. A systematic approach to therapeutic target selection in oesophago-gastric cancer. Gut; 2013; 62(10): 1415-24. Zamani A, Peters CJ, Chadwick SJ. The use of an ex vivo contrast study at the time of surgery to confirm the site of a perforated jejunal diverticulum. BMJ Case Rep. 2013 Jan 3; 2013. pii: bcr2012006788. Wormald JC, Dindyal S, Thomas R, Peters CJ, Sritharan K. Aorto-esophageal fistula: the multi-disciplinary team approach to management. Clin Case Rep. 2016 Jul 15;4(8):800-2

• Book Chapters (2)

Peters CJ, Fitzgerald RC, Esophageal Adenocarcinoma, Oxford Handbook of Gastrointestinal Cancer. 2012. Peters CJ, Bonanomi G., Efthimiou E. Management of Bariatric Emergencies for the General Surgeon, Obesity and Bariatric Surgery: A Practical Guide. In press.

• Abstracts (21)

Peters CJ, Pocock PV, Young AL, Millson CE, Prasad KR. Small adults wait longer than larger adults for liver transplantation (Abstract). Transplant International 2005; 18(S1): 31-2. Aldouri AQ, Young A, Prasad KR, Dave R, Peters CJ, Pollard SG, Lodge PA, Toogood, GT. Liver transplantation in elderly: Preoperative hyponatremia predicts patient survival (Abstract). Transplant International 2005; 18(S1): 144. Chalmers R, Wyatt J, Peters CJ, Menon K, Ahmad N, Toogood GT, Pollard SG, Lodge PA, Prasad R. A comparison of models for assessing donor liver steatosis: assessment by macroscopic appearance, histological and computer image analysis (Abstract). Transplant International 2005; 18(S1): 215. Peters CJ, Rees JRE, Vowler SL, Safranek PM, Save V, Carroll N, Dwerryhouse S, Maynard N, Clark GWB, Fitzgerald RC, Hardwick RH. The number of involved lymph nodes is prognostic in oesophageal adenocarcinoma–is it time to change how we stage the disease? (Abstract). British Journal of Surgery 2007; 94(S5): 39 Peters CJ, Rees JRE, Vowler SL, Safranek PM, Save V, Dwerryhouse S, Maynard N, Clark GWB, Alderson D, Fitzgerald RC, Hardwick RH. The resection margin is highly prognostically significant in oesophageal cancer (Abstract). British Journal of Surgery 2007; 94(S5): 39 Peters CJ, Hardwick RH, Rees JRE, Vowler SL, Safranek PM, Save V, Carroll N, Dwerryhouse Imrit SN, Maynard N, Clark GWB, Fitzgerald RC. An improved staging system for oesophageal adenocarcinoma based on the number of involved lymph nodes (Abstract). Gut 2008; 57 (Supplement 1): A13. Peters CJ, Hardwick RH, Rees JRE, Vowler SL, Safranek PM, Save V, Carroll N, Dwerryhouse Imrit SN, Maynard N, Clark GWB, Fitzgerald RC. An improved staging system for esophageal adenocarcinoma based on the number of involved lymph nodes (Abstract). Gastroenterology 2008; 134(4) (Supplement 1): A302. Peters CJ, Fitzgerald RC, Vowler SL, Rees JRE, Safranek PM, Save V, Carroll N, Dwerryhouse S, Berrisford RG, Wajed S, Sarsfield P, Chandler I, Going JJ, McKernan M, Stuart RC, Blazeby JM, Imrit N, Maynard N, Clark GWB, Hardwick RH. Using a revised N-stage to predict individual patient outcome for oesophageal adenocarcinoma (Abstract). British Journal of Surgery 2008; 95(S7): 10.

Peters CJ, Fitzgerald RC, Vowler SL, Rees JRE, Safranek PM, Save V, Carroll N, Dwerryhouse S, Berrisford RG, Wajed S, Sarsfield P, Chandler I, Going JJ, McKernan M, Stuart RC, Blazeby JM, Imrit N, Maynard N, Clark GWB, Hardwick RH. The incidence of involved lymph nodes in oesophageal adenocarcinoma- implications for preoperative staging (Abstract). British Journal of Surgery 2008; 95(S7): 50. Peters CJ, Rees JRE, Hardwick JS, Zhang C, Hardwick RH, Fitzgerald RC, on behalf of the OCCAMS Study Group. Generation and validation of a prognostic gene signature for oesophageal adenocarcinoma (Abstract). Gut 2009; 58 (Supplement 1): A31. Peters CJ, Hardwick RH, Vowler SL, Fitzgerald RC on behalf of the OCCAMS Study Group. Lymph node location improves the prognostic power of oesophageal adenocarcinoma staging (Abstract). Gut 2009; 58 (Supplement 1): A45. Young AL, Peters CJ, Pocock PV, Millson CE, Prasad KR. Do Smaller Adults wait longer for liver transplantation? A comparison of UK and US data (Abstract). British Journal of Surgery 2009; 96 (S4): 125. Peters CJ, Hardwick RH, Vowler SL, Fitzgerald RC on behalf of the OCCAMS Study Group. Lymph node location improves the prognostic power of esophageal adenocarcinoma staging (Abstract). Gastroenterology 2009; 136(5) (Supplement 1); P147-P339. Shannon N, Peters CJ, Rees JRE, Hardwick JS, Zhang C, Hardwick RH, Fitzgerald RC. Molecular classification of gastro-esophageal adenocarcinoma (Abstract). Gastroenterology 2009; 136(5) (Supplement 1); P147-P339. Peters CJ, Rees JRE, Hardwick JS, Zhang C, Hardwick RH, Fitzgerald RC, on behalf of the OCCAMS Study Group. Generation and validation of a prognostic gene signature for esophageal adenocarcinoma (Abstract). Gastroenterology 2009; 136(5) (Supplement 1); P23-P146. Peters CJ, Rees JRE, Hardwick JS, Zhang C, Vowler SL, Save V, O’Donovan M, Caldas C, Alderson D, Fitzgerald RC, Hardwick RH, on behalf of the OCCAMS Study Group. A seven gene signature outperforms clinical features at predicting survival in oesophageal adenocarcinoma (Abstract). British Journal of Surgery 2009; 98(S6): 1. Peters CJ, Rees JRE, Hardwick RH, Hardwick JS, Vowler SL. Ong C-A.J, Zhang C, Save V, O'Donovan M, Rassl D, Alderson D, Caldas C, Fitzgerald RC, on behalf of the OCCAMS Study Group. A seven gene signature outperforms clinical features at predicting survival in oesophageal and junctional adenocarcinoma (Abstract). Gut 2009; 58 (Supplement 2): A84. Shannon NB, Peters CJ, Rees JR, Hardwick JS, Zhang C, Hardwick RH, Fitzgerald RC, on behalf of the OCCAMS Study Group. Activation of WNT and MAPK pathways in oesophageal adenocarcinoma and during progression of Barrett’s Oesophagus (Abstract). Gut 2009; 58 (Supplement 2): A83. Peters CJ, Rees JRE, Hardwick RH, Hardwick JS, Vowler SL. Ong C-A.J, Zhang C, Save V, O'Donovan M, Rassl D, Alderson D, Caldas C, Fitzgerald RC, on behalf of the OCCAMS Study Group. A clinically applicable three gene signature independently predicts survival in oesophageal and junctional adenocarcinoma (Abstract). Gut 2010; 59 (Supplement 1): A24. Peters CJ, Rees JRE, Hardwick RH, Hardwick JS, Vowler SL. Ong C-A.J, Zhang C, Save V, O'Donovan M, Rassl D, Alderson D, Caldas C, Fitzgerald RC, on behalf of the OCCAMS Study Group. A clinically applicable three gene signature independently predicts survival in oesophageal and junctional adenocarcinoma (Abstract). Gastroenterology 2010; 138(5) (Supplement 1); S63.

Peters CJ, Rees JRE, Hardwick RH, Hardwick JS, Vowler SL. Ong C-A.J, Zhang C, Save V, O'Donovan M, Rassl D, Alderson D, Caldas C, Fitzgerald RC, on behalf of the OCCAMS Study Group. A model to predict survival in oesophageal and junctional adenocarcinoma incorporating both clinical and molecular features (Abstract). Diseases of the Esophagus 2010; 23 (s1), 1A-134A. Peters CJ. Getting genetics into the clinic- Can we stage Oesophageal Adenocarcinomas better? (Abstract) Journal of Pathology 2013; 231 (s1), S4.

• Oral Presentations (18)

Peters CJ, Botterill I, Ambrose NS, Hick D, Casey J, & Jayne DJ. LigasureTM vs. conventional diathermy haemorrhoidectomy: long term follow up of a randomised clinical trial. Presented at the Association of Coloproctology of UK and Ireland Annual Meeting Birmingham 2004.

Peters CJ, Pocock PV, Young AL, Millson CE, Prasad KR. Small adults wait longer than larger adults for liver transplantation. Presented at the European Society of Transplantation Meeting Geneva 2005. Young AL, Rajasundurum R, Asthana S, Peters CJ, Toogood GJ, Davies MH, Millson CE, Lodge JPA, Pollard SG and Prasad KR The Role Of The MELD Score In Predicting Outcome In Potential Liver Transplant Recipients. Presented at the British Transplantation Society (BTS) Congress Belfast 2005. Peters CJ, Pocock PV, Young AL, Millson CE, Prasad KR. Small patients wait longer for liver transplantation- a case for living liver donation? Presented at the British Transplantation Society (BTS) Congress Edinburgh 2006 in the Medwar Medal Session. Peters CJ, Rees JRE, Vowler SL, Safranek PM, Save V, Carroll N, Dwerryhouse S, Maynard N, Clark GWB, Fitzgerald RC, Hardwick RH. The number of involved lymph nodes is prognostic in oesophageal adenocarcinoma–is it time to change how we stage the disease? Presented at the Association for Upper GI Surgeons (AUGIS) Meeting Cardiff 2007 in the British Journal of Surgery Prize Session. Peters CJ, Hardwick RH, Rees JRE, Vowler SL, Safranek PM, Save V, Carroll N, Dwerryhouse Imrit SN, Maynard N, Clark GWB, Fitzgerald RC. An improved staging system for oesophageal adenocarcinoma based on the number of involved lymph nodes. Presented at the British Society of Gastroenterology (BSG) Birmingham 2008. Peters CJ, Fitzgerald RC, Vowler SL, Rees JRE, Safranek PM, Save V, Carroll N, Dwerryhouse S, Berrisford RG, Wajed S, Sarsfield P, Chandler I, Going JJ, McKernan M, Stuart RC, Blazeby JM, Imrit N, Maynard N, Clark GWB, Hardwick RH. Prognostic factors in oesophageal adenocarcinoma. Presented at the International Society for Diseases of the Esophagus (ISDE) Meeting Budapest 2008 in an Expert Opinions Session. Peters CJ, Fitzgerald RC, Vowler SL, Rees JRE, Safranek PM, Save V, Carroll N, Dwerryhouse S, Berrisford RG, Wajed S, Sarsfield P, Chandler I, Going JJ, McKernan M, Stuart RC, Blazeby JM, Imrit N, Maynard N, Clark GWB, Hardwick RH. Using a revised N-stage to predict individual patient outcome for oesophageal adenocarcinoma. Presented at the Association for Upper GI Surgeons (AUGIS) Meeting Liverpool 2008. Peters CJ, Rees JRE, Hardwick JS, Zhang C, Hardwick RH, Fitzgerald RC, on behalf of the OCCAMS Study Group. Generation and validation of a prognostic gene signature for oesophageal adenocarcinoma. Presented at the British Society of Gastroenterology (BSG) Glasgow 2009 (2nd place in Oesophageal Section).

Peters CJ, Rees JRE, Hardwick JS, Zhang C, Hardwick RH, Fitzgerald RC, on behalf of the OCCAMS Study Group. Generation and validation of a prognostic gene signature for esophageal adenocarcinoma. Presented at Digestive Disease Week (DDW) Chicago 2009. Peters CJ, Rees JRE, Hardwick JS, Zhang C, Vowler SL, Save V, O’Donovan M, Caldas C, Alderson D, Fitzgerald RC, Hardwick RH, on behalf of the OCCAMS Study Group. A seven gene signature outperforms clinical features at predicting survival in oesophageal adenocarcinoma. Presented at the Association for Upper GI Surgeons (AUGIS) Meeting Nottingham 2009 in the British Journal of Surgery Prize Session. Peters CJ, Rees JRE, Hardwick RH, Hardwick JS, Vowler SL. Ong C-A.J, Zhang C, Save V, O'Donovan M, Rassl D, Alderson D, Caldas C, Fitzgerald RC, on behalf of the OCCAMS Study Group. A seven gene signature outperforms clinical features at predicting survival in oesophageal and junctional adenocarcinoma. Presented at Gastro 2009 London 2009. Shannon NB, Peters CJ, Rees JR, Hardwick JS, Zhang C, Hardwick RH, Fitzgerald RC, on behalf of the OCCAMS Study Group. Activation of WNT and MAPK pathways in oesophageal adenocarcinoma and during progression of Barrett’s Oesophagus. Presented at Gastro 2009 London. Peters CJ, Rees JRE, Hardwick RH, Hardwick JS, Vowler SL. Ong C-A.J, Zhang C, Save V, O'Donovan M, Rassl D, Alderson D, Caldas C, Fitzgerald RC, on behalf of the OCCAMS Study Group. A clinically applicable three gene signature independently predicts survival in oesophageal and junctional adenocarcinoma. Presented at the British Society of Gastroenterology (BSG) Liverpool 2010. Peters CJ, Rees JRE, Hardwick RH, Hardwick JS, Vowler SL. Ong C-A.J, Zhang C, Save V, O'Donovan M, Rassl D, Alderson D, Caldas C, Fitzgerald RC, on behalf of the OCCAMS Study Group. A clinically applicable three gene signature independently predicts survival in oesophageal and junctional adenocarcinoma. Presented at Digestive Disease Week (DDW) New Orleans 2010 in the Plenary Distinguished Abstract Section. Peters CJ, Rees JRE, Hardwick RH, Hardwick JS, Vowler SL. Ong C-A.J, Zhang C, Save V, O'Donovan M, Rassl D, Alderson D, Caldas C, Fitzgerald RC, on behalf of the OCCAMS Study Group. A model to predict survival in oesophageal and junctional adenocarcinoma incorporating both clinical and molecular features. Presented at International Society for Diseases of the Esophagus (ISDE) Meeting Kagoshima Japan 2010. Martin JL, Peters C, Zafar N and Isla A. Laparoscopic Choledochoduodenostomy. Presented at 20th International Congress of the EAES Brussels 2012. Whibley J*, Peters CJ*Allum WH, and Chaudry AM (*= Joint First author). Poor performance in Incremental shuttle walk and cardiopulmonary exercise testing predicts poor overall survival for patients undergoing oesophago-gastric resection. Presented at BASO ~ ACS London 2015 in the BJS Prize session- Winner of BJS Prize.

• Invited talks (10)

Peters CJ. The role of molecular biology in GOJ cancer. British Society of Gastroenterology (BSG) Liverpool 2010. Peters CJ. An academic career- duties of a mentee. International Society for Diseases of the Esophagus (ISDE) Meeting Kagoshima Japan 2010. Peters CJ. How can oesophageal cancer staging be more clinically useful? British Oesophageal Group Meeting Cambridge 2011. Peters CJ. Predicting outcomes in Oesophageal Cancer: combining molecular and clinical staging. Digestive Diseases Federation (DDF) Liverpool 2012.

Peters CJ. Can genetic profiling be used to predict the outcome of esophageal cancer therapy? OESO Como 2012. Peters CJ. Getting genetics into the clinic- Can we stage Oesophageal Adenocarcinomas better? Edinburgh Pathology 2013. Peters CJ. Prognostic Signatures in OG Cancer. European Society of Surgical Oncology (ESSO) 2014. Peters CJ. Invited Chair Treatment strategies for Oesophagogastric cancers. Digestive Disease Federation (DDF) London 2015. Peters CJ. Molecular Staging of Oesophageal Cancer - Moving Beyond Shades of Purple. 10th TCD International Cancer Conference, Dublin, 2016. Peters CJ. Moving molecules into the MDT. OCCAMS/ICGC Annual Symposium, Cambridge, 2016.

• Posters (14)

Young AL, Peters CJ, Toogood GJ, Davies MH, Millson CE, Lodge JPA, Pollard SG, Prasad KR, Combined Liver-Pancreas En-Bloc Transplant in a patient with Cystic Fibrosis. Poster at the British Transplantation Society Congress Belfast 2005. Chalmers CR, Wyatt J, Peters CJ, Menon K, Ahmad N, Toogood GJ, Pollard SG, Lodge JPA, Prasad KR. A comparison of models for assessing donor liver steatosis: Assessment by macroscopic appearance, histological and computer image analysis. Poster at the European Society of Transplantation Geneva 2005. Aldouri AQ, Young A, Prasad KR, Dave R, Peters CJ, Pollard SG, Lodge JPA, Toogood GJ. Liver Transplantation in Elderly: Preoperative hyponatremia predicts patient survival. Poster at the European Society of Transplantation Geneva 2005. Peters CJ, Rees JRE, Vowler SL, Safranek PM, Save V, Dwerryhouse S, Maynard N, Clark GWB, Alderson D, Fitzgerald RC, Hardwick RH. The resection margin is highly prognostically significant in oesophageal cancer. Poster at the Presented at the Association for Upper GI Surgeons Meeting Cardiff 2007 Posters of Distinction session. Peters CJ, Hardwick RH, Rees JRE, Vowler SL, Safranek PM, Save V, Carroll N, Dwerryhouse Imrit SN, Maynard N, Clark GWB, Fitzgerald RC. An improved staging system for esophageal adenocarcinoma based on the number of involved lymph nodes. Poster at Digestive Disease Week San Diego 2008. Peters CJ, Fitzgerald RC, Vowler SL, Rees JRE, Safranek PM, Save V, Carroll N, Dwerryhouse S, Berrisford RG, Wajed S, Sarsfield P, Chandler I, Going JJ, McKernan M, Stuart RC, Blazeby JM, Imrit N, Maynard N, Clark GWB, Hardwick RH. The incidence of involved lymph nodes in oesophageal adenocarcinoma- implications for preoperative staging. Poster at the International Society for Diseases of the Esophagus Meeting Budapest 2008. Peters CJ, Fitzgerald RC, Vowler SL, Rees JRE, Safranek PM, Save V, Carroll N, Dwerryhouse S, Berrisford RG, Wajed S, Sarsfield P, Chandler I, Going JJ, McKernan M, Stuart RC, Blazeby JM, Imrit N, Maynard N, Clark GWB, Hardwick RH. The incidence of involved lymph nodes in oesophageal adenocarcinoma- implications for preoperative staging. Poster at the Association for Upper GI Surgeons Meeting Liverpool 2008. Peters CJ, Hardwick RH, Vowler SL, Fitzgerald RC on behalf of the OCCAMS Study Group. Lymph node location improves the prognostic power of oesophageal adenocarcinoma staging. Poster at the British Society of Gastroenterology Glasgow 2009.

Young AL, Peters CJ, Pocock PV, Millson CE, Prasad KR. Do Smaller Adults wait longer for liver transplantation? - A comparison of UK and US data. Presented at the ASGBI Association of Surgeons of Great Britain and Ireland (ASGBI) Glasgow 2009. Peters CJ, Hardwick RH, Vowler SL, Fitzgerald RC on behalf of the OCCAMS Study Group. Lymph node location improves the prognostic power of esophageal adenocarcinoma staging. Poster at Digestive Disease Week Chicago 2009. Shannon N, Peters CJ, Rees JRE, Hardwick JS, Zhang C, Hardwick RH, Fitzgerald RC. Molecular classification of gastro-esophageal adenocarcinoma. Poster at Digestive Disease Week Chicago 2009. Whibley J*, Peters CJ*, Chaudry AM, and Allum WH (*= Joint First author). A decline in the incremental shuttle walk test result following chemotherapy is associated with an increased incidence of postoperative complications. Poster at ERAS Edinburgh 2015- Winner of Best Poster prize.

Teaching Experience:

• Whilst at medical school I pioneered a scheme whereby final year medical students ran clinical tutorials for third years about to take their first clinical exams.

• After graduation I have taught clinical students and junior members of the team both

opportunistically on the wards and more formally during pre-arranged sessions. In the last couple of years I have acted as a mentor for new registrars helping them find their feet after the transition from core training.

• Since joining the London Deanery I have acted as a final year tutor to eight Imperial Medical

Students preparing for their finals. This involved meeting them regularly and facilitating their revision with small group teaching. I also organised teaching sessions for them with other specialities.

• In Chelsea and Westminster I was responsible for organising the Upper GI teaching

programme for third year medical students, allocating topics to my colleagues and running a third of the sessions myself. This programme was very well regarded by the students in formal feedback (overall rated as either excellent or very good).

• In St Mary’s Hospital I have supervised medical student case presentations to their peers,

and taught on the FY2 lecture programme where my talk was rated in feedback as excellent (13 out 15 of the FY2s attending) or very good (remaining 2 FY2s). A subsequent session was rated 4.8/5.

• I have been a faculty member on the CCrISP course and have been invited to attend the

ATLS Provider Course after recently renewing my ATLS accreditation. Management / Administrative Experience:

• I was one of the principle organisers of the United Kingdom and Ireland Liver Transplant Group meeting held in Leeds in November 2004. This included organising the venue and arranging sponsorship.

• In Cambridge I ran the GI Cancer Forum, a thrice yearly meeting attended by approximately 120 local clinicians and scientists. It aimed to provide a platform to present local research and encouraged collaborations between groups. Organising this meeting included raising the £2000 required for each event.

• As part of my PhD I created and ran the OCCAMS Study Group. This is now an 18 centre group of upper GI cancer tertiary centres all working together to find ways to better stratify patients with oesophageal and junctional adenocarcinoma.

• As a junior registrar in Northwick Park I worked with Professor Chadwick to reorganise the General Surgical firms from one six consultant unit into three firms of two consultants. This improved communication and patient satisfaction, decreased hospital stay and, importantly, improved training. I was also responsible for coordination of the general surgical rota in 3 of the 6 hospitals I have worked in as a registrar.

Information Technology:

• I am proficient with Windows and Apple operating systems including all Microsoft Office Applications. I am confident using SPSS and a number of database packages. I have been taught website design by Kodak and have published a peer reviewed website. I have also had some networking experience.

• I have experience of handling large clinical datasets and have a basic working knowledge of

R. I have had some exposure to working with large genomic datasets and understand the complex issues involved with such projects. I am quick to pick up new IT skills including programming.

Audit:

• I have participated in a number of audits during my training. During my A&E post I audited the time patients with abdominal pain spent in the department to attempt to identify delays to their admission/discharge. A repeat audit after changes showed a reduction in the number of patients who breached the four hour target. As a registrar I coordinated an audit looking at Northwick Park’s management of Appendicitis. Re auditing demonstrated that the hospital was following the Cochrane guidelines for choosing laparoscopic versus open appendicectomy.

• More recently I helped co-ordinate an audit of the accuracy of the information recorded on the bedside boards as to oral intake status. This showed there was poor correlation with the clinical teams intention, and the subsequent development of a sticker for the drug chart and then re audit showed much more accurate recording of this important information.

• In the Marsden I was the local lead for the National postoperative pneumonia audit (chief investigators Ravinder Vohra, Olga Tucker and Krishna Moorthy). We achieved 100% complete data submission.

Achievements / Extra-Curricular Activities:

• Prior to university I was a member of the school debating team (competing in the national finals of the Cambridge Union Competition) and St John Ambulance Hertfordshire ‘Cadet of the Year’.

• At university I played an active role in student representation and welfare. I was president of

the MSRC (Medical Students Representative Council) and played an in depth role in the introduction of the new curriculum for the first three years and the plans for the new fifth year.

• I also established the ‘Teacher of the Year’ awards 19 years ago, which are still running

today. I have also acted as a student BMA representative for Leeds and attended the student ARM.

• I won the Littlewood Prize for Anatomy and obtained honours points in nine subjects at medical school including a distinction in Public Health.

• I am a designated book reviewer for Oxford University Press. They send me both current

editions and new manuscripts to rate them in terms of both usefulness and style. They then use this information to develop new editions or make decisions about proposals for new books.

• I am a script advisor and on set consultant for BBCs Holby City (5 millions viewers) and

EastEnders (7 million viewers). For EastEnders I have been involved in the development of major story lines, including Phil Mitchel’s Liver failure, from conception though to filming. I check the medical accuracy of the plots and ensure that the portrayal of important health conditions is handled sensitively and compassionately.

• Outside of Surgery I am a passionate follower of Formula one. Signed:

Mr Christopher John Peters. BSc (Hons), MBChB, FRCS (Gen Surg), PhD