bs-300 service manual(v5.0)

8/17/2019 BS-300 Service Manual(v5.0)

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BS-300 Chemistry Analyzer

Service Manual


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© 2007-2010 Shenzhen Mindray Bio-medical Electronics Co., Ltd. All rightsReserved.

For this Service Manual, the issued Date is 2010-04 (Version: 5.0).

Intellectual Property Statement

SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD. (hereinafter calledMindray) owns the intellectual property rights to this Mindray product and thismanual. This manual may refer to information protected by copyrights or patents anddoes not convey any license under the patent rights of Mindray, nor the rights ofothers. Mindray does not assume any liability arising out of any infringements ofpatents or other rights of third parties.

Mindray intends to maintain the contents of this manual as confidential information.Disclosure of the information in this manual in any manner whatsoever without thewritten permission of Mindray is strictly forbidden.

Release, amendment, reproduction, distribution, rent, adaption and translation of thismanual in any manner whatsoever without the written permission of Mindray isstrictly forbidden.

, , , , , are theregistered trademarks or trademarks owned by Mindray in China and other countries.All other trademarks that appear in this manual are used only for editorial purposeswithout the intention of improperly using them. They are the property of their

respective owners.

Responsibility on the Manufacturer Party

Contents of this manual are subject to changes without prior notice.

All information contained in this manual is believed to be correct. Mindray shall notbe liable for errors contained herein nor for incidental or consequential damages inconnection with the furnishing, performance, or use of this manual.

Mindray is responsible for safety, reliability and performance of this product only in

the condition that:

all installation operations, expansions, changes, modifications and repairs ofthis product are conducted by Mindray authorized personnel;

the electrical installation of the relevant room complies with the applicablenational and local requirements;

the product is used in accordance with the instructions for use.

Upon request, Mindray may provide, with compensation, necessary circuit diagrams,calibration illustration list and other information to help qualified technician to

maintain and repair some parts, which Mindray may define as user serviceable.


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WARNING:

It is important for the hospital or organization that employs thisequipment to carry out a reasonable service/maintenance plan.Neglect of this may result in machine breakdown or injury of humanhealth.

NOTE:

This equipment is to be operated only by medical professionals trainedand authorized by Mindray or Mindray-authorized distributors.

Warranty

THIS WARRANTY IS EXCLUSIVE AND IS IN LIEU OF ALL OTHER WARRANTIES,

EXPRESSED OR IMPLIED, INCLUDING WARRANTIES OF MERCHANTABILITYOR FITNESS FOR ANY PARTICULAR PURPOSE.

Exemptions

Mindray's obligation or liability under this warranty does not include anytransportation or other charges or liability for direct, indirect or consequentialdamages or delay resulting from the improper use or application of the product or theuse of parts or accessories not approved by Mindray or repairs by people other thanMindray authorized personnel.

This warranty shall not extend to:

any Mindray product which has been subjected to misuse, negligence oraccident;

any Mindray product from which Mindray's original serial number tag or productidentification markings have been altered or removed;

any product of any other manufacturer.

Return Policy

Return ProcedureIn the event that it becomes necessary to return this product or part of this product toMindray, the following procedure should be followed:

Obtain return authorization: Contact the Mindray Service Department and obtaina Customer Service Authorization (Mindray) number. The Mindray number mustappear on the outside of the shipping container. Returned shipments will not beaccepted if the Mindray number is not clearly visible. Please provide the modelnumber, serial number, and a brief description of the reason for return.

Freight policy: The customer is responsible for freight charges when thisproduct is shipped to Mindray for service (this includes customs charges).

Return address: Please send the part(s) or equipment to the address offered byCustomer Service department.


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Company Contact

Manufacturer: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.

Address: Mindray Building, Keji 12th Road South, Hi-tech Industrial Park,Nanshan, ShenZhen 518057, P.R.China,

Tel: +86 755 26582479 26582888

Fax: +86 755 26582934 26582500


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Preface

Who Should Read This Manual

This manual is written for service professionals authorized by Mindray.

Conventions Used in This Manual

Safety Symbols

In this manual, the signal words BIOHAZARD, WARNING, CAUTION and NOTE are used regarding safety and other important instructions. The signalwords and their meanings are defined as follows. Please understand their meaningsclearly before reading this manual.

When you see … Then …

WARNING: Read the statement following the symbol. Thestatement is alerting you to an operating hazardthat can cause personal injury.

BIOHAZARD:Read the statement following the symbol. Thestatement is alerting you to a potentially

biohazardous condition.

CAUTION: Read the statement following the symbol. Thestatement is alerting you to a possibility ofsystem damage or unreliable results.

NOTE:Read the statement following the symbol. Thestatement is alerting you to information thatrequires your attention.

Graphics

All graphics, including screens and printout, are for illustration purpose only and

must not be used for any other purposes.

EC Representative

Name: Shanghai International Holding Corp. GmbH (Europe)

Address: Eiffestrasse 80 D-20537 Hamburg Germany

Tel: +49 40 2513174

Fax: +49 40 255726


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Contents

Preface........................................................................................................................................... i

Who Should Read This Manual .............................................................................................. i

Conventions Used in This Manual .......................................................................................... i

1 Specifications....................................................................................................................1-1

1.1 System Feature ...................................................................................................1-1 1.2 Loading System Feature .....................................................................................1-1 1.3 Analysis System Feature.....................................................................................1-2 1.4 Others ..................................................................................................................1-2

2 System Installation ...........................................................................................................2-1

2.1 Check before Installation .....................................................................................2-1

2.2

Installation Procedure..........................................................................................2-1

3 System Descriptions ........................................................................................................3-1

3.1 Dispensing System..............................................................................................3-1 3.1.1 Probe assemblies.................................................................................3-1 3.1.2 Disk assemblies ...................................................................................3-2

3.2 Feeder .................................................................................................................3-4 3.2.1 Feeder assemblies ...............................................................................3-4 3.2.2 Manipulator...........................................................................................3-5

3.3 Temperature Control System...............................................................................3-6 3.3.1 Temperature control assembly .............................................................3-6 3.3.2 Reagent preheating.............................................................................. 3-7 3.3.3 Reagent refrigeration............................................................................3-8

3.4

Photometric System ............................................................................................3-8

3.5 Fluid System........................................................................................................3-9 3.6 ISE Module (optional) ........................................................................................3-10

4 Functions of Boards.........................................................................................................4-1

4.1 Main Control Board..............................................................................................4-1 4.2 Power Drive Board ..............................................................................................4-2 4.3 A/D Conversion Board.........................................................................................4-2 4.4 Reagent Refrigeration Board...............................................................................4-2 4.5 Level Detection Boards .......................................................................................4-3 4.6 Feeder Connection Board ...................................................................................4-3

4.7

Manipulator Connection Board ............................................................................ 4-3 4.8 Probes Connection Board ...................................................................................4-4

4.9 Power Supply Assembly ......................................................................................4-4

5 Maintenance and Service.................................................................................................5-1

5.1 Replacing Light Filter Assembly .......................................................................... 5-1 5.2 Replacing Optical Fiber .......................................................................................5-4 5.3 Adjusting Reaction Disk, Manipulator and Feeder ..............................................5-7 5.4 Adjusting Probes and Disks.................................................................................5-95.5 Replacing the Filter Assembly………………………………………………………5-105.6 Replacing Components of ISE Unit (optional)....………………………………....5-13

5.6.1 Replacing Tubing................................................................................5-13

5.6.2

Replacing Pumps ...............................................................................5-16

5.6.3 Replacing ISE Module........................................................................ 5-16


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6 Software Introduction.......................................................................................................6-1

6.1 System Software..................................................................................................6-1 6.1.1 System initialization.............................................................................. 6-1 6.1.2 Shutdown processing ........................................................................... 6-2

6.2 Control Software..................................................................................................6-2

7

Service Flow......................................................................................................................7-1

7.1 Fluid Level Detection Failure of Reagent Probe..................................................7-1 7.2 Fluid Level Detection Failure of Sample Probe...................................................7-2 7.3 Liquid Dropping From Probes..............................................................................7-3 7.4 Failing to Detect Level of Water for Washing Exteriors .......................................7-4 7.5 Abnormal Results ................................................................................................7-5

7.5.1 All Results Being Abnormal ..................................................................7-5 7.5.2 Some Results Being Abnormal.............................................................7-5 7.5.3 Several Results Being Abnormal..........................................................7-6

7.6 Insufficient Light Intensity of Lamp ...................................................................... 7-7 7.7 Temperature Control Failure................................................................................7-8 7.8 Bar Code Scanner (optional) Failure...................................................................7-9

7.9

Feeder Failure ................................................................................................... 7-11 7.9.1 Transducer Distribution of the Feeder................................................ 7-11

7.9.2 Feeder Failure ....................................................................................7-12 7.9.3 Manipulator Failure.............................................................................7-13

7.10 Troubleshooting of ISE Unit (optional)...............................................................7-13

8 Mechanical Structure........................................................................................................8-1

9 Tools and Parts .................................................................................................................9-1

9.1 Service Tools .......................................................................................................9-1 9.2 Parts ....................................................................................................................9-1

10

Maintenance And Test Software....................................................................................10-1

10.1 General ..............................................................................................................10-110.2 Command ..........................................................................................................10-3

10.2.1 Single Command Area .......................................................................10-3 10.2.2 Macroinstruction Area.......................................................................10-10

10.3 PARA and Speed .............................................................................................10-13 10.4 Temperature.....................................................................................................10-19 10.5 Photoelectric ....................................................................................................10-20

Appendix A Boards Connection Diagrams ...............................................................................A-1

Appendix B Test Points of Boards .............................................................................................B-1


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1-1

1 Specifications

1.1 System Feature

Dimension: 980mm × 710mm × 1200mm (W × D × H)

Weight: 175kg

Power supply: AC100-130V ± 10% or 200-240V ± 10%

Input power: 1000VA

System: optional, multi-channel, multi-test

Scope: Clinical chemistries

Test types: end-point, kinetic and fixed-time. All support double-reagent and

double-wavelength Calibration type: Linear (single-point, two-point and multi-point), Logistic 4P,

Logistic 5P, Exponential 5P, Polynominal 5P, Parabola, Spline

QC rules: Westgard multi-rule,

−

X -R, Cumulative sum check, Cumulative error,Twin-plot

Tests analyzed simultaneously: 48 (single-reagent) / 24 (double-reagent); if theISE unit (optional) is connected, 3 (Na, K and Cl included) or 4 (Na, K, Cl and Liincluded) tests are added

Throughput: maximum 300tests/h; if the ISE (optional) is connected, maximum420tests/h (Na, K and Cl included) or maximum 480 tests/h (Na, K, Cl and Liincluded)

1.2 Loading System Feature

Sample volume: 3µl~45µl; Precision: 0.5µl; for the ISE (optional), 70µl serum,70µl plasma, 140µl diluted urine

Sample disk: general sample disk, including the inner circle and the outer circle

Sample tube position: 60 positions, including 6 calibrator positions, 3 controlpositions, 5 for STAT sample positions; 5 virtual disks for maximum 300 samples

Sample probe: with a built-in level detector; equipped with auto safeguard;capable of tracking sample level

Washing function: automatically washing interior and exterior of sample probe;carryover no more than 0.1%

Pre-dilution: 4 ≤ dilution rate ≤ 150, taking reaction cuvettes as the container

Reagent volume: 30-450ul; Precision: 1ul

Reagent disk: including the inner circle and the outer circle

Reagent position number: 25/50 reagent positions. Each reagent position isavailable for containing one Hitachi 7060 bottle, one Hitachi 7170 bottle, oneMindray inner-circle 50mL bottle, one Mindray outer-circle 50mL bottle, oneMindray Outer-circle 20mL bottle, one Mindray Inner-circle 40mL bottle, oneMindray Outer-circle 40mL bottle or one Mindray Outer-circle 62mL bottle

Reagent probe: One independent probe which has a built-in level detector; isequipped with auto safeguard and capable of tracking reagent level


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Specifications

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Washing function: automatically washing interiors and exteriors of reagent probes;carryover no more than 0.1%

Mixing bar: for single-reagent tests, it functions after sample dispensing; fordouble-reagent tests, it functions after the dispensing of the sample and thesecond reagent.

1.3 Analysis System Feature

Lamp house: 50w lamp

Light splitting mode: Splitting by optical fiber, filtering by an interference filter.

Half band-width: 10±2nm

Wavelength: 340, 405, 450, 510, 546, 578, 630, 670, 700nm

Absorbance range: -0.1~5, 10mm optical path conversion

Reaction cuvette: 5 × 6 × 25mm, optical path 5mm. Material: PP, disposable.

Volume: 750uL Reaction liquid volume: 180-500µl

Max. reaction time: 20 minutes

Reaction temperature: 37±0.3℃ with fluctuation of ±0.1℃

1.4 Others

Operating system: Windows XP or Windows Vista

Display: optional

System interface: RS-232 Printer: optional

Built-in bar code scanner: optional

ISE module: optional


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2 System Installation

NOTE:The analyzer should be installed or moved to another place byMindray-authorized personnel only.

2.1 Check before Installation

The user should provide the environment that meets the requirements mentioned inthe Operation Manual. Check if the environment meets the requirements beforeinstalling the analyzer. Refer to the chapter 2 of the Operation Manual for details.

2.2 Installation Procedure

1 Ensure available installation fields and environments in hospitals.

2 Confirm the reagents and calibrators.

3 Go to the installation field, and then check the delivery list for acceptance.

4 Install the four handles on the four angles of the analyzer. Move the analyzerto the installation field, fix the casters, and then remove the handles.

5 Install the computer, display and printer.6 Open the front plate, and check whether cable connections are loose. Open

the top plate, check whether the probe assemblies, reagent disk and sampledisk are intact and in good performance.

7 Connect the communication cable, power cable, grounding wire, waste tankand deionized water tank. Install the used-cuvette bucket, reagent probe,sample probe and mixing bar.

8 Top up the deionized water tank with deionized water.

9 Use syringe to inject water into the filter, and connect filter to the capassembly of the DI water tank.

10 Put reaction cuvettes in the feeder. Remember to check whether the surfacesof the cuvettes are smooth. In case of any bump, remove it before loading thecuvette to the compartment. Do not touch the light transmission part of thecuvette in which the colorimetric reading is taken.

11 Load acid and alkaline detergents to positions 46 and 47, and distilled waterto positions 49 on the reagent disk. Load distilled water to position 60 on thesample disk.

12 Switch on the analyzer as follows: POWER → ANALYZING UNIT POWER→display→ computer → printer.

13 After Windows is started, double-click the icon of BS-300 on the desktop tostart the system software. The system program will automatically finish the

self-test, become online and warm up the reaction cuvettes within about 30minutes.


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14 Select the [System/Status] menu, and then observe the system status andrecord it in the table below:

Feeder status Unconnected Full Half full Empty

Reaction disktemperature

Reagent disktemperature

Ambient temperature

Waste tank status Abnormal (full) Normal (not full)

Detergent status Abnormal (empty) Normal (available)

Printer status No printer Normal

Main control unit Unconnected Idle Running

Reaction disk unit Unconnected

Reagent disk unit Unconnected

Sample disk unit Unconnected

Loading/unloading unit Unconnected

Temperature controlunit

Unconnected

Lamp

Network connection Unconnected

Wavelength Dark current Light source base

340

405

450

510

546

578

630

670

700

Reference light system

15 Select the [System/Maintenance] menu. Then select the Motion tab page,and implement all sub-steps of each unit to see whether they are normal. Incase of any exception, adjust it.

16 Wash the interiors and exteriors of the sample probe, reagent probe andmixing bar for several times to make the fluid circuit filled.


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17 Set parameters for test, reagent and calibration under the Parameters menu.

18 Request for calibration and samples, run and then debug the results.

19 After debugging the results, fill them in the table below:

Test ALT CREA BUN

Target value

2sd range

Test value 1

Test value 2

Test value 3

Test value 4

Test value 5

Test value 6

Test value 7

Test value 8

Test value 9

Test value 10

20 Training

Can the user complete daily tests? Yes □ No □

Is the user familiar with the analytical methods such as

kinetic, two-point, endpoint?

Yes □ No □

Is the user familiar with the daily, weekly and monthlymaintenance and relevant maintenance methods?

Yes □ No □

Is the user skilled in washing dust screens? Yes □ No □

Is the user skilled in cleaning and replacing the probesand the mixing bar?

Yes □ No □

Is the user skilled in replacing the plunger assembliesof syringes?

Yes □ No □

Is the user familiar with replacing the filter? Yes □ No □

Is the user skilled in replacing the lamp? Yes □ No □

Is the user skilled in maintenance of built-in bar codescanner?

Yes □ No □

Is the user skilled in maintenance of ISE unit? Yes □ No □

Does the user know the positions, roles andpreparation methods of distilled water and acid andalkaline detergents?

Yes □ No □


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3-1

3 System Descriptions

The BS-300 analyzer consists of the analyzing unit, operation unit and output unit.

The analyzing unit consists of the dispensing system, feeder, temperature controlsystem, photometric system and fluid system.

3.1 Dispensing System

The dispensing system consists of the probe assemblies (including the reagentprobe assembly, sample probe assembly and mixing bar assembly), reagent disk,sample disk and reaction disk.

3.1.1 Probe assemblies

Among the probe assemblies, the mixing bar assembly is the same as the reagentprobe assembly and the sample probe assembly, except that the knurled axis is30cm shorter.


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System Descriptions

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Every probe assembly has a horizontal photoelectric switch and a verticalphotoelectric switch. These switches are used for defining horizontal and verticalinitial positions of probe assemblies. The horizontal and vertical step motorsprecisely control the horizontal and vertical movements of the probe assemblies, andthe synchronizing belts serve as the gearing.

The shaft and the bushing must corporate with each other precisely, so they cannotbe used confusedly.

3.1.2 Disk assemblies

The three disk assemblies are different in their coders. The coder corresponds to theposition where disks should stop. There is an initial-position mark under every coder.The three coders of the three disks have three coder transducers. Each transducerhas two photoelectric switches for inducing the rotation and initial position of thedisk.


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System Descriptions

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The step motors control the disk assemblies, and the synchronizing belts serve asthe gearing.

There is a build-in bar code scanner to the left of the sample disk. The scanner is

optional.


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System Descriptions

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Sample probe assemblyBuild-in bar code scanner

3.2 Feeder

The feeder consists of the feeder assemblies and the manipulator. It is designated tosend cuvette segments to the reaction disk, take out the used ones and abandonthem to the used-cuvette bucket.

3.2.1 Feeder assemblies

The feeder assemblies include the gearing assembly, cuvette compartmentassembly, cuvette-pushing assembly and no-cuvette detection assembly (see thefollowing figure).

The supporting plate of the feeder assemblies is a square piece of steel that isconnected to the analyzing unit by its four poles, which are secured by four nuts. Unscrewing the nuts, you can disassemble the feeder assemblies from the analyzingunit easily.


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System Descriptions

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There are five transducers that are shown in the figure below.

The no-cuvette transducer is used to detect whether there is a cuvette segment atthe loading position. The insufficient-cuvette transducer is used for determinewhether there are less than 10 reaction cuvettes in the compartment or not. If yes,the analyzer will give a prompt.

Pressure Transducer

No-CuvetteTransducer

Cuvette-PushingLimit Transducer

Insufficient-CuvetteTransducer

Cuvette-taking limittransducer

3.2.2 Manipulator

Two step motors (horizontal and vertical) supply power for horizontal and verticalmovements of the manipulator.

The upper finger and lower finger are same in their structures. They work together toreplace used cuvette segments with new ones.

The manipulator runs in a relatively complicated way. There are four transducers onit: vertical transducer, horizontal transducer and two finger transducers.


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System Descriptions

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3.3 Temperature Control System

3.3.1 Temperature control assembly

The temperature control assembly of the reaction disk consists of thetemperature-controlled pot, heat-insulating sheath/plate, top heater, bottom heater,reaction disk/cuvettes, photoelectric seat, temperature transducer, fan and controlcircuit.

1: Temperature transducer and the support

2: Fan

3: photoelectric seat

4: Heat-insulating sheath

5: top heater

6: Cover

7: temperature-controlled pot

8: bottom heater


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System Descriptions

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Upper heater: square in shape, 220/110VAC, 125W

Lower heater: ring in shape, 220/110VAC, 350W

Total power: 475W.

The function of heaters is to compensate the heat for incubating the reagent and formaintaining the temperature of the temperature-controlled chamber.

Fans are used in series in the temperature-controlled chamber. It makes the aircirculating in the chamber, and enhances the convective heat exchange. There arefour fans in the chamber. All have the alarm function.

The temperature transducer feeds back the air temperature at the position severalmillimeters from the bottom of the reaction cuvette.

The overheat protection switch is to switch off the power when the temperature

controller does work and the temperature-controlled chamber reaches 55℃, so as to

avoid overheat or fire. When the temperature-controlled chamber becomes 35℃

,this switch will automatically be reset.

3.3.2 Reagent preheating

The preheating assembly consists of two aluminum plates, a Teflon tube having nineloop sections, heating components, transducer, temperature protection switch,thermal conductive colloid, a section of tube and the reagent probe.

The temperature of the thermal source of the preheater is controlled at 45℃. The

initial temperature of the reagent is 4 ~ 10℃ when it is taken out of the refrigeration

chamber. When the reagent passes the heater, its temperature increases to 35 ℃.

Then the reagent is added into the reaction cuvette and the preheating process isfinished.


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System Descriptions

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3.3.3 Reagent refrigeration

The refrigeration module consists of refrigeration cabin, PU heat-insulating sheath,reagent disk, reagent bottle, temperature transducer, refrigeration flakes, heatsinking component, fan and control circuit. The refrigeration module is shown in thefollowing figure.

The refrigeration assembly consists of fan, hot-end radiator, POM connector,cold-end heat-conductive aluminum block, and PELTIER refrigeration flake. Eachanalyzer has two such refrigeration assemblies, as shown in the figure below. Thecold-side of the refrigeration flake clings to the refrigeration compartment, and thehot-side clings to the radiator (The side having letters should cling to the refrigerationaluminum block).

Each refrigeration flake corresponds to a heat-sinking block and a cooling fan. Itshould be installed with the cold side upward.

3.4 Photometric System

The photometric system consists of a measurement photometric system and areference photometric system. The measurement photometric system provides 9monochromatic lights to measure the absorbance of the reacting liquid in the rotatingreaction cuvettes. The reference photometric system compensates themeasurement photometric system to make the measurement more accurate.


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System Descriptions

3-9

共路

传光束小端

卤钨灯聚光镜传光束小透镜反应杯滤光片小透镜光电管

光电管

参考光路

测量光路

Tungsten-halogen

lamp Biconvex lens Main fiber

Fibers

Plano

convex lens Cuvette Fi lterPlano

convex lens Photodiode

Reference light

Photodiode

.

.

.

Measurement

lights

3.5 Fluid System

The fluid system is shown in the following figure.


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System Descriptions

3-10

As shown in the figure above, the fluid system consists of interior washing andexterior washing.

The syringe assembly controls the aspiration volume by controlling the travel of thesample/reagent syringe. It is the core part of the fluid system.

3.6 ISE Module (optional)

The ISE module that is used to measure the concentration of K+, Na

+, Cl

- and Li

+ in

serum, plasma and urine consists of ion-selective electrodes, peristaltic pumps andcalibrants.

Waste

ISEPump W Pump BPump A

Calibrant B Calibrant A


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System Descriptions

3-11


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4-1

4 Functions of Boards

The analyzer is integrated with the following boards:

Main control board

Power drive board

Sample level detection board

Reagent level detection board

A/D conversion board

Ten photoelectric conversion boards (340nm, 405nm, 450nm, 510nm, 546nm,578nm, 630nm, 670nm, 700nm and reference light)

Reagent refrigeration board

Power supply assembly

Manipulator connection board

Feeder connection board

Probes connection board

Main control board

Power drive board

Power supply assembly

PFC board

Heaters of reactiondisk

Reagent pre-heater

PC

Level detection boards

A/D conversion board Build-in sample barcode scanner

ISE module

Step motors

DC motorsLamp

Reagentrefrigeration board

Peltiers

transducers

Transducers12V&5V board

24V board

10 photoelectricconversion boards

Pumps, valves

ISE power supply board

4.1 Main Control Board

The main control board is the control center of the whole hardware system. Itconsists of the control circuits of 6 functional units (including main control unit,photoelectric unit, reagent unit, sample unit, loading/mixing unit, temperature controlunit). Each functional unit has an MCU. They communicate in the multi-unit modeand thus compose the whole control system.

The functions of the main control board are:

communicating with the PC through the RS232, receiving and analyzinginstructions from the PC and sending data to the PC.

controlling photoelectric conversion through the interface with the A/D conversionboard, reading and saving data from the A/D conversion board.

outputting control signals of each unit through the interface with the power driveboard.


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Functions of Boards

4-2

receiving signals of fluid level detection and bump collision through the interfacewith the level detection boards.

detecting signals from temperature transducers and controlling temperature of thereaction disk and reagent preheating.

receiving signals from position transducers, deionized water transducer and wastetransducer and controlling the transducers.

controlling the built-in sample bar code scanner, reading the data and sending it tothe PC.

controlling the ISE module, reading the results and sending them to the PC.

4.2 Power Drive Board

The main functions of the power drive board are to receive the control signals fromthe main control board and control drive components. The block diagram of thepower drive board is shown in the figure below.

Control signals fromMain Control Board

to 13 step motors to 2 DC motors

to 2 solenoid valves to 3 pumps

to 2 heaters ofreaction disk

to lamp powerto reagentpreheating

to 2 magnets

4.3 A/D Conversion Board

The 10 photoelectric conversion circuits convert the intensity signals of the lightstransmitting through the reaction cuvettes to electric signals, and then transmit themto the A/D conversion board through a 5-core shielded cable. Photoelectricconversion boards for different wavelengths have different gains and cannot bereplaced by each other.

The A/D conversion board filters and amplifies the 10 channels of electric signalsoutput from the photoelectric conversion boards, transmits them through themulti-way gating switch to the A/D converter and then sends them to the main controlboard for further processing.

4.4 Reagent Refrigeration Board

The circuits of the reagent refrigeration board include the refrigeration circuit and thefan circuit.

The refrigeration circuit is needed to work continuously, so it is powered separately.

The control objects of the reagent refrigeration board include:

Reagent refrigeration: 2 PELTIER components, 4 fans.


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Functions of Boards

4-3

Heat sink system for the whole device: 3 lamp-cooling fans, 4 temperature controlfans of the reaction disk.

4.5 Level Detection Boards

The level detection boards that include sample level detection board and reagentlevel detection board are used to detect the fluid level of sample and reagentseparately. When the analyzer aspirates reagents/samples, the probes dip into theliquid to a specific depth, so as to avoid carryovers that have impacts on test results,and to avoid air aspiration when the reagent/sample is insufficient.

4.6 Feeder Connection Board

The feeder connection board transfers the signals between the feeder transducerand the main control board, and connects the power drive board and the loadingmotor (DC).

Connections:

Connector Connected with

J91 Front transducer

J92 Back transducer

J93 Intermediate transducer

J94 No-cuvette transducerJ95 Pressure transducer

J96 Motor control wire (connected with the power drive board)

J97 Motor control wire (connected the motors)

J98 Cuvette-loading button

J99 Connection wire of the main control board

4.7 Manipulator Connection Board

The manipulator connection board transfers the signals between the manipulatortransducer and the main control board, and connects the power drive board and theelectromagnet.

Connections:


J101 Horizontal loading position transducer

J102 Vertical loading position transducer

J103 Electromagnet-closing transducer of the lower hand


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Functions of Boards

4-4


J108 Electromagnet-closing transducer of the upper hand

J104 Drive wire of the electromagnet of the upper hand

J105 Drive wire of the electromagnet of the lower hand

J106 Drive wire of the electromagnet (connected with the power driveboard)

J107 Connection wire of the main control board

J109 Safeguard transducer (reserved)

J110 Safeguard transducer (reserved)

4.8 Probes Connection Board

The probes connection board transfers the signals between the sample/reagent leveldetection board and the main control board, inputs the temperature signals, outputsthe reagent preheating signals, and transfers the signals between the power driveboard and the mixing motor (DC).


J200 Interface of the sample level detection board

J201 Interface of the reagent level detection board

J202 Interface of the mixing motor (DC)

J203 Sample detection signal interface of the main control board

J204 Reagent detection signal interface of the main control board

J205 Temperature control signal interface of the reaction disk

J206 Reagent preheating signal interface

J207 Interface of the power drive board

4.9 Power Supply Assembly

The power supply assembly consists of three boards: PFC board, 24V board,12V&5V board and ISE (optional) power supply board.

The functions of the PFC board include:

AC/DC conversion;

Supplying the +390V and VDD voltage to the 24V board and the 12V&5V board;

Supplying stable 12V voltage for the lamp;

Supplying control signals of the analyzing unit switch to control the C12V, 5V and24V outputs.

The 24V board converts the 390VDC current transmitted from the PFC board to theseparated 24VDC outputs through the forward converter.


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Functions of Boards

4-5

The 12V&5V board converts the 390VDC voltage from the PFC board to B12V,C12V and 5V voltages through the forward converter.

The ISE power supply board converts the 12V of the reagent refrigeration board to24V that provides power supply for the ISE unit (optional).


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5-1

5 Maintenance and Service

WARNING:

Before disassembling or assembling the analyzing unit, ensure thePOWER is placed to OFF.

The probe tip is sharp and can cause puncture wounds. To preventinjury, exercise caution when working around the probe.

BIOHAZARD:

Wear gloves and lab coat and, if necessary, goggles.

Dispose of the waste in accordance with your local or nationalguidelines for biohazard waste disposal.

CAUTION:Please use Mindray-recommended consumables. Other consumablesmay decrease the system performance.

Refer to the BS-300 Chemistry Analyzer Operation Manual for details about

unclogging the sample probe

unclogging the reagent probe

replacing the sample probe

replacing the reagent probe

replacing the mixing bar

replacing the plunger assembly of syringe

replacing the lamp

5.1 Replacing Light Filter Assembly

The light filter and optical assembly are fixed in the supporting sleeve. The back endis compacted and enclosed with the photoelectric amplification board and the screengland. Generally, the supporting sleeve is replaced together with the filter and opticalassembly.


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Maintenance and Service

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Figure 5-1 Light filter assembly

Supporting Sleeve

GasketFilter

Flat Spring

Lens

GasketLens Seat

PhotoelectricConversion Board

Screw Shield Box

WARNING:

Before operating, ensure to place the POWER (main switch) to OFF.

1 Unscrew (counter clockwise) the two cap screws on the screen glandwhose wavelength is to be replaced.

2 Open the cover of the A/D conversion board, and unplug the plugcorresponding to certain wavelength.


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5-3

3 Take out the photoelectric conversion board and the supporting sleeve.

4 Keep the photoelectric conversion board upward, and loosen the tworetaining screws on it.

5 Keep the photoelectric conversion board upward, and pull the photoelectricamplification board out of the supporting sleeve.

6 Unpack the new supporting sleeve containing the optical assembly. Be sureto keep the top side (where to assemble the photoelectric amplificationboard) of the supporting sleeve upward.

7 Install the original photoelectric conversion board onto the new supportingsleeve, and then fasten the two retaining screws.

8 Install the screen gland, and fasten the retaining screws.


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5-4

9 Connect the photoelectric conversion board to the A/D conversion board,and assemble the cover.

WARNING:

When replacing the light filter assembly, do not touch the opticalassembly in the supporting sleeve and the photoelectric receiving tubeof the photoelectric conversion board by hand.

The light filters and the photoelectric conversion boards are inone-to-one relationship. Do not disarrange them.

5.2 Replacing Optical Fiber

WARNING:

Before operating, ensure to place the POWER (main switch) to OFF.

1 Unscrew the four screws on the supporting pillars of the cuvette feeder, andremove the cuvette feeder.


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5-5

2 Unscrew the four screws on the reaction disk cover, and open the reactiondisk cover.

Attention should be paid to the power cable of the upper heater when thereaction disk cover is being opened.

3 Take out two cuvette segments in a diagonal with the needle-nose pliers tomake two spaces for disassemble the colorimetric disk.


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4 Unscrew three M3 cap screws, and then disassemble the colorimetric disk.

5 Use an M3 cap screwdriver to loosen the retaining screws of the opticalfibers on the colorimetric clamp and the reference light support.

6 Take out the optical fibers one by one, and fix the optical components in thecolorimetric clamp by fastening the screws slightly.

Screw of the reference light

7 Draw out all the nine optical fibers from the reaction compartment.


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5-7

8 Loosen the M3 cap screw (used for retaining optical fibers) on the lamphousing, and then draw out the optical fibers.

9 Put nine of the ten branches of the new optical fiber into the reaction diskfrom its bottom one by one, loosen the retaining screw, insert the opticalfiber to the end, and then fasten the retaining screw.

10 Fix the reference light optical fiber.

11 Fix the optical fiber of the lamp housing.

12 Put the colorimetric disk back and fix it.

13 Put the reaction disk cover back and fix it.

14 Install the cuvette feeder and fix it.

CAUTION:

When replacing the optical fiber, ensure that its bending radius is noless than 20cm. Otherwise, the optical fiber will be damaged.

5.3 Adjusting Reaction Disk, Manipulator and Feeder

NOTE:

Debug the lower arm first (The relation between the lower arm position

and the reaction cuvette position is very important.), and then the upperarm. When debugging the lower arm, move the cuvette compartmentaside.


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5-8

1 Disassemble the cuvette feeder, and adjust the circular position of thereaction disk (through the initial position transducer of the reaction disk) tothe standard position (The finger of the lower arm points to the center of theslot between reaction cuvette segments).

2 Horizontally adjust the manipulator to the standard position (The finger ofthe lower arm can work on reaction cuvettes well, and it should be 0.2mmaway from the nearest point of the reaction cuvette).

3 Vertically adjust the manipulator the standard position (The finger of thelower arm can work on reaction cuvette well, and the finger support of thelower arm should be 0.15mm above the reaction cuvette.).


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5-9

4 Run the manipulator to the position for taking new cuvettes, andhorizontally adjust the reaction cuvettes in the feeder. When catching acuvette, ensure a clearance of 0.4mm ~ 0.6mm between the finger of theupper arm and the cuvette, and center them.

5.4 Adjusting Probes and Disks

NOTE:Adjust the positions of the three probes and reaction cuvettes, and thenothers.

Adjust the working position of the reagent probe (To minimize thecumulative error, ensure that the reagent probe return to the initial positionbefore each adjustment.) as follows:

A For the reagent discharging position, ensure the reagent probe is inthe center of the reaction cuvette and the probe tin is 2 ~ 3mm awayfrom the bottom of the reaction cuvette.

B Adjust the position of the initial-position transducer of the reagentdisk. Ensure the mouths of reagent cuvettes in the inner and outercircles fit the reagent disk cover well.

C Adjust the washing position of the reagent probe. Ensure the reagentprobe is in the center of the wash well and the probe pin is 5mmaway from the bottom of the wash well. If necessary, adjust theposition of the wash well.

D Adjust the reagent probe’s position on the outer circle of the reagentdisk. Ensure the reagent probe is in the center of the hole of the outercircle.

1

E Adjust the reagent probe’s position on the inner circle of the reagentdisk. Ensure the reagent probe is in the center of the hole of the innercircle.

Adjust the working position of the sample probe (To minimize thecumulative error, ensure that the sample probe return to the initial positionbefore each adjustment.) as follows:

A For the sample discharging position, ensure the sample probe is inthe center of the reaction cuvette and the probe tin is 2 ~ 3mm awayfrom the bottom of the reaction cuvette.

2

B Adjust the position of the initial-position transducer of the sampledisk. Ensure the mouths of sample cuvettes in the inner and outer

circles fit the reagent disk cover well.


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5-10

C Adjust the washing position of the sample probe. Ensure the sampleprobe is in the center of the wash well and the probe pin is 5mmaway from the bottom of the wash well. If necessary, adjust theposition of the wash well.

D Adjust the sample probe’s position on the outer circle of the sampledisk. Ensure the sample probe is in the center of the hole of the outercircle.

E Adjust the sample probe’s position on the inner circle of the sampledisk. Ensure the sample probe is in the center of the hole of the innercircle.

Adjust the working position of the mixing bar.

A Switch off the analyzing unit first, and then rotate the mixing arm tosee if its rotation radius is proper. If the mixing bar cannot reach thecenter of the reaction cuvette, adjust the position of the mixing bar onthe mixing arm properly.

B Disassemble the mixing arm, and then switch on the analyzing unit to

run the reaction disk and stop it at any cuvette. Hold the mixing armby hand, and fix it at the center of the reaction cuvette.

C Vertically adjust the mixing bar’s position in the reaction cuvette.Ensure the mixing bar tip is 1 ~ 2mm away from the bottom of thereaction cuvette.

3

D Adjust the washing position of the mixing bar. Ensure the mixing baris in the center of the wash well and about 5mm away from thebottom of the wash well. If necessary, adjust the position of the washwell.

4 In the engineering adjustment software, select the Debug instruction menu, and rotate the reaction disk for one lap. Dive probes and mix thereactant at every position or every several positions to see if the threeprobes interfere with any reaction cuvette (Command 61). If the mixing barknocks the side or the bottom of any cuvette, repeat Step 3.

5.5 Replacing the filter assembly

1 Remove cap assembly from the DI water tank and place it on a cleandesktop. Carefully remove the filter assembly from the cap assembly.


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2 Inject water into the new filter assembly through the big adapter by usingthe syringe. When water wells up from the small adapter, the injection iscompleted. Purpose: increase the weight of the filter assembly to makeit sink to the bottom of the water tank.

3 Connect the new filter assembly to the tubes of the cap assembly.


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5-12

4 Expel air from the filter assemby

1) Put the assembly into the water tank and make sure that the filter

sink smoothly to the tank bottom and does not twist with the floater

connecting rod. Tighten the cap of the DI water until secure.

2) Place the Main Power and Power of the analyzer to ON. Turn on

the computer and start the operating software.

3) Reset 10 times (click Motion and then select Others , click Reset

Mechnical Parts ) to expel the air in the filter assemby and the

tubes.

4) Check for large amount of buubles in the outlet tube. If yes, continue the

resetting process; if not, the air expelling is completed.

5

The installation is completed.


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5-13

5.6 Replacing Components of ISE Unit (optional)

5.6.1 Replacing Tubing

NOTE:(1) Fluidic tubing can be divided into the following six types.

W1 with two adapters connects the ISE module and the pump W.

Pump module

ISE module

Reagent module to beplaced here

Pump tubing

Pump tubing adapter

Pump B Pump A Pump W

Pump head

Fluidic tubing adapter

W2 connects the reagent module and the pump W.

A1 (B1) with one adapter connects the sample entry port and the pump

A (pump B).

A2 (B2) with two adapters connects reagent module and the pump A(pump B).

They are different in length and W1, A2 and B2 are not directionalwhen they are installed.

Usually the adapter has not been mounted to the fluidic tubing, so youhave to do it by hand. The tubing should be mounted to a short metallictube on the adapter. For convenience, the connecting end of the tubingcan be dipped into hot water for several seconds.

(2) Pump tubing is used around a pump head. It has one adapter on

each end that makes connection with the fluidic tubing easy.


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5.6.1.1 Replacing Fluidic Tubing W1 and W2

1 Place the POWER to OFF.

2 Open the ISE unit door.

3 If you want to replace the W1, unscrew the screw of the ISE module andtake off the cover.

4 Put out the fluidic tubing W2 and insert it into a container such as a cup thatis used to contain the waste solution flowing from the W2.

5 Start the analyzing unit and the system software.

6 Enter the ISE Maintenance screen of the system software.

7 Click the Maintenance button several times until there is no solutionflowing out from the W2.


9 If you want to replace W1, pull out its two adapters directly from the wastepump tubing adapter and the right angle adapter that is fixed to thecompression plate.

Right angle adapter

The side matchesthe adapter offluid tubing W1

The side with a recessmatches the compressionplate of the ISE module.

Note that when pulling out the fluidic tubing adapter, in order not to releasethe right angle adapter, you can hold the right angle adapter with a finger.

After that, install a new W1. For W2 exchange, it just needs to replace theW2 with a new one.

10 If you want to replace the W2, replace it with a new one. Otherwise, insertthe W2 back to the reagent module.

11 Place the POWER to ON.

12 Enter the System Maintenance screen of the system software.

13 Select the Others tab and click the Download Settings button.

14 Enter the ISE Maintenance screen.

15 Click the A purge button to observe if there is solution leaking out. If thereis solution leaking out, repeat from the step 4 to install the tubing again.

16 Install the cover of the ISE module if it has been taken off.

17 Close the ISE unit door.


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5.6.1.2 Replacing Fluidic Tubing A1, A2, B1 and B2


2 Take off the panel under the sample disk and you can see the shielding boxand the peristaltic pumps.


4 Take out the reagent module.

5 Put the fluidic tubing W2 in a container such as a cup that is used to containthe fluid flowing out from the W2.



8 If you want to replace A1 or A2, click the A purge button. If you want toreplace B1 or B2, click the B purge button.

Repeat this step for several times until the received data indicates that theCalibrant A or Calibrant B has air bubble in it.


10 Replace the tubing with a new one.

Note that before installing the A1 or B1 to the sample entry port, you candip the connecting end of the A1 or B1 into hot water for several minutes tomake the following procedures easily performed.

11 Start the analyzing unit.

12 If the system software is not running, start it. Otherwise, enter the System Maintenance screen of the system software, select the Others tab and

click the Download Settings button.


14 If you have replaced A1 or A2, click the A purge button. If you havereplaced B1 or B2, click the B purge button.

Repeat this step for several times until the received data indicates that theCalibrant A or Calibrant B has no air bubble in it.

5.6.1.3 Replacing Pump Tubing



3 Pinch one adapter of the pump tubing and take it out from the tubing shelf.Then take off the whole tubing.

Tubing shelf


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5-16

4 Put one adapter of the new pump tubing onto the tubing shelf and make thetubing around the pump ahead, then put the other adapter onto the shelfwith a little strength.



7 Click the Pumps button to see if the calibration of pump is correct. If not,repeat the upper steps.

5.6.2 Replacing Pumps


2 Take off the pump tubing around the pump head.

3 Disconnect the cable and the pump motor.

Pump motor

Cable

4 Unscrew the four screws around the pump head.

5 Pull out the pump directly.

6 Put a new pump on the pump shelf, tighten the screws, connect the cableand pump motor, and then put the pump tubing around the pump head.



9 Click the Pumps button to see if the calibration of pump is correct. If not,repeat the upper steps.

5.6.3 Replacing ISE Module

Some times there is something wrong with the components in the ISE module suchas sample entry port, bubble detector, PCB and so on. In these cases, the ISEmodule should be replaced according to the following procedure.


2 Take off the panel under the sample disk and you can see the shielding boxand the pumps easily.





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5-17

6 Click the Maintenance button.


8 Unscrew the screw of the ISE module and take off the cover.

9 Take off all electrodes from above to below.

10 Disconnect the right angle adapter and the compression plate.

11 Disconnect the cable.

12 Unscrew the four screws that fix the ISE module to the shielding box. Thentake out the module from the shielding box.

13 Put a new ISE module to the shielding box. Then connect the cable andinstall the electrodes sequentially. At last mount the right angle adapter tothe compression plate.

14 Install the electrodes sequentially.

15 Enter the System Maintenance screen of the system software.

16 Select the Others tab and click the Download Settings button.


18 Click the A purge button to see if there is solution leaking out. If there is,take off the electrodes and install them again.

19 Check if the new ISE module can work normally.


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6-1

6 Software Introduction

The software of BS-300 analyzer is composed of the system software and the control

software.

6.1 System Software

The system software can, according to the requirements and inputs of users,generate a work schedule (instruction sequence), control the units of analyzing unit inthe sequence of instructions in the work schedule, receive photoelectric data,response messages or execution results from the analyzing unit, output them to thePC screen or the printer. With these outputs, users can obtain correct test results.

According to different functions, the entire PC software system can be divided into the

following parts:

System Initialization

This part includes the initialization of the PC operating system, the initialization of thecommunication between the PC and analyzing unit, and the controls of analyzing unitreset.

Control system

This part includes the formation of the work schedule, instruction data sending andreceiving.

GUI

This part includes the requests for tests (routine tests, emergency tests, calibrationtests and QC tests), the observation of test status (status of the reaction disk, sampledisk and reagent disk), test management, calibration management, QC management,result query, alarm management and the help system.

Shutdown Processing

This part includes the resets of sub-units.

6.1.1 System initialization

To initialize the PC operating system,

Check the PC operating system. The system software must run under Windows2000 or Windows XP. Otherwise, the system will prompt that the system softwarecannot run under other operating system, and then the system software systemexits automatically.

Check the current screen resolution for the operating system. The system software

must run under the resolution of 1024 × 768. Otherwise, the system prompts toreset the resolution before restarting the system software and exit the systemsoftware.

Disable the screen protection program. The system software must keep displayedwhile running. To prevent the screen protection program from disturbing users inthe operating and observing processes, disable it.

Lock the keyboard. When running, the system software will lock some keycombinations to prevent users from starting any other program and conducting any


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other operation. In this case, users cannot switch over to any other program orprint the current screen.

Check whether there is any username and password of themaintenance/debugging personnel in the registry. The system software has thedebugging function. Only the authorized maintenance/debugging personnel canenter the debugging window and maintain or debug the system and the host. For

the confidentiality, the username and password are saved in the registry. If theyare unavailable in the registry, the system will re-write the default username andpassword into the registry.

To initialize the communication and the units auto-check,

Set serial ports and initialize them, including such parameters as the baud rate,data bit, start bit, stop bit, parity bit, transmitting/receiving buffer, control protocoland so on. In addition, start the serial port receiving thread.

Handshake for communication. Send a handshake instruction to the analyzing unit.If the analyzing unit responds to this instruction (namely, send back a handshake

instruction to the PC), it indicates the PC handshakes with the host successfully. Ifthe host fails to respond to handshake instruction, it will re-send the handshakeinstruction back in a specific period. If it fails for continuously three times, thesystem will prompt to exit the system software. If you ignore that and continue toenter the system software, all tests cannot be conducted under the system.

Check whether the printer is connected. If not, the system will prompt to connect it.

Send an instruction for querying the auto-check results of the units, check theauto-check result of each unit. (The units are auto-checked when the analyzingunit is started, and the auto-check results are stored in the main unit.) In case ofany fault data in the auto-check result of any unit, the system will prompt to switchoff the analyzing unit and check the faulty unit.

6.1.2 Shutdown processing

In the BS-300 Chemistry Analyzer Control System window, click the Exit button.The Confirm dialog box appears. If you click OK, the system will

Switch off the lamp;

Unload all reaction cuvettes;

Wash the fluid tubing;

Reset all units;

Unlock the keyboard;

Prompt to exit the operating system and shut down the PC.

6.2 Control Software

The analyzing unit can be functionally divided into the following units: photoelectricunit, reaction disk unit, reagent disk unit, sample disk unit, reagent probe syringe unit,sample probe syringe unit, mixing bar unit, loading and manipulator unit, temperaturecontrol unit, fluid tubing unit and reagent refrigeration unit. The functions of thoseunits are listed in the following table.


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Unit Function

Main unit Receives macroinstructions from the PC, decomposes theminto a series of action instructions, and then delivers theaction instructions to destination sub-units (in specific order)at a certain interval.

Monitors the status of other units, and transmits datacollected by the photoelectric unit to the PC.

Photoelectricunit

Photoelectrically detects, amplifies and converts the solutionin reaction cuvettes, and stores A/D converted data at thetwin port FIFO for the main unit to read and transmit them tothe PC.

Reaction diskunit

Contains 80 cuvette No.

Runs the reaction cuvette with the specified No., followingthe instruction of the main unit, to the reagent dispensingposition, sample dispensing position, mixing position, andphotoelectric detection position at all wavelengths.

Reagent diskunit

Contains 50 bottle positions.

Carries reagents, and runs the reagent bottles with specifiedNo., following the instruction of the main unit, to the reagentaspirating position.

Sample diskunit

Contains 60 tube positions in the inner and outer circles.

Carries samples, and runs the sample tubes with specifiedNo., following the instruction of the main unit, to the sampleaspirating position.

Reagent probe

syringe unit

Receives instructions from the PC, and controls the reagent

probe in aspirating a specific volume of reagent from thereagent bottle and dispensing it to the specified reactioncuvette.

Sample probesyringe unit

Receives instructions from the PC, and controls the sampleprobe in aspirating a specific volume of sample from thesample tube and dispensing it to the specified cuvette.

Mixing bar unit Receives instructions from the PC, and controls the mixingbar in mixing the solution in the cuvette that has been run tothe mixing position.

Runs the mixing bar to the wash well, and wash it after eachmixing process to avoid carryover.

Loading andmanipulatorunit

Controls the cuvette feeder and manipulator.

The feeder assembly is responsible for detecting whetherthere are enough reaction cuvettes in the cuvettescompartment and pushing reaction cuvettes to the positionfor the manipulator to take cuvettes.

The manipulator is responsible for taking reaction cuvettesfrom the reaction disk, placing them into the used cuvettebucket, taking new reaction cuvettes from the cuvettecompartment, and putting them on the reaction disk.


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Unit Function

Temperaturecontrol unit

Controls the reaction disk temperature, reagent probepreheating temperature and fluid tubing.

Note: The reaction disk temperature should be kept at 37 ,℃the heating cavity of the reagent probe should be preheated

to 45℃.

Fluid tubing unit Controls the fluid tubing in washing the reagent probe,sample probe and mixing bar.

Reagentrefrigerationunit

Refrigerates the reagent chamber and controls itstemperature between 4 ~ 10 .℃


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7-1

7 Service Flow

WARNING:

Before disassembling or assembling the analyzing unit, ensure thePOWER is placed to OFF.

The probe tip is sharp and can cause puncture wounds. To preventinjury, exercise caution when working around the probe.

When you disassemble or replace any board, ensure to wear antistaticgloves.

BIOHAZARD:

Wear gloves and lab coat and, if necessary, goggles.

7.1 Fluid Level Detection Failure of Reagent Probe

Surfacedetectionfailure of

reagent

probe(The reagent

probedoes not

detect

thesurface

on thereaction

disk.)

Thereagent

probecannot

detect

thesurfaceon the

reagent

disk

Thereagent

probe mis-detected

the surface

Surface detection signal transmission error: The surface detectionboard does not have the working voltage, or when the probe touches

the surface, the indicator of the surface detection board is normal, but

there is always a host alarm indicating surface detection failure.Possible cause: The patch cord for the reagent surface detection is

disconnected, or the connector is not well connected.

Surface detection signal processing error: When the probe touches

the surface, the indicator of the surface detection board is normal, theconnection between the main control board and the surface detection

board is normal, and no surface detection signal reaches the maincontrol board, but there is always a host alarm indicating surfacedetection failure.

Possible cause: Main control board.

Surface detection board failure: When there is no probe

failure, but the indicator is always on, or the indicator isnot on when the probe touches the surface, there must

be a surface detection board failure.Troubleshooting: Replace the surface detection board.

Power failure: The working voltage of the surface

detection board is 12V. In case of no power supply, the

surface detection signal cannot be generated.Possible cause: Disconnection; the connector is not well

connected; there is no 12V output from the main controlboard.

Probe failure: The detection terminal has a changeablecapacitance. Loose exterior or interior of the probe, thesealing-off of the probe connecting wire and the probe

breakage will result in unsteady voltage or obvious

voltage changes. In this case, the capacitance signalwill be unavailable or exceed the range of the surfacedetection board.

Possible cause: Reagent probe assembly, connector.

The surfacedetection

signal failsto be

generatedby

capacitance

change.

When this failure occurs, the sample probe cannot detect

the surface at the reaction disk, but there is no alarm at

the reagent unit. For details, see Surface DetectionFailure: Sample Probe.


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7.2 Fluid Level Detection Failure of Sample Probe

Surface

detectionfailure of

the

sample

probe

The sampleprobe cannot

detect thesurface at the

reaction disk.

The sampleprobe cannot

detect thesurface at thereaction disk.

The sample

probe mis-detects thesurface (In

this case,there will beno alarm, buttest results

will becomeabnormal. Onthe reaction

curve, youcan see thatno sample isadded.)

No reagent in the reaction disk: The reagent probe mis-

detects the surface, aspirates air and dispenses into thereaction cuvette. Therefore, the reagent unit CPU fails tomake any judgment. In this case, the sample probe cannot

detect the surface when dispensing the sample into thisreaction cuvette.

Possible cause: Surface detection failure of the reagent probe

insufficient reagent: The reagent probe aspirates less reagent

than the set volume. As a result, the sample probe cannot

detect the surface at the preset height.Possible cause: The reagent is prepared in the bottle, the

reagent syringe is not fixed, leakage occurs in the tubing ofthe reagent probe, or there are bubbles in the reagent.

Position correction parameter error of the sample probe: Incase of such an error, the sample probe cannot reach the

surface in the steps.Troubleshooting: Re-correct the sample probe position.

Surface detection signal transmission failure: When the probe

touches the surface and stops, the indicator of the surfacedetection board is on for about 2 seconds. The output signalof the surface detection board switches normally, but there isalways a host alarm indicating that no surface is detected.Possible cause: The patch cord for detecting the sample

surface is disconnected, or the connector is not well

connected.

Surface detection signal failure: The indicator of the surface

detection board is not on or always on when the sample

probe touches the surface.

Surface mis-detection at the sample disk: In this case, there

will be no alarm, but the sample probe fails to aspirate thesample, and the test result and reaction curve becomeabnormal.

Possible cause: Sample probe, surface detection board,surface detection patch cord.

Signal processing failure of the main control board: When the

probe touches the surface, the indicator works normally. Butthere is always a host alarm indicating that no surface isdetected. Ensure that the sample surface detection signal is

transmitted to the relevant connector of the main controlboard.

Possible cause: Main control board failure

Surface mis-detection at the reaction disk: In this case, there

will be no alarm, but there is residual sample on the sampleprobe tip, and drops on the table when the probe leaves the

reaction disk.

Possible cause: The sub-unit software is later than V1.7, orthe sample probe is not in the center of the reaction cuvette.


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Service Flow

7-4

7.4 Failing to Detect Level of Water for Washing Exteriors

Surface detection signal failure:See relevant resolutions for the

surface detection failure.

No water in thewash well

Reagent or sample probe.Solution: Replace a probe

Failing toDetect theSurface ofthe Water

forWashingExteriors

No water in the wash water tank: Userscan see this failure in the alarm

information detergent empty . In case ofno alarm information, check whether

there is any problem in the detergent tank

cover assembly.

Pump damaged: In this case, there willbe no water in the three wash wells.

Troubleshooting: Replace the pump.

Tubing blocked: In this case, there will beinsufficient water for washing exteriors,the three water flows are not the same, orthere will be no water in any of the threewash wells.Possible cause: The unidirectional valveis blocked, or the detergent entrance is

blocked.

The tube is disconnected.Possible cause: The tube is degraded, orother causes.

Troubleshooting: Connect the tubesagain.


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7-5

7.5 Abnormal Results

7.5.1 All Results Being Abnormal

All testresults areabnormal

All results arelower than

normalresults.

Some resultsare higher,

and some arelower, with

badrepeatability.

No sample or insufficient sample is added.In this case, it can be seen on the reaction curve thatthe absorbance has not increased in the period foradding the sample. The reaction curve is even, andmany results are 0.

Possible cause: Sample probe blocked, tubing

leakage, syringe not fixed, valve not shut tightly.

The reaction is not thorough.If the sample is not mixed uniformly with the reagent,the reaction will not be thorough, and the light cannotdetect the changes of the absorbance.

Possible cause: The mixing bar did not mix thereacting liquid.

The volumes of dispensed sample are not the same.In this case, it can be seen from the reaction curvethat the response is proportional to the volume of thesample.Possible cause: Tubing leakage, valve not shuttightly, or cuvette segments not cleaned well.

7.5.2 Some Results Being Abnormal

Some test results areabnormal.

Good repeatabilityTroubleshooting: Re-calibrate it.

Bad repeatabilityObserve the reaction curve, and find the possible

causes.

All test results are approaching to 0.Observe the reaction curve first.

Possible cause: The lamp base of correspondingwavelength exceeds 65535; the photoelectricdetection unit fails to detect the change ofabsorbance, reagent failure and optical fiberdisconnection.


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7.5.3 Several Results Being Abnormal

Several test results areabnormal

Several test results are too low.In this case, observe the reaction curve first.

Possible cause: Drips dropping from the sampleprobe

Several test results suddenly become too high.In this case, observe the reaction curve first.

Possible cause: There are bubbles in the currentcuvette; the mixing bar knocks the cuvettes.


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7.6 Insufficient Light Intensity of Lamp

Estimate whether thelamp has worked for

2000h (lifetime),replace Lamb Replace the lamp.

Check whether the AD value of thechannel whose lamp vase value is

smaller increases obviously.

Record the lamp background value and gain

Measure and record the lamp background value and gain

Replace lamb

Insufficient LightIntensity of the Lamp

Lamp background values of allchannels decreases.

Lamp base values of severalchannels decreases

Adjust the gain parameter to make thelamp base AD values of all channel

lamps increase to about 62000.

Y E

S

YES

Replace the lamp withthe original lamp

Replace the photoelectric transducerassembly, and then check whether thelamp base value increases obviously.

Replace thephotoelectric

transducer assembly.Change the positions with thesmaller fiber end, and checkwhether the lamp base value

increases obviously.

Check whether the photometricsystem (such as the lens)

corresponding to the fiber channelis covered with dirt or the like. (Ifyes, clean it.) Then check whether

the lamp base value increasesobviously

Replace the opticalfiber

Clean thephotometric system(such as the lens)

Remove the fault alarm

N O

YES

NO

YES

N O

YES

Note:

Do not adjust the photoelectric gain parameter in case you have no idea about thecause for the alarm indicating insufficient light intensity of the lamp.


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7.7 Temperature Control Failure

Temperature control failure

Query and record thefault log codes and

descriptions.

Monitor the temperaturecurve.

Obtain the currenttemperature control

parameter, and checkwhether it is the same as the

factory parameter.

Enable and disable thetemperature control functionrepeatedly for 2 ~ 3 times

Check whether the temperaturetransducer is normal.

Check whether the heatingresistance is normal.

Replace thetemperature

transducer.

Replace the heatingassembly.

Restart the analyzer and thencheck whether it is normal.

y e s

NO

NO

Y E S

To monitor the temperature curve

A In the BS-300 Chemistry Analyzer Control System window, selectthe [System/Temperature] menu. A dialog box appears. EnterBS300DEBUG and MINDRAY respectively in the User Name andPassword text boxes. Then click OK to enter the TemperatureControl Curve window.

1

B Set a proper temperature range for observing the change of the

temperature curve, and then click the Start button.


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C Minimize the Temperature Control Curve window for futureobservation at any time.

D After that, print or snap the temperature curve and then return it tothe headquarters together with the service work report.

To measure the impedance of the temperature transducer

A Switch off the BS-300 analyzer.

B Open the left side plate of the BS-300 analyzing unit to expose themain control board.

C Unplug J45 (reagent preheating temperature transducer), andmeasure the resistance between PIN1 and PIN3 with a multimeter.

The relation between the resistance and the temperature is: 25℃

/1100Ω, 38.5℃ /1145Ω, 45℃ /1170Ω, 50℃ /1170Ω.

2

D Unplug J44 (reaction disk temperature transducer), and measure theresistance between PIN1 and PIN3 with a multimeter. The relation

between the resistance and the temperature is: 25℃ /1100Ω, 38.5℃

/1145Ω, 45℃ /1170Ω, 50℃ /1170Ω.

To measure the resistance of the heater

A Measure the impedance of the reagent preheater in the followingprocedures:

Unplug J24 (power driving board)

Measure the impedance between PIN1 and PIN2. Reagent preheater(BA30-10-06626)/24.6 to 28.5Ω.

3

B Measure the impedances of the upper and lower heaters of thereaction disk in the following procedures:

Disconnect the connecting wire from P406 of the power patchingboard.

Measure the impedances of the upper and lower heater:

For 220V heaters: Upper heater: 348.5 - 425.9Ω,

Lower heater: 124.2 - 151.8Ω;

For 110V heaters: Upper heater: 87.1 - 106.5Ω,

Lower heater: 31.1 - 38.0Ω;

7.8 Bar Code Scanner (optional) Failure

WARNING:

Light sent by the bar code scanner may hurt your eyes. Do not stareinto the laser beam from the bar code scanner.

If the bar code scanner cannot emit laser, you can service it according to the followingsteps.


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1 Place sample tubes with bar code labels that meet the requirementsmentioned in the operation manual.

2 Restart the analyzer.

3 Enter the Scanner Setup & Maintenance screen of the system software.

4 Enter the Maintenance tab.

5 Enter the sample position range in the Sample Position field and click theStep Scan button. Observe if the scanner can emit laser. If not, click theLaser on button. If the scanner still cannot emit laser, go to the next step.

If the bar code scanner emits laser normally but is failed in reading, you can service itaccording to the following steps.

1 Place the ANALYZING UNIT POWER to OFF.

2 Place sample tubes with bar code labels that meet the requirements

mentioned in the operation manual.

3 See if the window on the sample department is stained. If so, clean thewindow with absolute alcohol-dipped gauze and go to the next step. If not,go to the step 8.

4 Restart the analyzer.

5 Enter the Scanner Setup & Maintenance screen of the system software.


7 Enter the sample position range in the Sample Position field and click theStep Scan button. Observe the scanning procedures to see if the scanner

can read the bar codes. If not, go to the next step.8 Enter the Setup tab.

9 Select all symbologies but do not select any Check or Length.


11 Click the Scan button to see if the scanner can read the bar codes. If not,go to the next step.

12 Place the test fixture to the position 28 on the sample disk.

13 Click the Mechanism button at the System Maintenance screen to resetall mechanical parts. If the laser from the scanner cannot reach the bar

code through the slit on the test fixture, adjust the screws on the brackets until the laser from the scanner can reach the bar code.


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Bracket 1

Bracket 2

14 If the scanner cannot read the bar codes successfully, replace the bar codescanner. If the new scanner cannot read the bar code, you need to checkthe bar code labels the user used.

7.9 Feeder Failure

7.9.1 Transducer Distribution of the Feeder

Pressure Transducer

No-Cuvette

Transducer

Cuvette-Pushing

Limit TransducerInsufficient-Cuvette

Transducer

Cuvette-taking limittransducer


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7.9.3 Manipulator Failure

ManipulatorFailure

Manipulator vertical-move

bs-300 service manual(v5.0)

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