brochure june2019 organic - graduate center, cuny• bioorganic chemistry • organometallic...
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PublicationsA. Valles, D.J., Naeem, Y., Carbonell, C.,
Wong, A.M., Mootoo, D.R., Braunschweig,A.B. Maskless Photochemical Printing ofMultiplexes Glycan Microarrays for High-Throughput Binding Studies. ACSBiomaterials Science & Engineering, 2019,5, 3131-3138.
B. Zhao, S., Gensch, T., Murray, B., Niemeyer,Z.L., Sigman, M.S., Biscoe, M.R.Enantiodivergent Pd-catalyzed C-C bondformation enabled through ligandparameterization. Science, 2018, 362, 670-674.
C. M.K., Akula, H.K., Satishkumar, S., Stahl, L.,Lakshman, M.K. Ruthenium-Catalyzed C-HBond Activation Approach to Azolyl Aminalsand Hemiaminal Ethers, MechanisticEvaluations, and Isomer InterconversionACS Catalysis, 2016, 6, 1921-1928. (IssueCover)
Research Areas• Organic Synthesis • Catalysis • Carbohydrate chemistry• Bioorganic Chemistry • Organometallic Chemistry • Synthetic methodology• Medicinal Chemistry • Materials Science • Natural products
Organic chemistry research at CUNY involves over 25 facultycovering the full range of modern organic chemistry from totalsynthesis of natural products, to novel method development, tomaterials and medicinal applications. Faculty have receivedprestigious national awards including Fulbright Fellowships andthe Harry Wasser Award. Our graduates go on to successfulpost-doctoral positions, careers in industry (Merck;GlaxoSmithKline; LivWell) and academia (Emory University,North Dakota State University).
Organic ChemistryProf. Ryan Murelli, Subdiscipline [email protected]
Mark R. BiscoeAssistant Professor of ChemistryThe City College of New York160 Convent Ave.New York, NY [email protected]://www.sci.ccny.cuny.edu/~mbiscoe/index.html
PublicationsLi, L.; Zhao, S.; Joshi-Pangu, A.; Diane, M.;Biscoe, M. R. J. Am. Chem. Soc. 2014, 136,14027-14030.
Li, L; Wang, C.-Y.; Huang, R.; Biscoe, M. R.Nature Chem. 2013, 5, 607-612.
Joshi-Pangu, A.; Biscoe, M. R. Synlett 2012, 23,1103-1107.
Joshi-Pangu, A.; Ma, X.; Diane, M.; Iqbal, S.;Kribs, R.; Huang, R.; Wang, C.-Y.; Biscoe, M. R.J. Org. Chem. 2012, 77, 6629-6633.
Joshi-Pangu, A.; Wang, C.-Y.; Biscoe, M. R. J.Am. Chem. Soc. 2011, 133, 8478-8481.
Joshi-Pangu, A.; Ganesh, M.; Biscoe, M. R. Org.Lett. 2011, 13, 1218-1221.
Research InterestsKeywords: Transition metal catalysis, Organic synthesis, Asymmetric synthesis
Broadly, research in the Biscoe group focuses on catalysis. The two major types of catalysis in which weare interested are transition metal catalysis and macromolecular catalysis. Our primary goals involve thedevelopment of practical and reliable processes for the construction of C–C and C–X (X = heteroatom)bonds. We are particularly interested in the development of new processes for the formation of commonstructural motifs of importance in medicinal chemistry and drug discovery.
Prof. Biscoe is anorganic/organometallicchemist interested in thedevelopment of newreaction methodologies forapplication in drugdiscovery.
2009- current Professor, City College of New York2005-2008 NIH Postdoctoral Fellow, MIT2000-2005 PhD, Columbia University
Dr. Mark R. Biscoe
Elise ChampeilAssociate ProfessorJohn Jay College of Criminal Justice524 west 59th streetNew York, [email protected]://www.jjay.cuny.edu/faculty/elise-champeil
Publications
1- Aguilar W., Paz M. M., Vargas A., Clement C. C., Cheng S.Y., Champeil E. “Sequence-Dependent Diastereospecific and Diastereodivergent Crosslinking of DNA by Decarbamoylmitomycin C”, Chemistry a European Journal, 24, 2018 6030.2- Napolitano T. , Cheng S.Y., Nielsen B. , Choi C. , Aguilar W. , Paz M.M., Sapse A.M., Champeil E. “Acetone promoted 1,4-migration of an alkoxycarbonyl group on a syn-1,2-diamine”,Tetrahedron Letters, 58, 2017 597. 3- Cheng S. Y., Seo J., Huang B.T., Napolitano T. Champeil E. “Mitomycin C and decarbamoyl mitomycin C induce p53-independent p21WAF1/CIP1 activation” International Journal of Oncology, 49, 20161815. 4- Bose A., Surugihalli C., Pande P., Champeil E., Basu A. K. “Comparative error-free and error-prone translesion synthesis of the N2 -2'-deoxyguanosine adducts formed by mitomycin C and its metabolite, 2,7-diaminomitosene, in human cells” Chemical Research in Toxicology, 29, 2016933.5- Champeil E., Cheng S. Y., Huang B.T., Conchero-Guisan M., Martinez T. , Paz M.M., Sapse A.M. “Synthesis of MitomycinC and Decarbamoylmitomycin C N2
deoxyguanosine-adducts” Bioorganic Chemistry, 65, 2016 90.
Research Interests
Synthesis of Mitomycin C and Decarbamoyl mitomycin C DNA adducts: Our aim is to synthesize DNAinterstrand crosslinks generated by decarbamoyl mitomycin C (DMC) and mitomycin C (MC) (MC a-ICLand DMC b-ICLs). In addition, the role of p21 in the upstream p53-independent signaling pathway inresponse to these crosslinks is examined.
Analysis of drugs (recreational and medicinal) in bio fluids using NMR spectroscopy.
Prof. Champeil is a syntheticchemist interested in the DNAalkylating drug Mitomycin C(MC). She synthesized MC-DNA Interstrand crosslinks todetermine how the localstructure of these adducts isresponsible for the differentbiochemical responsesproduced by cancer cells upontreatment.
2014- 2010 Current position2006-2010 Assistant professor (John Jay College)2003-2006 Postdoc (CUNY)2002 PhD, Trinity College, Ireland
Dr. Elise Champeil
Yu ChenAssistant ProfessorDepartment of Chemistry & Biochemistry, QueensCollege65-30 Kissena Blvd.Flushing [email protected]://chem.qc.cuny.edu/~ychen/homepage.htm
Publications
Das, S.; Hong, D.; Chen, Z.; She, Z.; Hersh, W.H.; Subramaniam, G.; Chen, Y. “Auto-TandemPalladium Catalysis: From Isoxazole to 2-Azafluorenone”, Org. Lett., 2015, 17, 5578-5581.
Domaradzki, M. E.; Long, Y.; She, Z.; Liu, X.;Zhang, G.; Chen, Y. “Gold-Catalyzed AmmoniumAcetate Assisted Cascade Cyclization of 2-Alkynylarylketones”, J. Org. Chem., 2015, 80,11360-11368.
Chen, Y.; Huang, C.; Liu, X.; Perl, E.; Chen, Z.;Namgung, J.; Subramaniam, G.; Zhang, G.;Hersh, W. H. “Synthesis of Dibenzocyclohepten-5-ones by Electrophilic Iodocyclization of 1-([1,1'-Biphenyl]-2-yl)-alkynones”, J. Org. Chem. 2014,79, 3452-3464.
Chen, Y.; Liu, X.; Lee, M.; Huang, C.; Inoyatov,I.; Chen, Z.; Perl, A. C.; Hersh, W. H. “ICl-Induced Intramolecular Electrophilic Cyclizationof 1-(4'-Methoxy-[1,1'-biphenyl]-2-yl)-alkynones—A Facile Approach toSpiroconjugated Molecules”, Chem. Eur. J.2013, 19, 9795-9799.
Long, Y.; She, Z.; Liu, X.; Chen, Y. “Synthesis of1-Aminoisoquinolines by Gold(III)-MediatedDomino Reactions from 2-Alkynylbenzamidesand Ammonium Acetate”, J. Org. Chem. 2013,78, 2579-2588.
Research Interests
Keywords: late transition metal catalysis, heterocyclic chemistry, asymmetric catalysis
The Chen group is working in the area of late transition metal mediated catalysis, heterocyclicchemistry and asymmetric catalysis. They have been developing new synthetic methods forbiologically interesting frameworks using Lewis acid mediated transformations of alkynes, andhave successfully developed new atom-economical routes for the synthesis of a variety of corestructures, including isoxazoles, 2-azafluorenones, isoquinolines, indenones,dibenzocyclohepten-5-ones, and etc.
The Chen group isinterested in late transitionmetal catalysis, heterocyclicchemistry and asymmetriccatalysis.
2009-current Current position2007-2009 Postdoc1999-2004 PhD
Dr. Yu Chen
Junyong ChoiAssistant ProfessorDepartment of Chemistry and BiochemistryQueens College of the City University of New York65-30 Kissena Blvd.Queens, [email protected]
PublicationsJY Choi, et. al., Compara've structuralanalysis and molecular design for thedevelopment of highly potent and selec'veagents targe'ng Matrix Metalloproteinase13, J. Med. Chem., 2017, 60, 5816-5825
CM Calvet, JY Choi, et. al., 4-aminopyridyl-based lead compounds targe'ng CYP51prevent spontaneous parasite relapse in achronic model and improve cardiacpathology in an acute model ofTrypanosoma cruzi infec'on, PLoS Negl.Trop. Dis., 2017, 11: e0006132
JY Choi, et. al., Structure Based Design ofCYP51 Inhibitors, Curr. Top. in Med.Chem., 2017, 17, 30-39
JY Choi, et. al., Drug strategies targe'ngCYP51 in neglected tropical diseases, Chem.Rev., 2014, 114, 11242-11271
JY Choi, et. al., The R-Configura'on of 4-aminopyridyl-based inhibitors of CYP51confers superior efficacy againstTrypanosoma cruzi, ACS Med. Chem.Le:., 2014, 5, 434-439
Research InterestsKeywords: Medicinal Chemistry, Organic Synthesis, Computer-aided Drug Design, ChemicalBiology
My scientific objective is to develop specific, target-directed therapeutic candidates for human diseases.My laboratory integrates organic synthesis, medicinal chemistry, computer-aided drug design, andchemical biology to discover bioactive chemical probes. We are particularly interested in discovery of smallmolecule agents with novel mechanism of action to elucidate specific functions of biological targets. Thediscovery and techniques established in my laboratory will advance the chemical science in biomedicalresearch for the development of therapeutics
Junyong Choi is asynthetic and computationalmedicinal chemist. Hisresearch focuses ondevelopment of therapeuticcandidates by applyingorganic synthesis,computer-aided drugdesign, and chemicalbiology.
2017- current Assistant Professor, Queens College2012-2017 Sr. Research Associate, Scripps Florida2009-2012 Postdoc, Scripps Florida2009 PhD, Stony Brook University
Dr. Junyong Choi
Stephen Philip FearnleyAssociate ProfessorDepartment of ChemistryCUNY-York College94-20 Guy R. Brewer Blvd.Jamaica NY [email protected]/portal_college/sfearnley
PublicationsS. P. Fearnley* & P. M. Lory, “A concise synthesis of (�)-3-deoxyisoaltholactone�Tetrahedron Lett., 2014 55, 5207-5209.
S. P. Fearnley* & C. Thongsornkleeb, “Oxazolone Cycloadducts as Heterocyclic Scaffolds for Alkaloid Construction: Synthesis of (�)-2-epi-Pumiliotoxin C�J. Org. Chem. 2010 75, 933-936.
S. P. Fearnley* & P. M. Lory, “IntramolecularVinylsilane–Oxocarbenium Condensations –Concise Assembly of cis-Bicyclic Ether Arrays�Org. Lett. 2007 9, 3507-3510.
S. P. Fearnley*, "2-(3H)-oxazolone – A Simple Heterocycle with Manifold Potential” Current Organic Chemistry; Volume 8, Asymmetric Synthesis" 2004 8, 1289-1338.
S. P. Fearnley* & M. W. Tidwell, "Cyclization of Aryl Silanes with Unexpected Retention of Silicon”Org. Lett. 2002 4, 3797-3798.
S. P. Fearnley* & E. Market, “IntramolecularDiels-Alder Reactions of N-Substituted Oxazolones�Chem. Commun. 2002 438-439.
Research Interests
Keywords: Organic Synthesis • Organic Reactions • Natural Products• Investigation & use of oxazolone as a useful heterocyclic scaffold for alkaloid synthesis - studies of intramolecular Diels-Alder reactions with oxazolone as dienophile.
• Novel organosilane chemistry for approaches to bioactive ethers - concise assembly of cis-fused bicyclic ether arrays via intramolecular attack of vinylsilanes at tethered oxocarbenium ions. A related silyl-activated Friedel-Krafts process requires an unusual combination of electronic & steric effects.• Recently completed targets include 2-epi-pumiliotoxin C & deoxyaltholactone. Similar approaches to gephyrotoxin & dysiherbaine are underway.
As a synthetic organicchemist, my researchinvolves development ofnew methodology for theconstruction of bioactivenatural products: alkaloids,cyclic ether arrays, & C-glycosides.
2003- current York College1999-2003 Lamar University1998-1999 Postdoc, Penn State: Mike Coleman1995-1997 Postdoc, Penn State: Ray Funk1992-1994 Postdoc, Virginia Tech: Tomas Hudlicky1988-1992 Ph.D., University of Salford, U.K.
Dr. Stephen Philip Fearnley
Dr. Alexander Greer Publications
A. A. Ghogare; A. Greer “Synthesis of a Poly(ethylene glycol) Galloyl Sensitizer Tip for an ‘All-in-one’ Photodynamic Device” J. Biophotonics 2016 (in press).
A. A. Ghogare; A. Greer “Using Singlet Oxygen to Synthesize Natural Products and Drugs” Chem. Rev. 2016 (in press).
B. Malek; W. Fang; I. Abramova; N. Walalawela; A. A. Ghogare; A. Greer “Ene Reactions of Singlet Oxygen at the Air-Water Interface” J. Org. Chem. 2016, 81, 6395-6401 .
A. Mahendran; A. A. Ghogare; R. Bittman; G. Arthur; A. Greer “Synthesis and AntiproliferativeProperties of a New Ceramide Analog of Varacin” Chem. Phys. Lipids 2016, 194, 165-170.
A. A. Ghogare; D. Bartusik; G. Ghosh; N. Walalawela; I. Abramova; K. A. Cengel; J. M. Miller; T. M. Busch; A. Greer “Photodynamic Therapy by a Device Probe Tip” Photonics, Lasers in Medicine 2015, 4, 362-365.
M. S. Oliveira; A. A. Ghogare; I. Abramova; E. M. Greer; F. M. Prado; et al. “Mechanism of Photochemical O-Atom Exchange in Nitrosamines with Molecular Oxygen” J. Org. Chem. 2015, 80, 6119-6127.
Research Interests
We focus on synthesis and organic photochemical reactions to study molecular oxygen that are toxic to organisms and damaging to materials. Photo-generating intermediates in a clean and pure fashion is one goal, including the physical isolation of sensitizer and molecules at surfaces to “separate” reactive oxygen species (ROS) that can damage membranes and enzymes. Oxygen-dependent toxic effects are common in nature and our mechanistic studies have also focused on thiophene sulfoxides and mutagenic nitrosamines. We have also synthesized sulfanes related to natural product varacin, such as thianthrene, tetrathiocin, trithiole, and pentathiepin anticancer agents.
Our research areas are organic chemistry, synthesis,interfacial chemistry, photochemistry, natural products, and nano-technology
Alexander GreerProfessorCUNY Brooklyn College, Dept. ChemistryBrooklyn, NY 11210718-951-5000 ext [email protected]://academic.brooklyn.cuny.edu/chem/agreer/FirstPage.html
1999-current ProfessorPrevious UCLA and University of Wyoming
Wayne W. Harding, PhDAssociate ProfessorHunter CollegeChemistry Dept.695 Park AvenueNew York NY [email protected]://www.hunter.cuny.edu/chemistry/faculty/Harding/Wayne
Publications
Research InterestsKeywords: Medicinal chemistry, drug design, organic synthesis, central nervous system, CNS,receptor, serotonin, dopamine
Dr. Harding is aorganic/medicinalchemist with interests inthe design, synthesisand evaluation ofligands for centralnervous systemreceptors.
2013- current Associate Professor, Hunter College2006-2013 Assistant Professor, Hunter College2004-2006 Postdoctoral Fellow, University of Iowa1994-1999 Ph.D.
Dr. Wayne HardingAporphinoid antagonists of 5-HT2A receptors: further evaluation of ring A substituents and the size of ring C. S. Ponnala, N. Kapadia, H. A. Navarro, W. W. Harding, Chem. Biol. Drug Des. 2014, 84, 558 - 566.
Evaluation of structural effects on 5-HT2Areceptor antagonism by aporphines: identification of a new aprophine with 5-HT2Aantagonist activity. S. Ponnala, J. Gonzales, N. Kapadia, H. A. Navarro, W. W. Harding, Bioorg. Med. Chem. Lett. 2014, 24, 1664 -1667.
New Aporphinoid 5-HT2A and���� antagonists via structural manipulations of nantenine. S. Chaudhary, S. Ponnala, O. LeGendre, J. Gonzales, H. A. Navarro, W. W. Harding, Bioorg. Med. Chem. 2011, 19, 5861-5868.
Affinity of aporphines for the human 5-HT2Areceptor: insights from homology modeling and molecular docking studies. S. Pecic, S. Chaudhary, P. Makkar, B. J. Reddy, H. A. Navarro, W. W. Harding, Biorg. Med. Chem. 2010, 18, 5562 - 5575.
(±)-Nantenine analogs as antagonists at human 5-HT2A receptors: C1 and flexible congeners, S. Chaudhary, O. LeGendre, S. Pecic, H. A. Navarro, W. W. Harding Biorg. Med. Chem. Lett. 2009, 19, 2530 -2532.
William H. HershProfessorDepartment of Chemistry and BiochemistryQueens College65-30 Kissena Blvd.Queens, NY [email protected]://chem.qc.cuny.edu/~whersh
PublicationsS. Malik, A. Tarpanova, D. Lichtman, Y. Wallach,J. A. Mukhlall, W. H. Hersh, “Synthesis ofDixanthates and Dithiocarbonyl Disulfides asModels for Poly(disulfide)s, in preparation, 2015.
W. H. Hersh, “Synthesis of dinucleosideacylphosphonites by phosphonodiamiditechemistry and investigation of phosphorusepimerization,” Beilstein J. Org. Chem. 2015, 11,184-191.
W. H. Hersh, S. T. Lam, D. J. Moskovic, A. J.Panagiotakis, “A Non-Karplus Effect: Evidencefrom Phosphorus Heterocycles and DFTCalculations of the Dependence of VicinalPhosphorus-Hydrogen NMR Coupling Constantson Lone-Pair Conformation,” J. Org. Chem.2012, 77, 4968-4979.
J. A. Mukhlall, W. H. Hersh, “Sulfurizationof Dinucleoside Phosphite Triesters withChiral Disulfides,” Nucleosides, Nucleotides& Nucleic Acids 2011, 30, 706-725.
Dr. Hersh is an organic chemist with current research projects on synthesis of chiral oligonucleotide phosphorothioates and helical disulfide polymers. Specialties include NMR, X-ray crystallography, and DFT calculations.
1989 - current Queens College1982 - 1989 UCLA1980 – 1982 Postdoc, UC Berkeley1980 PhD, Columbia University
Dr. William Hersh
Qiao-Sheng HuProfessor and ChairDepartment of ChemistryCollege of Staten Island2800 Victory Blvd.Staten Island, NY [email protected]://www.csi.cuny.edu/departments/chemistry
PublicationsH.-H. Zhang, C.-H. Xing, G. B.Tsemo, Q.-S.Hu,t-Bu3P-Coordinated 2-Phenylaniline-BasedPalladacycle Complex as a Precatalyst for theSuzuki Cross-Coupling Polymerization of ArylDibromides with Aryldiboronic Acids, ACSMacroLett. 2013, 2, 10-13.
H.-H. Zhang, C.-H. Xing, Hu, Q.-S., ControlledPd(0)/t-Bu3P-Catalyzed Suzuki Cross-CouplingPolymerization of AB-Type Monomers withPhPd(t-Bu3P)I or Pd2(dba)3/t-Bu3P/ArI as theInitiator, J. Am. Chem. Soc. 2012, 134, 13156-13159.
T.-P. Liu, Y.-X. Liao, C.-H. Xing, Q.-S. Hu,Fluorenone Synthesis by Palladacycle-Catalyzed Sequential Reactions of 2-Bromobenzaldehydes with Arylboronic Acids,Org. Lett. 2011, 13, 2452-2455.
T.-P. Liu, C.-H. Xing, Q.-S. Hu, TandemReaction Synthesis of Fluorenes/Indenofluorenes Based on Pd(OAc)2/PCy3-Catalyzed Suzuki Cross-Coupling and C-H BondActivation Strategy, Angew. Chem. Int. Ed.2010, 49, 2971-2974.
C.-G. Dong, Q.-S. Hu, Preferential OxidativeAddition in Palladium(0)-Catalyzed SuzukiCross-Coupling Reactions of Dihaloarenes withArylboronic Acids, J. Am. Chem. Soc. 2005,127, 10006-10007.Research Interests
Keywords: catalysis, palladium, cross-coupling reaction, polymerization, conjugated polymers
The Hu group are interested in the development of new catalysts including transition metal and organiccatalysts for cross-coupling reactions and addition reactions, and novel reactions/processes from readilyavailable and cost-effective small organic molecules. These new reactions/processes and catalysts havepotential applications in chemical synthesis and polymer/materials synthesis.The approach is interdisciplinary, ranging from fundamental understandingof reaction mechanisms, reaction methodology development topolymer/materials synthesis.
Qiao-Sheng Hu isProfessor and Chair ofChemistry Department atthe College of Staten Island.His research is focused onthe development of newreactions/processes andcatalysts for chemicalsynthesis including polymer/materials synthesis.
2008- current Professor, CSI-CUNY2005-2007 Associate Professor, CSI2000-2005 Assistant Professor, CSI1997-2000 Postdoc, University of Virginia1995-1997 Postdoc, North Dakota state Univ.1991-1994 PhD, Shanghai Institute of Organic Chemistry,
Chinese Academy of Sciences
Dr. Qiao-Sheng Hu
Urs JansAssociate ProfessorDepartment of Chemistry and BiochemistryCity College of New York160 Convent AvenueNew York NY, [email protected]/profiles/urs-jans
Publications
D. Saint-Hilaire, U. Jans, Reactions of three halogenated organophosphorus flame retardants with reduced sulfur species. Chemosphere, 2013, 93, 2033-2039.
L. Yang, X. Li, P. Zhang, M. Melcer, Y. Wu, U. Jans. Concentrations of DDTs and dieldrin in Long Island Sound sediment, Journal of Environmental Monitoring, 2012, 14, 878-885.
K.W. Lo, S.C. Saha-Roy, U. Jans. Investigation of the reaction of hexabromocyclododecane with polysulfide in methanol/water solutions, Chemosphere, , 2012, 87, 158-162.
D. Saint-Hilaire, K.Z. Ismail, U. Jans. Reactions of tris(2-chloroethyl)phosphate with reduced sulfur species, Chemosphere, 2011, 83, 941-947.
L. Yang, X. Li, J. Crusius, U. Jans, M. E. Melcer, P. Zhang. Persistent chlordane concentrations in Long Island Sound sediment: Implications for chlordane, 210Pb, and 137Cs depth profiles. Environ. Sci. Technol., 2007, 41, 7723-7729.
Research Interests
Keywords: Environment, emerging contaminants, abiotic transformation, analytical chemistry
My research program at CCNY is addressing questions concerning environmental organic chemistry, witha focus on the mechanisms through which organic contaminants undergo abiotic transformations innatural aquatic environment (freshwater, seawater). We also determine the concentration of organiccontaminants in sediments and soils as a tool to understand their accumulation in the environment.
Dr. Jans is interested inthe fate of organic conta-minants (e.g., pesticides,flameretardants) in theenvironment.
1999- current City College of New York1996-1998 Postdoc, Johns Hopkins University1992-1996 PhD, ETH Zürich, Switzerland
Dr. Urs Jans
George JohnProfessor of ChemistryThe City College of New YorkCenter for Discovery and Innovation (CDI) -1430285 St. Nicholas Terrace, New York, NY [email protected]/~john/
Publications
Faure, L.; Nagarajan, S.; Hwang, H.; Montgomery, C.L.; Khan, B. R.; John, G.; Koulen, P.; Blancaflor, E. B.;Chapman, K. D. Synthesis of Phenoxyacyl-Ethanolamides and Their Effects on Fatty Acid AmideHydrolase Activity, J. Biol. Chem, 2014, 289, (13):9340-51.
Vijai Shankar, B.; Jadhav. S. R.; Vemula, P. K; John.G. Recent Advances in Cardanol Chemistry in aNutshell: From a Nut to Nanomaterials, Chem. Soc.Rev., 2013, 42, 427-438, Cover Page feature.
Reddy, A. L.M.; Nagarajan, S.; Chumyim, P.; Gowda,S. R.; Dubey, M.; Jadhav, S. R.; John, G.; Ajayan, P.M. Lithium storage mechanisms in purpurin basedorganic lithium ion battery electrodes, ScientificReports (Nature) 2012, 2, 960-964.
Shankar, B. V.; Jadhav, S. R.; Pradhan, P.; De Carlo,S.; John, G. Adhesive vesicles through adaptiveresponse of a biobased surfactant, Angew. Chem. Int.Ed., 2010, 49, 9509 –9512. Cover Page feature.
Jadhav, S. R.; Vemula, P. K.; Kumar, R.; Raghavan,S.; John, G. Sugar-derived phase-selective moleculargelators as model solidifiers for oil spills, Angew.Chem. Int. Ed., 2010, 49, 7695-7698, Cover Page.
Research Interests
Keywords: biobased materials, green chemistry, soft materials, biorefinery, biomimetics, phaseselective gels, oil structuring agents (food/cosmetics), antibacterial coatings, batterycomponents/energy storage, green surfactants
John’s research is rooted in the idea that innovation can be inspired by nature to develop economical andsustainable technologies for a greener future. The group has harnessed crop-based precursors such assugars, fatty acids and plant lipids to design a unique set of multifunctional soft-materials includingpolymers, gels and green surfactants. His group has successfully developed environmentally benignantibacterial paints, polymer-coatings, molecular gel technologies, oil spill recovery materials, batterycomponents and oil thickening agents. As soft materials researchis highly interdisciplinary and collaborative, John’s lab encouragesthe blending of such diverse elements including organic synthesis,green chemistry, material chemistry, interfacial phenomena, colloidscience and biomimetics.
George John is a Professorof Chemistry/the Center forDiscovery and Innovation,the City College of New York-CUNY. His research isfocused on molecular designof synthetic lipids, membranemimics, soft nanomaterials,green energy technologiesand organic materialschemistry.
Dr. George John
2012- current Professor of Chemistry, CCNY2004-2012 Associate Prof. of Chemistry, CCNY2002-2004 Research Faculty, RPI, NY1996-2002 JSPS Fellow/Scientist, Japan1994-1995 Postdoc, University of Twente, NL1993 PhD Kerala University, India
Akira KawamuraAssociate ProfessorHunter College695 Park AvenueNew York NY [email protected]/chemistry/faculty/Kawamura
Publications
Mihai, D.M., Hall, S., Deng, H., Welch, C.J., Kawamura, A. Bioorg. Med. Chem. Lett. 2015, Nov 15;25(22):5349-51. PMID: 26420066
Li, X., Kawamura, A., Andrews, C.D., Miller, J.L., Wu, D., Tsao, T., Zhang, M., Oren, D., Padte, N.N., Porcelli, S.A., Wong, C.H., Kappe, S.H., Ho, D.D., Tsuji, M. J. Immunol. 2015;195(6):2710-21. PMID: 26254338
Montenegro, D., Kalpana, K., Chrissian, C., Sharma, A., Takaoka, A., Iacovidou, M., Soll, C.E., Aminova O., Heguy, A., Cohen, L., Shen, S., Kawamura, A. Bioorg. Med. Chem. Lett. 2015;25(3):466-9. PMID: 25547935
Takaoka, A., Iacovidou, M., Hasson, T.H., Montenegro, D., Li, X., Tsuji, M., Kawamura, A. Planta Med. 2014;80(4):283-9. PMID: 24549928
Hasson, T.H., Takaoka, A., de la Rica, R., Matsui, H., Smeureanu, G., Drain, C.M. and Kawamura, A. Chem. Biol. Drug Design, 2014;83(4):493-7. doi: 10.1111/cbdd.12250. PubMed PMID: 24495243
Research Interests
Keywords: Natural Products, Phytobacteria, Glycolipids, Immunology
We currently focus on immunomodulatory glycolipids of phytobacteria that were detected in severalmedicinal plants. In addition to medicinal plants, these lipids exist in many other edible plants. At presentlittle is known about their potential health benefits and risks. This is an important problem because humanbody is continually exposed to various phytobacterial metabolites through consumption of vegetables,fruits, and herbs. To address this problem, we conduct structural and immunological characterization ofphytobacterial glycolipids with immunomodulatory activity.
Natural products chemistryfocused on phytobacterialmetabolites.
Chemical messages formicrobial interactions.
2008- current Associate Professor, Hunter College2002-2007 Assistant Professor, Hunter College1999-2002 Postdoc, Scripps Research Institute1994-1999 PhD, Columbia University
Dr. Akira Kawamura
Mahesh LakshmanProfessor and Former Executive Officer2018 Presidential Award for ExcellenceThe City College of New YorkDepartment of Chemistry160 Convent AvenueNew York [email protected]/~mkl
Publications
§ S. Satishkumar and M. K. Lakshman: Benz-imidazopurine nucleosides from N6-aryl adenosinederivatives by PhI(OAc)2-mediated C–N bondformation, no metal needed, ChemicalCommunications 2017, 53, 2226. (Featured onthe front cover)§ V. Basava, et al.: A novel bis(pinacolato)-diboron-mediated N–O bond deoxygenative routeto C6 benzotriazolyl purine nucleoside derivatives,Organic and Biomolecular Chemistry 2016, 14,7069.§ M. K. Singh et al.: Ruthenium-catalyzed C–Hbond activation approach to azolyl aminals andhemiaminal ethers, mechanistic evaluations, andisomer interconversion, ACS Catalysis 2016, 6,1921. (Featured on the front cover)§ P. F. Thomson et al.: Modular, metal-catalyzedcycloisomerization approach to angularly fusedpolycyclic aromatic hydrocarbons and theiroxidized derivatives, The Journal of OrganicChemistry 2015, 80, 7435.§ M. K. Lakshman et al.: Synthesis and biologicalproperties of C-2 triazolylinosine derivatives, TheJounal of Organic Chemistry 2012, 77, 5870.(Editor-selected featured article)§ M. K. Lakshman et al.: Direct arylation of 6-phenylpurine and 6-arylpurine nucleosides byruthenium-catalyzed C–H bond activation,Angewandte Chemie, International Edition 2011,50, 11400–11404. (Inside cover feature)Research Interests
Keywords: Chemical Methodology, Metal catalysis, Nucleoside Modification, Biomolecules
The program has many facets but can be broadly divided into the following areas.A. Development of new chemical methodology, ligand design for catalysis. B. Nucleoside modifications by metal-catalysis, uncatalyzed methods, and hypervalent iodine reagents. B. Unusual applications of peptide coupling agents. C. New chemistry of planar and nonplanar polycyclic aromatic hydrocarbons for novel studies. C. Novel reactions involving arynes. D. Development of new chemical methodology.Every aspect entails a detailed understanding of chemical process via mechanism studies involving various spectroscopic methods, multinuclear NMR, isotopic labeling, etc.
Lakshman is anorganic/bioorganic chemistwith interests in nucleosidemodification via metalcatalyzed, uncatalyzed, andhypervalent iodinereactions, new chemicalmethods, synthesis ofbiologically interestingentities,novel applicationsof peptide coupling agents,and arynes.
20008–current Professor2004–2008 Associate Professor2000–2004 Assistant Professor1998–2000 Assistant Professor (U North Dakota)1994–1997 Senior Scientist (Private Sector)1990–1994 Fogarty Fellow NIH (NIDDK)1985–1989 PhD
Dr. Mahesh Lakshman
David MootooProfessorHunter CollegeChemistry Department695 Park AvenueNew York NY [email protected]://www.hunter.cuny.edu/chemistry/faculty/Randy/Randy
Publications
Garg, H.; Francella, N.; Tony, K. A.; Augustin, L. A.; Fantini, J.; Barchi Jr, J. J.; Puri, A.; Mootoo; Blumenthal, R. Glycoside analogues of a-galactosylceramide, a novel class of small molecule inhibitors for HIV-1 entry. Antiviral Res. 2008 80, 54-61.
Hans, S. K.; Camara, F.; Martin-Montalvo, A.; Brautigan, D. L.; Heimark, D.; Larner, J.; Grindrod, S.; Brown, M.; Mootoo, D. R. Synthesis of the C-glycoside analog of b-galactosamine-(1->4)-3-O-methyl-D-chiro-inositol and assay as activator of protein phosphatases PDHP and PP2Ca. Bioorg. Med. Chem. 2010, 18, 1103-1110.
Bachan, S.; Fantini, J.; Joshi, A.; Garg, H.; Mootoo, D. R. Synthesis, gp120 binding and anti-HIV activity of fatty acid esters of 1,1-linked disaccharides. Bioorg. Med. Chem. 2011, 19, 14803-14811.
Bachan, S.; Tony, K. A.; Kawamura, A.; Montenegro, D.; Joshi, A.; Garg, H.Synthesisand anti-tumor activity of carbohydrate analogues of the tetrahydrofuran containing acetogenins. Bioorg. Med. Chem. 2013, 21, 6554-6564.
Intramolecular nitrogen delivery for the synthesis of C-glycosphingolipids. Altiti, A. S.; Mootoo, D. R. Application to the C-Glycoside of the immunostimulant KRN7000. Org. Lett, 2014, 16, 1466-1469.
Research Interests
Keywords:synthesis, glycomimetics, tumor targeting, immunostimulants
An broad area of current interest is the design and synthesis of molecules for interrogating anti-cancerpathways. Two strategies that center on targeting cytotoxic agents to tumors and glycolipids that boostthe immune system against cancer are being pursued. These projects entail the design and synthesis ofnovel small molecules and examination of their biological properties, in the context of specific diseasemechanisms.
Our research centerson the design,synthesis andapplication ofbiomechanisticprobes, and thedevelopment of newsyntheticmethodologies.
1989- current Professor1986-1989 Postdoc, Duke University1982-1986 Ph.D., University of Maryland
Dr. David R. Mootoo
Ryan P. MurelliAssociate ProfessorBrooklyn College2900 Bedford AvenueBrooklyn, [email protected]://userhome.brooklyn.cuny.edu/rpmurelli/
Publications
Bejcek, L. P.; Murelli, R. P. "Oxidopyrylium [5+2]Cycloaddition Chemistry: Historical Perspectiveand Recent Advances (2008-2018)"Tetrahedron, 2018, 74, 2501-21.
D'Erasmo, M. P.; Murelli, R. P. "Fluorous-PhaseApproach to α-Hydroxtropolone Synthesis" J.Org. Chem. 2018, 83, 1478-85.
Hirsch, D. R.; Schiavone, D. V.; Berkowitz, A. J.;Morrison, L. A.; Masaoka, T.; Wilson, J. A.;Lomonosova, E.; Zhao, H.; Patel, B. S.; Dalta, S.H.; Majidi, S. J.; Pal, R.; K.; Gallicchio, E.; Tang,L.; Tavis, J. E.; Le Grice, S. F. J.; Beutler, J. A.;Murelli, R. P. "Synthesis and BiologicalAssessment of 3,7-Dihydroxytropolones" Org.Biomol. Chem. 2018, 16, 62-9.
Fuhr, K. N.; Hirsch, D. R.; Murelli, R. P.;Brenner-Moyer, S. E. "Catalytic EnantioselectiveIntermolecular [5+2] Dipolar Cycloadditions of a3-Hydroxy-4-Pyrone-Derived OxidopyryliumYlide", Org. Lett., 2017, 19, 6356-9.
Research Interests
Keywords:Synthetic Organic Chemistry, Medicinal Chemistry, Chemical Biology.
Dr. Murelli and his groupdevelop and use tools ofsynthetic organic chemistryto meet challenges inmodern medicine. They areparticularly interested intropolones, which areunderexplored aromaticcompounds with a wealth ofpotential in biology andmedicine.
2017- current Associate Professor, Brooklyn College2010- 20017 Assistant Professor, Brooklyn College2007-2010 Postdoctoral Associate, Yale University2002-207 PhD Studies, Boston College
Dr. Ryan Murelli
Naphtali O�ConnorAssistant ProfessorLehman College, CUNY250 Bedford Park BlvdWest Bronx, NY [email protected]/academics/chemistry/prof-oconnor.php
Publications
O�Connor, N.A.; Abugharbieh, A.; Buabeng, E.;Yasmeen, F.; Mathew, S.; Samaroo, D.; Cheng,H. �The Crosslinking of Polysaccharides withPolyamines and Dextran-PolyallylamineAntibacterial Hydrogels� Int. J. Biol. Macromol.(2015) 72, 88-93.
Samaroo, D.; Perez, E.; Aggarwal, A.; Wills, A.;O�Connor, N.A. �Strategies for DeliveringPorphyrinoid-based Photosensitizers inTherapeutic Applications� Therapeutic Delivery(2014), 5(7), 859-872.
Solomon, M.R.; O�Connor, N.A.; Paik, D.C.;Turro, N.J. �Nitroalcohol Induced HydrogelFormation in Amine-Functionalized Polymers.�J. Appl. Polym. Sci. (2010), 117(2), 1193-1196.
O'Connor, N.A.; Stevens, N.; Samaroo, D.;Solomon, M.R.; Martí, A.A.; Dyer, J.;Vishwasrao, H.; Akins, D.L.; Kandel, E.R.; Turro,N.J. �A covalently linked phenanthridine-ruthenium(II) complex as a RNA probe.� Chem.Comm. (2009), 2640-2642.
Stevens, N.; O'Connor, N.A.; Vishwasrao, H.;Samaroo, D.; Kandel, E.R.; Akins, D.L.; Drain,Charles M.; Turro, N.J. �Two color RNAintercalating probe for cell imaging applications.�J. Am. Chem. Soc. (2008) 130, 7206-7207.Research Interests
Keywords: biomaterials, hydrogels, polymers
My current research focus is the development of materials for biomedical applications. We recentlydeveloped a method for preparing polysaccharide-polyamine crosslinked hydrogels. We are currentlyexploring their application as anti-microbial and wound healing materials.We are also working on the development of curcumin based biomaterialsas antibacterial agents and cancer therapeutics.
Naphtali has a variedresearch background thatreflects his wide researchinterests. His researchranges from developingbiomaterials to designingmolecular probes.
2008- current Current position2007-2008 Postdoc/Columbia University2000-2006 PhD/University of California, Irvine
Dr. Naphtali O�Connor
Associate ProfessorQueens College, and the Ph.D. Program inChemistry and Biochemistry, The Graduate Center ofthe City University of New York65-30 Kissena Blvd.Queen, NY - 11367Email. [email protected]://chem.qc.cuny.edu/~skumar/
Selected PublicationsWardman JH et al. �Identification of a small-molecule ligand that activates theneuropeptide receptor GPR171 andincreases food intake� Sci Signal. 2016,9(430):ra55.
Blazekovic F et al. "HLA-DR peptideoccupancy can be regulated with a widevariety of small molecules. Hum VaccinImmunother. 2016, 12(3):593-8
Dibyendu Dana et al. "Development of ahighly potent, selective, and cell-activeInhibitor of cysteine cathepsin L-A hybriddesign approach" ChemicalCommunications (Camb) 2014,50(74):10875-8
Hsin-Pin Ho, et al. �Studies on QuantitativePhosphopeptide Analysis by MALDI MassSpectrometry Without Label,Chromatography or Calibration Curves�Rapid Communications in MassSpectrometry 2014, 28(24):2681-9
Ivone Gomes et al. "GPR171 is aHypothalamic G Protein-Coupled Receptorfor BigLEN, a Neuropeptide involved inFeeding� Proceedings of the NationalAcademy of Sciences (PNAS) USA, 2013,110(40), 16211–16216
Tirtha K. Da et al. �Centrosomal KinaseNek2 Cooperates With Oncogenic PathwaysTo Promote Metastasis� Oncogenesis,2013, 2, e69; doi:10.1038/oncsis.2013.34
Research Interests: Chemical Biology of ProteinPhosphorylation and Proteolysis
Keywords: Cysteine Cathepsins, Protein Kinases, andTyrosine PhosphatasesDescription of research activities and strategy. Theresearch in Kumar�s laboratory spans at the interface ofchemistry and biology, and is broadly focused on discovery ofunknown enzyme function using chemical biologyapproaches. The current project includes the development ofsmall molecule probes for protein kinases, protein tyrosinephosphatases, and cysteine proteases and utilizing them tounderstand the enzyme function in both normal and diseasedhuman physiology. For more information, please visit thewebsite.
2014- current Associate Professor2007-2014 Assistant Professor2002-2007 Postdoc, Albert Einstein College of Medicine1996-2002 PhD, Wesleyan University
Dr. Sanjai Kumar Pathak
Adam A. Profit, Ph.D.Associate ProfessorYork College94-20 Guy R. Brewer BlvdJamaica, NY [email protected]/portal_college/aprofit
Publications
Profit, A. A., Vedad, J. Saleh, M., and Desamero,R.Z.B. �Aromaticity and Amyloid Formation:Effect of p-Electron Distribution and ArylSubstituent Geometry on the Self-Assembly ofPeptides Derived from hIAPP22-29 � ArchBiochem Biophys 2015, 567, 46-58.
Profit, A. A., Felsen, V., Chinwong, J., Mojica, E-R., and Desamero, R.Z.B. �Evidence of p-stacking Interactions in the Self-assembly ofhIAPP22-29� PROTEINS: Structure, Function andBioinformatics 2013, 81, 690-703.
Research Interests
Keywords: Amyloid, protein kinases, peptides, peptoids, enzymology, solid phase synthesis
The abnormal formation of protein aggregates, or amyloid deposits, is the hallmark of Alzheimer�s disease as wellas type 2 diabetes. My laboratory is investigating the molecular interactions that occur between key proteins thatcontribute to the formation of amyloid in these diseases. Through a more detailed understanding of how theseproteins self-assembly to form aggregates, we hope to design and develop small molecule and peptide mimeticinhibitors which may serve as potential therapeutic agents.
We are also developing compounds that inhibit the activity of key enzymes (kinases) which can cause tissues togrow out of control and develop into tumors. To accomplish this we are synthesizing molecules that exploit theunique molecular recognition motifs found in these enzymes to more effectively deliver inhibitory species to theactive site.
Protein-ligand interactions isthe unifying theme of myresearch interests. Inparticular, the design,synthesis and application ofbiologically relevant probemolecules to study andelucidate protein-protein andprotein-ligand interactionsinvolved in amyloid diseasesand cancer.
2014- current Associate Professor of Chemistry2004-2014 Assistant Professor of Chemistry2000-2004 Merck Research Laboratories1997-2000 Postdoc - Albert Einstein College of Medicine1997 PhD - Stony Brook University
Dr. Adam A. Profit
Name: Varattur D. ReddyPosition : ProfessorAffiliation: Kingsborough Community CollegeAddress: 2001 Oriental Blvd
Manhattan Beach, Brooklyn, NY [email protected] [email protected]
Publications
Reddy, V. D., Greener Organic Chemistry Experiments: A Miniscale and MicroscaleApproach 3rd Edition, John Wiley & Sons, 2015.
Reddy, V. D. Organometallic Anti-cancer Complexes�. U.S. Pat. 2012/032507 and Int. Pat. WO 2012/138988 A2.
Reddy, V. D.; Dayal, D.; Szalda, D.J. Cosenza, S.C.; Reddy, M.V.R. � Synthesis, structures, and anticancer activity of novel Organometallic ruthenium-maltolcomplexes�. J. Organomet. Chem, 2012, 700, 180.
Reddy, V. D.; Dayal, D.; Cosenza, S.C.; Reddy. M.V. R.; Pearl. Jr., W.C.; Adams, R.D. �Glycalruthenium carbonyl clusters: Synthesis, characterization, and anticancer activity,�J.Organomet. Chem, 2009, 694, 959.
Reddy, V. D. �Synthesis, characterization, and reactivity of a novel ruthenium carbonyl cluster containing tri-O-benzyl-D-glucal as a chiral carbohydrate ligand,� J. Organomet.Chem, 2006, 691, 27.
Research Interests
Synthesis of organic and organometallic compounds as anticancer and anti-Alzheimer's diseaseagents. Organic synthesis involves total synthesis of natural and unnatural products andmodified carbohydrates. Organometallic chemistry involves synthesis of novel organometalliccatalysts, efficient methodologies for the synthesis of biologically active molecules,bioorganometallics, and drug delivery systems. Research facilities at Kingsborough are 400MHz NMR Facility, IR, GC, and HPLC.
Our group research focuses on thefollowing areas: Synthesis oforganic and organometalliccompounds as anticancer and anti-Alzheimer�s disease agents, andcatalysis.
2001- current Kingsborough Community College-CUNY1993-2001 Schering Plough Pharmaceutical Company
currently Merck and American HealthFoundation
1990-1993 Hunter College and Queens College1990 Ph.D. Indian Institute of Technology, Mumbai
Dr. Varattur Reddy
CUNY by the Sea
Barbara ZajcProfessorThe City College of New YorkDepartment of Chemistry160 Convent AvenueNew York [email protected]://www.ccny.cuny.edu/profiles/Barbara-Zajc.cfm
Publications
Wei, W.; Khangarot, R. K.; Stahl, L.; Veresmortean,C.; Pradhan, P.; Yang, L.; Zajc, B.: GeneratingStereodiversity: Diastereoselective Fluorination andHighly Diastereoselective Epimerization of �-AminoAcid Building Blocks, Org. Lett. 2018, 20, in press.DOI: 10.1021/acs.orglett.8b01358.
Banerjee, S.; Sinha, S.; Pradhan, P.; Caruso, A.;Liebowitz, D.; Parrish, D.; Rossi, M.; Zajc, B.:Regiospecifically Fluorinated Polycyclic AromaticHydrocarbons via Julia-Kocienski Olefination andOxidative Photocyclization. Effect of Fluorine AtomSubstitution on Molecular Shape, J. Org. Chem. 2016,81, 3983–3993. Editor-Selected Featured ArticleFeatured on the Front Cover of Issue 10
Kumar, R.; Singh, G.; Todaro, L. J.; Yang, L.; Zajc, B.:E- or Z-Selective Synthesis of 4-Fluorovinyl-1,2,3-triazoles with Fluorinated Second-GenerationTriazole-Substituted Julia-Kocienski Reagents, Org.Biomol. Chem. 2015, 13, 1536–1549 .
Singh, G.; Kumar, R.; Swett, J.; Zajc, B.: ModularSynthesis of N-Vinyl Benzotriazoles, Org. Lett. 2013,15, 4086-4089.
Mandal, S. K.; Ghosh, A. K.; Kumar, R.; Zajc, B.:Expedient Synthesis of a-Substituted Fluoroethenes,Org. Biomol. Chem. 2012, 10, 3164-3167Featured on the Front Cover of Issue 16Research Interests
Keywords: Fluoroorganic chemistry, Biomolecules, Chemical Carcinogenesis
Fluoroorganics are highly important in diverse areas, but introduction of fluorine remains challenging. Ourresearch is focused in two main directions. One involves development of methods for regiospecificintroduction of fluorine atom into organic molecules. Here, we are developing and expanding a toolbox ofnovel reagents for the synthesis of variously functionalized vinyl fluorides, as also various novel fluorinatedsynthetic building blocks. Another area of research involves the use of fluorine as probe in structureactivity studies in the area of chemical carcinogenesis. Specifically fluorinated polycyclic aromatichydrocarbons, their metabolites and their DNA conjugates are synthesized as probes to understandingcellular events after metabolism and DNA binding. We are currentlyinvestigating the use of the new hydrocarbons for development ofnovel materials.
Zajc is anorganic/bioorganicchemist working in areasof (a) fluoroorganicchemistry, (b) chemicalcarcinogenesis, and (c)synthetic methodology.
2013 Professor2003 Associate Professor (CCNY)2001 Assistant Professor (Substitute, CCNY)1999 Associate Professor (U of Ljubljana)1993 Assistant Professor (Docent, U of Ljubljana)1991 Fogarty Fellow NIH (NIDDK)1989 PhD
Dr. Barbara Zajc
Guoqi ZhangAssistant ProfessorDepartment of SciencesJohn Jay College of Criminal Justice524 W 59th Street, 10019New York NYEmail: [email protected]://www.jjay.cuny.edu/faculty/guoqi-zhang
PublicationsZ. Yin, G. Zhang, S. Zheng, T. Phoenix, J. C.Fettinger, “Assembling mono-, di- and tri-nuclearcoordination complexes with a ditopic analogueof 2,2':6',2''-terpyridine: syntheses, structuresand catalytic studies”, RSC Advances, 2015, 5,36156-36166.
G. Zhang, G. Proni, S. Zhao, Ed C. Constable,C. E. Housecroft, J. A. Zampese, M. Neuburger,“Chiral tetranuclear and dinuclear copper(II)complexes for TEMPO-mediated aerobicoxidation of alcohols: are four metal centresbetter than two?”, Dalton Trans. 2014, 43,12313-12320
G. Zhang, K. V. Vasudevan, B. L. Scott, S. K.Hanson, “Understanding the mechanisms ofcobalt-catalyzed hydrogenation anddehydrogenation reactions”, J. Am. Chem. Soc.2013, 135, 8668-8681.
G. Zhang, S. K. Hanson, “Cobalt-catalyzedtransfer hydrogenation of C=O and C=N bonds”,Chem. Commun. 2013, 49, 10151-10153.
G. Zhang, B. L. Scott, S. K. Hanson, “Mild andhomogeneous cobalt-catalyzed hydrogenation ofC=C, C=O, and C=N bonds”, Angew. Chem. Int.Ed. 2012, 51, 12102-12106.
Research InterestsKeywords: Inorganic/Organometallic Catalysis, Energy Conversion; Forensic Chemistry
Description of research activities and strategy:Our research concerns over the design and synthesis of novel non-precious metal complexes and theirapplications in energy-related catalysis, supramolecular chemistry, anticancer drugs and forensic science.
Prof. Zhang is an inorganicchemist who has broadresearch interests ininorganic/organometalicchemistry, non-preciousmetal catalysis and forensicchemistry, with a focus onthe synthesis of novelorganic-inorganic functionalmaterials.
2013- current Assistant Professor2006-2013 Postdoc Los Alamos National Lab and
Uni. Basel2001-2006 Ph.D., Institute of Chemistry, CAS
Dr. Guoqi Zhang
Shengping ZhengAssistant ProfessorHunter College695 Park AvenueNew York, NY [email protected]://www.hunter.cuny.edu/chemistry/faculty/Shengping/Shengping
PublicationsYin, Z.; Zhang, J.; Wu, J.; Green, R.; Li, S.; Zheng, S. “Synthesis of o-Chlorophenols via an Unexpected Nucleophilic Chlorination of Quinone Monoketals Mediated by N, N’-Dimethylhydrazine Dihydrochloride” Org. Biomol. Chem. 2014, 12, 2854-2858.
Yin, Z.; Zhang, J.; Wu, J.; Liu, C.; Sioson, K.; Devany, M.; Hu, C.; Zheng, S. “Double Hetero-Michael Addition of N-Substituted Hydroxylamines to Quinone Monoketals: Synthesis of Bridged Isoxazolidines” Org. Lett.2013, 15, 3534-3537.
Zhang, J.; Wu, J.; Yin, Z.; Zeng, H.; Khanna, K.; Hu, C.; Zheng, S. “An Expedient Stereoselectiveand Chemoselective Synthesis of Bicyclic Oxazolidinones from Quinols and Isocyanates” Org. Biomol. Chem. 2013, 11, 2939-2942.
Zhang, J.; Yin, Z.; Leonard, P.; Wu, J.; Sioson, K.; Liu, C.; Lapo, R.; Zheng, S. “A Variation of Fischer Indolization Involving Condensation of Quinone Monoketals and Aliphatic Hydrazines” Angew. Chem. Int. Ed., 2013, 52, 1753-1757.
Research InterestsKeywords: Organic Synthesis, Anticancer, Antiviral, Heterocycles, Natural Products
1.New methodologies in heterocycle synthesis
2.Total synthesis of bioactive natural products
Our group focuses on thesynthesis of bioactiveheterocycles and their SARstudies.
2008- current Assistant Professor, Hunter College2005-2008 Postdoc, Columbia University2000-2005 PhD, Columbia University
Dr. Shengping Zheng
Shuiqin ZhouProfessor of ChemistryCollege of Staten Island2800 Victory BoulevardStaten Island, NY [email protected]
PublicationsH. Wang, Y. Sun, J. Yi, J. Fu, J. Di, A. del C.Alonso, S. Zhou. Fluorescent porous carbonnanocapsules for two-photon imaging, NIR/pHdual-responsive drug carrier, and photothermaltherapy. Biomaterials, 2015, 53, 117-126.
H. Wang, J. Yi, S. Mukherjee, P. Banerjee, S.Zhou. Magnetic/NIR-thermally responsive hybridnanogels for optical temperature sensing, tumorcell imaging and triggered drug release. Nanoscale,2014, 6, 13001–13011.
H. Wang, A. Mararenko, G. Cao, Z. Gai, K. Hong,P. Banerjee, S. Zhou, Multifunctional 1D magneticand fluorescent nanoparticle chains for enhancedMRI, fluorescent cell imaging, and combinedphotothermal/chemotherapy, ACS Appl. Mater.Interfaces 2014, 6, 15309–15317.
H. Wang, Z. Wei, H. Matsui, S. Zhou, One-potsynthesis of Fe3O4@Carbon quantum dots hybridnanoflowers for highly active and recyclable visible-light driven photocatalyst. J. Mater. Chem. A, 2014,2, 15740-15745.
Y. Li, S. Zhou. Facile one-pot synthesis of organicdye-complexed microgels for optical detection ofglucose at physiological pH. Chem. Commun.2013, 49, 5553-5555.Research Interests
Keywords: responsive polymers, hybrid nanogels, nanoparticles, carbon dots, assembly,biosensing, drug delivery, cell imaging, environmental remediation
The Zhou group is interested in the development of (1) glucose-responsive hybrid nanoparticles (NPs) forglucose sensing and self-regulated insulin delivery; (2) multifunctional nanomaterials from the combinationof optically active NPs with responsive polymers for sensing, imaging, and therapy; and (3) compositenanomaterials from the complex assembly of carbon-based NPs,inorganic NPs, and other amphiphilies in the confinement of(bio)polymers and colloids for sensing, catalysis, and environmentalremediation
Shuiqin Zhou is a Professor ofChemistry at CUNY College ofStaten Island. Her research isfocused on responsive polymer-nanoparticle (including carbondots) hybrid nanogels, inorganic-carbon composite nanoparticles,and complex assembly ofnanoparticles for sensing,imaging, drug delivery, andenvironmental remediation.
2008- current Professor of Chemistry, CUNY-CSI2002-2007 Associate Prof. of Chemistry, CUNY-CSI2000-2002 Senior Chemist, Dow Chemical Company1996-2000 Postdoc, SUNY at Stony Brook1993-1996 PhD, Chinese University of Hong Kong 1988-1991 MSc, Xiamen University, China1984-1988 BSc, Xiamen University, China
Dr. Shuiqin Zhou