35 I -I/ goats

A P T

I

O L ' J -14 -7 a 3 5 7 10 13 17

DAY

-14 -7' 0 3 5 7 10 13 17 20 24 DAY

P T !

I I 0' i i I -14 -7 0 3 6 9 11 14 16 19

DAY

A \

" -14 -7 0 3 6 9 11 14 16 19 22 25 29

DAY

2 5

horses 20

P

I 14

0' -14 -7 0 4 a 11

DAY Figure 1. Prothrombin times (PT) at -14 to +14 days after treatment of 3 animals dosed with pindone and 1 untreated animal for each species.

0 -14 -7 0 3 6 9

DAY

References BeauregardJR,TusingTWandHanzalRF(1955)JAgriFoodChem 3: 124 Charles OW, Dilworth BC, Bushong RD and Day El (1966) Poult Sci 4 5 387 Doerr JA, Wyatt RD and Hamilton PB (1975) Poult Sci 54: %9 Kirk RW (1989) Current Veterinary Therapy X Small Animal Practice,

Mount ME (1988) Vet Clin N Amer 18: 115 Mount ME and Feldman BT (1983) Am J Vet Res 44: 2009 Oliver AJ and Wheeler SH (1978)Aust WildlRes 5 135 Oliver AJ, Wheeler SH and Gooding CD (1982) Awl Wild Res 9 125 Quick AJ (1982) Thromb D@th Hemorrhage 27: 179 Wheeler SH and Oliver AJ (1978)Awt Wild Res 5 143

Saunden, Philadelphia, p 146

(Accepted for publication 24 April 1991)

BOOK REVIEW Animal Blotechnology, COmprehenSiVe Biotechnology First Supplement, LA Babiuk and JP Phillips, Pergamon Press, Oxiord, 1989, pp 260, US$95.

With chapters on synthetic peptides as vaccines, monoclonal antibodies, recombinant DNA technology, cytokines and their applications, nucleic acid probes, embryo micro manipulations and the use of biotechnologies in animal breeding strategies, this

book will be of value to those interested in veterinary research. In general the chapters are well written, contain up-to-date

information and give a comprehensive coverage of the subject area. The fmt chapter outlines the early promise of a peptide-based vaccine for foot-and-mouth disease, but this has not yet been released, and the most promising peptide vaccines now appear to be anti-hormone vaccines for the comol of reproduction.

While most of the chapters such as those on the application of monoclonal antibodies in animal health and production and the micro manipulation of embryos have a strong veterinary em- phasis, others such as the use of recombinant DNA for produc- tion, concentrate on the general technology and lack any real focus on the application of this technology in the veterinary field. The review on recombinant cytokines and their therapeutic value in veterinary medicine gives a good review of the general field but contains only a few pages on the application of these cytokines in veterinary medicine.

Thefinal4 chaptersonmicromanipulationof animalemhyos,sex selection, animal breeding strategies and transgenic livestock are written by authoritative authors and contain excellent descriptions of the technologies involved and their value to the livestock in- dustries. Irecommendthisbook asagoodrefaencesourceforthose interested in the application of biotechnology in animal science.

PR Wood

Australian Veterinary Journal, Vol68, No 7, July 1991 243