biotransport in biomedical engineering course at uprm
DESCRIPTION
Biotransport in Biomedical Engineering Course at UPRM. Rubén E. Díaz-Rivera, Ph.D. Department of Mechanical Engineering University of Puerto Rico – Mayagüez. Course Info. INME 5015/6065: Principles of Biomedical Engineering 3 credit hours, professional elective in ME - PowerPoint PPT PresentationTRANSCRIPT
Biotransport in Biomedical Engineering Course at UPRM
Rubén E. Díaz-Rivera, Ph.D.Department of Mechanical Engineering
University of Puerto Rico – Mayagüez
Course Info INME 5015/6065: Principles of Biomedical
Engineering
3 credit hours, professional elective in ME
Advanced undergraduate/graduate level course
Popular with student in ME, EE, & ChemE
Typical enrollment: 15-20 students
Course Objectives Describe several sub-areas of Biomedical
Engineering and the principles and applications that drive these sub-areas
Recognize the challenges and directions of the most dynamic core areas in Biomedical Engineering
Apply mechanics concepts (e.g. transport phenomena) to biological or medical problems
Course Textbook Multiple textbooks
“Introduction to Biomedical Engineering”, J. Enderle et al.
“Biomaterials: The intersection of Biology and Material Science”, J.S. Temenoff & A.G. Mikos
“Transport Phenomena in Biological Systems”, G.A. Truskey et al.
“Bioimpedance and Bioelectricity”, S. Grimmes & Ø.G. Martinsen
“Introduction to Bioengineering”, S.A. Berger et al.
“Fundamentals of Heat and Mass Transfer”, F.P. Incropera et al.
“Thermodynamics: An Engineering Approach”, Y.A. Çengel & M.A. Boles
Topics History of biomedical engineering FDA and ethical issues Basic biology Biomaterials Biomechanics Biofluid mechanics Heat Transfer and Thermodynamics in Bio-
systems Mass Transfer in Bio-systems Bioelectric Phenomena
Educational Strategy Lectures Homework Plant tours
Zimmer, Boston Scientific, Medtronic, Life Scan
Group Project
Educational Strategy Group Project
The purpose of the group project is to select a product from a recognized Biomedical Engineering company, compare it against similar products on the market, and develop an improved device based on the students engineering background and the engineering fundamentals learned in class.
The project is divided into several tasks
Improvement of Drug Eluting Stents Objectives
Analyze the of mass transport of the Drug Eluting Stent manufactured by Cordis (CYPHER)
Improve mass transport by proposing polymeric nanoparticles as an alternative for drug release
Manufactured by Cordis LLC, San German, Puerto
Rico Device Class 3
Product Code NIQ
Submission Type PMA
M. Alvarez-Berríos, M. García-Jiménez, Chemical Engineering at UPRM
Improvement of Drug Eluting Stents
M. Alvarez-Berríos, M. García-Jiménez, Chemical Engineering at UPRM
2 2.5 3 3.5 4 4.5
0
0.005
0.01
0.015
0.02
0.025
0.03
Radius (mm)
Rel
ease
Rat
e (n
g/s)
Release rate concentration as a function of radius and length
Concentration profile for the drug in the blood a function of time when using the stent (Co = 0.0226 g/cm3)
Outcomes
Positive Negative This course puts the students
right outside their comfort zone, which stimulates their creativity
The students get to tackle real life problems (or close to it)
Students realize that they can solve biological/medical related problems w/ their engineering background
Some students are not used to have such freedom in selecting the appropriate problem to solve and end up missing the relevance of the assignment
Most of the biotransport material is covered late in the semester
Undergrads feel they don’t have the appropriate tools (e.g. COMSOL Multiphysics) to solve some of the proposed problems
Thanks!