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Shailja Vaidya Gupta
Director, International Cooperation
Department of Biotechnology
Ministry of Science of Technology
Government of India
s
BIOTECHNOLOGY
SECTOR IN INDIA
1
OVERVIEW
Indian Biotech Industry Growth is at CAGR
18.5% & revenue from biotech sector is US$
3.766 billion
Export revenue: US$ 1.813 billion at 11%
growth
5 year CAGR growth for Biotech Sector
(2007-12): 19.2%
Biotech sector contribution to GDP by Year
2025 expected to be: US$ 20 - 25 billion
2
BIOTECH SECTOR COMPOSITION
1. BioPharma
2. BioServices
3. BioAgriculture
4. BioIndustrial
5. BioInformatics
62 %20 %
14 %
3 % 1 %
BIOPHARMA
BIOSERVICES
BIOAGRI
BIOINDUSTRY
BIOINFORMATICS
3
0
500
1000
1500
2000
2500
3000
3500
4000
2007-08 2008-09 2009-10 2010-11 2011-12BIOINFORMATICS 35,01 40,54 42,56 44,59 54,91
BIOINDUSTRY 75,54 88,08 103,92 115,33 128,43
BIOAGRI 221,3 260,36 356,73 465,97 556,99
BIOSERVICES 289,66 379,95 486,27 597,94 764,88
BIOPHARMA 1271,23 1452,55 1626,86 1963,33 2336,28
In U
S$ (
milli
on
)
Biotech Sector Overview
4
Biotech Parks & IncubatorsCentral and State governments are setting up
biotech parks, incubators as well as pilot projects.
Around 150 Incubators and Science & Technology
Parks are currently functional in India.
Distribution of parks in India and major ones are
listed:PARKS CITY
Alexandria Centre for Science
and Innovation
Hyderabad
ICICI Knowledge Park Hyderabad
International Biotech Park Pune
Lucknow Biotech Park Lucknow
Golden Jubilee Biotech Park Chennai
Ticel Bio Park Chennai
5
Department of Biotechnology, Ministry of Science &
Technology, Government of India is the Nodal Ministry for
Biotech Sector in India
Ministry of Science & Technology
Department of
Science &
Technology (DST)
Department of Biotechnology
(DBT)
Department of Scientific & Industrial
Research (DSIR)
6
Roles and Responsibilities of Department of
Biotechnology• Central coordinating and policy making organization in biotechnology
• Funds research and development in biotechnology
• Developing critical mass of skilled human resource
• Establishment of state-of-the-art infrastructure facilities
• Establishment of centres of excellence
• Provide framework and guidelines for regulatory policies
• Annual Budget : US$ 300 million (2013-2014)
US$ 2.4 billion (2012-2017)
• Provides Extramural grants to :
- Universities, research institutions and academia
- Provides R&D support to NGOs and Industry
• Core funding to 14 autonomous institutes
7
Discovery
Innovation
Enterprise
“Accelerating the pace of
research, innovation,
development and technology
transfer to advance
biotechnology as strategic area
by taking India's strengths in
foundational sciences to
globally competitive levels and
expanding the application of
biotechnologies for overall
growth of bio-economy within
the framework of inclusive
development”.
8
Agri Biotech & Allied Areas
22 %
Medical Biotech & Allied Areas
26 %Capacity Building21 %
Biodiversity, Bioresources & Environmental
14%
Basic Bio & Emerging Areas
17 %
Sector Wise Allocation of Budget During11th Five Year Plan Period (2007-12)
9
Basic Biotechnology
- Genomics- Proteomics- Structural Biology
Medical Biotechnology Vaccines and diagnostics– Bioactive Therapeutic Proteins– Stem cell research– Infectious, chronic and neurodegenerative diseases
Agriculture
- Crop Genomics- Genetically modified crops, plants and seeds for stress tolerance- Nutritional enhancement of crops- Marker assisted breeding- Biopesticides, biofertilizers and biocontrol agents
Priority Areas for Funding
10
Priority Areas for Funding: contd…
Environmental Biotechnology for sustainable utilization of bioresources
- Bioprospecting of bioactive genes and molecules- Characterisation of medicinal plants- Bioremediation technologies for treatment of waste
Animal Biotechnology
- Molecular epidemiology : diagnostics & vaccines- Improvement of breeds and productivity through transgenics- Immuno-stimulants - Animal feed
Aquaculture & Marine Biotechnology
- Molecular epidemiology : diagnostics & vaccines- Cell line development- Immuno-stimulants, antibacterial and anti-cancerous agents from marine sources
Food Biotechnology
- Nutraceuticals and probiotics
Development of new products
- Bioinstrumentation, biomaterials and bio-devices
11
FACTS SHEET: DBT SUPPRTED MAJOR PRGRAMMES
Discovery led
innovation (2410 )
Centres
of excellence (50)
Networks (52)
Total
Institutions (14)
Global Partnerships (16)
Bio-clusters(3)
Translational Platforms (10)
Grand Challenges (5)
Public-Private
Partnerships (200)
Promotion of
excellence
innovation
and
technology
development
12
Funding Mechanisms for R&D Projects
Research and Development projects through
competitive research grant scheme
Centres of Excellence
Public-Private-Partnerships through
Biotechnology Industry Research Assistance
Council (BIRAC)
Grand Challenges Programme
International Collaborations
13
0
200
400
600
800
1000
8th Plan 9th Plan 10th Plan 11th Plan
Government Investments in Biotechnology and Life Sciences
(In million US$)
12th Five Year Plan (2012-2017) allocation US$
2.5 billion14
International
Collaboration- update
COUNTRY Number of
projects
Australia 14
Canada 12
Denmark 12
Finland 31
Germany 49
Netherlands 2
Norway 3
Spain 3
Sweden 12
Switzerland 13
United
Kingdom
14
United States
of America
32
EU 1715
ONGOING BILATERAL/MULTILATERAL COLLABORATIONS
COUNTRY RESEARCH AREAS OF COLLABORATION
Australia • Agreement for collaboration in all areas of biotechnology, with the Australian
Department Of Education, Science and Training. Total 14 ongoing projects
Canada • Agreement on convergent medical technologies; application to clean technologies and
Bio-pharma & health with the International Science and Technology Partnerships
(ISTP); in plant sciences with National Research Council of Canada (NRC). Total 12
ongoing projects. Call for proposals announced.
Denmark • Medical Biotechnology : Stem cell research; chronic and infectious diseases; Agriculture
biotechnology and Environmental biotechnology with Ministry of Science, Technology and
Innovation , Denmark. Call for proposals announced in the area of health science
biotechnology.
Total 12 ongoing projects
Finland • Vaccine development and technologies herein; Development of new innovative diagnostics
using different technologies & Computational biology related to drug development with
Academy of Finland (AoF) and Tekes, Finland. Total 31 ongoing projects
Germany • Call for proposals in microbial biotechnology, bioprocess engineering, structural biology,
infectious diseases and neuroscience with International Bureau (IB) of the Federal
Ministry of Education & Research (BMBF). Total 49 ongoing projects
Netherlands • A Programme of Cooperation (PoC) has been signed between DBT and Directorate
General for Enterprise and Innovation, Ministry of Economic Affairs Agriculture and
Innovation, Govt. of Netherlands in the area of Plant Sciences, Food & Nutrition and
medical Biotechnology.
• A Letter of Intent (LoI) was signed between DBT and Erasmus Univ. 2 Projects funded.16
ONGOING BILATERAL/MULTILATERAL
COLLABORATIONS: contd….
COUNTRY RESEARCH AREAS OF COLLABORATION
Norway • Vaccine development for human, fish and animal with National Research Council (NRC).
Total 3 ongoing projects
Spain • A Programme of Cooperation (PoC) has been signed between DBT and Centre for
Development of Industrial Technology (CDTI), Spain. Call for proposals announced in
the area of biotechnology including biofuels and bioenergy and three proposals
recommended for funding.
Sweden • Biology, diagnosis and treatment of Tuberculosis with VINNOVA. Call for proposals
announced in the area of health science biotechnology. Total 12 ongoing projects.
Switzerland • Converting research leads into products and processes of social and economic value
with a focus in agriculture biotechnology. Total 13 ongoing projects
United Kingdom • Main area of focus Agriculture research and Food Security with Biotechnology &
Biological Sciences Research Council (BBSRC) and Department for International
Development (DFID). 5 ongoing projects: 4 proposals in the area of Sustainable
Crop Development; one project with Belfast University under Cancer Research
Programme Projects funded in the Bioenergy and Biofuelsand Livestock Health
and Diseases.
United States of
America
• Vaccine Development Programme; Contraceptive Research and Reproductive Health;
Agriculture Biotechnology and Vision Research with NIH. Biodesign programme with
Stanford University. Total 32 projects funded so far.
EU • India-EU synchronized joint calls announced. 4 projects funded.
• New Indigo ERA-NET. Total 17 ongoing projects
NGOs / Trusts • Wellcome Trust
• Bill and Melinda Gates Foundation
17
INTERNATIONAL CANCER
GENOME CONSORTIUM (ICGC)
International Cancer Genome Consortium (ICGC)programme: launched in November, 2008 at NIBMG,Kalyani
Participation along with fourteen countries includingIndia, Australia, Canada, China, France, Japan, Spain,United Kingdom, USA and others
Vision : to generate comprehensive, high-resolutionanalyses of genomic changes for 8 forms of cancerfound across the planet based on the NCI-NIHInternational Cancer Genome Atlas programme
ICGC - India specific programme. Oral cancer
Established state of art genome sequencing facility
Established sample collection repository: ACTREC,Mumbai.
18
The International Wheat Genome Sequencing
Consortium (IWGSC)
An internationally
coordinated
sequencing bread
wheat genome for
accelerating wheat
improvement
Indian Partners
DBT, NIPGR, UDSC
and IARI (ICAR)
INDIA
19
Proposed Biotech Science Clusters:
Strength of Synergy
20
(A Company set up by
Government of India to
promote Public-Private-
Partnership in Biotech
Sector)
Website:
www.birac.nic.in21
No. of projects funded: Around 200
Government Contribution: US$ 100 million
Private Sector Contribution: US$ 150 million22
Some Success Stories
23
S.
No.
Vaccine for Current Status
1. Leprosy Commercial
2. Swine Flu
(H1N1)
Commercial
3. Japanese
encephalitis
Approved for
commercial use
4. Rota viral
Diarrhoea
Phase III Clinical trials
successful.
Commercial
production to be
started
5. Cholera Phase III completed
6. Malaria Phase I
7. Anthrax Phase I
8. Dengue Pre-clinical
9. Typhoid Pre-clinical
Healthcare : Human Vaccines
24
Healthcare - Animal Vaccines
Sl.
No
.
Vaccine for Current Status
1. Rabies Approved for animal use
2. Swine fever in pigs Animal trials ( 3 types)
3. Paratuberclosis for
small ruminants and
cattle
Pre-clinical
4. Bovine herpes virus
I in cattle
Pre-clinical
5. Infectious Bovine
Rhinotracheitis (IBR)
in poultry
Pre-clinical
6. New Castle viral
disease in poultry
Pre-clinical25
Healthcare --Drug Development Healthcare –Medical devices and implants
The Integrated planning navigation and
Training Platform for Tumor Ablation
launched in the market
Multi deck shaker
Robio-targeting system for CT guided
interventional procedures
Affordable clinical chemistry analyzer –
Autochem ingenious26
DIAGNOSTICS
Transferred to the Industries & Launched in the Market
Western Blot for HIV-I & II -HIV/AIDS
Naked Eye Agglutination System (NEVA) -HIV/AIDS
Shantest for detection of Alpha-feto Protein
in Pregnant Women.
JEV-CHEX for Japanese encephalitis
SIGNAL – KA for Leishmania.
Signal MF - Filaria
ELISA- Hepatitis „C‟
Transferred, yet to be launched:- IgM Mac ELISA -Dengue
Japanese encephalitisWest Nile
- IgM – ELISA - Hepatitis ‘A’
DBT
27
Commercialized Dengue
NS1 Ag & Ab Combi test
DEVELOPED IN COLLABORATION WITH
INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY
Supported by Department of Biotechnology
Commercialized Dengue NS1
Antigen Microlisa:
28
An effective and consistent way to deliver chest
compressions to sudden cardiac arrest victims
A better way to gain intra-osseous access in emergency patients.
Non-invasive, rapid and definitive way of airway management.
Esophag
us
Entry
Trachea
Entry
Stanford-India Biodesign ProgrammeCreating Entrepreneurs
29
Rice Tomato
Discovery of genes and markers :
Genome Initiative: India Moves Ahead !
Sugarcane
Chickpea
Wheat
Coffee
Chromosome 11 Chromosome 5
Bacterial
Silk worm
CancerCompleted
30
Transgenic crops developed in public
sector under regulatory field trials
Crop Organisation Trait
Brinjal IARI, New Delhi Insect Resistance
Castor Directorate of Oilseeds Research
(DOR), Rajendranagar, Hyderabad
Insect resistance
Sorghum National Research Centre for
Sorghum (NRCS),Hyderbad
Insect resistance
Groundnut ICRISAT, Hyderabad Fungal disease
resistance
Potato Central Potato Research Institute
(CPRI), Shimla
Leaf blight disease
resistance
Rice IARI, New Delhi
Tamil Nadu Agricultural
University
Mahyco, Mumbai
Fungal diseases
resistance and drought
tolerance
Tomato IARI, New Delhi Virus disease and
insect resistance31
0.001.002.003.004.005.006.007.008.009.00
CONTROL
ODC 22
ODC 27
ODC 32
SAMDC 22
SAMDC 24
SAMDC 56
SAMDC 70
ADC 25
ADC 93
Line no.
Lyco
pene
(mg/
100g
)
Tomato with improved quality parameters and shelf life
70 R&D projects in 15 crops for development of
GM crop varieties in public sector institutions/ universities
for improvement of productivity, quality, pest and disease
resistance, water use efficiency and salinity resistance
Rice with water use efficiency Groundnut with virus disease resistance
32
Bioethanol
Algal Biofuel
Biodiesel
Energy
Bioscience
Centre
Capacity Building
• Re-engineered feed stock
• Re-engineered
microorganisms
• Process optimization • Collection and
characterization
• Establishment of
repositories
• Development of
production system
• Quality planting material
• Improved feed stock
• Process optimization • Biohydrogen
• Biobutanol
National Programme on Energy Biosciences
More than 53 research institutes, universities and industries involved
• Energy Bioscience
Chairs
• Energy Bioscience
Overseas Fellowships
Next generation Biofuels
33
DBT-IOC Centre
Ligno cellulosic ethanol plant
First such facility in India.
Developed with the help of NREL
DBT – ICT Centre
First CellulosicEthanol Pilot Plantdeveloped withIndigenous Technology
Biofuel technologies
34
The DBT-FINLAND
STORY
35
Finland2005- Memorandum of Understanding (MOU) signed between DBT and
Academy of Finland.
2009- Memorandum of Understanding (MoU) signed with Tekes, Finland
2011- Letter of Intent (LOI) signed with University of Turku
Eight joint and one trilateral call for proposals announced: 2006: medical biotechnology (with Academy of Finland)
2007: agriculture biotechnology (with Academy of Finland)
2008: environmental biotechnology (with Academy of Finland)
2009: first trilateral call on medical diagnostics (between DBT, Academy of Finland and Tekes)
2010: affordable medical diagnostics (between DBT and Tekes, with industrial participation)
2011: food biotechnology (bilateral call between DBT and Academy of Finland)
2012: health and well being (bilateral call between DBT and Tekes)
2013: synthetic biology (bilateral call between DBT and Academy of Finland)
Current call with Tekes on Health and Well being
Total projects funded: 31
Total publications: 43 (average IF 4.5)
Indo-Finland Diagnostic Research Center established between THSTI and University of Turku
Concluding Remarks
Successful collaborations with Finland is result of:
Flexibility in approach both administrative and scientific
Readiness to meet various models of collaborations,
bilateral/multilateral, basic research or translational
research involving industry(ies) and / or academia.
Availability of matching scientific expertise
Finally and most important, availability of funds on both
sides
DBT Website: www.dbtindia.nic.in
42