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1 | Bioenergy Technologies Office

BIOENERGY TECHNOLOGIES OFFICE

Biotechnology R&D to Enable Ultra-Low-Cost Lignocellulosic Biofuels

July 25, 2017

Kevin Craig

Conversion R&D Program Manager, Bioenergy Technologies Office (BETO)

U.S Department of Energy


BETO’s Mission & Vision

BETO reduces risks and costs to commercialization through R&D.

Vision

Mission

Strategic Goals

A thriving and sustainable bioeconomy fueled by innovative technologies

Developing and demonstrating transformative and revolutionary sustainable bioenergy technologies for a prosperous nation

Develop industrially relevant technologies to enable domestically produced biofuels and bioproducts without subsidies


Potential Markets for Fuels and Products

Bioproducts

Drop-in and

Functional Replacements

• High-value market

• Chemical composition often more similar to biomass than petroleum

• Opportunity to utilize lignin (hard to digest part of plants) more effectively

BiofuelsDrop-in

Blendstocks for

• Gasoline• Diesel• Jet

42 Gallon Barrel


Biobased products contain oxygen… like biomass

Vennestrøm, P.N. R. et al Angew. Chem. Int. Ed. 2011, 50, 10502-10509

Shen, J. et al Energy Conversion and Management 2010, 51, 983–987

Biomass

Avg. wt%:C 36-53%, H 5-7%, O 31-48%

Crude oil

Avg. wt%:C 83-87%H 10-14%O 0.1-1.5%

Consider the oxidation

state of chemicals –retain what

nature provides


Hydrocarbon/Sugar Intermediates

Low-Temperature Deconstruction and Catalytic Sugar Upgrading Pathway:


The Challenge: How can BETO enable cost-competitive (<$3/GGE) lignocellulosic biofuels in the near term (~5-10 years)?

We annually model and periodically verify 6 lignocellulosic biofuel pathways

The average MSFP at nth plant is $3.36/GGE

Can bioproducts be the thin edge of the wedge?

“An assessment of the potential products and economic and environmental impacts resulting from a billion ton bioeconomy” Biofuels, Bioprod. Bioref. 11:110–128 (2017). Z Haq (BETO) and partners at USDA, Energetics, AST, and ANL


How does the estimated product price needed to subsidize to $3/GGE and $2/GGE vary with % of product allocated to fuel vs product?

• 30% products offers the best trade-off between price for the co-product and maximizing fuel production

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Percentange total products to chemicals production (%)

$2/GGE biofuel MFSP (including 10% ROI)

30% CAPEX/OPEXincrease


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Percentange total products to chemicals production (%)

$3/GGE biofuel MFSP (including 10% ROI)




Scalability of Bioproducts

Chemicals from Biomass: A Market Assessment of Bioproducts with Near-Term Potential, Mary Biddy (NREL) and colleagues. Available at: http://www.nrel.gov/docs/fy16osti/65509.pdf

$0 $0.23 $0.46 $0.69 $0.92 $1.15 $1.38 $1.61 $1.84 $2.07 $2.30$/lb


Bioproducts uniformly showed emission reductions compared to their fossil-derived counterparts

9

Life-Cycle Fossil Energy Consumption and Greenhouse Gas Emissions of Bioderived Chemicals and Their Conventional Counterparts – Felix Adom, Jennifer Dunn, Jeongwoo Han, and Norm Sather.


How Can Renewable Chemicals Help?

Pros:

• Early Adopter Market. Greater return for

early risk.

• Breaks feedstock chicken/egg connudrum

• Consumer approval.

• Builds investor confidence.

• Proves common process steps.

• Simpler routes to some chemicals.

• Novel chemicals with improved properties.

• Smaller plants can fit supply/demand gaps.

• Lower investment sums per plant.

Cons:

• Spot pricing does not reflect long term

issues and potential market saturation.

• Industry will use cheapest sugar stream

exacerbating “food vs fuel” issues.

• Smaller individual markets for some high

value chemicals (BUT: S niches = “Real”

Market)


The Challenge: Cost and Time to Market

1,3-Propanediol (PDO)

Artemisinin

O

O

O

O

O

H

HH

Possible savings of billions of dollars by reducing

development time of products, reducing energy

intensity and increasing carbon efficiency

UC Berkeley,

Amyris,Sanofi

DuPont -Tate & Lyle

>$50M

>>$120M 15 years

10 years

Molecule Company Cost Time


Agile BioFoundry - Goal Statement

• Goal: Enable a biorefinery to achieve a positive return on investment through a 50% reduction in time-to-scale up compared to the average of ~10 years by establishing a distributed Agile BioFoundry that will productionize synthetic biology.

• Outcomes: 10X improvement in Design-Build-Test-Learn cycle efficiency, new host organisms, new IP and manufacturing technologies effectively translated to U.S. industry ensuring market transformation.

• Relevance: Public infrastructure investment that increases U.S. industrial competitiveness and enables new opportunities for private sector growth and jobs.


Agile BioFoundry Focus

• Drop-in and Bio-advantaged chemicals• Large aggregate markets that enable fuel

• Non-model organisms• Sweet spot: taking mg/L titers to

relevant TRY metrics• Democratization of integrated

synthetic biology tools• Background IP packages• Public datasets• Partnerships


Project Management – Org Chart

Subtask A.1

DesignJohn Gladden (SNL)

Subtask A.2

BuildSam Deutsch (LBNL)

Subtask A.3

TestJon Magnuson (PNNL)

Subtask A.4

LearnCorey Hudson (SNL)

Hector Garcia-Martin (LBNL)

Subtask A.5

IntegrationDayna Daubaras (INL)

Task A

Integrated DBTLNathan Hillson (LBNL)

Task B

Integrated AnalysisMary Biddy (NREL)

Task C

Host OnboardingTaraka Dale (LANL)Adam Guss (ORNL)

Task D

Process Integration and ScalingGregg Beckham (NREL)

Todd Pray (LBNL)

Executive

CommitteeIndustry Partnerships

Industry Advisory Board

Project Management

and IntegrationGarrett Peterson (LBNL)

BETO Technology

ManagerJay Fitzgerald


DBTL

• Finalize FY17 target/host Designs, submit for Build

• Prepare Test capabilities for selected targets/hosts

• Develop and refine Learn models

Process Scale & Integration

• Produce corn stover DMR-EH hydrolysate for fermentation

– Process optimization

– Hydrolysate characterization

Host Onboarding

• Characterization of promising “new” Host organisms for future years

Industry Engagement

• Webinars and one-on-one interviews with Industrial Advisory Board to strengthen partnerships and develop metrics on industry impact

Active Agile BioFoundry Consortium Efforts

Rotary drum filter


Biotechnology R&D to Enable Ultra-Low-Cost Lignocellulosic Biofuels

1. Performance Advantaged Biobased Chemicals

2. Agile BioFoundryhttp://agilebiofoundry.org/

3. Separations Consortiumhttps://www.bioesep.org/

4. Chemical Catalysis for BioenergyConsortium

https://www.chemcatbio.org/


Thank You!


BETO Budget

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