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What is Biotechnology? Chapter 1

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Biotechnology Chapter One Lecture- Intro to Biotech

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Page 1: Biotechnology Chapter One Lecture- Intro to Biotech

What is Biotechnology?

Chapter 1

Page 2: Biotechnology Chapter One Lecture- Intro to Biotech

Learning Outcomes

Page 3: Biotechnology Chapter One Lecture- Intro to Biotech

Learning Outcomes

Describe the science of biotechnology and identify its product domains

Page 4: Biotechnology Chapter One Lecture- Intro to Biotech

Learning Outcomes

Describe the science of biotechnology and identify its product domains

Give examples of careers and job responsibilities associated with biotechnology

Page 5: Biotechnology Chapter One Lecture- Intro to Biotech

Learning Outcomes

Describe the science of biotechnology and identify its product domains

Give examples of careers and job responsibilities associated with biotechnology

Outline the steps in producing and delivering a product made through recombinant DNA technology

Page 6: Biotechnology Chapter One Lecture- Intro to Biotech

Learning Outcomes

Describe the science of biotechnology and identify its product domains

Give examples of careers and job responsibilities associated with biotechnology

Outline the steps in producing and delivering a product made through recombinant DNA technology

Describe how scientific methodologies are used to conduct experiments and develop products

Page 7: Biotechnology Chapter One Lecture- Intro to Biotech

Learning Outcomes

Describe the science of biotechnology and identify its product domains

Give examples of careers and job responsibilities associated with biotechnology

Outline the steps in producing and delivering a product made through recombinant DNA technology

Describe how scientific methodologies are used to conduct experiments and develop products

Apply the strategy for values clarification to bioethical issues

Page 8: Biotechnology Chapter One Lecture- Intro to Biotech

1.1 Defining Biotechnology

Biotechnology is defined as the study and manipulation of living things or their component molecules, cells, tissues, or organs.

Page 9: Biotechnology Chapter One Lecture- Intro to Biotech

Biotechnology Workers and the Biotechnology Workplace

Page 10: Biotechnology Chapter One Lecture- Intro to Biotech

Biotechnology Workers and the Biotechnology Workplace

• Biotechnology Companies - goal is to produce and sell commercial “for-profit” products

Page 11: Biotechnology Chapter One Lecture- Intro to Biotech

Biotechnology Workers and the Biotechnology Workplace

• Biotechnology Companies - goal is to produce and sell commercial “for-profit” products

• Universities and Government Labs - conduct “pure science” research, nonprofit

Page 12: Biotechnology Chapter One Lecture- Intro to Biotech

Biotechnology Workers and the Biotechnology Workplace

• Biotechnology Companies - goal is to produce and sell commercial “for-profit” products

• Universities and Government Labs - conduct “pure science” research, nonprofit

• Growth in the Biotechnology Industry

Page 13: Biotechnology Chapter One Lecture- Intro to Biotech

5

Page 14: Biotechnology Chapter One Lecture- Intro to Biotech

1.2 The Increasing Variety of Biotechnology Products

Bioengineered ProductsAs the methods of manipulating living things have become more sophisticated, the number and variety of biological products have increased at an incredible rate.

Page 15: Biotechnology Chapter One Lecture- Intro to Biotech

Genetically modified organisms – organisms that contain DNA from another organism and produce new proteins encoded on the acquired DNA

Gene Engineered Plant. The organism that gets the new genes will then have the potential to express the new traits coded in the newly acquired genes.

Page 16: Biotechnology Chapter One Lecture- Intro to Biotech

Producing Genetically Engineered t-PA.

Humans make only a small amount of human tissue plasminogen activator (t-PA) naturally. By genetically modifying Chinese hamster ovary (CHO) cells, scientists can make large amounts of t-PA for therapeutic purposes, such as to clear blood vessels in the event of a heart attack or stroke.

Page 17: Biotechnology Chapter One Lecture- Intro to Biotech
Page 18: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary

Page 19: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary• DNA – abbreviation for deoxyribonucleic acid, a double-stranded

helical molecule that stores genetic information for the production of all of an organism’s proteins

Page 20: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary• DNA – abbreviation for deoxyribonucleic acid, a double-stranded

helical molecule that stores genetic information for the production of all of an organism’s proteins

• Recombinant DNA (rDNA) technology – cutting and recombining DNA molecules

Page 21: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary• DNA – abbreviation for deoxyribonucleic acid, a double-stranded

helical molecule that stores genetic information for the production of all of an organism’s proteins

• Recombinant DNA (rDNA) technology – cutting and recombining DNA molecules

• Polymerase chain reaction (PCR) – a technique that involves copying short pieces of DNA and then making millions of copies in a short time

Page 22: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary• DNA – abbreviation for deoxyribonucleic acid, a double-stranded

helical molecule that stores genetic information for the production of all of an organism’s proteins

• Recombinant DNA (rDNA) technology – cutting and recombining DNA molecules

• Polymerase chain reaction (PCR) – a technique that involves copying short pieces of DNA and then making millions of copies in a short time

• Cloning – method of asexual reproduction that produces identical organisms

Page 23: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary• DNA – abbreviation for deoxyribonucleic acid, a double-stranded

helical molecule that stores genetic information for the production of all of an organism’s proteins

• Recombinant DNA (rDNA) technology – cutting and recombining DNA molecules

• Polymerase chain reaction (PCR) – a technique that involves copying short pieces of DNA and then making millions of copies in a short time

• Cloning – method of asexual reproduction that produces identical organisms

• Fermentation – a process by which, in an oxygen-deprived environment, a cell converts sugar into lactic acid or ethanol to create energy

Page 24: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary• DNA – abbreviation for deoxyribonucleic acid, a double-stranded

helical molecule that stores genetic information for the production of all of an organism’s proteins

• Recombinant DNA (rDNA) technology – cutting and recombining DNA molecules

• Polymerase chain reaction (PCR) – a technique that involves copying short pieces of DNA and then making millions of copies in a short time

• Cloning – method of asexual reproduction that produces identical organisms

• Fermentation – a process by which, in an oxygen-deprived environment, a cell converts sugar into lactic acid or ethanol to create energy

• Proteases – proteins whose function is to break down other proteins

Page 25: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary• DNA – abbreviation for deoxyribonucleic acid, a double-stranded

helical molecule that stores genetic information for the production of all of an organism’s proteins

• Recombinant DNA (rDNA) technology – cutting and recombining DNA molecules

• Polymerase chain reaction (PCR) – a technique that involves copying short pieces of DNA and then making millions of copies in a short time

• Cloning – method of asexual reproduction that produces identical organisms

• Fermentation – a process by which, in an oxygen-deprived environment, a cell converts sugar into lactic acid or ethanol to create energy

• Proteases – proteins whose function is to break down other proteins

• Antibodies – proteins developed by the immune system that recognize specific molecules (antigens)

Page 26: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary• DNA – abbreviation for deoxyribonucleic acid, a double-stranded

helical molecule that stores genetic information for the production of all of an organism’s proteins

• Recombinant DNA (rDNA) technology – cutting and recombining DNA molecules

• Polymerase chain reaction (PCR) – a technique that involves copying short pieces of DNA and then making millions of copies in a short time

• Cloning – method of asexual reproduction that produces identical organisms

• Fermentation – a process by which, in an oxygen-deprived environment, a cell converts sugar into lactic acid or ethanol to create energy

• Proteases – proteins whose function is to break down other proteins

• Antibodies – proteins developed by the immune system that recognize specific molecules (antigens)

• Pharmaceutical – relating to drugs developed for medical use

Page 27: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary

Vocabulary

Page 28: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary• Antibiotics – molecular agents derived from fungi and/

or bacteria that impede the growth and survival of some other microorganisms (bacteria killers).

Vocabulary

Page 29: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary• Antibiotics – molecular agents derived from fungi and/

or bacteria that impede the growth and survival of some other microorganisms (bacteria killers).

• Restriction enzyme – enzyme that cuts DNA at a specific nucleotide sequence

Vocabulary

Page 30: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary• Antibiotics – molecular agents derived from fungi and/

or bacteria that impede the growth and survival of some other microorganisms (bacteria killers).

• Restriction enzyme – enzyme that cuts DNA at a specific nucleotide sequence

• DNA ligase – an enzyme that binds together disconnected strands of a DNA molecule

Vocabulary

Page 31: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary• Antibiotics – molecular agents derived from fungi and/

or bacteria that impede the growth and survival of some other microorganisms (bacteria killers).

• Restriction enzyme – enzyme that cuts DNA at a specific nucleotide sequence

• DNA ligase – an enzyme that binds together disconnected strands of a DNA molecule

• Recombinant DNA – DNA created by combining DNA from two or more sources

Vocabulary

Page 32: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary• Antibiotics – molecular agents derived from fungi and/

or bacteria that impede the growth and survival of some other microorganisms (bacteria killers).

• Restriction enzyme – enzyme that cuts DNA at a specific nucleotide sequence

• DNA ligase – an enzyme that binds together disconnected strands of a DNA molecule

• Recombinant DNA – DNA created by combining DNA from two or more sources

• Genetically modified organisms – organisms that contain DNA from another organism and produce new proteins encoded on the acquired DNA

Vocabulary

Page 33: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary• Antibiotics – molecular agents derived from fungi and/

or bacteria that impede the growth and survival of some other microorganisms (bacteria killers).

• Restriction enzyme – enzyme that cuts DNA at a specific nucleotide sequence

• DNA ligase – an enzyme that binds together disconnected strands of a DNA molecule

• Recombinant DNA – DNA created by combining DNA from two or more sources

• Genetically modified organisms – organisms that contain DNA from another organism and produce new proteins encoded on the acquired DNA

• E. coli – a rod-shaped bacterium native to the intestines of mammals; commonly used in genetics and biotechnology

Vocabulary

Page 34: Biotechnology Chapter One Lecture- Intro to Biotech
Page 35: Biotechnology Chapter One Lecture- Intro to Biotech

The Human Genome Project

Page 36: Biotechnology Chapter One Lecture- Intro to Biotech

The Human Genome Project

• Determining the human DNA sequence

Page 37: Biotechnology Chapter One Lecture- Intro to Biotech

The Human Genome Project

• Determining the human DNA sequence• Understanding the function of the

human genetic code

Page 38: Biotechnology Chapter One Lecture- Intro to Biotech

The Human Genome Project

• Determining the human DNA sequence• Understanding the function of the

human genetic code• Identifying all of the genes

Page 39: Biotechnology Chapter One Lecture- Intro to Biotech

The Human Genome Project

• Determining the human DNA sequence• Understanding the function of the

human genetic code• Identifying all of the genes• Determining their functions

Page 40: Biotechnology Chapter One Lecture- Intro to Biotech

The Human Genome Project

• Determining the human DNA sequence• Understanding the function of the

human genetic code• Identifying all of the genes• Determining their functions• Understanding how and when genes are

turned on and off throughout the lifetime of an individual

Page 41: Biotechnology Chapter One Lecture- Intro to Biotech

1.3 How Companies Select Products to Manufacture

Page 42: Biotechnology Chapter One Lecture- Intro to Biotech

1.3 How Companies Select Products to Manufacture

Each biotechnology company usually specializes in a group of similar products

Page 43: Biotechnology Chapter One Lecture- Intro to Biotech

1.3 How Companies Select Products to Manufacture

Each biotechnology company usually specializes in a group of similar products• Plant products

Page 44: Biotechnology Chapter One Lecture- Intro to Biotech

1.3 How Companies Select Products to Manufacture

Each biotechnology company usually specializes in a group of similar products• Plant products• Fermentation equipment

Page 45: Biotechnology Chapter One Lecture- Intro to Biotech

1.3 How Companies Select Products to Manufacture

Each biotechnology company usually specializes in a group of similar products• Plant products• Fermentation equipment• Viral therapies

Page 46: Biotechnology Chapter One Lecture- Intro to Biotech

1.3 How Companies Select Products to Manufacture

Each biotechnology company usually specializes in a group of similar products• Plant products• Fermentation equipment• Viral therapies• DNA sequencers for research

Page 47: Biotechnology Chapter One Lecture- Intro to Biotech

1.3 How Companies Select Products to Manufacture

Each biotechnology company usually specializes in a group of similar products• Plant products• Fermentation equipment• Viral therapies• DNA sequencers for research • Enzymes for food processing

Page 48: Biotechnology Chapter One Lecture- Intro to Biotech

1.3 How Companies Select Products to Manufacture

Developing Ideas for New Products

Page 49: Biotechnology Chapter One Lecture- Intro to Biotech

1.3 How Companies Select Products to Manufacture

Developing Ideas for New ProductsIdeas come from many sources:

Page 50: Biotechnology Chapter One Lecture- Intro to Biotech

1.3 How Companies Select Products to Manufacture

Developing Ideas for New ProductsIdeas come from many sources:• Discussions lead to new ideas

Page 51: Biotechnology Chapter One Lecture- Intro to Biotech

1.3 How Companies Select Products to Manufacture

Developing Ideas for New ProductsIdeas come from many sources:• Discussions lead to new ideas• Reading literature reviews can lead to new

ideas

Page 52: Biotechnology Chapter One Lecture- Intro to Biotech

1.3 How Companies Select Products to Manufacture

Developing Ideas for New ProductsIdeas come from many sources:• Discussions lead to new ideas• Reading literature reviews can lead to new

ideas• Sometimes even daydreaming can lead to

new ideas

Page 53: Biotechnology Chapter One Lecture- Intro to Biotech

A Product Development PlanBefore going into research and development, company officials must determine whether or not it is worth the investment of company resources.

Page 54: Biotechnology Chapter One Lecture- Intro to Biotech

A Product Development Plan

Product Development Plan usually includes the following criteria:

Before going into research and development, company officials must determine whether or not it is worth the investment of company resources.

Page 55: Biotechnology Chapter One Lecture- Intro to Biotech

A Product Development Plan

Product Development Plan usually includes the following criteria:• Does the product meet a critical need? Who will use the product?

Before going into research and development, company officials must determine whether or not it is worth the investment of company resources.

Page 56: Biotechnology Chapter One Lecture- Intro to Biotech

A Product Development Plan

Product Development Plan usually includes the following criteria:• Does the product meet a critical need? Who will use the product?• Is the market large enough to produce enough sales? How many

customers are there?

Before going into research and development, company officials must determine whether or not it is worth the investment of company resources.

Page 57: Biotechnology Chapter One Lecture- Intro to Biotech

A Product Development Plan

Product Development Plan usually includes the following criteria:• Does the product meet a critical need? Who will use the product?• Is the market large enough to produce enough sales? How many

customers are there?• Do preliminary data support that the product will work? Will the

product do what the company claims?

Before going into research and development, company officials must determine whether or not it is worth the investment of company resources.

Page 58: Biotechnology Chapter One Lecture- Intro to Biotech

A Product Development Plan

Product Development Plan usually includes the following criteria:• Does the product meet a critical need? Who will use the product?• Is the market large enough to produce enough sales? How many

customers are there?• Do preliminary data support that the product will work? Will the

product do what the company claims?• Can patent protection be secured? Can the company prevent

other companies from producing it?

Before going into research and development, company officials must determine whether or not it is worth the investment of company resources.

Page 59: Biotechnology Chapter One Lecture- Intro to Biotech

A Product Development Plan

Product Development Plan usually includes the following criteria:• Does the product meet a critical need? Who will use the product?• Is the market large enough to produce enough sales? How many

customers are there?• Do preliminary data support that the product will work? Will the

product do what the company claims?• Can patent protection be secured? Can the company prevent

other companies from producing it?• Can the company make a profit on the product? How much will it

cost to make it? How much can it be sold for?

Before going into research and development, company officials must determine whether or not it is worth the investment of company resources.

Page 60: Biotechnology Chapter One Lecture- Intro to Biotech

A Product Development Plan

Product Development Plan usually includes the following criteria:• Does the product meet a critical need? Who will use the product?• Is the market large enough to produce enough sales? How many

customers are there?• Do preliminary data support that the product will work? Will the

product do what the company claims?• Can patent protection be secured? Can the company prevent

other companies from producing it?• Can the company make a profit on the product? How much will it

cost to make it? How much can it be sold for?

Before going into research and development, company officials must determine whether or not it is worth the investment of company resources.

Situations That End Product Development

Page 61: Biotechnology Chapter One Lecture- Intro to Biotech

A Product Development Plan

Product Development Plan usually includes the following criteria:• Does the product meet a critical need? Who will use the product?• Is the market large enough to produce enough sales? How many

customers are there?• Do preliminary data support that the product will work? Will the

product do what the company claims?• Can patent protection be secured? Can the company prevent

other companies from producing it?• Can the company make a profit on the product? How much will it

cost to make it? How much can it be sold for?

Before going into research and development, company officials must determine whether or not it is worth the investment of company resources.

Situations That End Product Development• Product development is stopped if testing shows the product is not effective.

Page 62: Biotechnology Chapter One Lecture- Intro to Biotech

A Product Development Plan

Product Development Plan usually includes the following criteria:• Does the product meet a critical need? Who will use the product?• Is the market large enough to produce enough sales? How many

customers are there?• Do preliminary data support that the product will work? Will the

product do what the company claims?• Can patent protection be secured? Can the company prevent

other companies from producing it?• Can the company make a profit on the product? How much will it

cost to make it? How much can it be sold for?

Before going into research and development, company officials must determine whether or not it is worth the investment of company resources.

Situations That End Product Development• Product development is stopped if testing shows the product is not effective.• When this happens, companies can lose millions of dollars and years of

research and development time.

Page 63: Biotechnology Chapter One Lecture- Intro to Biotech

New non-pharmaceutical products must meet EPA and USDA guidelines.

Pharmaceutical products must pass clinical trials on human subjects (2-5 years) to receive FDA approval.

Environmental Protection AgencyUS Department of AgricultureFood and Drug Administration 17

Page 64: Biotechnology Chapter One Lecture- Intro to Biotech

Regulations Governing Product Development

New Biotech Drug Approvals. Even with all the government regulations, the number of new drugs approved for market increased nearly seven times in the 10 years between 1990 and 2000.

Page 65: Biotechnology Chapter One Lecture- Intro to Biotech

19

Page 66: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary

Page 67: Biotechnology Chapter One Lecture- Intro to Biotech

• Research and development (R&D) – refers to the early stages in product development that include discovery of the structure and function of a potential product and initial small-scale production

Vocabulary

Page 68: Biotechnology Chapter One Lecture- Intro to Biotech

• Research and development (R&D) – refers to the early stages in product development that include discovery of the structure and function of a potential product and initial small-scale production

• Pure science – scientific research whose main purpose is to enrich the scientific knowledge base

Vocabulary

Page 69: Biotechnology Chapter One Lecture- Intro to Biotech

• Research and development (R&D) – refers to the early stages in product development that include discovery of the structure and function of a potential product and initial small-scale production

• Pure science – scientific research whose main purpose is to enrich the scientific knowledge base

• Virus – a particle containing a protein coat and genetic materials (either DNA or RNA) that is not living and requires a host to replicate

Vocabulary

Page 70: Biotechnology Chapter One Lecture- Intro to Biotech

• Research and development (R&D) – refers to the early stages in product development that include discovery of the structure and function of a potential product and initial small-scale production

• Pure science – scientific research whose main purpose is to enrich the scientific knowledge base

• Virus – a particle containing a protein coat and genetic materials (either DNA or RNA) that is not living and requires a host to replicate

• Applied science – the practice of utilizing scientific knowledge for practical purposes, including the manufacture of a product

Vocabulary

Page 71: Biotechnology Chapter One Lecture- Intro to Biotech

• Research and development (R&D) – refers to the early stages in product development that include discovery of the structure and function of a potential product and initial small-scale production

• Pure science – scientific research whose main purpose is to enrich the scientific knowledge base

• Virus – a particle containing a protein coat and genetic materials (either DNA or RNA) that is not living and requires a host to replicate

• Applied science – the practice of utilizing scientific knowledge for practical purposes, including the manufacture of a product

• NIH – abbreviation for National Institutes of Health; the federal agency that funds and conducts biomedical research

Vocabulary

Page 72: Biotechnology Chapter One Lecture- Intro to Biotech

• Research and development (R&D) – refers to the early stages in product development that include discovery of the structure and function of a potential product and initial small-scale production

• Pure science – scientific research whose main purpose is to enrich the scientific knowledge base

• Virus – a particle containing a protein coat and genetic materials (either DNA or RNA) that is not living and requires a host to replicate

• Applied science – the practice of utilizing scientific knowledge for practical purposes, including the manufacture of a product

• NIH – abbreviation for National Institutes of Health; the federal agency that funds and conducts biomedical research

• CDC – abbreviation for Centers for Disease Control and Prevention; national research center for developing and applying disease prevention and control, environmental health, and health promotion and education activities to improve public health

Vocabulary

Page 73: Biotechnology Chapter One Lecture- Intro to Biotech

• Research and development (R&D) – refers to the early stages in product development that include discovery of the structure and function of a potential product and initial small-scale production

• Pure science – scientific research whose main purpose is to enrich the scientific knowledge base

• Virus – a particle containing a protein coat and genetic materials (either DNA or RNA) that is not living and requires a host to replicate

• Applied science – the practice of utilizing scientific knowledge for practical purposes, including the manufacture of a product

• NIH – abbreviation for National Institutes of Health; the federal agency that funds and conducts biomedical research

• CDC – abbreviation for Centers for Disease Control and Prevention; national research center for developing and applying disease prevention and control, environmental health, and health promotion and education activities to improve public health

• DNA fingerprinting – an experimental technique that is commonly used to identify individuals by distinguishing their unique DNA code

Vocabulary

Page 74: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary

Page 75: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary• Reagent – chemical used in an experiment

Page 76: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary• Reagent – chemical used in an experiment• Efficacy – the ability to yield a desired result or demonstrate that

a product does what it claims to do

Page 77: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary• Reagent – chemical used in an experiment• Efficacy – the ability to yield a desired result or demonstrate that

a product does what it claims to do• Clinical trials – a strict series of tests that evaluates the

effectiveness and safety of a medical treatment in humans

Page 78: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary• Reagent – chemical used in an experiment• Efficacy – the ability to yield a desired result or demonstrate that

a product does what it claims to do• Clinical trials – a strict series of tests that evaluates the

effectiveness and safety of a medical treatment in humans• FDA – abbreviation for the Food and Drug Administration; the

federal agency that regulates the use and production of food, feed, food additives, veterinary drugs, human drugs, and medical devices

Page 79: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary• Reagent – chemical used in an experiment• Efficacy – the ability to yield a desired result or demonstrate that

a product does what it claims to do• Clinical trials – a strict series of tests that evaluates the

effectiveness and safety of a medical treatment in humans• FDA – abbreviation for the Food and Drug Administration; the

federal agency that regulates the use and production of food, feed, food additives, veterinary drugs, human drugs, and medical devices

• Therapeutic – an agent that is used to treat diseases or disorders

Page 80: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary• Reagent – chemical used in an experiment• Efficacy – the ability to yield a desired result or demonstrate that

a product does what it claims to do• Clinical trials – a strict series of tests that evaluates the

effectiveness and safety of a medical treatment in humans• FDA – abbreviation for the Food and Drug Administration; the

federal agency that regulates the use and production of food, feed, food additives, veterinary drugs, human drugs, and medical devices

• Therapeutic – an agent that is used to treat diseases or disorders• EPA – abbreviation for the Environmental Protection Agency; the

federal agency that enforces environmental laws including the use and production of microorganisms, herbicides, pesticides, and genetically modified microorganisms

Page 81: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary• Reagent – chemical used in an experiment• Efficacy – the ability to yield a desired result or demonstrate that

a product does what it claims to do• Clinical trials – a strict series of tests that evaluates the

effectiveness and safety of a medical treatment in humans• FDA – abbreviation for the Food and Drug Administration; the

federal agency that regulates the use and production of food, feed, food additives, veterinary drugs, human drugs, and medical devices

• Therapeutic – an agent that is used to treat diseases or disorders• EPA – abbreviation for the Environmental Protection Agency; the

federal agency that enforces environmental laws including the use and production of microorganisms, herbicides, pesticides, and genetically modified microorganisms

• USDA – abbreviation for United States Department of Agriculture; the federal agency that regulates the use and production of plants, plant products, plant tests, veterinary supplies and medications, and genetically modified plants and animals

Page 82: Biotechnology Chapter One Lecture- Intro to Biotech

1.4 Doing Biotechnology: Scientific Methodology in a Research Facility

Conducting an Experiment Using Scientific Methodologies

Page 83: Biotechnology Chapter One Lecture- Intro to Biotech

1.4 Doing Biotechnology: Scientific Methodology in a Research Facility

Conducting an Experiment Using Scientific Methodologies1. State a testable scientific question or problem based

on some information or observation.

Page 84: Biotechnology Chapter One Lecture- Intro to Biotech

1.4 Doing Biotechnology: Scientific Methodology in a Research Facility

Conducting an Experiment Using Scientific Methodologies1. State a testable scientific question or problem based

on some information or observation.2. Develop a testable hypothesis.

Page 85: Biotechnology Chapter One Lecture- Intro to Biotech

1.4 Doing Biotechnology: Scientific Methodology in a Research Facility

Conducting an Experiment Using Scientific Methodologies1. State a testable scientific question or problem based

on some information or observation.2. Develop a testable hypothesis.3. Plan a valid experiment.

Page 86: Biotechnology Chapter One Lecture- Intro to Biotech

1.4 Doing Biotechnology: Scientific Methodology in a Research Facility

Conducting an Experiment Using Scientific Methodologies1. State a testable scientific question or problem based

on some information or observation.2. Develop a testable hypothesis.3. Plan a valid experiment.4. Conduct the outlined experiment and collect and

organize the data into tables, charts, graphs, or graphics.

Page 87: Biotechnology Chapter One Lecture- Intro to Biotech

1.4 Doing Biotechnology: Scientific Methodology in a Research Facility

Conducting an Experiment Using Scientific Methodologies1. State a testable scientific question or problem based

on some information or observation.2. Develop a testable hypothesis.3. Plan a valid experiment.4. Conduct the outlined experiment and collect and

organize the data into tables, charts, graphs, or graphics.

5. Formulate a conclusion based on experimental data and error analysis.

Page 88: Biotechnology Chapter One Lecture- Intro to Biotech

Develop a testable hypothesis

Page 89: Biotechnology Chapter One Lecture- Intro to Biotech

Data Table and Graph. Observations and measurements are reported in a data table. Individual trials (replications) as well as averages are shown. Numerical data are shown in picture form using graphs.

Page 90: Biotechnology Chapter One Lecture- Intro to Biotech

Sharing Experimental Results with the Scientific Community

Once an experiment is complete, the work is reported to others through:• Publications• Presentations• Annual conferences

Page 91: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary

Page 92: Biotechnology Chapter One Lecture- Intro to Biotech

• Data – information gathered from experimentationVocabulary

Page 93: Biotechnology Chapter One Lecture- Intro to Biotech

• Data – information gathered from experimentation• Hypothesis – an educated guess to answer scientific question;

should be testable

Vocabulary

Page 94: Biotechnology Chapter One Lecture- Intro to Biotech

• Data – information gathered from experimentation• Hypothesis – an educated guess to answer scientific question;

should be testable• Variable – anything that can vary in an experiment; the

independent variable is tested in an experiment to see its effect on dependent variables

Vocabulary

Page 95: Biotechnology Chapter One Lecture- Intro to Biotech

• Data – information gathered from experimentation• Hypothesis – an educated guess to answer scientific question;

should be testable• Variable – anything that can vary in an experiment; the

independent variable is tested in an experiment to see its effect on dependent variables

• Control – experimental trial added to an experiment to ensure that the experiment was run properly; see positive control and negative control

Vocabulary

Page 96: Biotechnology Chapter One Lecture- Intro to Biotech

• Data – information gathered from experimentation• Hypothesis – an educated guess to answer scientific question;

should be testable• Variable – anything that can vary in an experiment; the

independent variable is tested in an experiment to see its effect on dependent variables

• Control – experimental trial added to an experiment to ensure that the experiment was run properly; see positive control and negative control

• Positive control – a group of data that will give predictable positive results

Vocabulary

Page 97: Biotechnology Chapter One Lecture- Intro to Biotech

• Data – information gathered from experimentation• Hypothesis – an educated guess to answer scientific question;

should be testable• Variable – anything that can vary in an experiment; the

independent variable is tested in an experiment to see its effect on dependent variables

• Control – experimental trial added to an experiment to ensure that the experiment was run properly; see positive control and negative control

• Positive control – a group of data that will give predictable positive results

• Negative control – a group of data that will give predictable negative results

Vocabulary

Page 98: Biotechnology Chapter One Lecture- Intro to Biotech

• Data – information gathered from experimentation• Hypothesis – an educated guess to answer scientific question;

should be testable• Variable – anything that can vary in an experiment; the

independent variable is tested in an experiment to see its effect on dependent variables

• Control – experimental trial added to an experiment to ensure that the experiment was run properly; see positive control and negative control

• Positive control – a group of data that will give predictable positive results

• Negative control – a group of data that will give predictable negative results

• Concentration – the amount of a substance as a proportion of another substance; usually how much mass in some amount of volume

Vocabulary

Page 99: Biotechnology Chapter One Lecture- Intro to Biotech

• Data – information gathered from experimentation• Hypothesis – an educated guess to answer scientific question;

should be testable• Variable – anything that can vary in an experiment; the

independent variable is tested in an experiment to see its effect on dependent variables

• Control – experimental trial added to an experiment to ensure that the experiment was run properly; see positive control and negative control

• Positive control – a group of data that will give predictable positive results

• Negative control – a group of data that will give predictable negative results

• Concentration – the amount of a substance as a proportion of another substance; usually how much mass in some amount of volume

• Journals – scientific periodicals or magazines in which scientists publish their experimental work, findings, or conclusions

Vocabulary

Page 100: Biotechnology Chapter One Lecture- Intro to Biotech

1.5 Careers in the Biotechnology Industry

Page 101: Biotechnology Chapter One Lecture- Intro to Biotech

• One of the fastest growing commercial industries

1.5 Careers in the Biotechnology Industry

Page 102: Biotechnology Chapter One Lecture- Intro to Biotech

• One of the fastest growing commercial industries• Career opportunities in:

1.5 Careers in the Biotechnology Industry

Page 103: Biotechnology Chapter One Lecture- Intro to Biotech

• One of the fastest growing commercial industries• Career opportunities in:

• Bioscience

1.5 Careers in the Biotechnology Industry

Page 104: Biotechnology Chapter One Lecture- Intro to Biotech

• One of the fastest growing commercial industries• Career opportunities in:

• Bioscience• Medical

1.5 Careers in the Biotechnology Industry

Page 105: Biotechnology Chapter One Lecture- Intro to Biotech

• One of the fastest growing commercial industries• Career opportunities in:

• Bioscience• Medical• Agricultural

1.5 Careers in the Biotechnology Industry

Page 106: Biotechnology Chapter One Lecture- Intro to Biotech

• One of the fastest growing commercial industries• Career opportunities in:

• Bioscience• Medical• Agricultural• Environmental

1.5 Careers in the Biotechnology Industry

Page 107: Biotechnology Chapter One Lecture- Intro to Biotech

• One of the fastest growing commercial industries• Career opportunities in:

• Bioscience• Medical• Agricultural• Environmental

• Applied chemistry

1.5 Careers in the Biotechnology Industry

Page 108: Biotechnology Chapter One Lecture- Intro to Biotech

• One of the fastest growing commercial industries• Career opportunities in:

• Bioscience• Medical• Agricultural• Environmental

• Applied chemistry• Physics

1.5 Careers in the Biotechnology Industry

Page 109: Biotechnology Chapter One Lecture- Intro to Biotech

• One of the fastest growing commercial industries• Career opportunities in:

• Bioscience• Medical• Agricultural• Environmental

• Applied chemistry• Physics• Computer science

1.5 Careers in the Biotechnology Industry

Page 110: Biotechnology Chapter One Lecture- Intro to Biotech

• One of the fastest growing commercial industries• Career opportunities in:

• Bioscience• Medical• Agricultural• Environmental

• Applied chemistry• Physics• Computer science

• Industry will be studying DNA sequence for most of the 21st century

1.5 Careers in the Biotechnology Industry

Page 111: Biotechnology Chapter One Lecture- Intro to Biotech

Educational Requirements

Page 112: Biotechnology Chapter One Lecture- Intro to Biotech

Educational Requirements• Bachelor of Science Degree

Page 113: Biotechnology Chapter One Lecture- Intro to Biotech

Educational Requirements• Bachelor of Science Degree

• Biochemistry

Page 114: Biotechnology Chapter One Lecture- Intro to Biotech

Educational Requirements• Bachelor of Science Degree

• Biochemistry• Molecular biology

Page 115: Biotechnology Chapter One Lecture- Intro to Biotech

Educational Requirements• Bachelor of Science Degree

• Biochemistry• Molecular biology• Genetics

Page 116: Biotechnology Chapter One Lecture- Intro to Biotech

Educational Requirements• Bachelor of Science Degree

• Biochemistry• Molecular biology• Genetics

• 2-year college degree

Page 117: Biotechnology Chapter One Lecture- Intro to Biotech

Educational Requirements• Bachelor of Science Degree

• Biochemistry• Molecular biology• Genetics

• 2-year college degree• High school specialization

Page 118: Biotechnology Chapter One Lecture- Intro to Biotech

Educational Requirements• Bachelor of Science Degree

• Biochemistry• Molecular biology• Genetics

• 2-year college degree• High school specialization• More advanced degrees

Page 119: Biotechnology Chapter One Lecture- Intro to Biotech

Educational Requirements• Bachelor of Science Degree

• Biochemistry• Molecular biology• Genetics

• 2-year college degree• High school specialization• More advanced degrees

• Master of Science

Page 120: Biotechnology Chapter One Lecture- Intro to Biotech

Educational Requirements• Bachelor of Science Degree

• Biochemistry• Molecular biology• Genetics

• 2-year college degree• High school specialization• More advanced degrees

• Master of Science• Master of Arts

Page 121: Biotechnology Chapter One Lecture- Intro to Biotech

Educational Requirements• Bachelor of Science Degree

• Biochemistry• Molecular biology• Genetics

• 2-year college degree• High school specialization• More advanced degrees

• Master of Science• Master of Arts• Doctor of Philosophy

Page 122: Biotechnology Chapter One Lecture- Intro to Biotech

Educational Requirements• Bachelor of Science Degree

• Biochemistry• Molecular biology• Genetics

• 2-year college degree• High school specialization• More advanced degrees

• Master of Science• Master of Arts• Doctor of Philosophy• Postdoctoral research

experience

Page 123: Biotechnology Chapter One Lecture- Intro to Biotech

Educational Requirements• Bachelor of Science Degree

• Biochemistry• Molecular biology• Genetics

• 2-year college degree• High school specialization• More advanced degrees

• Master of Science• Master of Arts• Doctor of Philosophy• Postdoctoral research

experience

Nonscientific Positions

Page 124: Biotechnology Chapter One Lecture- Intro to Biotech

Educational Requirements• Bachelor of Science Degree

• Biochemistry• Molecular biology• Genetics

• 2-year college degree• High school specialization• More advanced degrees

• Master of Science• Master of Arts• Doctor of Philosophy• Postdoctoral research

experience

Nonscientific PositionsEmployees in nonscientific positions must have an interest in and understanding of the science of biotechnology.

Page 125: Biotechnology Chapter One Lecture- Intro to Biotech

Educational Requirements• Bachelor of Science Degree

• Biochemistry• Molecular biology• Genetics

• 2-year college degree• High school specialization• More advanced degrees

• Master of Science• Master of Arts• Doctor of Philosophy• Postdoctoral research

experience

Nonscientific PositionsEmployees in nonscientific positions must have an interest in and understanding of the science of biotechnology.

• Sales

Page 126: Biotechnology Chapter One Lecture- Intro to Biotech

Educational Requirements• Bachelor of Science Degree

• Biochemistry• Molecular biology• Genetics

• 2-year college degree• High school specialization• More advanced degrees

• Master of Science• Master of Arts• Doctor of Philosophy• Postdoctoral research

experience

Nonscientific PositionsEmployees in nonscientific positions must have an interest in and understanding of the science of biotechnology.

• Sales• Marketing

Page 127: Biotechnology Chapter One Lecture- Intro to Biotech

Educational Requirements• Bachelor of Science Degree

• Biochemistry• Molecular biology• Genetics

• 2-year college degree• High school specialization• More advanced degrees

• Master of Science• Master of Arts• Doctor of Philosophy• Postdoctoral research

experience

Nonscientific PositionsEmployees in nonscientific positions must have an interest in and understanding of the science of biotechnology.

• Sales• Marketing• Regulatory

Page 128: Biotechnology Chapter One Lecture- Intro to Biotech

Educational Requirements• Bachelor of Science Degree

• Biochemistry• Molecular biology• Genetics

• 2-year college degree• High school specialization• More advanced degrees

• Master of Science• Master of Arts• Doctor of Philosophy• Postdoctoral research

experience

Nonscientific PositionsEmployees in nonscientific positions must have an interest in and understanding of the science of biotechnology.

• Sales• Marketing• Regulatory• Legal

Page 129: Biotechnology Chapter One Lecture- Intro to Biotech

Educational Requirements• Bachelor of Science Degree

• Biochemistry• Molecular biology• Genetics

• 2-year college degree• High school specialization• More advanced degrees

• Master of Science• Master of Arts• Doctor of Philosophy• Postdoctoral research

experience

Nonscientific PositionsEmployees in nonscientific positions must have an interest in and understanding of the science of biotechnology.

• Sales• Marketing• Regulatory• Legal• Financial

Page 130: Biotechnology Chapter One Lecture- Intro to Biotech

Educational Requirements• Bachelor of Science Degree

• Biochemistry• Molecular biology• Genetics

• 2-year college degree• High school specialization• More advanced degrees

• Master of Science• Master of Arts• Doctor of Philosophy• Postdoctoral research

experience

Nonscientific PositionsEmployees in nonscientific positions must have an interest in and understanding of the science of biotechnology.

• Sales• Marketing• Regulatory• Legal• Financial• Human resources

Page 131: Biotechnology Chapter One Lecture- Intro to Biotech

Educational Requirements• Bachelor of Science Degree

• Biochemistry• Molecular biology• Genetics

• 2-year college degree• High school specialization• More advanced degrees

• Master of Science• Master of Arts• Doctor of Philosophy• Postdoctoral research

experience

Nonscientific PositionsEmployees in nonscientific positions must have an interest in and understanding of the science of biotechnology.

• Sales• Marketing• Regulatory• Legal• Financial• Human resources• Administrative staff

Page 132: Biotechnology Chapter One Lecture- Intro to Biotech

Categories of Biotechnology Jobs

Page 133: Biotechnology Chapter One Lecture- Intro to Biotech

Categories of Biotechnology Jobs

• Scientific Positions

Page 134: Biotechnology Chapter One Lecture- Intro to Biotech

Categories of Biotechnology Jobs

• Scientific Positions• Research and Development

Page 135: Biotechnology Chapter One Lecture- Intro to Biotech

Categories of Biotechnology Jobs

• Scientific Positions• Research and Development• Manufacturing and Production

Page 136: Biotechnology Chapter One Lecture- Intro to Biotech

Categories of Biotechnology Jobs

• Scientific Positions• Research and Development• Manufacturing and Production• Clinical Research

Page 137: Biotechnology Chapter One Lecture- Intro to Biotech

Categories of Biotechnology Jobs

• Scientific Positions• Research and Development• Manufacturing and Production• Clinical Research• Quality Control

Page 138: Biotechnology Chapter One Lecture- Intro to Biotech

Categories of Biotechnology Jobs

• Scientific Positions• Research and Development• Manufacturing and Production• Clinical Research• Quality Control

• Nonscientific Positions

Page 139: Biotechnology Chapter One Lecture- Intro to Biotech

Categories of Biotechnology Jobs

• Scientific Positions• Research and Development• Manufacturing and Production• Clinical Research• Quality Control

• Nonscientific Positions• Information Systems

Page 140: Biotechnology Chapter One Lecture- Intro to Biotech

Categories of Biotechnology Jobs

• Scientific Positions• Research and Development• Manufacturing and Production• Clinical Research• Quality Control

• Nonscientific Positions• Information Systems• Marketing and Sales

Page 141: Biotechnology Chapter One Lecture- Intro to Biotech

Categories of Biotechnology Jobs

• Scientific Positions• Research and Development• Manufacturing and Production• Clinical Research• Quality Control

• Nonscientific Positions• Information Systems• Marketing and Sales• Regulatory Affairs

Page 142: Biotechnology Chapter One Lecture- Intro to Biotech

Categories of Biotechnology Jobs

• Scientific Positions• Research and Development• Manufacturing and Production• Clinical Research• Quality Control

• Nonscientific Positions• Information Systems• Marketing and Sales• Regulatory Affairs• Administration/Legal Affairs

Page 143: Biotechnology Chapter One Lecture- Intro to Biotech

Vocabulary

Page 144: Biotechnology Chapter One Lecture- Intro to Biotech

• Genome – one entire set of an organism’s genetic material (from a single cell)

Vocabulary

Page 145: Biotechnology Chapter One Lecture- Intro to Biotech

• Genome – one entire set of an organism’s genetic material (from a single cell)

• Biochemistry – the study of the chemical reactions occurring in living things

Vocabulary

Page 146: Biotechnology Chapter One Lecture- Intro to Biotech

• Genome – one entire set of an organism’s genetic material (from a single cell)

• Biochemistry – the study of the chemical reactions occurring in living things

• Molecular biology – the study of molecules that are found in cells

Vocabulary

Page 147: Biotechnology Chapter One Lecture- Intro to Biotech

• Genome – one entire set of an organism’s genetic material (from a single cell)

• Biochemistry – the study of the chemical reactions occurring in living things

• Molecular biology – the study of molecules that are found in cells

• Genetics – the study of genes and how they are inherited and expressed

Vocabulary

Page 148: Biotechnology Chapter One Lecture- Intro to Biotech

1.6 Biotechnology with a Conscience - Bioethics

Page 149: Biotechnology Chapter One Lecture- Intro to Biotech

1.6 Biotechnology with a Conscience - Bioethics

• How do we learn what is right and wrong behavior?

Page 150: Biotechnology Chapter One Lecture- Intro to Biotech

1.6 Biotechnology with a Conscience - Bioethics

• How do we learn what is right and wrong behavior?• As new situations arise in your life, how do you decide

what is acceptable behavior and what is unacceptable?

Page 151: Biotechnology Chapter One Lecture- Intro to Biotech

1.6 Biotechnology with a Conscience - Bioethics

• How do we learn what is right and wrong behavior?• As new situations arise in your life, how do you decide

what is acceptable behavior and what is unacceptable?• How do you decide what is fair and just?

Page 152: Biotechnology Chapter One Lecture- Intro to Biotech

1.6 Biotechnology with a Conscience - Bioethics

• How do we learn what is right and wrong behavior?• As new situations arise in your life, how do you decide

what is acceptable behavior and what is unacceptable?• How do you decide what is fair and just?

Moral Standards

Page 153: Biotechnology Chapter One Lecture- Intro to Biotech

1.6 Biotechnology with a Conscience - Bioethics

• How do we learn what is right and wrong behavior?• As new situations arise in your life, how do you decide

what is acceptable behavior and what is unacceptable?• How do you decide what is fair and just?

Moral Standards• Being able to distinguish between right and wrong and to make

decisions based on that knowledge is considered “having good morals.”

Page 154: Biotechnology Chapter One Lecture- Intro to Biotech

1.6 Biotechnology with a Conscience - Bioethics

• How do we learn what is right and wrong behavior?• As new situations arise in your life, how do you decide

what is acceptable behavior and what is unacceptable?• How do you decide what is fair and just?

Moral Standards• Being able to distinguish between right and wrong and to make

decisions based on that knowledge is considered “having good morals.”

• The study of moral standards and how they affect conduct is called ethics.

Page 155: Biotechnology Chapter One Lecture- Intro to Biotech

1.6 Biotechnology with a Conscience - Bioethics

• How do we learn what is right and wrong behavior?• As new situations arise in your life, how do you decide

what is acceptable behavior and what is unacceptable?• How do you decide what is fair and just?

Moral Standards• Being able to distinguish between right and wrong and to make

decisions based on that knowledge is considered “having good morals.”

• The study of moral standards and how they affect conduct is called ethics.

• New technologies generate ethical questions that cannot be answered using scientific methods.

Page 156: Biotechnology Chapter One Lecture- Intro to Biotech

Define ethics

Create a code of conduct

Brainstorm bioethical issues or dilemnas

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Page 157: Biotechnology Chapter One Lecture- Intro to Biotech

Strategy for Values Clarification

Page 158: Biotechnology Chapter One Lecture- Intro to Biotech

Strategy for Values Clarification

• Identify and understand the problem or issue. Learn as much as possible about the issue.

Page 159: Biotechnology Chapter One Lecture- Intro to Biotech

Strategy for Values Clarification

• Identify and understand the problem or issue. Learn as much as possible about the issue.

• List all possible solutions to the issue.

Page 160: Biotechnology Chapter One Lecture- Intro to Biotech

Strategy for Values Clarification

• Identify and understand the problem or issue. Learn as much as possible about the issue.

• List all possible solutions to the issue.• Identify the pros and cons of adopting each solution.

Examine the consequences of adopting one solution (or position) as opposed to another. Consider legal, financial, medical, personal, social, and environmental aspects.

Page 161: Biotechnology Chapter One Lecture- Intro to Biotech

Strategy for Values Clarification

• Identify and understand the problem or issue. Learn as much as possible about the issue.

• List all possible solutions to the issue.• Identify the pros and cons of adopting each solution.

Examine the consequences of adopting one solution (or position) as opposed to another. Consider legal, financial, medical, personal, social, and environmental aspects.

• Based on the pros and cons for each solution, rank all solutions from best to worst.

Page 162: Biotechnology Chapter One Lecture- Intro to Biotech

Strategy for Values Clarification

• Identify and understand the problem or issue. Learn as much as possible about the issue.

• List all possible solutions to the issue.• Identify the pros and cons of adopting each solution.

Examine the consequences of adopting one solution (or position) as opposed to another. Consider legal, financial, medical, personal, social, and environmental aspects.

• Based on the pros and cons for each solution, rank all solutions from best to worst.

• Decide if the problem is important enough to take a position. If it is, decide what your position is and be prepared to describe and defend it.

Page 163: Biotechnology Chapter One Lecture- Intro to Biotech

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