biopharmaceutics chap5
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Chapter 5
Dosage Form Design: Biopharmaceutical and
Pharmacokinetic Considerations
Biopharmaceutic Considerations
Biopharmaceutics is the area of the study embracing the relationship between physical, chemical and biological sciences as they apply to drug and to drug action
ADME
Bioavailability - describe the rate and extent to which an active drug ingredient or therapeutic moiety is absorbed from a
drug product and becomes available at the site of the drug action.
Bioequivalence - refers to the comparison of bioavailabilities of different formulations, drug products, or batches of the same drug product.
Bioavailability Data are used to determine:
1. The amount or proportion of drug absorbed from a formulation or dosage form
2. The rate at which the drug was absorbed
3. The duration of the drug’s presence in the biologic fluid or tissue; and, when correlated with patient response
4. The relationship between drug blood levels and clinical efficacy and toxicity
Terms Used To define The Type or Level Of “Equivalency” Between Drug Products
Pharmaceutical Equivalents -are drug products that contain identical amounts of the identical active ingredient.
Example: the same salt or ester of the same therapeutic moiety
Pharmaceutical Alternatives - are drug products that contain the identical therapeutic moiety, or its precursor, but not necessarily in the same amount or dosage form or as the same salt or ester.
Bioequivalent Drug Products - are pharmaceutical equivalents or pharmaceutical alternatives whose rate and extent of absorption
do not show a significant difference when administered at the same molar dose of the therapeutic moiety under similar experimental conditions, either single dose or multiple dose.
Therapeutic Equivalent - has been used to indicate pharmaceutical equivalent which, when administered to the same individuals in the same dosage regimens, will provide essentially the same therapeutic effect.
The most common experimental plan to compare the bioavailability of two drug products is the
simple crossover design study.
(12 to 14 individuals, males between 18 to 40 years, same height and weight)
How A Drug Passes Through The Body
1. Absorption = The site at which a drug enters the body affects its rates of absorption
a. Skin c. Digestive Tract
b. Lungs d. Bloodstream
2. Distribution = Most drugs enter the bloodstream; many are then distributed to
cells of various organs
a. Bone e. Glands
b. Nerves f. Heart
c. Muscles g. Cells
d. Brain h. Other organs
3. Metabolism = A drug is partially broken down, usually in the liver, before or after distribution
a. Liver
4. Elimination = Finally, a drug is eliminated, mainly via kidneys, but also in stools
and tears or through breathing
a. Breast milk c. Tears
b. Saliva d. Sweat
APPROVAL REQUIREMENTS FOR GENERIC DRUG PRODUCTS
1. Contain the same active ingredients as the pioneer drug (inert ingredient may vary)
2. Be identical in strength, dosage form, and route of administration
3. Have the same indications and precautions for use and other labeling instructions
4. Be bioequivalent
5. Meet the same batch to batch requirements for identity, strength, purity, and quality
6. Be manufactured under the same strict standards of FDA’s CGMP regulations as required for pioneer products.
Some Factors Which Can influence The Bioavailability Of Orally Administered Drugs
I. Drug Substance Physiochemical Properties
II. Pharmaceutical Ingredients and Dosage Form Characteristics
III. Physiologic Factors and Patient Characteristics
Some Factors Which Can influence The Bioavailability Of Orally Administered Drugs
I. Drug Substance Physiochemical Properties
A. Particle Size
B. Crystalline or Amorphous Form
C. Salt Form
D. Hydration
E. Lipid/Water Solubility
F. pH and pKa
Some Factors Which Can influence The Bioavailability Of Orally Administered Drugs
II. Pharmaceutic Ingredients and Dosage Form Characteristics
A. Pharmaceutical Ingredients
1. Fillers 7. Surface Active Agents
2. Binders 8. Flavoring Agents
3. Coatings 9. Coloring Agents
4. Disintegrating Agents 10. Preservative Agents
5. Lubricants 11. Stabilizing Agents
6. Suspending Agents
Some Factors Which Can influence The Bioavailability Of Orally Administered Drugs
B. Disintegration Rate (Tablets)
C. Dissolution Time of Drug in Dosage Form
D. Product Age and storage Conditions
III. Physiologic Factors and Patient Characteristics
A. Gastric Emptying Time
B. Intestinal Transit Time
C. Gastrointestinal Abnormality or Pathologic Condition
D. Gastric Contents
1. Food
2. Other Drugs
3. Fluid
E. Gastrointestinal pH
F. Drug Metabolism (gut and during first passage through liver)
Examples Of Drugs That Undergo Significant Liver Metabolism and Exhibit Low Bioavailability when Administered by First-pass Routes
Drug Class Examples
Analgesics Aspirin, meperidine, Pentazocine
Propoxyphene
Antianginal Nitroglycerin
Antiarrhythmics Lidocaine
Beta-adrenergic Labetolol, Metoprolol, Propranolol
blockers
Calcium channel Verapamil
blockers
Sympathomimetic Isoproterenol
amines
Tricyclic Desipramine, Imipramine,
antidepressants Nortriptyline
Several Examples of Biotransformations occurring within the body are as follows:
1. Acetaminophen Conjugation Acetaminophen glucuronide(active) (inactive)
2. Amoxapine Oxidation 8-hydroxy-amoxaphine
(active) (inactive)
3. Procainamide Hydrolysis p-Aminobenzoic acid
(active) (inactive)
4. Nitroglycerin reduction 1-2 and 1-3 dinitroglycerol
(active) (inactive)
Some compound under full, partial no biotransformation
1. Lisinopril (zestril) - does not go metabolism, excreted unchanged
2. Verapamil (Calan) - 12 metanolites, the most prevalent is norverapamil
3. Diltiazem (Cardizem) - partially metabolized to desacetyldiltiazem
4. Indomethacin (Indocin) - metabolized in part to desmethyl, desbenzoyl, and
desmethylbenzoyl
5. Propoxypehene napsylate (Darvon N) - metabolized to norpropoxyphene
Routes Of Drug Administration
TERM SITE
oral mouth
peroral (per os, p.o.) gastrointestinal tract via mouth
sublingual under the tongue
parenteral other than GIT (by injection)
intravenous vein
intraarterial artery
intracardiac heart
intraspinal/intrathecal spine
intraosseous bone
intraarticular joint
intrasynovial joint-fluid area
intracutaneous/intradermal skin
subcutaneous beneath the skin
intramuscular muscle
Routes Of Drug Administration
TERM SITE
epicutaneous (topical) skin surface
transdermal skin surface
conjunctival conjunctiva
intraocular eye
intranasal nose
aural ear
intrarespiratory lung
rectal rectum
vaginal vagina
urethral urethra
DOSAGE FORM/DRUG DELIVERY SYSTEM APPLICATION
Route Of Administration Primary Dosage Forms
oral tablets, capsules, solutions, syrupselixirs, suspensions,magmas, gels
and powders
sublingual tablets, troches or lozenges
parenteral solutions, suspensions
epicutaneous/transdermal ointments, creams, infusion pumpspastes, plasters, powders, aerosolslotions, transdermal patches, discs
conjunctival contact lens inserts, ointments
intraocular/intraaural solutions, suspensions
intranasal solutions, sprays, inhalants, oint.
Intrarespiratory aerosols
DOSAGE FORM/DRUG DELIVERY SYSTEM APPLICATION
Route Of Administration Primary Dosage Forms
rectal solutions, ointments, suppositories
vaginal solutions, ointments, emulsion foams, tablets, inserts, suppositories, sponge
urethral solutions, suppositories
Factors That Determine A Dosage Regimen
Activity, Toxicity Pharmacoknetics
Minimum therapeutic dose Absorption
Toxic Dose Distribution
Therapeutic index Metabolism
Side effects Excretion
Dose-response relationship
Clinical Factors Other Factors
Clinical State of patient Management of Therapy
Age, weight, urine pH Multiple drug therapy Tolerance-dependence
Condition being treated Convenience of regimen Pharmacogenetics- idiosyncrasy
Existence of other disease states Compliance of patient Drug interactions
DosageRegimen