Keith Johnston Research GroupNanotechnology/Colloid Science

kpj@che.utexas.edu CPE 5.414 512-471-4617

Biomedical and Pharmaceutical Nanotechnology: Imaging and Therapeutics– Magnetic/optical/therapeutic nanoparticles -cancer and atherosclerosis– Protein drug delivery (oral, depot, pulmonary, parenteral)

Nanotechnology for Energy: Fundamentals and Applications

– Nanocrystal/Mesoporous composites• Supercapacitors and batteries• Catalysis- fuel cells, water oxidation

– Nanotechnology for Enhanced Oil Recovery and CO2 Sequestration• Electromagnetic imaging• Emulsions/foams for mobility control

Molec. Specific Magnetic/Optical Imaging and Therapy: Carcinogenesis and Atherosclerosis (Sokolov, Emelianov, Milner)

Portable imagingultrasound, photoacousticopt. coherence tomography Emelianov, Milner

Molecular MechanismsEarly DetectionPrognosisTreatmentMonitoring

D

Include drug payloadsAntibody, siRNA targeting

Optical properties- theory

Novel concept: build nanoclusters from nanoparticles

30 nm end-to-end

Antibodies,siRNA

Small size (20 to 50 nm): challenging to synthesize* permeation of cell membranes, leaky vasculature in cancers* prolonged circulation in bloodstream* modulate biological pathways including apoptosis

Nanoclusters of nanoparticles* pack intense and variable functionality (like viral capscids)* optical(gold), and magnetic(iron oxide) : imaging* targeting agents (Abs, siRNA)* drugs for delivery

4

Monoclonal Antibodies for Cancer, Cardiovascular and Infectious Diseases: Need for Drug Delivery

“

http://en.wikipedia.org/wiki/Image:MonoclonalAb.jpg

>20% of all biopharmaceuticals in clinical trials are mAbs

Apparent Viscosity vs. Concentration

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concentration of Lysozyme particles (mg/mL)

Ap

pare

nt V

isco

sity (cP

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Lysozymesuspension 1

Lysozymesuspension 2

Shire'smonoclonalantibodysolution

Therapeutic goal: 400 mg in 1 ml sub-Q injection instead of IV

Our approach: suspensions instead of solutions- min. electroviscous effects for particles instead of protein molecules

Nanoparticle-mesoporous support composites in catalysis and energy storage (Dan Slanac, Mehul Patel)

(Supercapacitors, batteries, fuel cells, water oxidation etc.)

Homogeneous Nucleation

Growth

Metal-org 1 precursor

Metal-org 2 precursor

Reduction in solvent in presence of ligands (oleic acid)

Support

Infusion

Presynthesis of bimetallic catalysts

control nanocrystal size, compostion, surface atoms

Infuse into well-ordered mesoporous materials

dispersibility

metal-support interactions

+

3-10 nm pores

Electrochemical supercapacitors for high power density and energy density (high stability vs batteries)

Adsoption of ions on surface(e.g. Li+)

(MnO2)surface + C+ + e- ↔ (MnO2-C+)surface

Surface redox reactionMnO2 + C+ + e- ↔ MnOOC

Energy Density (Wh/kg)

MnO2 nanoparticles in conformal film on mesoporous C- high surf area, rapid diffusion

16 wt% MnO2

Magnetic Nanoparticle Sensors for Oil reservoirs and CO2 sequestration

Nano size: flows freely in porous media Surface coating adjusts contact angle and adsorption at interface

Uniform size: well-structured monolayer at interface with unique rheology/elasticity

Electromagnetic field generates acoustic waves from moving interface

water

CO2

CO2

water

CO2

water

PV injected

C/Co

10-md Limestone

All injected particles eluted

Ultrasound transducerUltrasound transducer

– Bionanoparticles: Avi Murthy, Jasmine Tam murthy@che.utexas.edu 5.432

– Protein delivery: Andrea Miller mam5228@che.utexas.edu 5.428

– Energy: Dan Slanac dslanac@che.utexas.edu 5.426, 30