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October 2, 2007. Biomedical and Health Informatics Lecture Series. Peter Tarczy-Hornoch MD Head and Professor, Division of Biomedical and Health Informatics University of Washington. Biomedical and Health Informatics Lecture Series. Focus: current topics and developments in informatics - PowerPoint PPT Presentation


  • Biomedical and Health InformaticsLecture SeriesPeter Tarczy-Hornoch MDHead and Professor, Division of Biomedical and Health InformaticsUniversity of Washington

    October 2, 2007

  • Biomedical and Health Informatics Lecture SeriesFocus: current topics and developments in informaticsPresenters: faculty, students, researchers and developers from UW, other academic institutions, government, and industry (locally and nationally)Intended audience: Broader UW & Seattle community interested in BHI BHI faculty and studentsHistory:Early 1990s: initiated as part of IAIMS (MEDED 590)2003-2006: temporarily changed to closed journal club formatFall 2006: return to public lecture series formatFall 2007: 10th year of Division of Biomedical & Health Informatics

  • MEBI 590 & BHI Lecture SeriesBiomedical and Health Informatics (BHI) Lecture series available for credit as MEBI 590Details & upcoming lectures available at: points for those taking for creditNeed to sign in each lecture to get creditCR/NC courseMust attend 9 of 10 lectures for credit

  • Informatics and theNew Northwest Institute of Translational Health SciencesPeter Tarczy-Hornoch MDDirector, Biomedical Informatics CoreNorthwest Institute of Translational Health Sciences

    Head and Professor, Division of Biomedical and Health InformaticsProfessor, Division of Neonatology

  • OutlineClinical Translational Science Awards Northwest Institute of Translational Health SciencesBiomedical Informatics Core of NW ITHSData IntegrationSummary

  • NIH Roadmap - ProcessInitiated in 2002 by NIH Director (Zerhouni) a roadmap for medical research in 21st c.NIH LeadershipWhat are todays scientific challenges?What are the roadblocks to progress?What do we need to do to overcome roadblocks?What cant be accomplished by any single Institute but is the responsibility of NIH as a wholeWorking GroupsImplementation GroupsImplementation Groups => RFAsSummer/Fall 2006: New initiatives (Roadmap 1.5)

  • NIH Roadmap ThemesNew Pathways to DiscoveryBuilding Blocks, Biological Pathways, and Networks Molecular Libraries & Molecular Imaging Structural Biology Bioinformatics and Computational Biology (BISTI/NCBC) Nanomedicine Research Teams of the FutureHigh-Risk Research Interdisciplinary Research Public-Private Partnerships Re-engineering the Clinical Research EnterpriseClinical Research Networks/NECTAR Clinical Research Policy Analysis and Coordination Clinical Research Workforce Training Dynamic Assessment of Patient-Reported Chronic Disease Outcomes Translational Research (Clinical Translational Science Awards)

  • NIH RoadmapClinical Translational Science AwardsInitial request for applications October 2005Current RFA: RFA-RM-07-007CTSA planning grants (one year), implementation grants (five years)The purpose of this initiative is to assist institutions to create a uniquely transformative, novel, and integrative academic home for Clinical and Translational Science that has the resources to train and advance a cadre of well-trained multi- and inter-disciplinary investigators and research teams with access to innovative research tools and information technologies to promote the application of new knowledge and techniques to patient care.

  • Definition of Translational Research Translational research transforms scientific discoveries arising from laboratory, clinical or population studies into clinical or population-based applications to improve health by reducing disease incidence, morbidity and mortalityModified from the NCI translational research working group (2006) UW: human subjects, specimens or plansCTSA: From Bench to Bedside to Community

  • NIH RoadmapClinical Translational Science AwardsIntegrate existing Clinical Research Centers (CRCs) with existing clinical/translational science training grants (K12, K30, T32) and expand capabilities through new cores (e.g. Biomedical Informatics, Evaluation, Novel Technologies, etc.)Establish regional and national consortia with the aim of transforming how clinical and translational research is conducted, and ultimately enabling researchers to provide new treatments more efficiently and quickly to patients When fully implemented in 2012, the initiative is expected to provide a total of about $500 million annually to 60 academic health centers in the US

  • National CTSA Awards 2006 & 2007

  • CTSA Full Center Awards2006Columbia University Health SciencesDuke UniversityMayo Clinic College of MedicineOregon Health & Science UniversityRockefeller UniversityUniversity of California, DavisUniversity of California, San FranciscoUniversity of PennsylvaniaUniversity of PittsburghUniversity of RochesterUniversity of Texas Health Science Center at HoustonYale University2007Case Western Reserve University Emory UniversityJohns HopkinsUniversity of ChicagoUniversity of IowaUniversity of MichiganUniversity of Texas Southwestern Medical Center University of Washington University of WisconsinVanderbilt University Washington University Weill Cornell Medical College

  • OutlineClinical Translational Science Awards Northwest Institute of Translational Health SciencesBiomedical Informatics Core of NW ITHSData IntegrationSummary

  • Institute of Translational Health SciencesNorthwest ITHS is the name for the regional inter-disciplinary consortium funded through the NIH-NCRR Clinical Translational Science Award (CTSA)Planning grant: 2006-7Full Center grant: 2007-12 funded $62MNW ITHS will provide an academic home and integrated resources to:Advance clinical and translational science;Create and nurture a cadre of well-trained clinical investigators;Speed translation of discoveries into clinical practice Foster interactions between the university, non-profit, and business research communitiesCreate an incubator for novel ideas and collaborations that cross disciplines

    Institute of Translational Health Sciences

  • NW ITHS Collaboratory Model

  • NW ITHS - PartnersFounding Members of the NW ITHS and Key CollaboratorsUniversity of WashingtonChildrens Hospital and Regional Medical CenterFred Hutchinson Cancer Research Center Group Health Cooperative Center for Health StudiesBenaroya Research InstitutePATHSix proposed American Indian and Alaska Native Network Sites6 Health Sciences School, 12 sites, 67 key scientific personnel, more than 150 centers Drs. Nora Disis (UW), Bonnie Ramsey (CHRMC), Mac Cheever (FHCRC/SCCA) co-leadersInstitute of Translational Health Sciences

  • Eleven ITHS CoresAdministrativeNovel clinical and translational methodologiesPilot and collaborative translational and clinical studiesBiomedical informatics Study design and biostatistics Regulatory knowledge, support and research ethicsParticipant clinical interactions resources (CRC+)Community engagementTranslational technologies and resourcesResearch education, training and career developmentTracking and evaluationInstitute of Translational Health Sciences

  • OutlineClinical Translational Science Awards Northwest Institute of Translational Health SciencesBiomedical Informatics Core of NW ITHSData IntegrationSummary

  • CTSA RFA & Biomedical InformaticsBiomedical Informatics is the cornerstone of communication within (CTSAs) and with all collaborating organizationsApplicants should describe: support provided for operations, administration, research and clinical/translational research activities plan to establish communication with external organizations relevant to their mission the process by which standards and other mechanisms will be developed and used to maximize interoperability between internal systems and systems in outside organizations assessment of informatics performance across the CTSA programs and with external partners inter- and intra-organizational sharing of data, technology and best practices Biomedical Informatics is expected to be the subject of an overall NIH CSTA Informatics Steering Committee that ensures interoperability between the CTSA institutions and with their external partners.

  • Biomedical Informatics Core TeamPeter Tarczy-Hornoch MD, Core DirectorJim Brinkley MD PhD, Core Co-DirectorNick Anderson PhD, Core Deputy DirectorBill Lober MDJim LoGerfo MD MPHDan Suciu PhDDan Ach (GCRC Informatics Lead)To be hired: ~14 professional staff and 3 RA slots

  • ITHS Biomedical Informatics CoreAim 5: Develop & maintain ITHS administrative databases & Web interfacesAim 1Aim 2Aim 3Aim 4

  • Aim 1: Provide access to electronic health data at ITHS institutionsInventory and model recurring common queriesDevelop new interfaces to electronic health data from partner institutionsProvide ITHS researchers access to electronic health data from partner institutions via a new common web interfacePilot a Virtual Data Warehouse (VDW) across the ITHS partner institutes building on the common web interfaceExtend the pilot VDW to include clinics in the WWAMI region

  • Access to electronic health record dataExisting resources: MIND Access Project (UW), Cerner Research Query System (CHRMC), Clinical Data Repository (FHCRC), Research-O-Matic (CHS)Gaps: no convenient access, repository data limitedGoals: Simplify appropriate access to existing dataExtend appropriate access to existing dataExtend sources of electronic health record dataNote: research still needed to solve Aim 1-4 gaps

  • Aim 2: Support access to study data management tools for translational researchProvide consultation to ITHS researchers regarding choosing and implementing study management toolsContinue to develop and enhance existing


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