Principles of Immunology, Fall ‘17

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BIO 431/531 Principles of Immunology Course Syllabus

Fall 2017

Fridays 8:45 – 11:15 AM 200 Payson Smith

Course Identification Course Title: Principles of Immunology Credit Hours: 3 CRN# 69759/70701 Class: BIO 431/531

Required TextbookJaneway’s Immunobiology, 9th Edition, by Murphy, K. & C. Weaver. Garland Science, NY. ISBN: 978-0-8153-4505-3.

Instructor Contact Information Instructor Name: Blake Whitaker, PhD Office: Lewiston Campus 208B Office Phone #: 753-6535Email address: blakew@maine.edu

Office Hours By appointment after class

Catalog Description An introduction to the fundamentals of immunology, especially as they relate to human diseases. Topics include history of immunology, basic elements of immune systems, principles of natural and acquired immunity, cellular and molecular basis of B cell and T cell development and diversity, and clinical aspects of immunology. Prerequisites: CHY 107 or CHY 115, junior standing, and grade of C- or higher in either BIO 107 or BIO 113; or permission of instructor. Cr 3.

Course Objectives/Outcomes To develop in each student a beginning understanding of the human immune system and its

organization To develop a practical understanding of the immune system’s contributions to maintaining

homeostasis To review the molecular underpinnings of immunobiology including antigen recognition

and presentation, receptor-ligand signaling cascades. and genetics To explore the initiation’ development, and control of T and B lymphocyte responses to

antigens To identify, differentiate, and describe various aspects of clinical immunology

Copyright 2018 Blake Whitaker

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Principles of Immunology, Fall ‘17

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How to succeed

The course material is interesting, challenging, and requires all of us to work hard. The following are some common sense suggestions made to support your course performance- 1. Come to class, attendance is mandatory. The lectures will clarify the reading and

expand upon it. Reading the material ahead of time and then hearing about it will also increase the retention of the material.

2. Read the material for the class ahead of time. Keep ahead on the reading. This is extremely important. Because of the tremendous amount of material, it is almost impossible to catch up once you have fallen behind. This is especially true in the summer sessions.

3. Ask questions in class. It is very likely that you are not the only one having difficulty with the concept or principle in question and you will be doing others a favor by asking the question. Asking and answering questions also helps develop skills with the terminology that you will be learning and gives you a chance to express yourself using that terminology.

4. If you have a problem with the material, ask for help immediately. We can go over the problem immediately or make an appointment to go over it.

5. Form study groups which can meet in person or electronically. The hardest thing to know is what you don’t know. Support one another and learn how to work effectively in teams. Teamwork is required in nursing, medicine, and science.

Assignments/Grading

Final grades will be determined by summing the scores on 1. Two essay exams each worth 45% of the final grade.

a. There are no makeup exams except for very good reasons. b. Exams will include definitions, essay questions, and multiple choice

questions. c. Each exam will be graded on a 100 point scale and include 110 points of

assessments, i.e. there will be 10 bonus points on each exam 2. Class participation will account for the remainder of the grade 3. Students enrolled in BIO 531 will be required to:

a. prepare and submit a 10 page literature research paper using the APA format, and

b. present the topic of the research paper in class during a 10 minute oral presentation followed by a 5 minute question period

Copyright 2018 Blake Whitaker

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Principles of Immunology, Fall ‘17

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Lecture Topics & Reading Assignments

Class/Date Topic Reading Assignment 1/Sep 1 Basic Concepts in Immunology Janeway Ch. 1 pp 1-36 2/Sep 8 Induced Innate Responses Janeway Ch. 2 & 3 pp 37 - 138 3/Sep 15 Antigen Recognition Janeway Chs. 4 & 5 pp 139 -256 4/Sep 22 Antigen Presentation Janeway Ch. 6 pp 213 - 256 5/Sep 29 Lymphocyte Receptor Signaling Janeway Ch. 7 pp 257 - 294 6/Oct 6 Development of T & B Lymphocytes Janeway Ch. 8 pp 295-344 7/Oct 13 EXAM #1 NA 8/Oct 20 T-cell-Mediated Immunity Janeway Ch. 9 pp 345 - 398 9/Oct 27 The Humoral Immune Response Janeway Ch. 10 pp 399 - 444 10/Nov 3 Integration of Innate and Adaptive IR Janeway Ch. 11 pp 445 - 492 11/Nov 17 Mucosal Immunity Janeway Ch. 12 pp 493 - 532 12/Dec 1 Failures of Host Defense Mechanisms Janeway Ch. 13 pp 533 - 600 13/ Dec 8 Manipulation of Immune Responses Janeway Ch. 16 pp 701 - 748 14/Dec 15 EXAM #2 NA

Copyright 2018 Blake Whitaker

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Blackboard A&P I course content is available on Blackboard. To access this material, go to the LAC website and click “Blackboard” under LAC Quick Links and then select BIO 431/531 Fall 2017. Attendance Policy Class attendance is critical to the success of the class as a whole and for the individual student. If possible, advance notice of class absence is requested and must be accompanied by a reasonable excuse. Excessive absences or tardiness will result in forfeiture of 2% of the total grading points per unexcused instance. Cell Phones and Other Distractions Use of electronic devices for class purposes is allowed. However, cell phone ringers and all other potentially disruptive notifications, including vibrations, must be silenced. Disability Accommodations The syllabus should include information for those students having difficulty in a class or needing accommodations due to a disability. For example: At any point in the semester, if you encounter difficulty with the course or feel that you could be performing at a higher level, consult with me. Students experience difficulty in courses for a variety of reasons. The following resources are available on campus for student:

Please feel free to drop by The Learning Commons in Portland or Gorham, or the Writing Center at Lewiston-Auburn College. If there is a tutor available, he or she will be happy to work with you. It is always best, though, to plan ahead and schedule an appointment in advance.This is especially true toward the end of the semester.

If you are familiar with how to schedule an appointment, click HERE to begin. If you are not sure how to use the scheduling system, or if you would like to see how to request an online tutoring session, please see below.

Through partnerships with academic departments at USM, we are able to offer tutoring in multiple subject areas at the Learning Commons. We are a peer support service, meaning that all of our tutors are current USM students.

Students are allowed two appointments per week per subject area. For example, a student can schedule two writing appointments as well as two math appointments. There are also some drop-in groups, which do not count towards the two appointments in that subject.

Appointments are available in Gorham, Portland, LAC, and online.

Copyright 2018 Blake Whitaker

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If you need course accommodations because of a disability, please contact the Disability Services Center in Portland at 780-4706, as soon as possible. For more information, visit http://usm.maine.edu/dsc.

University Health and Counseling Services is a student resource that promotes the health and well-being of the USM community. A personal counselor will be available weekly at LAC; please call Wendy at 753-6685 to make an appointment. More information can be found at www.usm.maine.edu/uhcs.

Academic Integrity Responsible behavior and academic integrity will be expected in this class. Remember honesty is required of all professionals!! Plagiarism, cheating, facilitated academic dishonesty, and falsification of information violates academic integrity. Violation of these policies is subject to penalties up to and including failure for the course.

Plagiarism, cheating, and falsification of information are violations of academic integrity that will not be tolerated in this class. For more information, see http://usm.maine.edu/deanofstudents/student-academic-integrity-policy-0

Campus Safety & Title IX The University of Southern Maine is committed to making our campuses safer places for students. Because of this commitment, and our federal obligations, faculty and other employees are considered mandated reporters when it comes to experiences of interpersonal violence (sexual assault, sexual harassment, dating or domestic violence, and stalking). Disclosures of interpersonal violence must be passed along to the University’s Deputy Title IX Coordinator who can help provide support and academic remedies for students who have been impacted. More information can be found online at http://usm.maine.edu/campus-safety-project or by contacting Sarah E. Holmes at sarah.e.holmes1@maine.edu or 207-780-5767.

If students want to speak with someone confidentially, the following resources are available on and off campus: University Counseling Services (207-780-4050); 24 Hour Sexual Assault Hotline (1-800-871-7741); 24 Hour Domestic Violence Hotline (1-866-834-4357).

Copyright 2018 Blake Whitaker

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