beginning of the chapter nutrime complete: personalized micronutrients based on your genetic profile...
TRANSCRIPT
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Beginning of the ChapterNutriMe Complete: Personalized
Micronutrients Based on Your Genetic Profile
6
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Genetically Personalized Dietary Supplements
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Bone healthOsteoporosis (calcium, vitamin D, magnesium)
Eye healthMacular degeneration (antioxidants)
Heart healthCholesterol (Omega3)Homocysteine (folic acid, vitamin B)
Food intolerancesLactose intolerance (calcium)Gluten intolerance (multivitamin)
Joint healthRheumatoid Arthritis (Omega3)
Metabolism healthHemochromatosis (iron)
Mental healthAlzheimer's disease (antioxidants)
DetoxificationHeavy metals (calcium, selenium, iron)
MICRONUTRIENTSGenetics allows us to recognize the
micronutrient requirements
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MICRONUTRIENTS
An example of a micronutrient needed in higher doses
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OXIDATIVE STRESS
GPX1 – A Selenoprotein which neutralizes free radicals
GPX1
GPX1
Free Radical
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GPX1
GPX1Selenium
OXIDATIVE STRESS
Free Radical
GPX1 – A Selenoprotein which neutralizes free radicals
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GPX1
GPX1
SeleniumFree Radical
OXIDATIVE STRESS
GPX1 – A Selenoprotein which neutralizes free radicals
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GPX1
GPX1
OXIDATIVE STRESS
Selenium
GPX1 – A Selenoprotein which neutralizes free radicals
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GPX1
GPX1
Neutralized
OXIDATIVE STRESS
Selenium
GPX1 – A Selenoprotein which neutralizes free radicals
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Selenium deficiency30% activity
OXIDATIVE STRESS
GPX1 – A Selenoprotein which neutralizes free radicals
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More selenium 70% activity
OXIDATIVER STRESSSelenium deficiency and GPX1 activity
Selenium deficiency30% activity
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GPX1
GPX1
OXIDATIVE STRESSGenetic variations reduce activity
FreeRadical
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GPX1
GPX1
Selenium
OXIDATIVE STRESS
Free Radical
Genetic variations reduce activity
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GPX1
GPX1
weaker binding(e.g., 50% less)
OXIDATIVE STRESS
Selenium
Genetic variations reduce activity
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Normal selenium35% activity
OXIDATIVE STRESSGenetic variations reduce activity
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OXIDATIVE STRESS
Normal selenium35% activity
More selenium60% activity
Genetic variations reduce activity
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OXIDATIVE STRESSThe GPX1 Gene
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GPX1
55 µg / day
OXIDATIVE STRESSDosage Based on Genetics
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GPX1GPX1
96 µg / Day
OXIDATIVE STRESSDosage Based on Genetics
55 µg / Day
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OXIDATIVE STRESS
An example of how a micronutrient has no effect
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Coenzyme Q10 must be activated
Q10 Q10 – No effect
OXIDATIVE STRESS
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Q10
NQO1
Q10
UBIUbiquinolantioxidant protection
Coenzyme Q10 must be activated
Q10 – No effect
OXIDATIVE STRESS
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Q10
NQO1
Q10
UBI Free Radical
UBIUbiquinol
antioxidant protection
Q10 – No effect
OXIDATIVE STRESS
Coenzyme Q10 must be activated
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NQO1 Activates the Q10 Coenzyme
OXIDATIVE STRESS
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Q10
NQO1
Q10
Coenzyme Q10 Must Be Activated
Q10 – No effect
OXIDATIVE STRESS
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Q10
NQO1
Free Radicals
Q10
Coenzyme Q10 Must Be Activated
Q10 – No effect
OXIDATIVE STRESS
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Q10
NQO1
Q10
UBI
UBI
UBI
UBI UBI
UBIUBI
Free Radicals
Coenzyme Q10 Must Be Activated
Q10 – No effect
OXIDATIVE STRESS
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Q10
NQO1
Q10
C
E
ALA
CE
E ALAC
ALA
E
Free Radicals
Coenzyme Q10 Must Be Activated
Q10 – No effect
OXIDATIVE STRESS
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NQO1
Q10
Coenzyme Q10 Must Be Activated
OXIDATIVE STRESS
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NQO1NQO1
Q10Q10 UBIC
E
ALA
Coenzyme Q10 Must Be Activated
OXIDATIVE STRESS
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MIKRONÄHRSTOFFE
Various factors which affect the calcium requirement
Factor 1) Lactose intolerance
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MICRONUTRIENTS
Lactose Intolerance and Calcium
Lactase geneAge++
LACTOSE TOLERANT
= 600mg calcium
through diet
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Calcium RDA800mg/day
Ca
Ca 200mg/day
= 800mg Calcium/day
MICRONUTRIENTS
Lactose Intolerance and Calcium
Lactase geneAge++
LACTOSE TOLERANT
= 600mg Calcium
through diet
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Lactase geneAge++
LACTOSE INTOLERANT
= 30mg Calcium
through dietCalcium RDA800mg/day
Ca
Ca 200mg/day
= 800mg Calcium/day
MICRONUTRIENTS
Lactose Intolerance and Calcium
Lactase geneAge++
LACTOSE TOLERANT
= 600mg Calcium
through diet
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Ca
Ca Ca
CaCaCa
Ca
770mg/day
Lactase geneAge++
LACTOSE INTOLERANT
= 30mg Calcium
through dietCalcium RDA800mg/day
Ca
Ca 200mg/day
= 800mg Calcium/day
MICRONUTRIENTS
Lactose Intolerance and Calcium
Lactase geneAlter++
LACTOSE TOLERANT
= 600mg Calcium
through diet
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MICRONUTRIENTS
Various factors which affect the calcium requirement
Factor 1) Lactose intoleranceFactor 2) Osteoporosis
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OSTEOPOROSIS
Bone Density and Age
Osteoporosis
Osteopenia
Bone
den
sity
Age (years)10 20 30 40 50 60 70
Normal: bone density increases until 30 years of age and then gradually decreases
Gene variations:The bone density decreasesfaster
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OSTEOPOROSIS
Bone Density and Age
Osteoporosis
Osteopenia
Bone
den
sity
Age(years)10 20 30 40 50 60 70
PREVENTION
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OSTEOPOROSIS
What Calcium Dosage is Optimal?
0 mg
1500 mg
RDA according to EFSA800 mg
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0 mg
1500 mg
Effective, according to studies
OSTEOPOROSIS
What Calcium Dosage is Optimal?
RDA according to EFSA800 mg
1200 mg
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0 mg
1500 mg
800 mg
1200 mg
800mgNormal (low) risk
Effective, according to studies
OSTEOPOROSIS
What Calcium Dosage is Optimal?
RDA according to EFSA
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0 mg
1500 mg
1200mgMaximum risk
800 mg
1200 mg
800mgNormal (low) risk
Effective, according to studies
OSTEOPOROSIS
What Calcium Dosage is Optimal?
RDA according to EFSA
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MICRONUTRIENTS
Various factors which affect the calcium requirement
Factor 1) Lactose intoleranceFactor 2) OsteoporosisFactor 3) Detoxification of heavy metals
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Detoxification of heavy metals
MICRONUTRIENTS
Is the RDA sufficient??
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PHASE 2 DETOXIFICATION
Enzymes remove heavy metals from the body
LEAD
Enzymatic modification
Neutralized
GSTM1
GSTT1
GSTP1
Removed by the kidneys
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GSTM1
GSTT1
GSTP1
Poisoning, cancer
LEAD
PHASE 2 DETOXIFICATIONGenetic variation leads to less
protection against lead
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GSTM1
GSTT1
GSTP1
Calcium binds lead
Ca
Ca
Ca
Calcium supplement binds lead
Removed by kidneys
LEAD
PHASE 2 DETOXIFICATIONGenetic variation leads to less
protection against lead
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MICRONUTRIENTS
Various Factors Which Affect the Calcium Intake
Factor 1) Lactose intoleranceFactor 2) OsteoporosisFactor 3) Detoxification of heavy metals
To summarize: what is the right dosage?
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CALCIUM
What affects the optimal calcium intake?
Lactose intolerant
Osteoporosis risk
Limited detoxification
RecommendedRDA
800 mg
No+0 mg
Yes+150 mg
No+0 mg
No+0 mg
Yes+100 mg
=800mg
Yes+150 mg
Yes+150 mg
Yes+150 mg
Yes+100 mg
NO+0 mg
No+0 mg
No+0 mg
=1050mg
=950mg
=1200mg
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MICRONUTRIENTS
An example of how a micronutrient can have different
effects
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OMEGA 3
An observations often made by doctors
Person 1 with low HDL cholesterol
The doctor recommends omega 3 supplements
HDL cholesterol improves
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Person 2 with low HDL cholesterol
The doctor recommends omega 3 supplements
HDL cholesterol is becoming worse
What is the difference?
APOA1 (A/A) APOA1 (G/G)
OMEGA 3
An Observations Often Made by Doctors
Person 1 with low HDL cholesterol
The doctor recommends omega 3 supplements
HDL cholesterol improves
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Person 2 with low HDL cholesterolPerson 1 with low HDL cholesterol
The doctor recommends omega 3 supplementsThe doctor recommends omega 3 supplements
APOA1 (A/A) APOA1 (G/G)
The doctor recommends phytosterols
Various micronutrients achieve similar results
HDL cholesterol improvesHDL cholesterol improves
OMEGA 3
An Observations Often Made by Doctors
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RDA: 250 mg
Based on studies: 1000-2900mg
OMEGA 3
What dosage is optimal?
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0 mg
3000 mg
250mg
1000mg
1500mg
2900mg Study 3
Study 1
Study 2
RDA according to EFSADose recommended for the
general population = RDA
Effective dose, according to studies
Daily dose
OMEGA 3
What dosage is optimal?
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CETP
APOA5
HDL Cholesterol
OK
CHOLESTEROL
Cholesterol is affected by genes
Genes that influence HDL
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CETP
APOA5APOA1
250mgOMEGA3
HDL Cholesterol
OK
CHOLESTEROL
Cholesterol is affected by genes
Genes that influence HDL
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APOA1250mgPhytoster.
CETP
APOA5APOA1
250mgOMEGA3
HDL Cholesterol
OK
CHOLESTEROL
Cholesterol is affected by genes
Genes that influence HDL
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CETP
APOA5
HDL Cholesterol
too low
APOA1250mgPhytoster.
CETP
APOA5APOA1
250mgOMEGA3
HDL Cholesterol
OK
CHOLESTEROL
Cholesterol is affected by genes
Genes that influence HDL
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APOA1 1500mgOMEGA3
CETP
APOA5
HDL Cholesterol
too low
APOA1250mgPhytoster.
CETP
APOA5APOA1
250mgOMEGA3
HDL Cholesterol
OK
CHOLESTEROL
Cholesterol is affected by genes
Genes that influence HDL
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APOA11500mgPhytoster.
APOA1 1500mgOMEGA3
CETP
APOA5
HDL Cholesterol
too low
APOA1250mgPhytoster.
CETP
APOA5APOA1
250mgOMEGA3
HDL Cholesterol
OK
Genes that influence HDL
CHOLESTEROL
Cholesterol is affected by genes
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SUMMARY
Genes Influence the Micronutrient requirement
Genes influence the effect of MN’s
Genes influence the necessary dosage
By analysing 50+ genes, we can individually dose 20 + micronutrients
For 50 genes, there are 717 000 000 000 000 000 000 000 possible genetic profiles
Each nutrient mixture is unique
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MICRONUTRIENTS
How can you follow such a detailed requirement?
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How Can You Follow Such an Extensive Recommendation?
Standard products?
The dosages are always too high or too low
Very expensive
Easy to produceOptimal absorption
MICRONUTRIENTS
Microtransporter technology
Personalized mixed capsules?
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Vitamin C mix50% w/w
Vitamin A mix4% w/w
Zinc mix11% w/w
Mixture for one genetic
profile
38g6g 22g
Instructions: ingest 8g/day
Zinc mix
Vitamin A mix
Vitamin C mix
Molecule of fillerMolecule of Vitamin CMolecule of Vitamin AMolecule of Zinc
Amounts differ depending on genetic profile
Various micro transporters are mixed in different ratios to produce an unique combination
How Can You Follow Such an Extensive Recommendation?
MICRONUTRIENTS
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A spoon of microtransporters
MICRONUTRIENTS
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MICRONUTRIENTS
Slow Release – absorbed by the body over a period of 8 hours
Absorption-inhibiting micronutrients are released at different locations in the intestine
The pellets can be swallowed or mixed with yogurt
A spoon of microtransporters
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End of the ChapterNutriMe Complete: Personalized
micronutrients based on your genetic profile
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