associate editor takashi tsuruo, ph.d

Associate Editor Takashi Tsuruo, Ph.D. Dr. Tsuruo re- ceived his Ph.D. in pharmaceutical sciences from the University of To- kyo in 1972, where he served as an instructor until 1977. During that time, he was also a research associate at St. Louis Univer- sity in Missouri (1974±1976) and at the University of California, Los Angeles (1976± 1977). He was on the research staff (1977±1983), chief- in-research (1983±1986), and chief (1986±present) of the Division of Experimental Chemotherapy at the Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo. Dr. Tsuruo has been professor at the Institute of Applied Microbiology (1989±1993) and professor (1993±present) and director (1999±present) of the Laboratory of Cell Growth and Regulation, Department of Cell Biology, Institute of Molecular and Cellular Biosciences, the University of Tokyo. Dr. Tsuruo was a Yamagiwa-Yoshida Memorial Inter- national Cancer Study Grants (UICC) visiting researcher at the NCI Frederick Cancer Research Center, working with Dr. Isaiah J. Fidler (1980), and a guest researcher at the NCI Division of Cancer Treatment, Bethesda, working with Dr. Bruce A. Chabner and Dr. Robert F. Ozols (1984±1985). Dr. Tsuruo's research interest is in cancer chemotherapy and the reversal of the multidrug resistance (MDR) phenotype in cancer cells. He discovered the MDR-reversing agent verapa- mil in 1981 and developed the anti-P-glycoprotein antibody MRK-16, which is now being tested in clinical trials. His chief research focus is on the effect of MDR-reversing agents on vincristine transport across the blood-brain barrier, how glucose starvation and hypoxia induce the nuclear accumulation of proteasome in cancer cells, the induction mechanisms of apoptosis by antitumor agents, the function of Akt in apoptosis, and the reversal of drug resistance using various chemicals. Dr. Tsuruo is a member of AACR and the European Association for Cancer Research. He is also a board member of the Japanese Cancer Association, the Japanese Biochemical Society, and the Pharmaceutical Society of Japan. He has been a coordinator of the U.S.-Japan Co-operative Cancer Research Program and a member of the Evaluation of Research Grant and the Investigational Evaluation of New Antitumor Agents committees, the Ministry of Health and Welfare, Japan. He is currently the principal investigator on the grant ``General Promotion of Cancer Research in Japan,'' which is supported by the Ministry of Education and Science, Japan. His honors and awards include the Japanese Cancer Association Research Award (1984), the Princess Takamatsu Cancer Research Fund Award (1991), the Japanese Foundation for Cancer Research Award (1997), and the Japan Pharmaceutical Society Award (1997). Dr. Tsuruo has published over 500 papers, and he is the Asian editor of Oncology Research and an associate editor of Cancer Research and the Japanese Journal of Cancer Research. He has served on the editorial boards of many journals, including Cancer Chemotherapy and Pharmacology, Japanese Journal of Clinical Oncology, British Journal of Cancer, Biochemical Pharmacology, and International Journal of Cancer. 252 Journal of Experimental Therapeutics and Oncology Vol. 2 2002 D 2002 Blackwell Publishing Inc.

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Page 1: Associate Editor Takashi Tsuruo, Ph.D

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