Aproach to bone tumours

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Post on 07-May-2015



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<ul><li>1.Dr Nikrish S Hegde</li></ul> <p>2. TUMOUR = MASS = NEOPLASM MALIGNANT TUMOUR / MALIGNANT NEOPLASM BENIGN TUMOURS MAY SHOW MALIGNANT PROPERTIES 3. The radiologic modalities most often used in analyzing tumors and tumor-like lesions include: conventional radiography angiography (usually arteriography) computed tomography (CT) magnetic resonance imaging (MRI) scintigraphy (radionuclide bone scan) and fluoroscopy- or CT-guided percutaneous soft tissue and bone biopsy. 4. suffice to make a correct diagnosis . confirmed by biopsy and histopathologic examination. Conventional radiography yields the most useful information about the location and morphology of a lesion, Location Calcification Ossification Periosteal Reaction 5. Provide a precise evaluation of the extent of a bone lesion . CT is moreover very helpful in delineating a bone tumor having a complex anatomic structure. CT examination is crucial in determining the extent and spread of a tumor in the bone if limb salvage is contemplated, so that a safe margin of resection can be planned . CT is also useful for monitoring the results of treatment. Evaluating the relationship between the tumor and the surrounding soft tissues and neurovascular structures is particularly important for planning limb-salvage surgery. 6. Arteriography is used mainly to map out bone lesions and to assess the extent of disease. Demonstrate the vascular supply of a tumor 1) Preop intra-arterial chemo 2) Biopsy Arteriography is often useful in planning for limb-salvage procedures because it demonstrates the regional vascular anatomy. Interventional procedures 7. MRI offers distinct advantages over CT. It has a few disadvantages as well. In the evaluation of intraosseous and extraosseous extensions of a tumor, MRI is crucial because it can determine with high accuracy the presence or absence of soft-tissue invasion by a tumor . Assist in differentiation of intraarticular tumor extension from joint effusion. Cant assess ossification and calcification. 8. Indicator of mineral turnover. A bone scan is useful in localizing tumors and tumor-like lesions in the skeleton. In most instances a radionuclide bone scan cannot distinguish benign lesions from malignant tumors. 9. AGE DURATION RACE 10. With so many imaging techniques available to diagnose and characterize the bone tumor further, radiologists and clinicians are frequently at a loss as to how to proceed in a given case. Clinical presentation Effectiveness Benefits Cost Restrictions 11. In the evaluation of bone tumors, conventional radiography are still the standard diagnostic procedures. It should always be done. Most of the time, the choice of further imaging technique is dictated findings on radiograph. If osteoid osteoma is suspected based on the clinical history conventional radiography followed by scintigraphy and then it should be followed by CT. 12. If radiographs are suggestive of a malignant bone tumor, MRI or CT should be used next to evaluate both the intraosseous extent of the tumor and the extraosseous involvement of the soft tissues. If there is no definite evidence of soft-tissue extension, then CT is superior to MRI. If the radiographs suggest cortical destruction and softtissue mass, then MRI would be the preferred modality . 13. The site of a bone lesion is an important feature, because some tumors have a predilection for specific bones or specific sites in the bone .The sites of some lesions are so characteristic that a diagnosis can be suggested on this basis alone, as in the case of parosteal osteosarcoma or chondroblastoma . Moreover, certain entities can be readily excluded from the differential diagnosis on the basis of the lesion's location 14. IA WELL DEFINED WITH SCLEROSIS IB- WELL DEFINED BUT NO SCLEROSIS IC- POORLY DEFINED 15. Only two of theseosteoblastic and cartilaginous tissuecan usually be clearly demonstrated radiographically. Identification of tumor bone within or adjacent to the area of destruction should alert the radiologist to the possibility of osteosarcoma/reactive sclerosis. Osteosarcoma-cloudy - cotton like fluffy deposits. Cartilage is identified by the presence of typically popcorn-like, punctate, annular, or comma-shaped calcifications in lobules. A completely radiolucent lesion may be either fibrous or cartilaginous . 16. The type of bone destruction caused by a tumor is primarily related to the tumor growth rate. Not pathognomonic for any specific neoplasm. Geographic. Moth Eaten. Permeative. 17. Categorized as uninterrupted or interrupted . The first type of reaction is marked by solid layers of periosteal density, indicating a long-standing benign process. Also seen in nonneoplastic processes such as Langerhans cell histiocytosis, osteomyelitis, bone abscess or in fractures in the healing stage. The interrupted type of periosteal reaction suggests malignancy or a highly aggressive nonmalignant process and may present as a sunburst pattern, a lamellated (onion-skin) pattern, a velvet pattern, or a Codman triangle. 18. Benign tumors and tumor-like bone lesions usually do not exhibit soft-tissue extension; thus, almost invariably, a soft-tissue mass indicates an aggressive lesion and one that is in many instances malignant . With few exceptionssuch as giant cell tumors, aneurysmal bone cysts, osteoblastomas, or desmoplastic fibromas. In the case of a bone lesion associated with a soft-tissue mass, it is always helpful to determine which condition arose first. 19. A multiplicity of malignant lesions usually indicates metastatic disease, multiple myeloma, or lymphoma. Very rarely do primary malignant lesions, such as an osteosarcoma or Ewing sarcoma, present as multifocal disease. Benign lesions, however, tend to involve multiple sites, as in polyostotic fibrous dysplasia multiple osteochondromas, enchondromatosis, Langerhans cell histiocytosis. 20. Although it is sometimes very difficult to distinguish benign from malignant bone lesions on the basis of radiography alone, certain characteristic features favour one designation over the other. 21. Radiography is used mainly to document the results of surgical resection of benign lesions such as osteoid osteoma or to follow-up after curettage of benign tumors or tumor-like lesions and application of bone gratfs. In the case of malignant tumors, radiographic films permit one to demonstrate the position of endoprostheses or bone grafts in limb-salvage procedures. The effectiveness of chemotherapy is best CT and MRI. Recurrence or metastatic spread of a tumor can be effectively shown at an early stage on scintigraphy, CT, or MRI. </p>


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