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Slide 1
Anxiety Disorders
Chapter 6
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Slide 2 Anxiety Disorders
Def: behaviors that include phobias, obsessions, compulsions and extreme worry. People with an anxiety disorder share a pre-occupation with , or persistent avoidance of thoughts or situations that provoke fear or anxiety, and frequently have a negative impact on aspects of a person’s life.
Similarities with mood disorders: Both are defined in terms of negative emotional responses Both involve feelings of guilt, worry, and anger. Common etiological features, such as cognitive distortions,
triggers by stressful life events, and biological factors such as neurotransmitter imbalances.
Close relationship of symptoms for anxiety and mood disorder suggests the possibility of common causal features (e.g. stressful life events)
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Slide 3 Anxiety as a Mood vs. a Syndrome
Fear-experienced in the face of real or immediate danger, builds quickly and helps organize a person’s behavioral responses to threats from the environment.
Anxious Mood-general or diffuse emotional reaction that is beyond simple fear and out of proportion to threats in the environment. Not always directed at the person’s present circumstance
can be associated with the anticipation of future problems.
Adaptive at low levels as it signals a person must prepare for an upcoming event.
Anxious apprehension- a pervasively anxious mood associated with pessimistic thoughts, negative self-evaluation and negative concern for future events.
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Slide 4 Symptoms of Anxiety Disorders
Excessive Worry-
Panic Attacks-
Phobias- persistent, irrational narrowly defined fears that are associated with a specific object or situation.
Obsessions and Compulsions Obsessions (def)-repetitive unwanted, intrusive cognitive
events that may take the form of thoughts images or impulses and lead to an increase in subjective anxiety.
Compulsions-repetitive behaviors or mental acts that are used to reduce anxiety.
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Slide 5 Excessive Worry
Cognitive activity associated with anxiety that manifests as a relatively uncontrollable sequence of negative, emotional thoughts that are concerned with possible future threats or dangers.
Lack of perceived control
Negative Affect
Quantity
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Slide 6 Panic Attacks
Panic attacks- sudden overwhelming experience of terror or fright. More focused than anxiety believed to be a normal fear response triggered at an inappropriate time.
Physical sensations of which the patient must experience at least four, which develop suddenly and reach peak intensity within 10 minutes:
Heart palpitations Sweating Trembling or shaking Sensation of shortness of breath Choking feeling Chest pain Nausea or abdominal distress Dizziness Feelings of unreality or detachment from oneself Fear of losing control or going crazy Fear of dying Numbness or tingling sensation Chills or hot flushes
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Slide 7 Phobias
Persistent, irrational narrowly defined fears that are associated with a specific object or situation. Avoidance Agoraphobia-Fear becomes more intense as the
distance between the person and his or her familiar surroundings increases, or as avenues of escape are closed off.
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Slide 8 Obsessions and Compulsions
Obsessions and Compulsions- Obsessions (def)-repetitive unwanted, intrusive cognitive events that may
take the form of thoughts images or impulses and lead to an increase in subjective anxiety.
Compulsions-repetitive behaviors or mental acts that are used to reduce anxiety.
Obsessions Seem to come out of the blue Content of obsessions
Compulsions-Must perform the ritual to keep something “bad” from happening. Most common are cleaning and checking
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Slide 9 Diagnostic Systems of Anxiety Disorders (DSM-IV-TR)
Panic Disorder Recurrent unexpected panic attacks with at least half of the
attacks followed by a period of one month or more in which the person fears having another attack. (fear of fear)
Avoidance of the situation (change in behavior)
Agoraphobia Avoid the situation or endure it with great distress Insist on being accompanied by a safe person.
Specific Phobia-marked and persistent fear that is excessive or unreasonable, cued by the presence of specific object or situation. Exposure produces immediate fear response Awareness that fear is unreasonable Avoidance
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Slide 10 History of Anxiety as a Disorder Early classification of Anxiety disorders were under the
classification of neurosis.
Distinguished from the psychotic disorders as the patient has awareness.
Contemporary classification of anxiety disorder includes:
Panic disorder
Phobic Disorder
Obsessive Compulsive Disorder
Post Traumatic Stress Disorder
Acute Stress Disorder
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Slide 11 Diagnostic Systems of Anxiety Disorders (DSM-IV-TR)
Panic Disorder-recurrent unexpected panic attacks . For one month or more following at least one attack, the person must experience persistent concern about having another attack, worry about implications of the attack or a significant change in behavior due to the attack. Two Categories:
With or Without Agoraphobia Agoraphobia-complication that follows experience of panic attacks in which the
person fears the inability to escape the situation. With agoraphobia, the person must either avoid the agoraphobic situation, endure it with great distress, or insist they be accompanied by another person who can offer comfort or security.can exist in the absence of panicP disorder (rare)
Phobic Disorders: Specific Phobia-marked and persistent fear that is excessive or unreasonable
cued by the presence or anticipation of a specific object or situation. Social Phobia-identical to specific phobia, except must be afraid of social
categories. Fear of being humiliated lies at the heart of the disorder. Two Categories: Performance Anxiety Interpersonal Interactions
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Slide 12 DSM Classification
Generalized Anxiety Disorder-excessive anxiety or worry that lead to significant distress or impairment in occupational or social functioning. Free-floating anxiety must be accompanied by at least three of the following symptoms: Restlessness or feeling on edge Fatigue Difficulty concentrating Irritability Muscle Tension Sleep Disturbance
Obsessive-Compulsive Disorder-defined in terms of the presence of either obsessions or compulsions. Obsessions-thoughts must not be excessive worries about real problems must be
unreasonable Compulsions-rituals that cause marked distress if not performed, take more than an hour a
day to perform or interfere with normal occupational and social functioning.
Post traumatic Stress Disorder (Chapter 7) Acute Stress Disorder (Chapter 7) Separation Anxiety- (Chapter 16)
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Slide 13 Course and outcome
Chronic conditions Research based predictive
course and outcomes: Long term outcome unpredictable
Panic Disorder-Greatest predictor of poor outcomes was onset of symptoms at a relatively young age and the presence of agoraphobia with panic disorder.
Social phobia-Symptoms usually appear first in early adolescence and remain stable over time, indicating chronic condition.
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Slide 14 Course and Outcome
OCD-follows a pattern of improvement mixed with some persistent symptoms. Longitudinal study shows 50% of patients exhibit symptoms for over 30 years. However, more than 80% of the patients showed improved levels of functioning considered a chronic condition.
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Slide 15 Frequency
Only about 25% of people who qualify for a diagnosis of anxiety disorder ever seek psychological treatment. Therefore estimates of the frequency and severity of these problems are likely inaccurate.
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Slide 16 Prevalence
Anxiety disorders more common than any other mental disorder in the U.S.
Specific phobia-most common-9%
Social phobia-7%
Panic Disorder and GAD-3%
OCD and Agoraphobia-1%
Gender Differences
Women have much higher incidence of anxiety disorders than men, except for OCD which is relatively equal. Women also three times more likely to relapse.
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Slide 17 Etiology
Evolutionary Theoretical Perspective
Social Factors
Psychological Factors
Biological Factors
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Slide 18 Evolutionary Theoretical Perspective
Suggests that generalized forms of anxiety probably evolved to prepare for threats that could not be clearly defined. More specific forms of anxiety and fear probably evolved to provide more effective responses to certain types of danger. For example: Fear of heights is associated with a freezing of muscles
which could lead to a fall
Social threats were likely seen as establishment of dominance hierarchies within pack behavior and were likely to provoke responses such as shyness or embarrassment.
The evolutionary model views each type of anxiety as a dysregulation of a mechanism that evolved to deal with a particular kind of danger.
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Slide 19 Social Factors
Stressful life events that involve danger, interpersonal conflicts or parent-child relationships are thought to contribute to vulnerability to the development of anxiety disorders.
Childhood Adversity
Attachment Relationships and Separation Anxiety
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Slide 20 Psychological Factors
Learning Processes and Phobias Preparedness Model-theory that brain contans certain modules or circuitry that
has been shaped by evolution to serves some adaptive purpose. Operate at maximal speed and perform without conscious awareness. Humans develop intense persistent fears to only a select set of objects or
situations. Development of social and specific phobias could be related to evolutionary lag.
Observational Learning Social Learning Theory
Cognitive Factors: Perception and Memory Four General Areas that play a role in anxiety Disorders. Perception of Control Catastrophic Misinterpretation Attention to Threat and Biased Information Processing Thought Suppression (OCD)
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Slide 21 Biological Factors
Family Studies-relatives of people with panic disorder show an elevated risk of panic disorder, but not GAD, and vice versa.
Twin Studies
Neuroanatomy-brain circuitry involved in fear and conditioning
Emotional Stimuli follows two primary pathways both of which involve the amygdala.
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Slide 22 Pathway One
Fastest and represents the evolved fear module for conditioned fear.
Has direct connections to the amygdale which registers danger and then projects to the hypothalamus which activates fight or flight behavioral responses.
This pathway does not involve higher level cognitive function such as conscious memory and decisions via the cortical areas.
However the amygdale does store unconscious emotional memories such as those generated through prepared learning.
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Slide 23 First Pathway: Fear and Conditioning
Stimulus
Thalamus
Amygdala
Hypothalmus
FLIGHT OR FIGHT RESPONSE
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Slide 24 Second Complementary Pathway
Pathway from the thalamus leads to higher cortical areas and provides a detailed and slower analysis of the information.
Once the pattern has been identified in the appropriate modality the data would be integrated with additional information from memory about is emotional significance.
The message would then be sent to the amygdala which would tiger an organized response to threat as well as to other cortical areas that also initiate plans against dangers.
Second pathway takes longer than the first.
Sensitivity of the first pathway (fear module) is thought to be more sensitive than the second.
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Slide 25 Second Pathway
Stimulus
Thalamus
Amygdala
Hypothalamus
FLIGHT OR FIGHT RESPONSE
Lobe Identification and recognition of stimulus
EmotionalitySomatosensory cortex
Motor Cortex
Planned Voluntary Movements
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Slide 26 Neurotransmitters
Various pharmacological challenge studies suggest the influence of serotonin, NE, GABA, and DA in triggering panic attacks.
Efficacy of drug treatments affecting these neurotransmitters suggest they may be involved (convergent evidence)
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Slide 27 Treatment
Psychological Interventions Insight therapy-Freudian analysis of unconscious motives
that presumably lie at the heart of the symptoms. Behavioral Therapies
Systematic Desensitization-client is first taught progressive relaxation. Then the therapist constructs a hierarchy of feared stimuli, beginning with those items that provoke only small amounts of fear and progressing through items that are more frightening then while the client the client is in a relaxed state, he or she imagine the lowest item on the hierarchy. This item is mentally presented until the thought of the object or situation is no longer anxiety producing. The client moves systematically up the hierarchy sequentially confronting stimuli that were originally rated as being more frightening.
Flooding- exposure to the most frightening experience without avoidance.
Interoceptive Exposure- have patient engage in exercises known to produce physical sensations associated with panic attacks such as increased heart rate, respiration or dizziness and attempt to reduce the person’s fear of the symptoms.
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Slide 28 Treatment
Cognitive Therapy Identify faulty logic such as over-
generalizations and jumping to conclusions.
Decatastrophisizing-imagine the worst case scenario and confront the negative predictions, and gross exaggerations based on cognitive errors.
Extensive practice, homework and journaling.
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Slide 29 Treatment
Biological Therapy Anti-Anxiety Medications.
Benzodiazepenes--reduce anxiety symptoms primarily by inhibiting GABA neuron activity. Drug of choicexanax.
Panic attacks and agoraphobia
Problems: high rate of addiction and dependence. Many patients relapse after discontinuation of medication
Azapirones-inhibit serotonin activity. BusParGAD Does not work as quickly
Antidepressants-often preferred over anti-anxiety drugs due to problems with addiction.
SSRI’s- first line treatment due to tolerability of side effects.
SNUB-Effexor, Cymbalta
Tricyclics-used for the longest period of time. Work as well as the SSRI’s but range of side effects leads to non-compliance.
Anafranil (OCD)-tricyclic especially helpful with OCD, not used with any other panic disorder, however relapse is common after discontinuation of the drug.
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Slide 30 Case Study: Paula
Paula: 27 year old white female Single
Education: BA –economics
Occupation: Securities and Bond Trader
Presentation: Blunted Affect, Good eye contact, fidgety
Extremely uncomfortable talking about painful subjects in the past, Before the end of the first session, patient became so uncomfortable discussing a subject, she left the session early.
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Slide 31 Reason for appointment
Recurring attacks that she thought were heart attacks.
Patient experienced chest pains, dizziness and shortness of breath resulting in multiple trips to the emergency room.
Cardiology testing
Zanax prescribed
Acceleration of symptoms and avoidance behaviors
Medical leave from job.
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Slide 32 Family Background
Mother: Homemaker
Father: Deceased five years from Congestive heart Failure
Siblings: younger brother born with multiple birth defects including severe heart problems The died when he was three years old and the family still grieved his loss.
Maternal Grandfather: Alcoholic
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Slide 33 Evaluation
Assessment Tools Unstructured Interview
Psychiatric Evaluation
Symptoms:
Onset : shortly after entering college where she experienced adjustment problems.
Unresolved grief.
Acceleration of symptoms
Avoidance Behaviors
Abuse of alcohol and over the counter drugs for a short period
Suicidal Ideations
Irrational thoughts
Anger at Mother
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Slide 34 Etiology
Learningnegative reinforcement
Irrational thinking
Biological
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Slide 35 Treatment:
Group Therapy
Medication: zoloft
Relaxation Therapy
Hypnosis
Duration: 7 months
Prognosis-good
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Slide 36 DSM IV TR
Axis One: Panic Disorder with Agoraphobia
Axis Two:
Axis Three:
Axis Four:
Axis Five:
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