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ANTIMICROBIAL AGENTS ANDCHEMOTHERAPY
VOLUME 27 * JUNE 1985 * NUMBER 6
Leon H. Schmidt, Edlitor in Chief (1985)Unlivevr.sity of Alabana in Bi-inif'/igllamBirmiiinghattn
Herbert L. Ennis, Editor (1987)Roche Institiute of AMole(ula(l BiologyNmutlev, Newi, Jer-seyv
Robert L. Hamill, Editor (1985)Eli Lil//, & Colfnpany l(c.Indiaina(lpolis, lntdianlal
George A. Jacoby, Jr., Elitor (1985)Massachusetts Generatil HospitalBoston
Robert C. Moellering, Jr., Etlitor (1987)NVw' Etiglant Dco(t0iesS ILHoJspitalBostoti, Ma.so(lahsetts
Christine C. Sanders, Editor, (1989)Creightoni Universitv Sc(0hoolfoV'(lidcil(Omaha, Nebraska
Peter G. Welling, Eklitor (1988)Warl Clr-La/Ub/t Co.A tin Arbor, Michigall
John A. Washington II, Editor (1986)Mayo ClinicRochester. NIilhlC 'vota
EDITORIAL BOARDNorris Allen (1986)Vincent T. Andriole (1987)Bascom F. Anthony (1985)George R. Aronoff (1986)Robert Austrian (1986)Richard H. Baltz (1987)Rashmi H. Barbhaiya (1986)Arthur L. Barry (1986)John G. Bartlett (1987)Michael Barza (1985)William M. Bennett (1987)Richard F. Bergstrom (1985)Karen K. Biron (1987)Gerald P. Bodey (1986)Arthur E. Brown (1987)Lawrence E. Bryan (1985)Ward Bullock (1987)Tsun Chang (1986)Anthony Chow (1985)C. Glenn Cobbs (1986)Paul S. Cohen (1986)William A. Craig (1987)Naomi Datta (1987)Lawrence E. Day (1986)William E. Dismukes (1987)R. Gordon Douglas, Jr. (1986)John C. Drach (1987)George L. Drusano (1987)Theodore Eickhoff (1985)Gertrude B. Elion (1987)
Arthur English (1986)Robert J. Fass (1985)Stuart Feldman (1985)Sydney Finegold (1985)Robert J. Fitzgerald (1986)Martin Forbes (1986)John N. Galgiani (1987)Dale N. Gerding (1985)Anthony J. Glazko (1987)Irving H. Goldberg (1985)Jack Gwaltnev (1986)Scott NI. Hammer (1986)W. Lee Hand (1986)H. Hunter Handsfield (1986)Joseph Hawkins, Jr. (1985)Frederick G. Hayden (1987)Nlichael Higgins (1986)David C. Hooper (1987)Richard Hornick (1986)George Gee Jackson (1986)James H. Jorgensen (1987)William J. Jusko (1986)A. W. Karchmer (1985)Donald Kaye (1985)George S. Kobayashi (1985)Donald J. Krogstad (1986)Felix Leitner (1986)Stephen A. Lerner (1986)Stuart B. Levv (1986)
Joan Lusk (1986)R. Luthy (1986)Francis L. Macrina (1985)Gerald L. Mandell (1986)Garv R. Matzke (1986)George H. McCracken (1987)Antone A. Medeiros (1987)Gerald Medoff (1986)NMichael Miller (1987)Barbara Minshew (1985)Thomas P. Moyer (1986)Barbara E. Murrav (1987)John D. Nelson (1986)Harold C. Neu (1986)Lawrence A. Pachla (1987)Joseph S. Pagano (1987)James 'T. Park (1985)James E. Pennington (1986)T. J. Perun (1986)Lance R. Peterson (198X5)Michael Rein (1986)W. H. G. Richards (1986)Richard Roberts (1985)Ian M. Rollo (1985)Allan Ronald (1987)Richard Root (1986)John P. Rosazza (1986)Jon E. Rosenblatt (1985)Robert H. Rubin (1987)
Nlerle Sande (198>()NV. Eugene Sanders, Jr. (1987)WV. NMichael Scheld (1986)Jerome J. Schentag (1985)Raymond F. Schinazi (1986)Fritz D. Schoenknecht (1986)F. C. Sciavolino (1985)VW'illiam NI. Shannon (1986)Charles Shipman, Jr. (1985)Robert NV. Sidwell (1987)P. Frederick Sparling (1987)Harold Standiford (1985)I)avid A. Stevens (1986)Stephen E. Straus (1987)R. Sutherland (1985)Morton N. Swartz (1985)Richard B. Sykes (1985)Francis P. Tally (1987)Alexander Tomasz (1985)Ralph Tompsett (1985)Francis L. S. Tse (1986)Richard J1. Wallace, Jr. (1987)Michael W'aring (1987)Bernard XN'eisblum (1985)Richard NI. Welch (1986)Richard Wise (1986)John S. Wolfson (1987)Lowell Young (1985)Pauline K. WV. Yu (1985)
Helen R. Whiteley, Chairman,ti. Publication.s BoardLinda M. Illig, Managing Editor, Jourtnals
Walter G. Peter III, Director of PublicationsDeborah J. Shuman, Production Edit(or
Antimicrobial Agents antid Chemotherapy (ISSN 0066-4804). an interdisciplinary publication of the American Societs for Microbiology.1913 I St., NW, Washington, DC 20006, is devoted to the dissemination of knowledge relating to all aspects of antimicrobial. antiparasitic. andanticancer agents and chemotherapy. Instructions to authors are published in the JamnuIary issue each year; reprints clre available fr-om theeditors and the Publications Departmient. Antimicrobial A,cnts anditl CheMotherIaP is published monthly. and the twelve number-s are dividedcinto two volumes per year. The nonmember suLbscription price is $157 per year: single copies are $21. The member subscription price is $31(foreign, $41 [surface rate]) per year; single copies are $7. Correspondence relating to subsCIiptions, reprints, defective copies. illlability ofback issues, lost or late proofs. disposition of submittedimanuscripts, and general editorial matters shouLld be directed to the ASM PublicationsDepartment. 1913 I St.. NW, Washington. DC 20006 (phone: 202 833-9680).
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Author IndexAlving, Carl R., 903Attfield, P. V., 985Ayers, Leona W., 982
Beale, Angela S., 980Bennett, William M., 897Bergeron, Michel G., 928Berman, Jonathan D., 916Boon, Ronald J., 980Brander, Pirkko, 948Brochu, Gilles, 928Brooks, Dandrea L., 912
Canonico, Peter G., 903
Dale, Jeremy W., 989Dandu, Vijay R., 977De Grandis, Stephanie A., 938Desaulniers, Denis, 928Despres, Jean-Paul, 928Diana, G. D., 883Dias, M. Beatriz Souza, 968Didolkar, Mukund S., 977
English, Jan, 897
Fancher, M. J., 883Fiore, Dario, 977Fowlston, S., 966Fox, M. P., 883
Gavan, Thomas L., 982George, W. Lance, 966Gerlach, E. Hugh, 982Gilbert, David N., 897Giles, Penelope, 953Giovenella, Albert J., 961Gorbach, Sherwood L., 968Grappel, Sarah F., 961Greenberg, Stephen B., 953
Hadley, W. Keith, 958Hanson, Brian D., 916Harris, Deborah, 953Holland, Susan, 989Houang, Elizabeth T., 964Houghton, Donald C., 897
Jackson, Andre J., 977Jacobus, Nilda V., 968Jokipii, Anssi M. M., 948Jokipii, Liisa, 948Jones, J., 966Jones, Ronald N., 982
Kasbekar, Durgadas P., 974Katz, Eugene, 974Kende, Meir, 903Kohlhepp, Sue, 897Kohnen, Paul W., 897
Kuhrt, M. F., 883
Lawrence, Adam G., 964Leathers, Timothy, 892Lemieux, Michel, 928Lessard, Celine, 928Lindqvist, Lennart, 943Lin, Jung-Chung, 971Luman, J. Ileice, 912
Madigan, Sanford, 974Marks, Melvin I., 908Martin, R. Russell, 953Mayor, Gilbert, 897McColm, Andrew A., 925McKinlay, M. A., 883McLarty, Jerry W., 912Mdtras, Jacques, 928Mordenti, Joyce, 887
Nagata, Akihisa, 921Nisbet, Louis J., 961Nord, Carl Erik, 943
Ohm-Smith, Marilyn J., 958Ono, Yasuko, 921Otto, M. J., 883
Pagano, Joseph S., 971Pinney, R. J., 985
Raymond, Gilles, 928Reinhardt, John F., 966Rill, Wayne L., 903Ryan, D. Michael, 925
San Joaquin, Venusto H., 908Shalit, Itamar, 908Skold, Ola, 933Smith, M. Carolyn, 971Sommers, Herbert M., 982Steele, Lorraine C., 912Steen, Rolf, 933Stevenson, Roselynn M. W., 938Suzuki, Yasuhiko, 921Swartz, Glenn M., Jr., 903Sweet, Richard L., 958Sypherd, Paul S., 892
Tally, Francis P., 968Tuner, Kajsa, 943
Waddell, David, 916Wallace, Richard J., Jr., 912, 953Welch, David F., 908Wilson, Rebecca W., 912
Yamada, Takeshi, 921Yamanouchi, Takahisa, 921
AUTHOR INDEX
VOLUME 27
Aalen, Odd, 107Adams, M., 275Aiba, Shuichi, 367Alexander, W. James, 760Allan, J. Davis, 782Alpert, Martin L., 422Alvarez, Salvador, 646Alving, Carl R., 903Ambinder, Richard F., 217Anderson, R., 257Anwar, Hosmin, 220Aoki, Fred Y., 753Aoyama, M., 595Apicella, Michael A., 16Arao, Nakako, 565Araujo, Fausto G., 491Arizpe, H. M., 184Arnold, Keith, 192Aronoff, George R., 812Attfield, P. V., 985Ayers, Leona W., 982Ayers, Ouida M., 324Aznar, Javier, 76
Bailey, Denis M., 4Baird, Anne, 858Baker, Carol J., 511Baker, Neil R., 468Balber, Andrew E., 33Baldwin, Jack N., 234Bansal, Madhu B., 640Barry, Arthur L., 679Barry, David W., 167Baucks, Regina, 632Bawdon, R. E., 436Bawdon, Roger E., 874Bayoumi, Samir M., 487Beale, Angela S., 980Beaubien, Arthur R., 720Bechard, Douglas L., 263Beck, C. F., 879Bellora, Mauricio J. Gatto, 137Benavente, Maria C., 282Benes, Solomon, 724Bennett, William M., 897Benziger, David P., 769, 774Berens, Randolph L., 33Bergeron, Michel G., 928Berk, Steven L., 646Berman, Jonathan D., 916Bertram, Miriam A., 515Bettex, Jean-David, 350, 353Bibler, Mark, 291Bies, M., 207Bint, Adrian J., 508Birk, R. J., 424Bistoni, F., 625Blaser, Jurg, 343Blayo, Marie-Claude, 561Blumer, Jeffrey L., 583Bode, Robert, 291Bodey, Gerald P., 265Boere, Wil A. M., 802Bonner, Daniel P., 555Boon, R. J., 495Boon, Ronald J., 980Boozer, Richard M., 42Borner, Klaus, 375Boscia, Jerorne A., 708Bowdre, Jean H., 525
Bowman, Bernard U., Jr., 399,404, 408
Box, Quellin T., 181Brajtburg, Janina, 172Brammer, Keith W., 832Brander, Pirkko, 948Brandis, Henning, 836Brater, D. C., 436Brier, Michael E., 812Brier, Richard A., 812Brion, Nils, 520, 660Brochu, Gilles, 928Brooks, Dandrea L., 912Brown, Michael R. W., 220Brummer, Elmer, 363Bruns, Wolfgang, 632Bryan, Elza R., 102Buck, R. E., 207Bulkacz, Jaime, 427Bullock, Ward E., 291Burkey, Linda J., 817Burns, Jane L., 46Bush, Karen, 555Butzler, Jean-Paul, 388
Caballero, Maria C., 76Cafarell, Robert F., 16Canonico, Peter G., 903Carbon, Claude, 520, 660Carek, Peter J., 817C,rlson, Karin, 107Carter, Walker T., 876Carter, W. T., 674Casal, Manuel J., 282Cauchy, Michael J., 720Chaffin, Donald, 531Chamberlain, Paul D., 858Chambers, Henry F., 685Chan, Ying-Pui M., 192Chau, P. Y., 872Cheng, Yuan Rong, 828Cheng, Yung-Chi, 416, 445Cheriyan, U. O., 184Chiou, Jwo-Farn, 416Chisholm, D. R., 207Chonmaitree, Tasnee, 181Chow, Anthony W., 749Christenson, Bernard, 570Citron, Diane M., 162, 657Clavier, Francoise, 561Cohenford, Menashi, 479, 715Coignau, Hugo, 388Colby, Steven D., 71Congeni, Blaise L., 181Contrepois, Alain, 520, 660Cook, James L., 11Cooksey, Robert C., 234Coombes, James D., 535Corey, Lawrence, 203Cornett, James B., 4Costerton, J. W., 619Couch, Robert B., 309Couetdic, Gerard, 280Cramer, William A., 836Craven, Philip C., 868Crawmer, Bruce P., 769Creger, Richard J., 413Crider, Steven R., 71Critchlow, Cathy, 203Crooke, Stanley T., 460
Dale, Jeremy W., 989Dandu, Vijay R., 977D'Aquino, Miguel, 137Datema, Roelf, 753David, Hugo L., 701Debbia, Eugenio, 615De Grandis, Stephanie A., 938DeHertogh, Deborah A., 670Delaha, Edward C., 485Delatour, Frederique, 520Del Bene, Victor E., 817DeLong, Donald C., 102de Lorenzo, Victor, 666de Miguel, Constantino, 76De Mol, Patrick, 388Desaulniers, Denis, 928Desjardins-Giasson, Suzanne,720
Desjardins, Robert E., 525Despres, Jean-Paul, 928Deybach, Jean-Charles, 520Dhruv, R., 263Diana, G. D., 883Dias, M. Beatriz Souza, 968Dickins, Cathy S., 332Didolkar, Mukund S., 977DiPiro, Joseph T., 487DiVincenzo, Cathy A., 712Divo, Alan A., 21Dobson, Richard A., 4Donowitz, Gerald R., 125Douce, Richard, 291Douglas, John M., 203Dowling, John N., 272Drake, Thomas A., 320Dromer, Francoise, 660Drupa, Ilga, 11Drusano, G. L., 605Duff, Ronald G., 197Duke, Arit E., 277Dupont, Marie-Jeanne, 280Dure, Leon, 309Dzink, JoAnn L., 663
Edwards, Morven S., 511Elberg, Svetlana, 172Eliopoulos, George M., 357, 782Eliopoulos, G. M., 28Ellis, M. Nixon, 167Ellner, Jerrold J., 413Emmerman, J., 424English, Jan, 897Eng, Robert H. K., 688Ericson, Ann-Christin, 753Exeiby, Alice, 102
Fairgrieve, John S., 197Fancher, M. J., 883Fanucchi, Michael P., 733Faurisson, Francois, 520Feinberg, Aaron, 733Fenwick, Raymond G., 460Ferraro, Mary Jane, 782Finegold, S. M., 674Finegold, Sydney M., 876Fiore, Dario, 977Fisher, Melanie A., 745Fish, R. G., 275Fish, Wallace R., 33Flepp, Markus, 350, 353
Fliegelman, Robert M., 429Fontana, Roberta, 828Forrest, A., 605Fowlston, S., 966Fox, Jack J., 733Fox, M. P., 883Frank, Karl B., 445Freij, Bishara J., 431Friedhoff, Lawrence T., 263Friedman-Kien, Alvin E., 763Fuchs, Peter C., 679Fujii, Tadashi, 608, 612Fujiwara, Tatsushi, 65
Galask, Rudi, 337Gallion, Corinne, 503Garaci, E., 625Garagusi, Vincent F., 485Garaud, Jean-Jacques, 520Garcia-Bustos, Jose F., 791Garcia-Prats, Joseph A., 511Garcia-Riestra, Carlos, 114Gauntt, C. J., 184Gavan, Thomas L., 982Geary, Timothy G., 21Gebhart, Connie J., 55Gentry, Layne O., 683George, W. Lance, 643, 966Gerlach, E. Hugh, 413, 982Gerson, Benjamin, 357Ghysels, Guido, 388Gibson, Gene A., 745Gilbert, Brian E., 309Gilbert, David N., 897Giles, Penelope, 953Gillespie, Matthew T., 79Ginsberg, Bernard P., 422Giovenella, Albert J., 961Goering, Richard V., 455Gokhale, Rajeev, 487Goldstein, Ellie J. C., 162, 422,
657Goodman, Larry J., 429Goossens, Herman, 388Gootz, Thomas D., 739Gorbach, Sherwood L., 968Gorbea, Hector F., 570Gordin, Fred M., 452, 648Gordon, Kathryn P., 37Gordon, Kathy P., 739Gottlieb, Alan, 270Grados, Oscar, 388Grappel, Sarah F., 961Greenberg, Stephen B., 953Gremillion, David H., 868Griffin, Karen E., 495Grimont, Patrick A. D., 806Grossgarten, Michaela, 836Gruber, William C., 511Guarderas, Juan, 646Guibert, Jacqueline, 177Gurney, Michael, 652Gurusiddaiah, S., 239
Hackbarth, Corinne J., 135, 224,320, 340, 452, 685
Hadley, W. Keith, 958Hamilton, Bruce, 291Hancock, Counce, 733Hand, W. Lee, 42
i
ANTIMICROB. AGENTS CHEMOTHER.
Hanson, Brian D., 916Hara, Tetsuro, 589Harman, Colleen P., 125Harmsen, Theo, 802Hatris, Betty, 876Harris, B. H., 674Harris, Deborah, 953Hatin, Isabelle, 561Hawkins, Stephen S., 263Hayes, Nancy, 309Hedges, Robert W., 479Heifets, Leonid B., 11Herrin, Thomnas R., 197Higgins, Peter G., 846Hill, Gale B., 324Hoagland, Vicki L., 297Ho, bah Hsi, 265H6ffken, Gert, 375Holland, Susan, 989Holmes, King K., 203Holtsclaw-Berk, Shirley, 646Hori, Seiji, 650Hornstein, Michele J., 806Houang, Elizabeth T., 964Houghton, Donald C., 897Huang, Cheng-Hsiung, 460
lida, Kyoko, 93Ikeuchi, Toru, 473Imada, Akira, 821Imanaka, Tadayuki, 367Ings, Robert M. J., 535Innocent, Habyaremye, 388Inoue, Matsuhisa, 608, 612Inouye, Shigeharu, 589Iravani, Abdollah, 158, 449Iseman, Michael D., 11Ishitsuka, H., 595Isono, Kiyoshi, 230Iwanaga, Tomoaki, 93
Jackson, Andre J., 977Jacobus, Nilda V., 968Jacoby, George A., 479, 715Janicke, David M., 16Jantzen, Jan-Peter, 874Jehl, Franqois, 503Jensen, James B., 21Johansson, Nils-Gunnar, 753Johnson, Curtis A., 578Johnson, J., 468Johnson, Judith A., 774Johnson, Kenneth, 874Johnson, Paulette, 314Jokipii, Anssi M. M., 948Jokipii, Liisa, 948Jones, J., 966Jones, Mary, 646Jones, Ronald N., 413, 679, 982Jonsson, Monica, 128Joos, Beda, 350, 353Joshi, J., 605Jouvenot, Michelle, 280Jupeau, Annie M., 806Jusko, William J., 16
Kadurugamuwa, Jagath L., 220Kany, Robert J., Jr., 1Kaplan, Raymond L., 429Karney, Walter W., 652Kasbekar, Durgadas P., 974Kato, H., 132Katz, Eugene, 974Kaye, Donald, 708Kazuno, Yuzo, 589
Kelley, Eileen, 600Kelly, Jesse P., 760Kende, Meir, 903Keppeler, Hans, 632Kessler, R. E., 207King, Charles H., 413King-Thompson, Neva L., 42Klein, Claire, 660Klein, Richard J., 763Knight, Susan S., 277Knight, Vernon, 60, 309Knowlton, Douglas R., 306Kobasa, William D., 708Kobayashi, George S., 172Kobayashi, G. S., 302Kobayashi, Seiki, 65Koeppe, Peter, 375Kohlhepp, Sue, 897Kohnen, Paul W., 897Kondo, Masahiro, 821Konno, Masatoshi, 851Kraaijeveld, Cornelis A., 802Krieger, John N., 332Kuhrt, M. F., 883Kung, J. T., 184Kuno, Mitsuzo, 821Kurioka, Susumu, 650Kurtz, Harold J., 55Kwok, Y.-Y., 427
LaFon, Stephen W., 33Laishley, Edward J., 863Larsson, Alf, 753Lawrence, Adam G., 964Leathers, Timothy, 892LeBlanc, Barbara, 265LeBlanc, Donald J., 439LeBras, Jacques, 561Lecaillon, Jean-B., 177Ledergerber, Bruno, 350, 353Lee, Ken, 652Lee, Linda N., 439Lefler, Eli, 363Leitner, F., 207Lemieux, Michel, 928Lerner, Stephen A., 114, 670Leslie, J., 605Lessard, Celine, 928Leung, Y. K., 872Levy, Jack, 46, 388Levy, Jean-Claude, 520Leyland-Jones, Brian, 733Lietman, Paul S., 217Lindholm-Levy, Pamela J., 11Lindqvist, Lennart, 943Lin, Jung-Chung, 971Little, J. R., 302Livermore, D. M., 872Lockerby, Deirdre L., 863Lode, Hartmut, 375Longfield, Jenice N., 652Looker, Douglas L., 33L6pez-Nieto, Manuel J., 380Louv, William C., 760Lozano, Maria C., 76Lu, Y.-S., 436Luft, Friedrich C., 812Luman, J. Ileice, 912Luthy, Ruedi, 350, 353Lyon, Bruce R., 79
MacCulloch, Donald, 672Macdonald, Cameron M., 535MacGregor, Rob Roy, 745Madigan, Sanford, 974
Makinen, Kauko K., 96Maniatis, Antony, 515Mao, James C.-H., 197Marconi, P., 625Marion, Patricia L., 277Markowitz, Sheldon M., 419Marks, Melvin I., 908Marriott, Michael S., 832Marr, J. Joseph, 33Marshall, Rosemarie, 640Martin, Jerry R., 314Martin, Juan F., 380Martin, R. Russell, 953Masters, P. J., 495Matsuda, Makoto, 650Matsuhashi, Yuji, 589Matthews, Thomas R., 277Mayer, Philip R., 812May, John W., 79Mayor, Gilbert, 897Mazzolla, R., 625McCabe, Robert E., 491McColm, Andrew A., 925McCormack, William M., 724McCoy, Leslie F., 769McCracken, George H., Jr., 141,
431, 655McDevitt, David A., 272McKinlay, M. A., 883McLarty, Jerry W., 912Medeiros, Antone A., 479, 715Medoff, G., 302Medoff, Gerald, 172Mellits, E. David, 217Mendelman, Paul M., 46Mendez, Enrique, 791Menzies, Rosalie E., 672Merola, A. John, 399, 404, 408Metras, Jacques, 928Michel-Briand, Yvon, 280Milhous, Wilbur K., 525Miller, F. DeWolfe, 102Miller, Mahlon F., 314Mills, John, 270, 648Mintz, Paul D., 125Mirabelli, Christopher K., 460Misiek, M., 207Mitsuhashi, Susumu, 473, 608,
612Mizuguchi, Yasuo, 541Modai, Jacques, 177Moellering, R. C., Jr., 28Moellering, Robert C., Jr., 357,
782Monteil, Henri, 503Monto, Arnold S., 102Moore, Richard D., 217Mordenti, Joyce, 887Murakami, Kazuhisa, 727Myers, Carolyn M., 583
Nacucchio, Marcelo C., 137Nagata, Akihisa, 921Nakanishi, Hiroshi, 93Nam, Doo H., 798Natelson, Ethan A., 683Needham, Cynthia A., 499Nelson, Donald J., 33Nesbit, Robert R., 487Nevarez, Minerva, 246Newton, Bruce R., 449Ng, Wilson W. S., 872Nickel, J. C., 619Nikaido, Hiroshi, 84, 393Ninomiya, Y, 595
Nisbet, Louis J., 961Nohara, Chieko, 565Nolan, Charles, 37Nombela, Cesar, 120Nord, Carl Erik, 943Norrby, S. Ragnar, 128Nozawa, R. T., 132Nugent, K. M., 692Nunn, Barbara, 858
Oberg, Bo, 753O'Brien, Cheryl A., 583Ogawa, Hidemasa, 473Ogawa, Midori, 541Ogilvie, K. K., 184Ohm-Smith, Marilyn J., 958Ohnuki, Tetsuo, 367Okamoto, Ryoichi, 612Okonogi, Kenji, 821Olsen, Kurt D., 431, 655Ono, Yasuko, 921Opheim, Kent E., 531Osada, Hiroyuki, 230Osada, Yasuaki, 473Otani, Tsuyoshi, 473Otis, Ellen R., 197Ottolenghi, Abramo C., 399, 404,408
Otto, M. J., 883
Pagano, Joseph S., 971Palomares, Jose C., 76Parker, Steven W., 16Pasculle, A. William, 272Pedler, Stephen J., 508Perea, tvelio J., 76Perlin, Michael H., 114Perlman, Alon M., 363Petrak, Russell M., 429Petzold, C. Rosemarie, 337Pezzi, Nieves, 791Philippon, Alain M., 806Philips, Frederick S., 733Phillpotts, Robert J., 846Piehl, Evelyn, 337Pijck, Jacques, 574Pinney, R. J., 985Pintado, Concepci6n, 120Plorde, James J., 37Plorde, J. J., 739Prabhala, Rao H., 640Price, K. E., 207Prinzing, Claus, 375Puccetti, P., 625Pugsley, Anthony P., 666Pursiano, T. A., 207
Quarles, John M., 309
Rabin, Harvey R., 863Rakusan, Tatnara A., 181Ramfrez-Ronda, Carlos H., 246,
570Ramos, Filomena R., 380Randall, Eileen, 424Rao, Bhavani, 640Rastogi, Nalin, 701Rayburn, William, 337Raymond, Gilles, 928Reed, Michael D., 583Reeves, William C., 203Reinhardt, John F., 643, 966Rein, Michael F., 332Reiszner, E., 28Remington, Jack 5., 491
ii AUTHORINDEX
AUTHOR INDEX iiiVOL. 27, 1985
Remington, Michael L., 203Rench, Marcia A., 511Reynolds, Rolfe B., 760Richard, George A., 158, 449Richardson, Kenneth, 832Rill, Wayne L., 903Rissing, J. Peter, 487Robinson, William S., 277Rodriguez, Fernando C., 282Rodriguez, Julie R., 246, 570Rogge, Mark C., 578Rollins, Larry D., 439Roselle, Gary A., 291Rosenstock, Joel, 652Rossi, Lucia, 828Rotgef, Rafael, 120Rouan, Marie-C., 177Ruhr, Elke, 841Ruseska, I., 619Rusnak, Michael G., 340Ruxer, R., 605Ryan, D. Michael, 925Ryder, Neil S., 252Ryu, Dewey D. Y., 798
Sabbaj, Jacobo, 297Sahl, Hans-G., 836, 841Sakata, Yasutaka, 141, 655Salvador, Concepci6n, 120Sande, Merle A., 135, 224, 320,
340, 452, 685Sander, Donna S., 306Sanders, Christine C., 455Sanders, W. Eugene, Jr., 455San Joaquin, Venusto H., 908Sato, Kenichi, 473, 608, 612Sato, Masamichi, 473Scavizzi, Maurice R., 806Schimpff, S., 605Schito, Gian Carlo, 615Schlessinger, David, 172Schmidt, L. H., 146, 151Schoeller, Jean-P., 177Schwartz, Daniel R., 172Scott, Kenyon G., 340, 452, 685Segreti, John, 429Shafran, Stephen D., 749Shalit, Itamar, 908Shelley, M. D., 275Shih, W. J., 297Shimada, Jingoro, 650Shipkowitz, Nathan L., 197Shoeb, Hussein A., 399, 404, 408Siegenthaler, Walter, 353
Sievers, Gunnel, 96
Singh, S. K., 239Skold, Ola, 933Skurray, Ronald A., 79Slocombe, B., 495Smee, Donald F., 277Smith, Arnold L., 46, 531Smith, Craig R., 217Smith, L. Patrick, 652Smith, M. Carolyn, 971Smith, Sharon M., 688Snippe, Harm, 802Socransky, Sigmund S., 663Sommers, Herbert M., 982Sordelli, Daniel O., 137Spector, Stephen A., 600Speelman, Peter, 227Srivastava, Sujan, 102Stagno, Sergio, 760Stamm, Walter E., 203Standiford, H., 605Staneck, Joseph L., 291Stapleton, M. J., 468Steele, Lorraine C., 912Steen, Rolf, 933Stern, Robert C., 583Stevens, David A., 363Stevenson, Roselynn M. W., 938Stone, Benjamin B., 343Stull, Terrence L., 46Sugi, H., 132Suhara, Y., 595Sullam, Paul M., 135, 224, 320,
685Sullivan, Robert, 291Sun, Chong-Son, 60Sun, Ming, 192Susaki, Kiyoshi, 565Sutherland, R., 495Sutter, Vera L., 424, 427Suzuki, Yasuhiko, 921Swartz, Glenn M., Jr., 903Sweeney, Kristin G., 499Sweet, Richard L., 958Sykes, Richard B., 555Sypherd, Paul S., 892
Tachibana, Akio, 565Takeuchi, Tsutomu, 65Tally, Francis P., 968Tanabe, Masanobu, 65Tanaka, S. Ken, 555Tauber, Martin G., 135, 224,
320, 340, 685
Tauber, William B., 652Tennent, Jan M., 79Tenover, Fred C., 37, 739Tenovuo, Jorma, 96Thadepalli, Haragopal, 640Thauvin, Claudie, 357Thierry, Robert C., 503Thomas, Debra, 125Thornsberry, Clyde, 679Threlkeld, Norma, 431Toda, Masato, 565Tomasz, Alexander, 695Tonin, Enrico, 828Traub, B., 879Trenholme, Gordon M., 429Troke, Peter F., 832Tsai, Y. H., 207Tsuji, Akioyoshi, 515Tuner, Kajsa, 943Turcan, Robert G., 535Twitty, James A., 817Tyrrell, David A. J., 846
Ubukata, Kimiko, 851Udou, Takezo, 541Umeda, I., 595Une, Tsutomu, 473
Vaara, Martti, 548Vallner, Joseph J., 487van Tiel, Frank H., 802Varaldo, Pietro Emanuele, 615Varner, Michael, 337Vecchiarelli, A., 625Venezio, Frank R., 712Verdier, Francoise, 561Verghese, Abraham, 499Vertut-Croquin, Aline, 172Vidal, Pedro M., 733Viljanen, Petri, 548Visscher, David, 812von Esch, Anne M., 197Vontver, Louis A., 203Vorland, Lars H., 107Vu, Hanh, 393Vuye, Armand, 574
Waddell, David, 916Wade, J., 605Wagner, Roland B., 4Wallace, Richard J., Jr., 912, 953Ward, Gilbert E., 55Ward, Richard L., 306Warren, Richard L., 468
Watanabe, Kyoichi A., 733Weatherly, Norman F., 525Weber, Allan, 531Weinberg, Winkler G., 652Weisholtz, Steven, 695Welch, David F., 908Welch, William D., 874Welling, Peter G., 578Welty, Gina S., 449Wentland, Mark P., 4Werner, Georges H., 846Werner, Vicki, 455Wexler, H., 674Wexler, Hannah M., 876Whalen, J. W., 239White, A. R., 495Widger, William R., 836Williams, Denise S., 419Williams, Linda, 733Williams, Michael E., 125Williams, Sue, 37Willis, Greg, 309Willmann, John S., 846Wilson, Rebecca W., 912Wilson, Samuel Z., 60, 309Wofsy, Constance B., 648Wong, Justina, 749Wood, Bruce A., 683Wood, N. C., 692Wyde, Philip R., 60
Yamada, Hozumi, 93Yamada, Takeshi, 921Yamaguchi, Masaya, 93Yamanouchi, Takahisa, 921Yamashita, Naoko, 851Yamashita, Toyoko S., 583Yisak, Wolde-Ab, 753Yokota, T., 132Yoshida, Tadashi, 589, 727Yoshimura, Fuminobu, 84Young, Charles W., 733Young, Lowell S., 515Young, Stephen A., 739Yukishige, Koichi, 821
Zabransky, R. J., 424Zajac, Barbara A., 745Zak, Oto, 220Zar, Fred A., 1Zerial, Aurelio, 846Zhou, Hong-Hao, 192Zimmerman, Stephen W., 578Zinner, Stephen H., 343
SUBJECT INDEXVOLUME 27
A21978C,in vitro activity, 357mechanism of action, 357
AC 1370see cefpimizole
2-Acetylpyridine thiosemicarbazonesN. gonorrhoeae, 570
Acyclovircombined with vidarabine, 600cytomegalovirus, 600experimental infections
herpes simplex virus, 167Adenylyl dihydrostreptomycin
accumulation in E. coli, 114Aeromonas hydrophila
P-lactamasesAER-1, 479carbenicillin-hydrolyzing, 479
Aeromonas spp.ciprofloxacin, 643enoxacin, 643norfloxacin, 643tetracycline, 643trimethoprim-sulfamethoxazole, 643
African trypanosomesinosine analogs, 33
Alafosfalinanaerobic bacteria, 961
Alcaligenes faecalis,-lactamase, 608
Alveolar macrophagesantibiotic uptake, 42smokers, 42
AMA-1080see carumonam
Amifloxacinantibacterial activity, 4comparative activity, 449disposition in laboratory animals, 774E. coli, 449high-pressure liquid chromatography,
769in vitro activity
culture medium, 449inoculum size, 449pH changes, 449
metabolism, 774pharmacokinetics, 769S. saprophyticus, 449urinary tract infections, 449
Amikacinconcentrations in body fluids
pentobarbital, 720renal disposition, 520
b-(L-Aminoadipyl)-L-cysteinyl-D-valineconversion to isopenicillin N, 380
-y-Aminobutyric acidcephalosporins, 650rat synaptic membranes, 650
Aminoglycosides2"-O-nucleotidyltransferaseenzymatic modification, 670resistance, 670
3-phosphotransferaseDNA probes, 739structural genes, 739
polymorphonuclear leukocytes, 712pseudodisaccharide
dactimicin, 589renal disposition, 520
5-Aminoimidazole-4-carboxamide
high-pressure liquid chromatography,977
Amoxicillin-clavulanic acid
bacteriuria, 508B. catarrhalis, 912H. influenzae, 912lower respiratory tract infections, 912
Amphotericin Bcomparative activity, 302, 363erythrocyte lysis, 172experimental infections
blastomycosis, 363C. albicans, 625
immunoadjuvant activity, 625methyl ester
comparative activity, 302N-D-ornithyl, 302
oxidative damage, 172rapid infusion
ventricular fibrillation, 868AmpicillinCampylobacter spp., 429combined with sulbactam
anaerobic bacteria, 876comparative activity, 429
Anaerobic bacteriaalafosfalin, 961ampicillincefbuperazone, 162, 640, 674, 749ciprofloxacin, 427female genital tract infections
antimicrobial susceptibilities, 324HR 810, 413moxalactam MICs, 424quinolones, 657Sch 34343, 749sulbactam
Antiglobulin testsclavulanic acid, 125
Antimalarial drugsantifol
in vitro activity, 525mechanism of resistance, 525
P. falciparum, 21Antimycotic agentsSF 86-327, 252
Antiviral agentsenzyme immunoassay, 802MICs, 802
Apalcillincomparative activity, 782platelet function, 683
Aphidicolinherpesvirus DNA polymerase, 445
Arabinosyladenine monophosphateground squirrel hepatitis virus, 277virion-associated DNA polymerase re-
duction, 277Ascamycinmechanism of action, 230selective toxicity, 230
2-Azahypoxanthinehigh-pressure liquid chromatography,977
Aztreonamcombinations
clindamycin, 246respiratory tract infections, 246
comparative activity, 1, 388, 872endocarditis, 1
enteropathogens, 388experimental infections
E. coli Kl, 655H. influenzae type b, 655meningitis, 655
gonorrhea, 265P. aeruginosa, 1, 872penetration into bronchial secretions,
263pharmacokinetics, 16
BA-41,799experimental infections
malaria, 146P. cynomolgi, 146
Bacillus cereuslactoperoxidase, 96myeloperoxidase, 96
Bacillus circulansbutirosin
biosynthesis, 798sporulation, 798
Bacteriodes spp.cefbuperazone, 968
Bacteriuriaamoxicillin-clavulanic acid, 508pregnancy, 508
Bay 1 9139comparative activity, 363experimental infections
blastomycosis, 363Bay n 7133comparative activity, 363experimental infections
blastomycosis, 363BCG vaccine
herpes simplex virus infections, 203Bioassay
ciprofloxacin, 353comparative studies, 353
BIOLF-70antimyocarditic activity, 184experimental infections
coxsackievirus, 184Bismuth salts
echovirus, 306poliovirus, 306reovirus, 306rotavirus, 306
Bis-triazolederivatives
UK-49,858, 832Bithionol
G. lamblia, 65T. vaginalis, 65
Blastomycosisexperimental
amphotericin B, 363Bay 1 9139, 363Bay n 7133, 363ICI 153066, 363ketoconazole, 363
BleomycinE. coli DNA breakage, 460plasmid R6K elimination, 985
BMY-25182see cefbuperazone
BMY-28142comparative activity, 207, 515experimental infections
iv
SUBJECT INDEX v
meningitis, 340in vitro activity, 265, 574, 679
Branhamella catarrhalisamoxicillin-clavulanic acid, 912antibiotic susceptibility, 499comparison with colonizing isolates, 4993-lactamase-positive, 912
,B-lactamase production, 646lower respiratory tract infections, 912pneumonia, 499R plasmid, 120susceptibility, 646
Butirosinbiosynthesis, 798sporulation, 798
Campylobacter coliresistance factors, 37R plasmids, 37
Campylobacter jejuniresistance factors, 37R plasmids, 37
Campylobacter spp.ampicillin, 429antimicrobial agent activity, 55cefotaxime, 429cephalothin, 429chloramphenicol, 429ciprofloxacin, 429clindamycin, 429doxycycline, 429erythromycin, 429gentamicin, 429nalidixic acid, 429pigs, 55sulbactam, 429trimethroprim-sulfamethoxazole, 429
Cancer patientsceftazidime pharmacokinetics, 605
Candida albicansexperimental infections
amphotericin B, 625UK-49,858, 832
Candida spp.chlorpromazine, 692
Carbenicillinhydrolysis by ,B-lactamaseA. hydrophila AER-1, 479
Carumonamantibacterial activity, 821
Cefamandolecardiac surgery, 928concentration in atrial appendages, 928
Cefazolinprophylaxis
cesarean section, 337Cefbuperazone
anaerobic bacteria, 162, 640, 674, 749,817
Bacteriodes spp., 968comparative activity, 162, 817female genital tract isolates, 958P-lactamase contribution to resistance,817
CefmetazoleM. chelonei, 282M. fortuitum, 282
Cefoperazoneexperimental infections
comparative activity, 708E. aerogenes, 708endocarditis, 708
M. avium-intracellulare, 132pleural fluid
clearance, 93penetration, 93
CeforanideM. tuberculosis, 11pharmacokinetics, 487protein binding, 487
CefotaximeCampylobacter spp., 429comparative activity, 429experimental infections
meningitis, 340valvular lesions, 320
M. avium-intracellulare, 132resistance test, 672
Cefotiampharmacokinetics, 177
Cefpimizoleclinical isolates, 982comparative activity, 982experimental infections
meningitis, 340Cefpiramide
comparative activity, 782Cefsulodin
comparative activity, 1endocarditis, 1P. aeruginosa, 1renal interaction, 660urinary pH, 660
Ceftazidimecancer patients, 605cardiac vegetations, 925combinations
piperacillin, 605tobramycin, 605
fibrin clots, 925pharmacokinetics, 605, 925
CeftizoximeM. avium-intracellulare, 132
Ceftriaxonepediatric infections, 181pharmacokinetics, 192skin infections, 648soft tissue infections, 648urinary tract infections, 158
CephalosporinasesC. freundii, 727moxalactam binding, 727
Cephalosporins-y-aminobutyric acid inhibition, 650BMY-28142, 679broad-spectrumBMY-28142, 265
DN-9550, 473half-lives, 887HR 810, 388M. tuberculosis, 11rat synaptic membranes, 650subinhibitory concentrationsK. pneumoniae, 220
CephalothinCampylobacter spp., 429comparative activity, 429
Cephamycinscefbuperazone, 640
CephemsM. avium-intracellulare susceptibility,
132Cesarean section
prophylaxiscefazolin, 337
moxalactam, 337Chlamydia trachomatisgrowth inhibition, 953HeLa cells, 953human prostate cells, 953McCoy cells, 953nonoxynol-9, 720, 760zinc, 953
ChloramphenicolCampylobacter spp., 429comparative activity, 429H. influenzae, 46resistance
permeability barrier, 46Chloroquine
erythrocytesuptake, 561
P. falciparum, 561ChlorpromazineCandida spp., 692
Cilastatincombined with imipenem
pharmacokinetics, 511cystic fibrosis patients, 583imipenem-
high-dose treatment, 745pharmacokinetics, 431
pharmacokinetics, 583Ciprofloxacin
absorption, 350Aeromonas spp., 643anaerobic bacteria, 427bioassay, 353Campylobacter spp., 429comparative activity, 388, 427, 429enteropathogens, 388experimental infections
P. aeruginosa, 452pneumonia, 452
high-pressure liquid chromatography,353, 531
pharmacokinetics, 350, 375P. shigelloides, 643S. aureus, 688
Citrobacter freundiicephalosporinase, 727moxalactam, 727
Clavulanic acidamoxicillin-
B. catarrhalis, 912H. influenzae, 912lower respiratory tract infections, 912
antiglobulin tests, 125combined with amoxicillin
bacteriuria, 508efficacy, 291safety, 291
ClindamycinCampylobacter spp., 429combinations
aerobic gram-negative bacilli, 246aztreonam, 246respiratory tract infections, 246tobramycin, 246
comparative activity, 429Clofazimine
prostaglandins, 257Clostridium difficile
L-Cysteine, 419penicillin, 419
Clostridium pasteurianummetronidazole reduction, 863phosphoroclastic reaction, 863
VOL. 27, 1985
ANTIMICROB. AGENTS CHEMOTHER.
Cloxacillincardiac surgery, 928concentration in atrial appendages, 928
ColistinM. aurum, 701
Colitisexperimental
temocillin, 980Continuous ambulatory peritoneal dialysisvancomycin pharmacokinetics, 578
Coxsackievirusexperimental infectionsBIOLF-70, 184
Cyclic lipopeptide antibioticsA21978C1, 357
L-CysteineC. difficile, 419penicillin, 419
Cystic fibrosiscilastatin, 583imipenem, 583
Cytomegalovirusacyclovir, 600vidarabine, 600
Dacarbazinedegradation product
2-azahypoxanthine, 977high-pressure liquid chromatography,977
metabolite5-aminoimidazole-4-carboxamide, 977
Dactimicincomparative activity, 589
Dapsoneprostaglandins, 257
[2-"C]-(2-Deoxy-2-fluoro-o-D-arabinofur-anosyl)-5-iodocytosinebiotransformation, 733elimination, 733herpesvirus infections, 733immunosuppressed patients, 733
Dibekacinrenal disposition, 520
cis-Dichlorodiammineplatinum (II)biliary excretion, 275
4,6-Dichloroflavincomparative activity, 595mechanism of action, 595
DichloropheneG. lamblia, 65T. vaginalis, 65
Dictyostelium discoideumnystatin resistance, 974
9-(3,4-Dihydroxybutyl)guanineenantiomers
antiherpesvirus effects, 753pharmacokinetics, 753
9-(1,3-Dihydroxy-2-propoxymethyl)-guanineground squirrel hepatitis virus, 277herpes simplex virus
infections in mice, 763latency, 763
virion-associated DNA polymerase re-duction, 277
DN-9550in vitro activity, 473
DNA polymeraseEpstein-Barr virus, 416herpesvirus
aphidicolin, 445
phosphonoformate, 445nucleoside analogs, 416, 445
DNA probesaminoglycoside 3-phosphotransferase
structural genes, 739DoxycyclineCampylobacter spp., 429comparative activity, 429
Echovirusbismuth salts, 306
Edwardsiella tardacomparative activity of selected antimi-
crobial agents, 966Endocarditis
experimentalcefoperazone, 708E. aerogenes, 708enoxacin, 708gentamicin, 224pefloxacin, 685S. aureus, 685teicoplanin, 135
EnoxacinAeromonas spp., 643experimental infections
comparative activity, 708E. aerogenes, 708endocarditis, 708
P. shigelloides, 643Enteric virusesbismuth salts, 306
Enterobacter aerogenesexperimental infections
cefoperazone, 708endocarditis, 708enoxacin, 708
Enterobacter cloacae,B-lactamases, 393, 4553-lactams
hydrolylsis, 393penetration, 555resistance, 455
mechanism of resistance, 393outer membrane proteins, 455
EnterococciSch 34343, 28trimethoprim
alone, 71with sulfamethoxazole, 71
Enteropathogensaztreonam, 388ciprofioxacin, 388HR 810, 388norfloxacin, 388ofloxacin, 388RU28965, 388
Enviroximecomparative activity, 595mechanism of action, 595rhinovirus infections, 102
Enzyme immunoassaysantiviral agents, 802monoclonal antibodies, 802
Epstein-Barr virusDNA polymerase, 416nucleoside analogs, 416, 971
Erythrocytesamphotericin B, 172chloroquine uptake, 561lysis, 172oxidative damage, 172
ErythromycinCampylobacter spp., 429comparative activity, 429resistance
L. micdadei, 272L. pneumophila, 272
streptococciresistance determinant, 439
tissue culture cellsaccumulation, 314egress, 314uptake, 314
Escherichia coliadenylyl dihydrostreptomycin accumula-
tion, 114amifloxacin, 449bleomycin, 460cytoplasmic membrane, 666DNA breakage, 460experimental infections
aztreonam, 655meningitis, 655
13-lactam diffusion, 84microcin E492, 666peptides
microcin 7, 791porin channels, 84resistance, 107R plasmids
cloning from S. aureus, 79urinary tract infections, 107
spheroplasts, 114talisomycin, 460tetracycline resistanceTnJO-mediated, 879
urinary tract infections, 107, 449whole cells, 114
["C]Ethanol"CO, production, 535
Experimental infectionsblastomycosis
amphotericin B, 363Bay 1 9139, 363Bay n 7133, 363ICI 153066, 363ketoconazole, 363
C. albicansamphotericin B, 625UK-49,858, 832
colitistemocillin, 980
coxsackievirusBIOLF-70, 184
endocarditiscefoperazone, 708E. aerogenes, 708enoxacin, 708enterococci, 135gentamicin, 224pefloxacin, 685S. aureus, 685teicoplanin, 135
herpes simplex virusacyclovir, 167
malariaBA-41,799, 146P. cynomolgi, 146
meningitisaztreonam, 655BMY-28142, 340cefotaxime, 340cefpimizole, 340E. coli Kl, 655
vi SUBJECT INDEX
SUBJECT INDEX vii
H. influenzae type b, 655pneumococcal, 340S. pneumoniae, 141
pneumoniaciprofloxacin, 452P. aeruginosa, 452pefloxacin, 452
T. mentagrophytesUK-49,858, 832
valvular lesionscefotaxime, 320
Flavobacterium odoratum,-lactamase, 612
FluoroquinolonesWIN 49375
antibacterial activity, 4Formycin B
T. cruzi, 491Fusidic acid
cardiac surgery, 928concentration in atrial appendages, 928
Fusobacterium nucleatum1-lactamase, 943
GarlicAllium sativum
mycobacterial inhibition, 485Genital pathogens
quinoline derivatives, 76Genital tract infections
femaleanaerobic bacterial susceptibility, 324
GentamicinCampylobacter spp., 429comparative activity, 429experimental infections
endocarditis, 224nephrotoxicity, 812P. aeruginosa extracellular proteases,
468pharmacokinetics, 285renal accumulation, 812renal disposition, 520
Giardia lambliabithionol, 65dichlorophene, 65giardiasis, 227growth inhibition, 65hexachlorophene, 65tinidazole, 227
GiardiasisG. lamblia, 227tinidazole, 227
Gonorrheaaztreonam, 265
Gram-negative bacteriapolymyxin B nonapeptide, 541
Gram-positive bacteriaSch 34343, 28
Ground squirrel hepatitis virusarabinosyladenine monophosphate, 2779-(1,3-dihydroxy-2-propoxymethyl)guanine,
277Guanine
derivativesBIOLF-70, 184
Haemophilus influenzaeamoxicillin-clavulanic acid, 912
chloramphenicol, 46experimental infections
aztreonam, 655meningitis, 655
P-lactamase-positive, 912lower respiratory tract infections, 912resistance
permeability barrier, 46HeLa cells
C. trachomatis inhibition, 953Herpes simplex virusBCG vaccine, 203DNA polymerase
aphidicolin, 445nucleoside analogs, 445phosphonoformate, 445
experimental infectionsacyclovir, 1679-(1,3-dihydroxy-2-propoxymethyl)-
guanine, 763latency, 763
genital infections, 203Herpesvirus
12-'1C]-(2-deoxy-2-fluoro-o-D-arabinofu-ranosyl)-5-iodocytosinebiotransformation, 733elimination, 733
9-(3,4-dihydroxybutyl)guanine, 7539-(4-hydroxybutyl)guanine, 753
HexachloropheneG. lamblia, 65T. vaginalis, 65
High-pressure liquid chromatographyamifloxacin, 7695-aminoimidazole-4-carboxamide, 9772-azahypoxanthine, 977ciprofloxacin, 353, 531comparative studies, 353dacarbazine, 977HR 810, 436vancomycin, 503
HR 810anaerobic bacteria, 413comparative activity, 388enteropathogens, 388high-pressure liquid chromatography,436
pharmacokinetics, 436Human prostate cells
C. trachomatis inhibition, 9539-(4-Hydroxybutyl)guanine
antiherpesvirus effects, 753pharmacokinetics, 753
ICI 153066comparative activity, 363experimental infections
blastomycosis, 363Imipenem
-cilastatinpharmacokinetics, 431, 511
comparative activity, 1cystic fibrosis patients, 583endocarditis, 1high-dose treatment, 745P. aeruginosa, 1pharmacokinetics, 583
Influenza virusribavirin aerosol, 309
Inosineanalogs
African trypanosomes, 33
metabolism, 33tissue culture efficacy, 33
Interferonaerosol, 60vesicular stomatitis virus, 60
IsoniazidM. tuberculosis oxygen generation, 404oxidation
mediation by peroxidase, 399superoxide-generating reactions, 408
Isopenicillin Nconversion from 8-(L-aminoadipyl)-L-
cysteinyl-D-valine, 380P. chrysogenum, 380
Ketoconazolecomparative activity, 363experimental infections
blastomycosis, 363Klebsiella pneumoniae
cephalosporins, 220iron-depleted, 220siderophore production, 220surface properties, 220
1-LactamasesAER-1, 479A. faecalis, 608B. catarrhalis, 646E. cloacae resistance, 393, 455F. nucleatum, 943F. odoratum, 612induction test, 6721-lactam hydrolysis, 393OXA-2
immunological comparison, 989OXA-4, 715OXA-5, 715OXA-6, 715OXA-7, 715TLE-1, 715
P-Lactamsanaerobic bacteria, 817comparative activity, 1, 817, 872disulfiram-like effects in rats, 535E. cloacae
penetration, 555resistance, 393, 455
E. coli porin channels, 84endocarditis, 1expanded-spectrum, 393hydrolysis, 393L. pneumophila, 695M. avium-intracellulare complex, 541P. aeruginosa, 1, 872N-sulfonated monocycliccarumonam, 821
Y. enterocolitica, 806Lactoperoxidase
B. cereus, 96Legionella micdadei
erythromycin-resistant, 272Legionella pneumophila
erythromycin-resistant, 272P-lactams, 695
Leishmania spp.sodium stibogluconate, 916
Liposomespiperacillin activity, 137
VOL. 27, 1985
ANTIMICROB. AGENTS CHEMOTHER.
Macrolide antibioticsRU28965, 388
Malariaantifol drugs, 525experimental
BA-41, 799, 146P. cynomolgi, 146
McCoy cellsC. trachomatis inhibition, 953
Membrapescytoplasmic
nisin, 841whole cell
nisin, 841Meningitis
experimentalaztreonam, 655BMY-28142, 340cefotaxime, 340cefpimizole, 340E. coli Kl, 655H. influenzae type b, 655pneumococcal, 340S. pneumoniae, 141
MetronidazoleC. pasteurianum phosphoroclastic re-
action, 863reduction, 863
Microcin 7mode of action, 791structure, 791
Microcin E492E. coli cytoplasmic membrane, 666
Mirincamycinprimaquine activity enhancement, 151
Mitochondrial inhibitorsP. falciparum, 21
Monobactamshalf-lives, 887
Moxalactamanaerobic bacteria, 424bleeding times, 858cephalosporinase binding, 727C. freundii, 727MICs, 424platelet responsiveness, 858pleural fluid
clearance, 93penetration, 93
prophylaxiscesarean section, 337
susceptibility testingagar dilution, 424microdilution, 424
Mucor racemosusresistance, 892
Mupirocinantibacterial activity, 495
Mycobacteriainhibition
garlic (A. sativum), 485Mycobacterium aurum
colistin, 701Mycobacterium avium-intracellulare
cefoperazone, 132cefotaxime, 132ceftizoxime, 132cephem susceptibility, 132complex
P-lactams, 541morphological changes, 541
Mycobacterium cheloneisusceptibility
cefmetazole, 282Mycobacterium fortuitum
susceptibilitycefmetazole, 282
Mycobacterium tuberculosisceforanide, 11cephalosporins, 11isoniazid, 404oxygen generation, 404ribosome alteration, 921RNA polymerase, 9Mtsusceptibility
radiometry, 11Myeloperoxidase
B. cereus, 96
Nalidixic acidCampylobacter spp., 429comparative activity, 429
Neisseria gonorrhoeae2-acetylpyridine thiosemicarbazones,
570Neisseria spp.R plasmid, 120
Nephrotoxicitygentamicin, 812netilmicin, 812tobramycin, 812
Netilmicinkinetic model, 343nephrotoxicity, 812renal accumulation, 812renal disposition, 520
Nisinmembranes
cytoplasmic vesicles, 841whole cells, 841
mode of action, 841structural similarities to Pep-S, 836
Nonoxynol-9C. trachomatis, 720, 760
NorfloxacinAeromonas spp., 643comparative activity, 388, 419enteropathogens, 388P. shigelloides, 643urinary tract infections, 297, 419
Nucleoside analogsEpstein-J3arr virus, 416, 971herpesvirus DNA polymerase, 4455-triphosphates, 416
Nucleoside antibioticsascamycin, 230
2"-O-Nucleotidyltransferaseaminoglycosidesenzymatic modificatiop, 670resistance, 670
NystatinD. discoideum resistance, 974
Ofloxacincomparative activity, 388enteropathogens, 388
Oral microbessangvinarine, 663
Outer membrane proteinsE. cloacae, 455
Pediatric infectionsceftriaxone, 181
Pefloxacinexperimental infections
endocarditis, 685P. aeruginosa, 452pneumonia, 452S. aureus, 685
PenemsSch 34343, 28, 128
PenicillinC. difficile, 419L-Cysteine, 419S. pneumoniae susceptibility
experimental meningitis, 141streptococci
reverse inoculum effect, 948Penicillin-binding proteins
activity regulation, 828P-lactan-inducible, 851methicillin-inducible, 828S. aureus, 828staphylococci, 851
Penicillium chrysogenumisopenicillin N synthetase, 380
Pentobarbitalamikacin concentrations in body fluids,
720Pep-5
structural similarities to nisin, 836Peptide antibiotics
nisin, 836, 841Pep-5, 836, 841
Peroxidaseisoniazid oxidation, 399
Pharmacokineticsamifloxacinmonkeys, 769
aztreorlamgram-negative infections, 16
cefazolineffects of anestheia, 874orthopedic surgery patients, 874
ceforanideintraoperative, 487pr-otein binding, 487
cefotiamhumans, 177
ceftazidimecancer patients, 605cardiac vegetations, 9'5fibrin clots, 925
ceftriaxoneChinese adults, 192
cilastatincombined with imipenem, 511cystic fibrosis patients, 583neonates, 431, 511
ciprofloxacinabsorption, 350administration routes, 375effect of breakfast, 350multiple-dose, 350
9-(3,4-dihydroxybutyl)guanine, 753gentamicin
drug abusers, 285HR 810
rabbits, 4369-(4-hydroxybutyl)guanine, 753imipenemcombined with cilastatin, 511cystic fibrosis patients, 583neonates, 431, 511
netilmicintwo-compartment model, 343
viii SUBJECT INDEX
SUBJECT INDEX ix
tobramycindrug abusers, 285
vancomycincontinuous ambulatory peritoneal di-
alysis, 578peritoneal drug transport, 578
Phosphonoacetatestructure-activity studies, 197
Phosphonoformateherpesvirus DNA polymerase, 445
PicornavirusWIN 51711, 883
Piperacillincombined with ceftazidime
cancer patients, 605liposome-mediated activity, 137staphylococci, 137
PlasmidsR6K
elimination by bleomycin, 985resistance
B. catarrhalis, 120C. coli, 37C. jejuni, 37E. coli, 79, 107Neisseria sp., 120S. aureus, 79staphylococci, 234tetracycline
trimethoprim resistanceTn7, 933
Plasmodium cynomolgiexperimental infections
BA-41, 799, 146malaria, 146
Plasmodium falciparumantimalarial activity
oxygen-dependent, 21time-dependent, 21
chloroquineresistance, 561uptake, 561
erythrocytes, 561mitochondrial inhibitors, 21
Platinumbiliary excretion, 275cis-dichlorodiammineplatinum (II), 275
Plesiomonas shigelloidesciprofloxacin, 643enoxacin, 643norfloxacin, 643tetracycline, 643trimethoprim-sulfamethoxazole, 643
Pneumococciexperimental infectionsBMY-28142, 340cefotaxime, 340cefpimizole, 340meningitis, 340
PneumoniaB. catarrhalis, 499experimental
ciprofloxacin, 452P. aeruginosa, 452pefloxacin, 452
PolidocanolS. aureus penicillin resistance, 632
Poliovirusbismuth salts, 306
Polymorphonuclear leukocytesaminoglycosides, 712prostaglandin production, 257
Polymyxin B
nonapeptidegram-negative bacteria, 541
Polymyxin Esee colistin
Pregnancybacteriuria, 508
Primaquineactivity enhancement
mirincamycin, 151Probenecid
renal interaction, 660urinary pH, 660
Prodrugsalafosfalin, 961
Prostaglandinsclofazimine, 257dapsone, 257polymorphonuclear leukocytes, 257
Pseudomonas aeruginosaaztreonam, 1, 872cefsulodin, 1endocarditis, 1experimenital infections
ciprofloxacin, 452pefloxacin, 452pneumonia, 452
extracellular proteases, 468gentamicin, 468imipenem, 1,-lactams, 1, 872peritoneal dialysis, 908Ro 17-2301, 872ticarcillin, 1tobramycin
extracellular proteases, 468resistance, 619
urinary catheters, 619Pseudomonic acid
antibacterial activity, 495
Quinolinesderivatives
genital pathogens, 76Quinolones
anaerobic bacteria, 657comparative activity, 657
RadiometryM. tuberculosis susceptibility, 11
Reovirusbisnmuth salts, 306
Resistance factorsC. coli, 37C. jejuni, 37
Respiratory tract infectionsamoxicillin-clavulanic acid, 912aztreonam, 246'B. catarrhalis, 912clindamycin, 246H. influenzae, 912tobramycin, 246
Rhinovirus4,6-dichloroflavin, 595enviroxime, 102, 595RMI-15,731, 595Ro 09-0179, 595Ro 09-0410, 59544 081 R.P., 846
Ribavirinaerosol
influenza virus, 309
Rift Valley fever virus, 903RibosomesM. tuberculosis, 921
Rifampincombinations, 615staphylococci, 615
Rifapentinecombinations, 615staphylococci, 615
Rift Valley fever virusribavirint, 903
RMI-15,731comparative activity, 595mechanism of action, 595
RNA polymeraseM. tuberculosis, 921
Ro 09-0179comparative activity, 595mechanism of action, 595
Ro 09-0410comparative activity, 595mechanism of action, 595
Ro 17-2301comparative activity, 872P. aeruginosa, 872
Rotavirusbismuth salts, 306
44 081 R.P.cell cultures, 846
RU28965comparative activity, 388enteropathogens, 388
Sanguinarinecomparative activity, 663oral microbes, 663
Sch 34343anaerobic bacteria, 749comparative activity, 28, 128enterococci, 28gram-positive bacteria, 28
SF 86-327fungal sterol biosynthesis, 252mechanism of action, 252
Skin infectionsceftriaxone, 648
Sodium stibogluconatebiochemical mechanisms, 916
Soft tissue infectionsceftriaxone, 648
Spermicidesnonoxynol-9, 760
Staphylococcicoagulase-negativeR plasmids, 234tetracycline, 234
methicillin-resistantpenicillin-binding protein, 851
piperacillin, 137Staphylococcus aureus
experimental infectionsendocarditis, 685pefloxacin, 685
methicillin-resistantciprofloxacin, 688
penicillin-binding protein, 828penicillin resistance
suppression, 632polidocanol, 632R plasmids
cloning into E. coli, 79Staphylococcus saprophyticus
VOL. 27, 1985
ANTIMICROB. AGENTS CHEMOTHER.
amifloxacin, 449urinary tract infections, 449
Streptococcigroup D
erythromycin resistance determinant,439
Tn917-like sequences, 439penicillin
reverse inoculum effect, 948Streptococcus pneumoniae
experimental infectionsmeningitis, 141penicillin susceptibility, 141
Streptomyces albovinaceoustreponemycin, 239
Streptomycinmutants
dihydrostreptose, 367streptidine biosynthesis, 367
SulbactamCampylobacter spp., 429combined with ampicillin
anaerobic bacteria, 876comparative activity, 429
Sulfamethoxazoletrimethoprim-Aeromonas spp., 643Campylobacter spp., 429comparative activity, 419, 429enterococci, 71P. shigelloides, 643urinary tract infections, 158, 297, 419V. cholerae resistance, 280
Susceptibility testingmoxalactam
agar dilution, 424microdilution, 424MICs, 424
T. vaginalistime-kill method, 332
T-1982see cefbuperazone
TalisomycinE. coli DNA breakage, 460
Teicoplaninexperimental infections
endocarditis, 135Temocillin
bleeding times, 858experimental infections
colitis, 980platelet responsiveness, 858
TetracyclineAeromonas spp., 643P. shigelloides, 643resistance
E. coli K-12, 879TnlO-mediated, 879
staphylococcal resistance, 234urinary tract infections, 652
Tetrahydrofuranderivatives
BA-41,799, 146Ticarcillin
comparative activity, 1efficacy, 291endocarditis, 1P. aeruginosa, 1safety, 291tobramycin nephrotoxicity, 897
Tinidazolegiardiasis, 227G. lamblia, 227
Tioconazoleabsorption, 964persistence in vaginal fluid, 964
Tissue culture cellserythromycin
accumpulation, 314egress, 314uptake, 314
Tobramycincombinations
cancer patients, 605ceftazidime, 605clindamycin, 246respiratory tract infections, 246
nephrotoxicity, 812, 897P. aeruginosa
extracellular proteases, 468urinary catheters, 619
pharmacokinetics, 285renal accumulation, 812renal disposition, 520renal function
shock, 217Topical antibiotics
mupirocin (pseudomonic acid), 495Treponema hyodysenteriaetreponemycin, 239
TreponemycinT. hyodysenteriae, 239
Trichomonas vaginalisbithionol, 65dichlorophene, 65growth inhibition, 65hexachlorophene, 65susceptibility testing
time-kill method, 332Trichophyton mentagrophvtesexperimental infections
UK-49,858, 832Trimethoprim
enterococci, 71resistancechromosomally mediated, 933plasmid-borne, 933Tn7, 933
-sulfamethoxazoleAeromonas spp., 643Campylobacter spp., 429comparative activity, 419, 429enterococci, 71P. shigelloides, 643urinary tract infections, 158, 297, 419V. cholerae resistance, 280
Trypanosoma cruziformycin B, 491
U63196-Esee cefpimizole
UK-49,858experimental infections
C. albicans, 832T. mentagrophytes, 832
Urinary cathetersP. aeruginosa, 619
Urinary tract infectionsamifloxacin, 449ceftriaxone, 158E. coli, 107, 449norfloxacin, 297, 419S. saprophyticus, 449tetracycline hydrochloride therapy, 652trimethoprim-sulfamethoxazole, 158,
297, 419
Valvular lesionsexperimental
cefotaxime, 320Vancomycin
high-pressure liquid chromatography,503
pharmacokineticscontinuous ambulatory peritoneal di-
alysis, 578peritoneal drug transport, 578
Ventricular fibrillationamphotericin B infusion, 868
Vesicular stomatitis virusinterferon aerosol, 60
Vibrio choleraeresistance
plasmid-mediated, 280trimethoprim-sulfamethoxazole, 280
Vidarabinecombined with acyclovir, 600cytomegalovirus, 600
WIN 39375see amifloxacin
WIN 51711in vitro activity, 883picornavirus, 883
Yersinia enterocoliticaP-lactams, 806
Yersinia ruckeriplasmid-mediated resistance, 938susceptibility patterns, 938
YM-13115in vitro activity, 565
ZincC. trachomatis inhibition, 953
x SUBJECT INDEX
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