angiodysplasia occurring inthere has been one report of angio dysplasia and diverriculosis occurring...

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BRIEF COMMUNI CATION Angiodysplasia occurring in jejunal diverticulosis EDWARD A JONES, MD, H UGI I CHAUN, BM, FRCP, FRCPC, PHILLIP SWITZER, MD, FRC PC, DAVID J CLOW, MD, RONALD J H ANCOCK, MD, FRCSC ABSTRACT: The first case of angiodysplasia occurring in acquired jejuna! diverciculosis is reported. The patient presented with occult gastrointestinal bleeding and chronic anemia, and was created successfully by resection of a 25 cm long scpme nt of jejunum. Possible pathogenetic mechanisms for both angio- dysplasia and jejuna! diverticulosis are discussed. Can J Gastroenterol 1990;4(4 ): 151-153 Key Words: Anemia , Angiodysplasia, )ejunal diverticulos is , Occult gastrointest inal bleeding Angiodysplasie et diverticulose jejunale RESUME: O n rapporte le premier cas d'angio<lysplasie survenant dans une d1verticulose jejunale acq uise. Le patient so uffrair d'un sa ignement gastro-intes- unal occulte et d'anemie chronique et fut traite avec succcs par la resection c.lu segment de jejunum en cause (25 cm de longueur). Les mecanismes pathogenes possibles et de l'angiodysplas ie et de la diverticulose jejunale sont examines. A NGIODYSPLASIA OF THE GASTRO- intesri na I tract is an acquired l esion of s mall submucosal and mu co al blood vesse ls whi ch can give rise to hemorrhage (1). It is co mmonly fo und 111 the colon but also occurs with l ess frequency in the small intestine and sco mach ( 2). Similarly, diverticulosis of the gastrointestinal tract can he an ac- quired co ndition which arises with h ighesr frequency in the colon but which may also be fo und in che small intestine (3 ). Hemorrhage from such diverticula is a well recognized com- Departmenr.s of Patho logy, Medicine, Radiol ogy and Sur gery, University Hospir.al, Universi ty of Brrtish Columbia . Vancouver, British Columbia Correspondence arul reprinr.s: Dr Hugh Chaim , Suite 601, 805 West Broadway, Vanco u ver, Bnash Columbia VSZ I KI. Telephone (604) 872-07 I 7 R eceived for publicaticm November 6. 1989. Acce/n ed February 26. 1990 CAN J GASTROE NTEROL VOL 4 No 4 MAY/JUNE 1 990 plication which is cons ide red co be secondary to erosion o( normal blood vesse ls (3). Th is report describe~ a case of angiodys plasia whi ch arose in cliver- tic ul a of acq uired Jejuna I di ve rci cul os is and was the ca u ~e of chro ni c bl ooJ l oss. CASE PRESENTATION A 68-year-okl man was admitt ed en h ospita l for investigation of iron deficiency anemi a. He had pr ese med fo ur year~ earl i er with mark ed fa tigu e and occult gas troint e~tinal bleeding, and wa~ fo und w have chronic antrnl gastritis, a large du odenal Jiveniculum, jejuna! diverticulosis and seve ral ~ma ll beni gn colo ni c adenomas. He had no evidence of inflammatory bowel di sease or any disease of an imm un ol og ical na- ture which might be associat ed with jejuna! di ve rcicul os i s. There was no family hi sto ry of jejuna I divercicul os i s. His se rum B12 was normal. Despite removal o( the colonic adeno mas, his scoo ls continued co be positive fo r oc- cult blood, and even though he was treated with iron, his hemoglobin remained about 80 g/L. Physi ca l ex- amination and a labe ll ed r ed blood ce ll study for gastrointestinal tract bleeding were normal. A superior mcsc nre ri c arten ogram demonstrated , 111 ea rl y fill - 151

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  • BRIEF COMMUNICATION

    Angiodysplasia occurring in jejunal diverticulosis

    EDWARD A JONES, MD, H UGI I CHAUN, BM, FRCP, FRCPC, PHILLIP SWITZER, MD, FRC PC, DAVID J CLOW, MD, RONALD J H ANCOCK, MD, FRCSC

    ABSTRACT: The first case of angiodysplasia occurring in acquired jejuna! diverciculosis is reported. The patient presented with occult gastrointestinal bleeding and chronic anemia, and was created successfully by resection of a 25 cm long scpment of jejunum. Possible pathogenetic mechanisms for both angio-dysplasia and jejuna! diverticulosis are discussed. Can J Gastroenterol 1990;4(4 ): 151-153

    Key Words: Anemia , Angiodysplasia, )ejunal diverticulosis , Occult gastrointestinal bleeding

    Angiodysplasie et diverticulose jejunale

    RESUME: On rapporte le premier cas d'angio

  • JONES er al

    ing jejuna[ vein and a vascular tuft (Fig-ure l ), features comistent with a diag-nosis of a ngioc.l ysp las ia. Prev iou:. endoscopic examinations had revealed no angiodysplastic lesions in the large bowel, sromach or duodenum. The

    patient had no evidence of aortic stcnosis orother cardiac disease. He had not taken nonsteroida l arni- inflam-matory drugs or potassium tablets which might have caused mucosa! damage and precipitated bleeding of the vascular

    Figure 1) Later arterial phase of superior mesenceric arteriogram showing early i,enous filling ( left arrow) and vascular tuft (right a1,ow)

    lesion. Preoperativcly, the superior mesenteric arteriogram was repeateJ and rhe catheter left in situ, with the tip lying in the fourth arcade of the jejuna[ branch artery. Ar laparotomy before the small bowel was manipulated, a bolus of methylene blue

  • DISCUSSION Jejuna! Jiverciculosis is not a rare

    condition; prospective autopsy studies using specimen insufflation techni4ues have documented an incidence of up to 4.6% (4). Although often innocuous, they are a potential cause of malabsorp-tion, pseudo-obstruction, mechanical obstruction, volvulus, perforation, anemia, abscess formation and hemor-rhage (3,5). Bleeding from jejuna! diverticulosis was first re po rted by Braithwaite in l 923 (6). Most bleed ing from diverticula arises from no rmal blood vessels. An injury LO the mucosa due co ulceration or direct trauma from

    concretions may breach vascular in-tegrity. In the present case, the hemor-rhage arose from angio

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