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An RNA Reset Button Bumgarner and colleagues Molecular Cell 2012 Presented by Nacho Caballero Friday, September 7, 12

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Page 1: An RNA reset button

An RNA Reset ButtonBumgarner and colleagues

Molecular Cell 2012

Presented by Nacho Caballero

Friday, September 7, 12

Page 2: An RNA reset button

Friday, September 7, 12

Page 3: An RNA reset button

Flo11 is a yeast cell surface glycoprotein required to form invasive filaments

Flo11

Friday, September 7, 12

Page 4: An RNA reset button

Flo11 is a yeast cell surface glycoprotein required to form invasive filaments

Flo11

Flo11 shows variegated expression

Friday, September 7, 12

Page 5: An RNA reset button

FLO11

Friday, September 7, 12

Page 6: An RNA reset button

PWR1

FLO11ICR1

Long non-coding RNAs regulatethe variegated transcription of Flo11

Friday, September 7, 12

Page 7: An RNA reset button

PWR1

FLO11ICR1

Flo11

Long non-coding RNAs regulatethe variegated transcription of Flo11

Flo11

Friday, September 7, 12

Page 8: An RNA reset button

PWR1

FLO11ICR1

Flo11

Long non-coding RNAs regulatethe variegated transcription of Flo11

Flo11

Friday, September 7, 12

Page 9: An RNA reset button

PWR1

FLO11ICR1

Flo11

Long non-coding RNAs regulatethe variegated transcription of Flo11

But who regulates them?

Flo11

Friday, September 7, 12

Page 10: An RNA reset button

PWR1

ICR1 FLO11

Friday, September 7, 12

Page 11: An RNA reset button

PWR1

ICR1 FLO11

Rpd3LRemodeler

Friday, September 7, 12

Page 12: An RNA reset button

PWR1

ICR1

Transcription factor Flo8 activates Flo11 expression

FLO11

Flo8 Rpd3LRemodeler

Sfl1

Friday, September 7, 12

Page 13: An RNA reset button

PWR1

ICR1

Transcription factor Flo8 activates Flo11 expression

FLO11

Flo8 Rpd3LRemodeler

Sfl1

Friday, September 7, 12

Page 14: An RNA reset button

PWR1

ICR1

Transcription factor Flo8 activates Flo11 expression

FLO11

Flo8 Rpd3LRemodeler

Flo11

Sfl1

Friday, September 7, 12

Page 15: An RNA reset button

PWR1

ICR1 FLO11

Friday, September 7, 12

Page 16: An RNA reset button

PWR1

ICR1

Sfl1

FLO11

Transcription factor Sfl1 silences Flo11 expression

Friday, September 7, 12

Page 17: An RNA reset button

PWR1

ICR1

Sfl1

FLO11

Transcription factor Sfl1 silences Flo11 expression

Flo8

Friday, September 7, 12

Page 18: An RNA reset button

PWR1

ICR1

Sfl1 Hda1 Remodeler

FLO11

Transcription factor Sfl1 silences Flo11 expression

Flo8

Friday, September 7, 12

Page 19: An RNA reset button

PWR1

ICR1

Sfl1

Flo11

Hda1 Remodeler

FLO11

Transcription factor Sfl1 silences Flo11 expression

Flo8

Friday, September 7, 12

Page 20: An RNA reset button

PWR1

ICR1 FLO11

Friday, September 7, 12

Page 21: An RNA reset button

Infrequent transcription of ICR1 resets the system

PWR1

ICR1 FLO11

Flo8 Sfl1

Friday, September 7, 12

Page 22: An RNA reset button

Infrequent transcription of ICR1 resets the system

PWR1

ICR1 FLO11

NowFlo8 and Sfl1 can compete for bindingFlo8 Sfl1

Friday, September 7, 12

Page 23: An RNA reset button

Flo8 Sfl1

PWR1 ICR1

ONFLO11

Friday, September 7, 12

Page 24: An RNA reset button

Flo8 Sfl1

PWR1 ICR1

OFFFLO11

Friday, September 7, 12

Page 25: An RNA reset button

Flo8 Sfl1

PWR1 ICR1

RESET

FLO11

Friday, September 7, 12

Page 26: An RNA reset button

Friday, September 7, 12

Page 27: An RNA reset button

Chromatin remodeling makes each state heritable

Hda1 Remodeler

Rpd3LRemodeler

Friday, September 7, 12

Page 28: An RNA reset button

The act of transcription is functional, not the

transcriptICR1

Chromatin remodeling makes each state heritable

Hda1 Remodeler

Rpd3LRemodeler

Friday, September 7, 12

Page 29: An RNA reset button

The act of transcription is functional, not the

transcriptICR1

Most information in the non-coding genome

remains hidden

Chromatin remodeling makes each state heritable

Hda1 Remodeler

Rpd3LRemodeler

Friday, September 7, 12


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