an efficient and cost-effective synthesis of 3-ethoxy-4-ethoxycarbonyl-phenylacetic acid: a key acid...

2002 polycarboxylic acids and esters polycarboxylic acids and esters (benzene compounds) Q 0425 48 - 082 An Eﬃcient and Cost-Eﬀective Synthesis of 3-Ethoxy-4- ethoxycarbonyl-phenylacetic Acid: A Key Acid Synthon of Repaglin- ide (VI). — A new method for the synthesis of (V) acid is developed starting from 2-hydroxy-4-methylbenzoic acid. Deprotonation of (III) is accomplished with in situ generated LDA followed by subsequent reaction of the carbanion with carbon dioxide. — (SALMAN, MOHAMMAD; BABU, SURESH J.; RAY, PURNA C.; BISWAS, SUJOY; KUMAR, NARESH; Org. Process Res. Dev. 6 (2002) 2, 184-186; Chem. Res. Div., Ranbaxy Lab. Ltd., Gurgaon 122 001, India; EN) 1

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Page 1: An Efficient and Cost-Effective Synthesis of 3-Ethoxy-4-ethoxycarbonyl-phenylacetic Acid: A Key Acid Synthon of Repaglinide (VI)

2002 polycarboxylic acids and esters

polycarboxylic acids and esters (benzene compounds)Q 0425

48 - 082An Efficient and Cost-Effective Synthesis of 3-Ethoxy-4-ethoxycarbonyl-phenylacetic Acid: A Key Acid Synthon of Repaglin-ide (VI). — A new method for the synthesis of (V) acid is developed startingfrom 2-hydroxy-4-methylbenzoic acid. Deprotonation of (III) is accomplishedwith in situ generated LDA followed by subsequent reaction of the carbanionwith carbon dioxide. — (SALMAN, MOHAMMAD; BABU, SURESH J.;RAY, PURNA C.; BISWAS, SUJOY; KUMAR, NARESH; Org. Process Res.Dev. 6 (2002) 2, 184-186; Chem. Res. Div., Ranbaxy Lab. Ltd., Gurgaon 122001, India; EN)

1 C: formic acid, methanoic acid 2 C’s: acetic acid, ethanoic acid 3 C’s: propionic acid, propanoic acid 4 C’s: butyric acid, butanoic acid Carboxyli c

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884-0001 - Amneal Pharmaceuticals · PRANDIN® (repaglinide) Tablets (1 mg and 2 mg) Rx only DESCRIPTION PRANDIN® (repaglinide) is an oral blood glucose-lowering drug of the meglitinide

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1 C: formic acid, methanoic acid 2 C’s: acetic acid, ethanoic acid