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Quantitative Information for Juergen Reichardt, Ph.D.
Universitaet Freiburg B.S 1978 Biology
Universitaet Freiburg B.A. 1979 Philosophy
Universitaet Basel M.S. 1981 Biochemistry
Standford University Ph.D. 1989 Biochemistry
1. List of thesis (PhD and/or MS) supervised
MS Students Trained:
1993-1995: Hsien-Chin Lin (USC)
1993‐1995: Sriveda Koritala (USC) 1994‐1996: Sunita Devgan (USC) 1997‐1999: Jeffrey Jim (USC; graduated from med. school at UCI) 1999‐2000: Lana Ali (USC)
Justin Fuess (USC) Jonathan Koo (USCgraduated med. School Canada) 1999‐2002: Soorena Izadifar (USC)
2000‐2002: Eugene Kim (USC) Patricia Sharpe (USC)
Yahsuan “Nancy” Hsu (USC) Shih‐chi “Nancy” Chen (USC; attended Dental School at Penn)
2001: Duk‐Won “Duck” Kang (USC) 2001‐2003: Prutha Badiani ( USC) 2002: Tom Reese (USC) Althea McCourty (USC) 2002‐2004: Frank Luh (USC) 2003‐2005: Xuemei “Mei” Deng (USC) Albert Kim (USC; graduated med. school in Virginia) Chirag Patel (USC) 2006‐2008: Francine Marques (Brazil) 2009: Adena Spiro (USyd) Nguyen Viet Trung (USyd) 2009‐2010: Dominique Petit (USyd).
PhD Students Trained: 1993‐1995: Nathalie Daude (PhD obtained in Bordeaux, France) 1994‐1997: Nick Makridakis (USC PhD)
1999‐2003: Lucio Ferraz (PhD obtained in Brazil) 2001‐2006: Troy Phipps (USC PhD; DoD Fellowship Recipient) 2002‐2004: Eugene Kim (USC) 2007‐2012: Florence Cheung (USyd).
2. List of publications (at least 100)
Peer‐Reviewed Article
. Reichardt, J.K.V. and Q.H. Gibson (1982) Spectra of Intermediates in Oxidation and Reduction of Cytochrome c Oxidase, J. Biol. Chem. 257, 9268‐ 9270
2. Reichardt, J.K.V. and Q.H. Gibson (1983) Turnover of Cytochrome c Oxidase
from Paracoccus denitrificans, J. Biol. Chem. 258, 1504‐1507
3. Reichardt, J.K.V. and P. Berg (1988) Cloning and Characterization of a cDNA Encoding Human Galactose‐1‐phosphate Uridyl Transferase, Molec. Biol. Med. 5, 107‐122
4. Reichardt, J.K.V. and P. Berg (1988) Conservation of Short Patches of Amino
Acid Sequence Amongst Proteins with a Common Function but Evolutionarily Distinct Origins: Implications for Cloning Genes and for Structure‐Function Analysis, Nucl. Acids Res. 16, 9017‐9026
5. Flach, J.E., J.K.V. Reichardt and L.J. Elsas (1990) Sequence of a cDNA
Encoding Human Galactose‐1‐Phosphate Uridyl Transferase, Mol. Biol. Med. 7, 365‐369
6. Reichardt, J.K.V. and S.L.C. Woo (1991) Molecular Basis of Galactosemia:
Mutations and Polymoprhisms in the Gene Encoding Human Galactose‐1‐ Phosphate Uridylyltransferase, Proc. Natl. Acad. Sci. 88, 2633‐2637
7. Petry, K., H.T. Greinix, E. Nudelman, H. Eisen, S. Hakomori, H.L. Levy and J.K.V.
Reichardt (1991) Characterization of a Novel Biochemical Defect in Galactosemia: Deficiency of Glycolipids Containing Galactose or N‐ Acetylgalactosamine and Accumulation of Precursors, Biochem. Med. Metabol. Biol. 46, 93‐104
8. Reichardt, J.K.V., S. Packman and S.L.C. Woo (1991) Molecular
Characterization of Two Galactosemia Mutations: Correlation of Mutations with Highly Conserved Domains in Galactose‐1‐Phosphate Uridyl Transferase, Am. J. Hum. Genet. 49, 860‐867
9. Reichardt, J.K.V. (1991) Molecular Analysis of 11 Galactosemia Patients,
Nucl. Acids Res. 19, 7049‐7052
10. Reichardt, J.K.V., J.W. Belmont, H.L. Levy and S.L.C. Woo (1992) Characterization of Two Missense Mutations In Human Galactose‐1‐ Phosphate Uridyl Transferase: Different Molecular Mechanisms for Galactosemia, Genomics 12, 596‐600
11. Reichardt, J.K.V., H.L. Levy and S.L.C. Woo (1992) Molecular Characterization
of Two Galactosemia Mutations and One Polymorphism: Implications for
Structure‐Function Analysis of Human Galactose‐1‐phosphate Uridyl Transferase, Biochem. 31, 5430‐5433
12. Reichardt, J.K.V. (1992) Genetic Basis of Galactosemia, Human Mut. 1, 190‐
196
13. Reichardt, J.K.V. (1993) The Molecular Genetic Basis of Galactosemia, Int. Ped. 8, 110‐113
14. Reichardt, J.K.V., G. Novelli and B. Dallapiccola (1993) Molecular
Characterization of the H319Q Galactosemia Mutation, Hum. Molec. Genet. 2, 325‐326
15. Lin, H.‐C., L.T. Kirby, W.G. Ng and J.K.V. Reichardt (1994) On the Molecular
Nature of the Duarte Variant of Galactose‐1‐phosphate Uridyl Transferase (GALT), Hum. Genet. 93, 167‐169
16. Podskarbi, T., J. Reichardt and Y.S. Shin (1994) Studies of DNA in Galactose‐1
phosphate Uridyl Transferase Deficiency and the Duarte Variant in Germany, J. Inher. Metabol. Dis. 17, 149‐150
17. Kaufman, F.R., Reichardt, J.K.V., Ng, W.G., Xu, Y.‐K., Manis, F.R., McBride
Chang, C. and Wolff, J.A. (1994) Correlation of Cognitive, Neurologic and Ovarian Outcome with the Q188R Mutation of the Galactose‐1‐phosphate Uridyltransferase Gene, J. Ped. 125, 225‐227
18. Ng, W.G., Xu, Y.‐K., Kaufman, F.R., Donnell, G.N., Wolff, J., Allen, R.J., Koritala, S.
and Reichardt, J.K.V. (1994) Biochemical and Molecular Studies of 132 Patients with Galactosemia, Hum. Genet. 94, 359‐363
19. Cramer, D.W., Muto, M.G., Reichardt, J.K.V., Xu, H., Welch, W.R., Valles, B. and
Ng, W.G. (1994) Characteristics of Women With a Family History of Ovarian Cancer: I. Galactose Consumption and Metabolism, Cancer: 74, 1309‐1317
20. Cramer, D.W., Barbieri, R.L., Xu, H. and Reichardt, J.K.V. (1994) Determinants
of Basal Follicle Stimulating Hormone Levels in Premenopausal Women, J. Clin. Endo. Metabol. 79, 1105‐1109
21. Lin, H.‐C. and Reichardt, J.K.V. (1995) Linkage Disequilibrium Between a Sac
I Restriction Fragment Length Polymorphism and two Galactosemia Mutations, Hum. Genet. 95, 353‐355
22. Reichardt, JKV (1995) Mutations in Galactosemia, Am. J. Hum. Genet. 57, 978‐
979
23. Ashino, J., Okano, Y., Suyama, I., Yamazaki, T., Yoshino, M., Furuyama, J.‐I., Lin, H.‐C., Reichardt, J.K.V. and Isshiki, G. (1995) Molecular Characterization of Galactosemia Mutations (Type 1) in Japanese, Hum. Mut. 6, 36‐43
24. Ross, R.K., Coetzee, G., Reichardt, J., Skinner, E. and Henderson, B.E. (1995)
Does the Racial‐Ethnic Variation in Prostate Cancer Have a Hormonal Basis?, Cancer 75, 1778‐1782
25. Daude, N., Gallaher, T.K., Zeschnigk, M., Starzinski‐Powitz, A., Petry, K.G.,
Haworth, I.S. and Reichardt, J.K.V. (1995) Molecular Cloning, Characterization and Mapping of A Full‐Length cDNA Encoding Human UDP‐ Galactose 4' Epimerase, Biochem. Molec. Med. 56, 1‐7
26. Reichardt, J.K.V., Makridakis, N., Henderson, B.E., Yu. M.C., Pike, M.C. and
Ross, R.K. (1995) Genetic Variability of the Human SRD5A2 Gene: Implications for Prostate Cancer Risk, Cancer Res. 55, 3973‐3975
27. Maceratesi, P., Sangiulo, F., Novelli, G., Ninfali, P., Magnani, M., Reichardt,
J.K.V. and Dallapiccola, B. (1996) Three New Mutations (P183T, V150L, 528insG) and Eleven Sequence Polymorphisms in Italian Patients with Galactose‐1‐phosphate Uridyltransferase (GALT) Deficiency, Hum. Mut. 8, 369‐372
28. Gathof, B.S., Sommer, M., Podskarbi, T., Reichardt, J.K.V., Braun, A., Gresser,
U. and Shin, Y.S. (1995) Characterization of Two Stop Codon Mutations in the Galactose‐1‐phosphate Uridyltransferase Gene of Three Male Galactosemic Patients with Severe Clinical Manifestation, Hum. Genet. 96, 721‐ 725
29. Daude, N., Lestage, J., Reichardt, J.K.V. and Petry, K.G. (1996) Expression of
Galactose‐1‐phosphate Uridyltransferase (GALT) in the Anterior Pituitary of Rat During the Estrous Cycle, Neuroendocrin. 64, 42‐48
30. Cramer, D.W., Goldstein, D.P., Fraer, C. and Reichardt, J.K.V. (1996) Vaginal
Agenesis (Mayer‐Rokitansky‐Kuster‐Hauser Syndrome) Associated with the N314D Mutation of Galactose‐1‐phosphate Uridyl Tranferase (GALT), Molec. Hum. Reprod. 2, 145‐148
31. Daude, N., Ellie, E., Reichardt, J.K.V. and Petry, K.G. (1996) In Vivo and InVitro
Expression of Rat Galactose‐1‐phosphate Uridyltransferase (GALT) in Developing Central and Peripheral Nervous System, Develop. Brain Res. 94, 190‐196
32. Feigelson, H.S., Ross, R.K., Yu, M.C., Coetzee, G.A., Reichardt, J.K.V. and
Henderson, B.E. (1996) Genetic Susceptibility to Cancer from Exogenous and Endogenous Exposures, J. Cell. Biochem. 25, 15‐22
33. Devgan, S.A., Henderson, B.E., Yu, M.C., Shi, C.‐Y., Pike, M.C., Ross, R.K. and Reichardt, J.K.V. (1997) Genetic Variation of 3‐Hydroxysteroid Dehydrogenase Type II in Three Racial/Ethnic Groups: Implications for Prostate Cancer Risk, The Prostate 33, 9‐12
34. Makridakis, N., Ross, R.K., Pike, M.C., Chang, L., Stanczyk, F.Z., Kolonel, L.N.,
Shi, C.‐Y., Yu, M.C., Henderson, B.E. and Reichardt, J.K.V (1997) A Prevalent Missense Substitution that Modulates Activity of Prostatic Steroid 5‐ Reductase, Cancer Res. 57, 1020‐1022
35. Feigelson, H.S., Ross, R.K., Yu, M.C., Coetzee, G.A., Reichardt, J.K.V. and
Henderson, B.E.H. (1998) Sex Steroid Hormones and Genetic Susceptibility to Breast and Prostate Cancer, Drug Metab. Rev. 30, 421‐434
36. Maceratesi, P., Daude, N., Dallapiccola, B., Novelli, G., Allen, R., Okano, Y. and
Reichardt, J. (1998) Human UDP‐Galactose 4’ Epimerase (GALE) Gene and Identification of Five Missense Mutations in Patients with Epimerase Deficiency Galactosemia, Molec. Genet. Metabol. 63, 26‐30
37. Petry, K.G. and Reichardt, J.K.V. (1998) The Fundamental Importance of
Human Galactose Metabolism: Lessons from Genetics and Biochemistry, Trends Genet. 14, 98‐102
38. Ross, R.K., M.C. Pike, G.A. Coetzee, J.K.V. Reichardt, M.C. Yu, H. Feigelson, F.Z.
Stanczyk, L.N. Kolonel and B.E. Henderson (1998) Androgen Metabolism and Prostate Cancer: Establishing a Model of Genetic Susceptibility, Cancer Res. 58, 4497‐4504
39. Akalu , A., Elmajian, D.A., Highshaw, R.A., Nichols, P.W. and Reichardt, J.K.V.
(1999) Somatic Mutations at the SRD5A2 Locus Encoding Prostatic Steroid 5‐Reductase During Prostate Cancer Progression, J. Urol. 161, 1355‐1358
40. Ross RK, Coetzee GA, Pearce CL, Reichardt JK, Bretsky P, Kolonel LN,
Henderson BE, Lander E, Altshuler D, Daley G (1999) Androgen Metabolism and Prostate Cancer: Establishing a Model of Genetic Susceptibility, Eur. Urol. 35, 355‐361
41. Reichardt JK (1999) GEN GEN: the Genomic Genetic Analysis of Androgen
Metabolic Genes and Prostate Cancer as a Paradigm for the Dissection of Complex Phenotypes, Frontiers in Bioscience 4, D596‐600
42. Tyfield, L., Reichardt, J., Fridovich‐Keil, J. et al. (1999) Classical
Galactosaemia and Mutations at the Galactose‐1‐phosphate Uridyl Transferase (GALT) Gene, Hum. Mut. 13, 417‐430
43. Makridakis, N.M, Ross, R.K, Pike, M.C., Crocitto, L.E., Kolonel, L.N., Pearce, C.L., Henderson, B.E. and Reichardt, J.K.V. (1999) A Missense Substitution in the SRD5A2 Gene is Associated with Prostate Cancer in African‐American and Hispanic Men in Los Angeles, The Lancet 354, 975‐978
44. Reichardt, J.K.V. (2000) Prostatic Steroid‐5‐Alpha Reductase, an Androgen
Metabolic Gene, Mayo Clin. Proc. 75, S36‐39
45. Akalu, A. and Reichardt, J.K.V. (1999) A Reliable PCR Amplification Method for Microdissected Tumor Cells Obtained from Paraffin‐Embedded Tissue, Gen. An. 15, 229‐233
46. Makridakis, N.M., di Salle, E. and Reichardt, J.K.V. (2000) Biochemical and Pharmacogenetic Dissection of Human Steroid 5‐Reductase Type II, Pharmacogenet. 10, 407‐413
47. Novelli, G and Reichardt, J.K.V. (2000) Molecular Basis of Disorders of Galactose Metabolism: Past, Present and Future, Molec. Genet. Metabol. 71, 62‐65
48. Margiotti, K, Sangiulo, F, de Luca, A, Froio, F, Pearce, CL, Ricci‐Barbine, V, Micali, F, Bonafe, M, Dallapicccola, B, Novelli, G and Reichardt, JKV (2000) Evidence for an Association between the SRD5A2 (Type II Steroid 5‐ Reductase) Locus and Prostate Cancer in Italian Patients. Dis. Markers 16, 147‐150
49. Novelli, G, Margiotti, K, Sangiulo, F and Reichardt, JKV (2001) Pharmacogenetics of Human Androgens and Prostatic Diseases, Pharamacogenom. 2, 65‐72
50. Okano, Y, Asadal, M, Fujimoto, A, Ohtake, A, Murayama, K, Hsiao, K‐W, Choe, K, Reichardt, JKV, Niihira, S, Imamura, T and Yamano, T (2001) A Genetic Factor for Age‐Related Cataract: Identification and Characterization of a Novel Galactokinase Variant "Osaka" in Asians, Am. J. Hum. Genet. 68, 1036‐ 1042
51. Hsing, AW, Chen, C, Chokkalingam, AP, Gao, Y‐T, Dightman, DA, Nguyen, HT, Deng, J, Cheng, J, Sesterhenn, IA, Mostofi, FK, Stanczyk, FW and Reichardt, JKV (2001) Polymorphic Markers in the SRD5A2 Gene and Prostate Cancer Risk: A Population‐Based Case‐Control Study, Cancer Epi. Biom. Prev. 10, 1077‐1082
52. Ross RK, Reichardt JKV, Ingles SA, Coetzee GA (2001) The Genetic Epidemiology of Prostate Cancer: Closing in on a Complex Disease, in: Prostate Cancer: Biology, Genetics, and the New Therapeutics. (Eds) Chung LWK, Isaacs WB, Simons JW. Humana Press Inc., Totowa, NJ, 111‐121
53. Makridakis, NM and Reichardt, JKV (2001) Molecular Epidemiology of Hormone‐Metabolic Loci in Prostate Cancer, Epidemiol. Rev. 23, 24‐29
54. Hsing, AW, Reichardt, JKV and Stanczyk, FW (2002) Hormones and Prostate Cancer: Current Perspectives and Future Directions, Prostate 52, 213‐235
55. Makridakis, NM and Reichardt, JKV (2001) MAPA: Multiplex Automated Primer Extension Analysis: Simultaneous Genotyping of up to Four Polymorphisms, Biotech. 31, 1374‐1380
56. Pearce, CL, Makridakis, NM, Ross, RK, Pike, MC, Kolonel, LN, Henderson, BE and Reichardt, JKV (2002) SRD5A2 V89L Substitution is Not Associated with Significant Risk of Prostate Cancer in a Multi‐Ethnic Population Study, Cancer Epi., Biom., Prev. 11, 417‐418
57. Cozen W, Peters R, Reichardt JK, Ng W, Felix JC, Wan P, Pike MC (2002) Galactose‐1‐phosphate Uridyl Transferase (GALT) Genotype and Phenotype, Galactose Consumption, and the Risk of Borderline and Invasive Ovarian Cancer (United States), Cancer Causes Control. 13, 113‐120
58. Goodman, MT, Wu, AH, Tung K‐H, McDuffie K, Cramer DW, Wilkens LR, Terda K, Reichardt JKV and WG Ng (2002) Association of the Galactose‐1‐ Phosphate Uridyltransferase (GALT) Activity and N314D Genotype with the Risk of Ovarian Cancer, Am. J. Epidem. 156, 693‐701
59. Margiotti, K, Kim, E, Pearce, CL, Spera, E, Novelli, G and Reichardt, JKV (2002) Association of the G289S Polymorphism in the HSD17B3 Gene with Prostate Cancer in Italian Men, The Prostate 53, 65‐68
60. Allen, NE, Reichardt, JKV, Nguyen, H, and Key, TJ (2003) Association
between Two Polymorphisms in the SRD5A2 Gene and Serum Androgen Concentrations in British Men, Cancer Epidemiol. Biomarkers Prev. 12, 578‐ 581
61. Kobayashi, K, Lu YB, Li MX, Nishi I, Hsiao K‐J, Choeh K, Yang Y, Hwu W‐L,
Reichardt, JKV, Palmieri F, Okano Y and Saheki T (2003) Screening for Nine SLC25A13 Mutations: Their Frequency in Patients with Citrin Deficiency and High Carrier Rates in Asian Populations, Molec. Genet. Metabol. 80, 356‐359
62. Makridakis, NM and Reichardt, JKV (2004) Molecular Epidemiology of Androgen Metabolic Loci in Prostate Cancer and Progression, J. Urol. 171, S25‐S29
63. Foti, D and Reichardt, JKV (2004) YY1 Binding within the Human HSD3B2
Gene Intron 1 is Required for Maximal Basal Promoter Activity: Identification of YY1 as the 31‐A Factor, J. Molec. Endocrin. 33, 99‐119
64. Novelli G, Margiotti K, Chiocca AM, Spera E, Micali F, Reichardt JK (2004)
Pharmacogenetics of Human Androgens and Prostate Cancer--an Update,
Pharmacogenom. 5, 283-294
65. Makridakis, NM, Akalu A, and Reichardt, JKV (2004) Identification and
Characterization of Somatic Steroid 5‐Reductase (SRD5A2) Mutations in Human Prostate Cancer Tissue, Oncogene 23, 7399‐7405
66. Mehrian-Shai, R and Reichardt, JKV (2004) A Renaissance of “Biochemical
Genetics”? SNPs, Haplotypes, Function and Complex Diseases, Molec. Genet. Metabol. 83, 47‐50
67. Salam, MT, Ursin, G, Skinner, EC, Dessissa, T and Reichardt, JKV (2005)
Associations between Polymorphisms in the Steroid 5‐ Reductase Type II (SRD5A2) Gene and Benign Prostatic Hyperplasia and Prostate Cancer, Urol. Oncol., 23, 246‐253
68. Makridakis, N and JKV Reichardt (2005) Pharmacogenetic Analysis of
Human Steroid 5 Reductase Type II: Comparison of Finasteride and Dutasteride, J. Molec. Endocrin. 34, 617‐623
69. Mehrian Shai R, JKV Reichardt, Y-H Hsu, T Kremen, L Liau, T Cloughesy, P
Mischel, SN Nelson (2005) Robustness of Gene Expression Profiling in Glioma
Specimen Samplings and Derived Cell Lines, Molec. Brain Res. 136, 99-103
70. Makridakis, NM, Buchanan, G, Tilley, W and JKV Reichardt (2005) Androgen
Metabolic Genes in Prostate Cancer Predisposition and Progression, Frontiers in
Bioscience 10, 2899-2903
71. Mehrian-Shai, R and Reichardt, JKV (2006) Genomics in Breast and Prostate
Cancer: Assessment of the Current State and Future Perspectives, Fut. Oncol. 2,
357-362
72. Reichardt, JKV (2006) Unexpected Biochemical and Pharmacogenetic
Consequences of SNPs and Haplotypes: A Cautionary Tale for Human Molecular
Genetics and Epidemiology, Genomics 88, 673-674
73. Chokkalingam AP, Stanczyk FZ, Reichardt JKV and Hsing AW (2007)
Molecular Epidemiology of Prostate Cancer: Hormone-Related Genetic Loci,
Frontiers in Bioscience 12, 3436-3460
74. Mehrian Shai R, Chen CD, Shi T, Horvath S, Nelson SF, Reichardt JKV and
Sawyers CL (2007) IGFBP2 is a Biomarker for PTEN Status and PI3K/Akt
Pathway Activation in Glioblastoma and Prostate Cancer, Proc. Natl. Acad. Sci.
104, 5563-5568
75. Reichardt JKV and Tilley WD (2007) The 3rd Pacific Rim Meeting on Breast
and Prostate Cancer: Progress in Hormonal Carcinogenesis and the Enduring Influence of Ron Ross, Cancer Res. 67, 4550‐4552
76. D’Amico F, Biancolella M, Reichardt JKV and Novelli G (2007) Single
Nucleotide Polymorphisms in the Androgen Pathway and Prostate Cancer, Pharmacogenomics 8, 645‐661
77. Reichardt JKV (2007) Quo vadis, genoma? A Call to Pipettes for Biochemists,
Trends Biochem. Sci. 32, 529‐530
78. Reichardt, JKV (2008) Realizing the Potential of the Sequenced Human Genome, Trends Genet. 24, 219‐220
79. Pearce, CL, Van Den Berg, DJ, Makridakis, N, Reichardt, JKV, Ross, RK, Pike,
MC, Kolonel, LN and Henderson, BE (2008) No Association Between the SRD5A2 Gene A49T Missense Variant and Prostate Cancer Risk: Lessons Learned, Hum. Molec. Genet. 17, 2456‐2461
80. Mehrian Shai, R, Reichardt, JKV and Chen, T (2008) Pharmacogenomics of
Brain Cancer and Personalized Medicine in Malignant Gliomas, Fut. Oncol., 4, 525-534
81. Chu, LW, Reichardt, JKV and Hsing, AW (2008) Androgens and the Molecular
Epidemiology of Prostate Cancer, Curr. Opin. Endocrin. Diab. Obes. 15, 261‐ 270
82. Makridakis, NM, Phipps, T and Reichardt, JKV (2009) Genomic Analysis of
Cancer Tissue Reveals that Somatic Mutations Commonly Occur in a Specific Motif, Hum. Mut. 30, 39‐48
83. Flanagan, JM, McMahon, G, Chia, SHB, Fitzpatrick, P, Tighe, O, O’Neill, C,
Briones, P, Gort, L, Kozak, L, Naughten, AME, Radomyska, B, Schwartz, M, Shin, JS, Strobl, W, Tyfield, LA, Waterham, HR, Russell, H, Bertorelle, G, Reichardt, JKV, Mayne, PD, Croke, DT (2010) The Role of Human Demographic History in Determining the Distributionand Frequency of Transferase‐Deficient Galactosaemia Mutations, Heredit. 104, 148‐154
84. Makridakis, NM, Phipps, T, Srivastav, S and Reichardt, JKV (2009) PCR‐Free Method Detects High Frequency of Genomic Instability in Prostate Cancer, Nucl. Acids Res. 37, 7441‐7446
85. Musumeci, L, Arthur, JW, Cheung, FSG, Hoque, A, Lippman, S and Reichardt,
JKV (2010) Single Nucleotide Differences (SNDs) in the dbSNP Database May Lead to Errors in Genotyping and Haplotyping Studies, Hum. Mut. 31, 67‐73 (Commentary by Day, I (2010), Hum. Mut. 31, 2‐4)
86. Das, K Lorena, DN, Ng, LK, Lim, D, Shen, L, Siow, WY, Teh, M, Reichardt, JKV,
Salto‐Tellez, M (2010) Differential Expression of Steroid 5‐Reductase Isozymes and Association With Disease Severity and Angiogenic Genes Predict Their Biological Role in Prostate Cancer, Endocr. Relat. Cancer 17, 757‐770
87. Goodman, P, Tangen, C, Kristal, A, Thompson, I, Lucia, S, Platz, E, Figg, W,
Hoque, A, Hsing, A, Neuhouser, M, Parnes, H, Reichardt, J, Santella, R, Till, C and Lippman, S (2010) Transition of a Clinical Trial into Translational Research: The Prostate Cancer Prevention Trial Experience, Cancer Prev.
Research 3, 1523‐1533
88. Hulin‐Curtis, SL, Petit, D, Figg, WD, Hsing, AW and Reichardt, JKV (2010) Finasteride Metabolism and Pharmacogenetics: New Approaches to Personalised Prevention of Prostate Cancer, Fut. Oncol. 6, 1897‐1913
89. Price, DK, Chau, CH, Till, C, Goodman, PJ, Baum, CE, Ockers, SB, English, BC,
Minasian, L, Parnes, HL, Hsing, AW, Reichardt, JKV, Hoque, A, Tangen, CM, Kristal, AR, Thompson, IM, Figg, WD (2010) Androgen Receptor CAG Repeat Length and Association with Prostate Cancer Risk: Results from the Prostate Cancer Prevention Trial, J. Urol. 184, 2297‐2302
90. Arthur, JW and Reichardt, JKV (2010) Modelling Single Nucleotide
Polymorphisms in The Human AKR1C1 And AKR1C2 Genes: Implications for Functional and Genotyping Analyses, PLoS ONE 5, 1‐9
91. Tang, L, Song, Y, Till, C, Goodman, P, Tangen, C, Yu, W, Kristal, A, Platz, E,
Neuhouser, M, Stanczyk, F, Reichardt, J, Santella, R, Hsing, A, Hoque, A, Lippman, S, Thompson, I, Ambrosone, C (2011) Repeat Polymorphisms in Estrogen Metabolism Genes and Prostate Cancer Risk: Results From the Prostate Cancer Prevention Trial, Carcinogen. 32, 1500‐1506
92. Yao, S, Till, C, Kristal, AR, Goodman, PJ, Hsing, AW, Tangen, CM, Platz, EA,
Stanczyk, FZ, Reichardt, JKV, Tang, L, Neuhouser, ML, Santella, RM, Figg, WD, Price, DK, Parnes, HL, Lippman, SM, Thompson, IM, Ambrosone, CB and Hoque, A (2011) Serum Estrogen Levels and Prostate Cancer Risk in the
Prostate Cancer Prevention Trial: a Nested Case‐Control Study, Cancer Causes Control 22, 1121‐1131
93. Cheung, FSG, Lovicu, FJ and Reichardt, JKV (2012) Current Progress In Using
Vitamin D And Its Analogs For Cancer Prevention And Treatment, Expert Rev. Anticancer Ther., 12, 811‐837
94. AR Kristal, C Till, CM Tangen, PJ Goodman, ML Neuhouser, FZ Stanczyk , LW Chu, SK Patel, I Thompson, JK Reichardt, A Hoque, EA Platz, WD Figg, A Van Bokhoven, SM Lippman, AW Hsing (2012) Associations of serum sex steroid hormones and 5α‐androstane‐3α,17β‐diol glucuronide concentrations with prostate cancer risk among men treated with finasteride, Cancer Epi. Biomark. Prev. 21, 1823‐1832
95. Makridakis, NM and Reichardt, JKV (2012) Translesion DNA Polymerase and
Cancer, Front. Pharmacogen. 3, article 174
96. Ho, G, Reichardt, J and Christodoulou, J (2013) In Vitro Read‐through Of Phenylalanine Hydroxylase (PAH) Nonsense Mutations Using Aminoglycosides: A Potential Therapy For Phenylketonuria, J. Inh. Metabol. Dis. 36, 955‐959
97. WD Figg, CH Chau, DK Price, C Till, PJ Goodman, Y Cho, M Varella‐Garcia, JKV
Reichardt, CM Tangen, RJ Leach, A van Bokhoven, IM Thompson, MS Lucia (2014) Androgen Receptor CAG Repeat Length and TMPRSS2:ETS Prostate Cancer Risk: Results From the Prostate Cancer Prevention Trial, Urology, 84, 127‐131
98. Toren A, Reichardt JK, Andalibi A, Hsu NY, Doherty J, Slattery W, Mehrian‐
Shai R (2014) Novel Age‐Dependent Targets in Vestibular Schwannomas, Hum Genom. 8, doi: 10.1186/1479‐7364‐8‐10
99. Yao, S, Till, CA, Kristal, AR, Goodman, PJ, Hsing, AW, Tangen, CM, Platz, EA,
Stanczyk, FZ, Reichardt, J, van Bokhoven, A, Neuhouser, ML, Santella, RM, Figg, WD, Price, DK, Parnes, HL, Lippman, SL, Ambrosone, CB and Thompson, IM (2015) Effect of Finasteride on Serum Androstenedione and Risk of Prostate Cancer within the Prostate Cancer Prevention Trial: Differential Effect on High and Low Grade Disease, Urology, in press
100.Arthur, JW, Cheung, FSG and Reichardt, JKV (2015) Single Nucleotide
Differences (SNDs) Continue to Contaminate the dbSNP Database With Consequences For Human Genomics and Health Hum. Mut. in press.
Book Chapters
101. Reichardt, J and B Ludwig (1981) Cytochrome c Interacts with Subunit II of the Cytochrome c Oxidase Isolated from Paraccccus denitrificans, in Vectorial Reactions in Electron Transport in Mitochondria and Bacteria (Palmieri, F. et al., eds.), 3‐10 102. Greenwood, C, AJ Thomson, CP Barrett, Peterson, GN George, JA Fee
and J Reichardt (1988) Some Spectroscopic Views of the CuA Site in Cytochrome c Oxidase Preparations, Ann. NY Acad. Sci. 550, 47‐52
103. Reichardt, JKV (1993) Galactosemia is Caused by Missense Mutations: Molecular Studies and Implications for Therapy, in Galactosemia: New Frontiers for Research (Donnell, G.N., ed.), 199‐213 104. Reichardt, JKV (1993) Molecular Analysis of Galactosemia, in Current
Progress in Perinatal Medicine (Cosmi, E.V. and G.C. Di Renzo, eds.), Parthenon, 225‐229
105. Daude, N and JKV Reichardt (1996) Molecular Genetic Basis of Epimerase-Deficiency Galactosemia, in Diagnosis and Treatment of Inborn Errors of Metabolism (Demirkol, M. and Y.S. Shin, eds.), Turkish Society for PKU, 49‐55
106. Reichardt, JKV (1996) Molecular Genetic Basis of Galactosemia, in Diagnosis and Treatment of Inborn Errors of Metabolism” (Demirkol, M. and Y.S. Shin, eds.), Turkish Society for PKU, 39‐48
107. Petry, KG, N Daude, LLC Prestoz, E Ellie and JKV Reichardt (1996) Implication of Galactose‐1‐phosphate Uridyl Transferase (GALT) in the Process of Myelination and in the Ovarian Cycle, in Diagnosis and Treatment of Inborn Errors of Metabolism (Demirkol, M. and Y.S. Shin, eds.), Turkish Society for PKU, 153‐164
108. Akalu, A and Reichardt, JKV (2002) Increasing PCR Sensitivity for Amplification from Paraffin‐Embedded Tissues, in PCR Cloning Protocols, 2nd Edition (Chen, B.‐Y. and H.W. James, eds.), Methods Molec. Biol. 192, 67‐74 109. Ross RK, Makridakis NM, Reichardt JKV (2003) Prostate Cancer: Epidemiology and Molecular Endocrinology, in: Hormones, Genes, and Cancer, (Henderson BE, Ponder B, Ross RK, eds.), Oxford University Press, Inc., New York, NY, 273‐287
110. Makridakis, NM, Ross RK and Reichardt, JKV (2004) Human Genetic Variation at Hormone‐Metabolic Loci and Prostate Cancer Risk, in Disorders of the Prostate (Habib, F, ed.) 63‐69
111. Novelli, G, Margiotti, K, Spera, E, Micali, F and Reichardt, JKV (2005)
Pharmacogenetics of Androgen‐Metabolic Genes and Prostate Cancer, in Horizons in Cancer Research vol. 1 “Prostate Cancer” (Lucas, JN ed.), 81‐101
112. Reichardt, JKV and Hsing, AW (2009) Androgen Metabolic Genes in
Prostate Cancer Predisposition and Progression, in Androgen Action in Prostate (Tindal, DJ and Mohler, JL, eds.), 141‐154
113. Mehrian‐Shai, R, and Reichardt, JKV (2009) The Future of Human
Genomics Research: Three Unanswered Questions, in Human Genome: Features, Variations and Genetic Disorders (Columbus, F., ed.), in press
114. Cheung, FSG and Reichardt, JKV (2010) Molecular Biology of Vitamin
D Metabolism and Skin Cancer, in Vitamin D and Cancer (Johnson, C and Trump, D, eds.) Springer, 191‐219
115. Marques, FZC and Reichardt, JKV (2010) Pharmacogenetics of the
Androgen Metabolic Pathway, in Drug Management of Prostate Cancer
(Figg, WD et al., eds.), Springer, 109-121. Webpublications
116. Reichardt, JKV (2008) The Future of Human Genomics, The Science Advisory Board: http://www.scienceboard.net/community/perspectives.205.html
117. Reichardt, JKV and Mehrian‐Shai, R (2008) Can Human Genomics Research Fulfill Its Promise? Science (E‐Letter online), 3 july 2008 http://www.sciencemag.org/cgi/eletters/319/5871/1733#10837 118. Reichardt, JKV and Mehrian‐Shai, R (2009) The Future of the Human SNP Identification: Which Individuals to Sequence? (Letter (Online Only)) Proc. Natl.
Acad. Sci., 12 may 2009 http://www.pnas.org/content/106/19/E50.full?sid=b14eab01‐bd71‐4045‐88f3‐
3add6a556879
3. List of high‐impact publications (at least 30)
1. Reichardt, J.K.V. and Q.H. Gibson (1982) Spectra of Intermediates in Oxidation and Reduction of Cytochrome c Oxidase, J. Biol. Chem. 257, 9268‐ 9270
2. Reichardt, J.K.V. and Q.H. Gibson (1983) Turnover of Cytochrome c Oxidase
from Paracoccus denitrificans, J. Biol. Chem. 258, 1504‐1507
3. Reichardt, J.K.V. and P. Berg (1988) Conservation of Short Patches of Amino Acid Sequence Amongst Proteins with a Common Function but Evolutionarily Distinct Origins: Implications for Cloning Genes and for Structure‐Function Analysis, Nucl. Acids Res. 16, 9017‐9026
4. Reichardt, J.K.V. and S.L.C. Woo (1991) Molecular Basis of Galactosemia:
Mutations and Polymoprhisms in the Gene Encoding Human Galactose‐1‐ Phosphate Uridylyltransferase, Proc. Natl. Acad. Sci. 88, 2633‐2637
5. Reichardt, J.K.V., S. Packman and S.L.C. Woo (1991) Molecular
Characterization of Two Galactosemia Mutations: Correlation of Mutations with Highly Conserved Domains in Galactose‐1‐Phosphate Uridyl Transferase, Am. J. Hum. Genet. 49, 860‐867
6. Reichardt, J.K.V. (1991) Molecular Analysis of 11 Galactosemia Patients,
Nucl. Acids Res. 19, 7049‐7052
7. Reichardt, J.K.V., J.W. Belmont, H.L. Levy and S.L.C. Woo (1992) Characterization of Two Missense Mutations In Human Galactose‐1‐ Phosphate Uridyl Transferase: Different Molecular Mechanisms for Galactosemia, Genomics 12, 596‐600
8. Podskarbi, T., J. Reichardt and Y.S. Shin (1994) Studies of DNA in Galactose‐1
phosphate Uridyl Transferase Deficiency and the Duarte Variant in Germany, J. Inher. Metabol. Dis. 17, 149‐150
9. Cramer, D.W., Barbieri, R.L., Xu, H. and Reichardt, J.K.V. (1994) Determinants
of Basal Follicle Stimulating Hormone Levels in Premenopausal Women, J. Clin. Endo. Metabol. 79, 1105‐1109
10. Reichardt, JKV (1995) Mutations in Galactosemia, Am. J. Hum. Genet. 57, 978‐
979
11. Daude, N., Gallaher, T.K., Zeschnigk, M., Starzinski‐Powitz, A., Petry, K.G., Haworth, I.S. and Reichardt, J.K.V. (1995) Molecular Cloning, Characterization and Mapping of A Full‐Length cDNA Encoding Human UDP‐ Galactose 4' Epimerase, Biochem. Molec. Med. 56, 1‐7
12. Reichardt, J.K.V., Makridakis, N., Henderson, B.E., Yu. M.C., Pike, M.C. and
Ross, R.K. (1995) Genetic Variability of the Human SRD5A2 Gene: Implications for Prostate Cancer Risk, Cancer Res. 55, 3973‐3975
13. Devgan, S.A., Henderson, B.E., Yu, M.C., Shi, C.‐Y., Pike, M.C., Ross, R.K. and
Reichardt, J.K.V. (1997) Genetic Variation of 3‐Hydroxysteroid Dehydrogenase Type II in Three Racial/Ethnic Groups: Implications for Prostate Cancer Risk, The Prostate 33, 9‐12
14. Makridakis, N., Ross, R.K., Pike, M.C., Chang, L., Stanczyk, F.Z., Kolonel, L.N.,
Shi, C.‐Y., Yu, M.C., Henderson, B.E. and Reichardt, J.K.V (1997) A Prevalent Missense Substitution that Modulates Activity of Prostatic Steroid 5‐ Reductase, Cancer Res. 57, 1020‐1022
15. Ross, R.K., M.C. Pike, G.A. Coetzee, J.K.V. Reichardt, M.C. Yu, H. Feigelson, F.Z.
Stanczyk, L.N. Kolonel and B.E. Henderson (1998) Androgen Metabolism and Prostate Cancer: Establishing a Model of Genetic Susceptibility, Cancer Res. 58, 4497‐4504
16. Akalu , A., Elmajian, D.A., Highshaw, R.A., Nichols, P.W. and Reichardt, J.K.V.
(1999) Somatic Mutations at the SRD5A2 Locus Encoding Prostatic Steroid 5‐Reductase During Prostate Cancer Progression, J. Urol. 161, 1355‐1358
17. Makridakis, N.M, Ross, R.K, Pike, M.C., Crocitto, L.E., Kolonel, L.N., Pearce, C.L.,
Henderson, B.E. and Reichardt, J.K.V. (1999) A Missense Substitution in the SRD5A2 Gene is Associated with Prostate Cancer in African‐American and Hispanic Men in Los Angeles, The Lancet 354, 975‐978
18. Akalu, A. and Reichardt, J.K.V. (1999) A Reliable PCR Amplification Method
for Microdissected Tumor Cells Obtained from Paraffin‐Embedded Tissue, Gen. An. 15, 229‐233
19. Makridakis, N.M., di Salle, E. and Reichardt, J.K.V. (2000) Biochemical and
Pharmacogenetic Dissection of Human Steroid 5‐Reductase Type II, Pharmacogenet. 10, 407‐413
20. Okano, Y, Asadal, M, Fujimoto, A, Ohtake, A, Murayama, K, Hsiao, K‐W, Choe,
K, Reichardt, JKV, Niihira, S, Imamura, T and Yamano, T (2001) A Genetic Factor for Age‐Related Cataract: Identification and Characterization of a Novel Galactokinase Variant "Osaka" in Asians, Am. J. Hum. Genet. 68, 1036‐ 1042
21. Hsing, AW, Chen, C, Chokkalingam, AP, Gao, Y‐T, Dightman, DA, Nguyen, HT, Deng, J, Cheng, J, Sesterhenn, IA, Mostofi, FK, Stanczyk, FW and Reichardt, JKV (2001) Polymorphic Markers in the SRD5A2 Gene and Prostate Cancer Risk: A Population‐Based Case‐Control Study, Cancer Epi. Biom. Prev. 10, 1077‐1082
22. Makridakis, NM and Reichardt, JKV (2001) MAPA: Multiplex Automated
Primer Extension Analysis: Simultaneous Genotyping of up to Four Polymorphisms, Biotech. 31, 1374‐1380
23. Pearce, CL, Makridakis, NM, Ross, RK, Pike, MC, Kolonel, LN, Henderson, BE
and Reichardt, JKV (2002) SRD5A2 V89L Substitution is Not Associated with Significant Risk of Prostate Cancer in a Multi‐Ethnic Population Study, Cancer Epi., Biom., Prev. 11, 417‐418
24. Goodman, MT, Wu, AH, Tung K‐H, McDuffie K, Cramer DW, Wilkens LR, Terda
K, Reichardt JKV and WG Ng (2002) Association of the Galactose‐1‐ Phosphate Uridyltransferase (GALT) Activity and N314D Genotype with the Risk of Ovarian Cancer, Am. J. Epidem. 156, 693‐701
25. Margiotti, K, Kim, E, Pearce, CL, Spera, E, Novelli, G and Reichardt, JKV
(2002) Association of the G289S Polymorphism in the HSD17B3 Gene with Prostate Cancer in Italian Men, The Prostate 53, 65‐68
26. Allen, NE, Reichardt, JKV, Nguyen, H, and Key, TJ (2003) Association
between Two Polymorphisms in the SRD5A2 Gene and Serum Androgen Concentrations in British Men, Cancer Epidemiol. Biomarkers Prev. 12, 578‐ 581
27. Foti, D and Reichardt, JKV (2004) YY1 Binding within the Human HSD3B2
Gene Intron 1 is Required for Maximal Basal Promoter Activity: Identification of YY1 as the 31‐A Factor, J. Molec. Endocrin. 33, 99‐119
28. Makridakis, NM, Akalu A, and Reichardt, JKV (2004) Identification and
Characterization of Somatic Steroid 5‐Reductase (SRD5A2) Mutations in Human Prostate Cancer Tissue, Oncogene 23, 7399‐7405
29. Makridakis, N and JKV Reichardt (2005) Pharmacogenetic Analysis of
Human Steroid 5 Reductase Type II: Comparison of Finasteride and Dutasteride, J. Molec. Endocrin. 34, 617‐623
30. Reichardt, JKV (2006) Unexpected Biochemical and Pharmacogenetic
Consequences of SNPs and Haplotypes: A Cautionary Tale for Human Molecular
Genetics and Epidemiology, Genomics 88, 673-674
31. Mehrian Shai R, Chen CD, Shi T, Horvath S, Nelson SF, Reichardt JKV and
Sawyers CL (2007) IGFBP2 is a Biomarker for PTEN Status and PI3K/Akt
Pathway Activation in Glioblastoma and Prostate Cancer, Proc. Natl. Acad. Sci.
104, 5563-5568
32. Reichardt JKV (2007) Quo vadis, genoma? A Call to Pipettes for Biochemists,
Trends Biochem. Sci. 32, 529‐530
33. Reichardt, JKV (2008) Realizing the Potential of the Sequenced Human Genome, Trends Genet. 24, 219‐220
34. Reichardt, JKV and Mehrian‐Shai, R (2008) Can Human Genomics Research
Fulfill Its Promise? Science (E‐Letter online), 3 july 2008 http://www.sciencemag.org/cgi/eletters/319/5871/1733#10837
35. Makridakis, NM, Phipps, T and Reichardt, JKV (2009) Genomic Analysis of
Cancer Tissue Reveals that Somatic Mutations Commonly Occur in a Specific Motif, Hum. Mut. 30, 39‐48
36. Makridakis, NM, Phipps, T, Srivastav, S and Reichardt, JKV (2009) PCR‐Free
Method Detects High Frequency of Genomic Instability in Prostate Cancer, Nucl. Acids Res. 37, 7441‐7446
37. Goodman, P, Tangen, C, Kristal, A, Thompson, I, Lucia, S, Platz, E, Figg, W,
Hoque, A, Hsing, A, Neuhouser, M, Parnes, H, Reichardt, J, Santella, R, Till, C and Lippman, S (2010) Transition of a Clinical Trial into Translational Research: The Prostate Cancer Prevention Trial Experience, Cancer Prev.
Research 3, 1523‐1533
38. Price, DK, Chau, CH, Till, C, Goodman, PJ, Baum, CE, Ockers, SB, English, BC, Minasian, L, Parnes, HL, Hsing, AW, Reichardt, JKV, Hoque, A, Tangen, CM, Kristal, AR, Thompson, IM, Figg, WD (2010) Androgen Receptor CAG Repeat Length and Association with Prostate Cancer Risk: Results from the Prostate Cancer Prevention Trial, J. Urol. 184, 2297‐2302
39. AR Kristal, C Till, CM Tangen, PJ Goodman, ML Neuhouser, FZ Stanczyk , LW
Chu, SK Patel, I Thompson, JK Reichardt, A Hoque, EA Platz, WD Figg, A Van Bokhoven, SM Lippman, AW Hsing (2012) Associations of serum sex steroid hormones and 5α‐androstane‐3α,17β‐diol glucuronide concentrations with prostate cancer risk among men treated with finasteride, Cancer Epi. Biomark. Prev. 21, 1823‐1832
40. Ho, G, Reichardt, J and Christodoulou, J (2013) In Vitro Read‐through Of
Phenylalanine Hydroxylase (PAH) Nonsense Mutations Using
Genetic and Biochemical Basis of Galactosemia J. Reichardt, PI 1992‐1995
Zumberge Faculty Research and Innovation Fund Award A Combined Biochemical and Genetic Analysis of Human Galactose‐1‐phosphate Uridyl Transferase J. Reichardt, PI 1993‐1995
ACS‐IRG (American Cancer Society) Ovarian Cancer and the Human Galactose‐1‐phosphate Uridyl Transferase (GALT) Gene J. Reichardt, PI 1994‐1995
Wright Foundation Ovarian Cancer and the Human Galactose‐1‐phosphate Uridyl Transferase (GALT) Gene J. Reichardt, PI 1994‐1996
NIDDK P30 DK48522 New Investigator Award J. Reichradt, PI 1995‐1996
NIDDK P30 DK48522
Aminoglycosides: A Potential Therapy For Phenylketonuria, J. Inh. Metabol. Dis. 36, 955‐959
41. WD Figg, CH Chau, DK Price, C Till, PJ Goodman, Y Cho, M Varella‐Garcia, JKV
Reichardt, CM Tangen, RJ Leach, A van Bokhoven, IM Thompson, MS Lucia (2014) Androgen Receptor CAG Repeat Length and TMPRSS2:ETS Prostate Cancer Risk: Results From the Prostate Cancer Prevention Trial, Urology, 84, 127‐131
42. Arthur, JW, Cheung, FSG and Reichardt, JKV (2015) Single Nucleotide
Differences (SNDs) Continue to Contaminate the dbSNP Database With Consequences For Human Genomics and Health Hum. Mut. in press
4. List of research projects Funded: March of Dimes Basil O’ Connor (Young Investigator) Award
Molecular Basis of Epimerase Deficiency Galactosemia (P/F Project)
N. Kaplowitz, PI,; J. Reichardt, PI of P/F project 1995‐1997 NCI P30 CA14089‐22 Translational Research Project Benign Prostatic Hyperplasia and the Human SRD5A2 Gene P. Jones, PI; J. Reichardt, PI of project 1997‐1998
NCI R01 CA61132 Case/Control Study of Ovarian Cancer in Los Angeles M. Pike, PI; J. Reichardt, Co‐PI 1994‐1998 NCI R01 CA68581 5‐Alpha Reductase Genotype, Race and Prostate Cancer Risk J. Reichardt, PI 1995‐2004 NIDDK P30 DK48522 USC Liver Disease Research Center N. Kaplowitz, PI; J. Reichardt, Associate Director, Molecular Biology Core 1995‐2000 ACS 4‐21‐98 (American Cancer Society) Molecular Epidemiology of Prostate Cancer and Hyperplasia
J. Reichardt, PI (for Nick Makridakis, PhD; postdoctoral fellow)
1998‐2000
NCI U01 CA63464 Genetic Susceptibility to Cancer in Multiethnic Cohorts B. Henderson, PI; J. Reichardt, Co‐PI 1996‐2006 NCI R03 CA83112
Variation of the HSD17B3 Gene and Prostate Cancer
J. Reichardt, PI 1999‐2001 Martell Foundation
Androgen‐Metabolic Genes and Prostate Cancer Risk: A Molecular Epidemiologic Investigation of the HSD3B2 Gene
J. Reichardt, PI 2001‐2004
J. Reichardt, PI 1998‐2002
CRP 864A‐8704‐S3516 Mutations, Oral Contraceptives and Ovarian Cancer W. Cozen, PI; J. Reichardt, Co‐PI 1999‐2001
CRP 99‐0053V‐10150 Benign Prostatic Hypertrophy (BPH) and the SRD5A2 Gene
J. Reichardt, PI 1999‐2001
SWOG COOP‐02014 Androgen and 5‐Alpha Reductase Pilot for the PCPT J. Reichardt, PI 2002‐2003
NCI R01 CA84979 Risk Factors for Advanced Prostate Cancer S. Ingles, PI; J. Reichardt, Co‐PI 1999‐2004 DoD Prostate Cancer Center PC992018
Molecular Determinants of Prostate Cancer Risk and Progression Across Racial‐Ethnic Groups
R. Ross, PI; J. Reichardt, Co‐PI; PI (JR) of Project 1 2000-2003
Wright Foundation Molecular Epidemiology of the Human 3‐Hydroxy 3‐
methylglutaryl Coenzyme A Reductase (HMGCR) Gene and Atherosclerosis
J. Reichardt, PI 2003‐2004
Fondazione Berti per l’ Arte e la Scienza Supplementation for Dr. Clemente Capasso J. Reichardt, PI 2004‐2005
DoD PC 001280 Genetic Variation of the HSD3B2 Gene and Prostate Cancer
GSK
Steroid 5 Alpha Reductase Inhibitors: Biochemical, Genetic and Molecular Investigations J. Reichardt, PI 2003‐2004
DoD PC020368 SRD5A1 Genetic Variation and Prostate Cancer Epidemiology Predoctoral Fellowship for Troy Phipps J. Reichardt, nominal PI 2003‐2006
CRP 3GS0106 SRD5A1 Genetic Variation and Prostate Cancer Epidemiology Predoctoral Fellowship for Troy Phipps J. Reichardt, nominal PI
2003‐2006 (declined due to overlap with the DoD fellowship above)
NCI R01 CA96830 Molecular Epidemiology of Colorectal Adenomas R. Haile, PI; J. Reichardt, Co‐PI 2003‐2006
NHLBI R01 HL079353 Role of the 5‐Lipoxygenase Pathway in Atherosclerosis H. Allayee, PI; J. Reichardt, Co‐PI (Co‐PI declined because of move to Australia) 2005‐2009
ARC LE0775587
Correlating Genomics and Proteomics for Systems Biology: integrating the '‐omics'
Bergquist, Baker, Ferrari, Dawes, Graham, Stock, Trent, Hunt, Reichardt, Scott
2007
Cancer Institute NSW 07/RIG/01‐36
PHERAstar and POLARstar Optima Multi‐functional Plate Readers with Robotic High Throughput Screening System for Multi‐Disciplinary Cancer Research Richardson (CI1), Reichardt (CI5) et al. 2007
ARC DP0771015 Discovering Genes for Complex Traits Involving Gene‐Environment Interactions
Yu, Trent, Pamphlett, Reichardt 2007
ARC LE0882512 Advanced High Throughput Functional Genomics and Gene Mapping
Dawes, Bergquist, Trent, Scott, Hogg, Wilkins, Reichardt, Hunt, Baker, Dunkley 2008 NHMRC equipment grant
A Large‐Scale Recombinant Protein Production System for the New Multi‐User PC2 Molecular Biology Facility in the Blackburn‐Bosch Precinct DR Richardson, Stocker R. Halliday, G.M., Hunt N.H., Vandenberg R, Twigg S, Black J.L., Bishop G.A., King, N.J.C., Allen D.G., Mason R.S., Sharland, A.F., Lee C.S., Grau G. E., Chan‐Ling T, Ju Y.K., Lovicu F. J., Joshua D.E., McLennan S.V., Dampney R.A.L, Bao S., Zreiqat H., Chadban S.J., Ho P.J., Burgess J.K., Wu H., Ryan R.M., Lovejoy D.B., Hambly B.D., Codd R., Reichardt JK. 2008
Medical Foundation; University of Sydney J. Reichardt, CI 2005‐2009 NHMRC 402516
Pharmacogenetics of Androgen Action: Activating Metabolism and Tissue Sensitivity
D. Handelsman (CI A); J. Reichardt (CI B)
2006‐2009 NCI P01 CA108964
Biology of the Prostate Cancer Prevention Trial (PCPT) S. Lippman, PI (up to 2009; then I. Thompson); J. Reichardt PI of project 1
2005‐2010 (no cost extension to 2014) ARC LE100100130
Next Generation Sequencing
Bergquist, Baker, Ferrari, Dawes, Graham, Stock, Trent, Hunt, Reichardt, Scott
2010
Cancer Institute NSW 07/RIG/01‐36 PHERAstar and POLARstar Optima multi‐functional plate readers with robotic high throughput screening system for multi‐ disciplinary cancer research DR Richardson, Halliday GM, Lee CS, Joshua D, Reichardt J, Ho PJ, Dong Q, Iland HJ, Mason R, Grau GE, Assinder S, King NJC, Hunt N, Lovejoy D, Murphy C, Bishop GA, Sharland AF, Conigrave A, Cook D. 2007‐2011
Cancer Institute NSW 09/REG/1‐07 PALM Microbeam Laser Microdissection (LM) Microscope for the Multi‐User Sydney Cancer Gene Expression Facility Prof. Des Richardson, Prof. Gary Halliday, Prof. Rebecca Mason, Prof. Chris Murphy, A/Prof. Naresh Kumar, Dr Lisa Horvath, Prof. Wolfgang Weninger, Prof Cheok Soon Lee, Dr Guy Lyons, Prof. Peter Lay, Dr Michael Boyer, Dr Scott Byrne, Dr Stephen Assinder, Dr Yohan Rahmanto, A/Prof Harry Iland, A/Prof Joanne Jamie, A/Prof Subramanyan Vemulpad, Prof. Mathew Vadas, Dr Jenny Gamble, A/Prof Shisan Bao, Prof. Trevor Hambley, Dr Nikolas Haass, Prof. Mathew Vadas, Dr Phillipa O'Brien, Prof. James Kench, A/Prof. Qihan Dong, Dr Danuta Kalinowski, Prof. Jeurgen Reichardt, Prof. John Rasko, Dr David Lovejoy, Prof Nick King 2009‐2014
PCFA 2009 Luminex 200 Analysis System for the Bosch Prostate Cancer Research Focus Group in the Multi‐User Bosch Institute Molecular Biology Facility Richardson DR, Reichardt JKV, Dong Q, Lee CS, Assinder SJ, Kalinowski D, Lovejoy D, Mangs H, Dixon K, Murphy CR 2009‐2012
Cancer Institute of NSW Research Equipment Grant 10/REG/1‐16
GenomeLab GeXP Genetic Analysis System for the Multi‐ Disciplinary Sydney Cancer Gene Expression Facility Richardson DR, Halliday GM, Scolyer R, Clarke S, Lee CS, Reichardt JK, Murray M, Clarke C, Boyer M, Kefford R, Mason
RS, Murphy CR, McLachlan, Gamble JR, Lay P, Dong Q, Kumar N, Lyons G, Byrne G, Gurney HP, Davies M, Assinder SJ, Rahmanto Y, Jamie J, Vemulpad S, Bao S, Haass NK, Kench , JG, Kalinowski DS, Lovejoy DB, Groundwater P, Hawkins C, De Souza P, Lane D, Zhang D, Moscato P, Lai D 2010‐2011
PCFA 2011 xCELLigence Real Time Cell Analysis System
Richardson D, Reichardt J, Dong Q, Lee C, Assinder S, Kalinowski D, Lovejoy D, Dixon, K, Mangs H, Murphy C 2011‐2014
Heart Foundation (Australia) G 10S 5276 Molecular Characterization of Genetic Variants in HMG CoA Reductase (HMGCR) and Their Association with Response to Statins Reichardt, J (PI), Keech, A, Tonkin, A, Yu, B 2011‐2013 (declined due to heavy administrative load)
5. List of patents filed List all patents filed Patent Awarded: “Androgen‐Metabolic Gene Mutations and Prostate Cancer Risk”;
US Patent 09/235,538; 2/2002. 6. Track record of positions held List all academic or relevant professional positions held
1982 Visiting Scientist: Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY; mentor: Dr. Quentin H. Gibson
1982‐1989 Graduate Education (PhD): Department of Biochemistry,
Stanford University School of Medicine, Stanford, CA; advisor: Dr. Paul Berg
1989‐1991 Postdoctoral Training: Baylor College of Medicine/Howard
Hughes Medical Institute, Houston, TX; mentor: Dr. Savio L. C. Woo.
1991‐1992 Research Instructor: Department of Cell Biology, Baylor
College of Medicine, Houston, TX, USA
1992‐2000 Assistant Professor: Institute for Genetic Medicine and Department of Biochemistry and Molecular Biology, University of Southern California School of Medicine, Los Angeles, CA, USA
2000‐2005 Associate Professor with tenure: Institute for Genetic Medicine
and Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
2000‐2005 Associate Professor (dual appointment): Department of
Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
2005‐2011 Plunkett Chair and Professor of Molecular Biology (Medicine), University of Sydney, Camperdown NSW, Australia
2011‐present Professor and Head, School of Pharmacy and Molecular
Sciences, James Cook University, Townsville QLD, Australia 2012‐present Associate Dean Research, Faculty Medicine, Health and
Molecular Sciences, James Cook University, Townsville QLD, Australia
7. Fund raising capacity List all funded research projects or any other funds raised
March of Dimes Basil O’ Connor (Young Investigator) Award Genetic and Biochemical Basis of Galactosemia J. Reichardt, PI 1992‐1995
Zumberge Faculty Research and Innovation Fund Award A Combined
Biochemical and Genetic Analysis of Human Galactose‐1‐phosphate Uridyl Transferase J. Reichardt, PI 1993‐1995
ACS‐IRG (American Cancer Society) Ovarian Cancer and the Human Galactose‐1‐phosphate Uridyl Transferase (GALT) Gene J. Reichardt, PI 1994‐1995
Wright Foundation Ovarian Cancer and the Human Galactose‐1‐phosphate
Uridyl Transferase (GALT) Gene J. Reichardt, PI 1994‐1996
NIDDK P30 DK48522 New Investigator award J. Reichradt, PI 1995‐1996
NIDDK P30 DK48522 Molecular Basis of Epimerase Deficiency Galactosemia Project)
N. Kaplowitz, PI,; J. Reichardt, PI of P/F project 1995‐1997
NCI P30 CA14089‐22, Translational Research Project, Benign Prostatic
Hyperplasia and the Human SRD5A2 Gene P. Jones, PI; J. Reichardt, PI of project 1997‐1998
J. Reichardt, PI 1999‐2001
NCI R03 CA83112 Variation of the HSD17B3 Gene and Prostate Cancer
J. Reichardt, PI 1999‐2001 Martell Foundation
Androgen‐Metabolic Genes and Prostate Cancer Risk: A Molecular Epidemiologic Investigation of the HSD3B2 Gene
J. Reichardt, PI 1998‐2002
CRP 864A‐8704‐S3516 Mutations, Oral Contraceptives and Ovarian Cancer W. Cozen, PI; J. Reichardt, Co‐PI 1999‐2001 CRP 99‐0053V‐10150
Benign Prostatic Hypertrophy (BPH) and the SRD5A2 Gene
NCI R01 CA68581 5‐Alpha Reductase Genotype, Race and Prostate Cancer Risk J. Reichardt, PI 1995‐2004
NIDDK P30 DK48522 USC Liver Disease Research Center N. Kaplowitz, PI; J. Reichardt, Associate Director, Molecular Biology Core 1995‐2000
ACS 4‐21‐98 (American Cancer Society) Molecular Epidemiology of Prostate Cancer and Hyperplasia J. Reichardt, PI (for Nick Makridakis, PhD; postdoctoral fellow) 1998‐2000
NCI U01 CA63464 Genetic Susceptibility to Cancer in Multiethnic Cohorts B. Henderson, PI; J. Reichardt, Co‐PI 1996‐2006
SRD5A1 Genetic Variation and Prostate Cancer Epidemiology Predoctoral Fellowship for Troy Phipps J. Reichardt, nominal PI 2003‐2006
SWOG COOP‐02014
Androgen and 5‐Alpha Reductase Pilot for the PCPT J. Reichardt, PI 2002‐2003
NCI R01 CA84979 Risk Factors for Advanced Prostate Cancer S. Ingles, PI; J. Reichardt, Co‐PI 1999‐2004 DoD Prostate Cancer Center PC992018
Molecular Determinants of Prostate Cancer Risk and Progression Across Racial‐Ethnic Groups
R. Ross, PI; J. Reichardt, Co‐PI; PI (JR) of Project 1 2000-2003
Wright Foundation Molecular Epidemiology of the Human 3‐Hydroxy 3‐
methylglutaryl Coenzyme A Reductase (HMGCR) Gene and Atherosclerosis
J. Reichardt, PI 2003‐2004
Fondazione Berti per l’ Arte e la Scienza Supplementation for Dr. Clemente Capasso J. Reichardt, PI 2004‐2005
DoD PC 001280 Genetic Variation of the HSD3B2 Gene and Prostate Cancer
J. Reichardt, PI 2001‐2004
GSK Steroid 5 Alpha Reductase Inhibitors: Biochemical, Genetic and Molecular Investigations J. Reichardt, PI 2003‐2004
DoD PC020368
CRP 3GS0106 SRD5A1 Genetic Variation and Prostate Cancer Epidemiology Predoctoral Fellowship for Troy Phipps J. Reichardt, nominal PI
2003‐2006 (declined due to overlap with the DoD fellowship above)
NCI R01 CA96830 Molecular Epidemiology of Colorectal Adenomas R. Haile, PI; J. Reichardt, Co‐PI 2003‐2006
NHLBI R01 HL079353 Role of the 5‐Lipoxygenase Pathway in Atherosclerosis H. Allayee, PI; J. Reichardt, Co‐PI (Co‐PI declined because of move to Australia) 2005‐2009
ARC LE0775587
Correlating Genomics and Proteomics for Systems Biology: integrating the '‐omics'
Bergquist, Baker, Ferrari, Dawes, Graham, Stock, Trent, Hunt, Reichardt, Scott
2007
Cancer Institute NSW 07/RIG/01‐36
PHERAstar and POLARstar Optima Multi‐functional Plate Readers with Robotic High Throughput Screening System for Multi‐Disciplinary Cancer Research Richardson (CI1), Reichardt (CI5) et al.
2007
ARC DP0771015 Discovering Genes for Complex Traits Involving Gene‐Environment Interactions
Yu, Trent, Pamphlett, Reichardt 2007
ARC LE0882512 Advanced High Throughput Functional Genomics and Gene Mapping
Dawes, Bergquist, Trent, Scott, Hogg, Wilkins, Reichardt, Hunt, Baker, Dunkley
2008 NHMRC equipment grant
A Large‐Scale Recombinant Protein Production System for the New Multi‐User PC2 Molecular Biology Facility in the Blackburn‐Bosch Precinct DR Richardson, Stocker R. Halliday, G.M., Hunt N.H., Vandenberg R, Twigg S, Black J.L., Bishop G.A., King, N.J.C., Allen D.G., Mason R.S., Sharland, A.F., Lee C.S., Grau G. E., Chan‐Ling T, Ju Y.K., Lovicu F. J., Joshua D.E., McLennan S.V., Dampney R.A.L, Bao S., Zreiqat H., Chadban S.J., Ho P.J., Burgess J.K., Wu H., Ryan R.M., Lovejoy D.B., Hambly B.D., Codd R., Reichardt JK. 2008
Medical Foundation; University of Sydney J. Reichardt, CI 2005‐2009 NHMRC 402516
Pharmacogenetics of Androgen Action: Activating Metabolism and Tissue Sensitivity
D. Handelsman (CI A); J. Reichardt (CI B)
2006‐2009 NCI P01 CA108964
Biology of the Prostate Cancer Prevention Trial (PCPT) S. Lippman, PI (up to 2009; then I. Thompson); J. Reichardt PI of project 1
2005‐2010 (no cost extension to 2014) ARC LE100100130
Next Generation Sequencing
Bergquist, Baker, Ferrari, Dawes, Graham, Stock, Trent, Hunt, Reichardt, Scott
2010
Cancer Institute NSW 07/RIG/01‐36 PHERAstar and POLARstar Optima multi‐functional plate readers with robotic high throughput screening system for multi‐ disciplinary cancer research DR Richardson, Halliday GM, Lee CS, Joshua D, Reichardt J, Ho PJ, Dong Q, Iland HJ, Mason R, Grau GE, Assinder S, King NJC,
Hunt N, Lovejoy D, Murphy C, Bishop GA, Sharland AF, Conigrave A, Cook D. 2007‐2011
Cancer Institute NSW 09/REG/1‐07 PALM Microbeam Laser Microdissection (LM) Microscope for the Multi‐User Sydney Cancer Gene Expression Facility Prof. Des Richardson, Prof. Gary Halliday, Prof. Rebecca Mason, Prof. Chris Murphy, A/Prof. Naresh Kumar, Dr Lisa Horvath, Prof. Wolfgang Weninger, Prof Cheok Soon Lee, Dr Guy Lyons, Prof. Peter Lay, Dr Michael Boyer, Dr Scott Byrne, Dr Stephen Assinder, Dr Yohan Rahmanto, A/Prof Harry Iland, A/Prof Joanne Jamie, A/Prof Subramanyan Vemulpad, Prof. Mathew Vadas, Dr Jenny Gamble, A/Prof Shisan Bao, Prof. Trevor Hambley, Dr Nikolas Haass, Prof. Mathew Vadas, Dr Phillipa O'Brien, Prof. James Kench, A/Prof. Qihan Dong, Dr Danuta Kalinowski, Prof. Jeurgen Reichardt, Prof. John Rasko, Dr David Lovejoy, Prof Nick King 2009‐2014
PCFA 2009 Luminex 200 Analysis System for the Bosch Prostate Cancer Research Focus Group in the Multi‐User Bosch Institute Molecular Biology Facility Richardson DR, Reichardt JKV, Dong Q, Lee CS, Assinder SJ, Kalinowski D, Lovejoy D, Mangs H, Dixon K, Murphy CR 2009‐2012
Cancer Institute of NSW Research Equipment Grant 10/REG/1‐16
GenomeLab GeXP Genetic Analysis System for the Multi‐ Disciplinary Sydney Cancer Gene Expression Facility Richardson DR, Halliday GM, Scolyer R, Clarke S, Lee CS, Reichardt JK, Murray M, Clarke C, Boyer M, Kefford R, Mason RS, Murphy CR, McLachlan, Gamble JR, Lay P, Dong Q, Kumar N, Lyons G, Byrne G, Gurney HP, Davies M, Assinder SJ, Rahmanto Y, Jamie J, Vemulpad S, Bao S, Haass NK, Kench , JG, Kalinowski DS, Lovejoy DB, Groundwater P, Hawkins C, De Souza P, Lane D, Zhang D, Moscato P, Lai D 2010‐2011
PCFA 2011 xCELLigence Real Time Cell Analysis System
Richardson D, Reichardt J, Dong Q, Lee C, Assinder S, Kalinowski D, Lovejoy D, Dixon, K, Mangs H, Murphy C
2011‐2014
Heart Foundation (Australia) G 10S 5276 Molecular Characterization of Genetic Variants in HMG CoA Reductase (HMGCR) and Their Association with Response to Statins Reichardt, J (PI), Keech, A, Tonkin, A, Yu, B 2011‐2013 (declined due to heavy administrative load)
EIF (Education Investment Fund; Department of Industry, Innovation, Climate Change, Science, Research and Tertiary Education; Australia)
The Science Place (TSP); JC 2013‐2016.
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