p.r. smith, histology - 2004. interactive questions pop-quizzes lab “intros” (experimental)...

P.R. Smith, Histology - 2004.

Interactive QuestionsPOP-QuizzesLab “Intros”(experimental)

Download Lecture

http://endeavor.med.nyu.edu

Curriculum

Histology

Courseware Syllabus

P.R. Smith, Histology - 2004.

Skeletal Muscle

P.R. Smith, Histology - 2004.

VocabularySarcolemma Plasma MembraneSarcoplasm CytoplasmSarcoplasmic Reticulum Endoplasmic ReticulumNexus Gap Junction

P.R. Smith, Histology - 2004.

Muscle

FasciculusGroup ofMuscle Fibers

from Gray’s Anatomy

P.R. Smith, Histology - 2004.

from Wheater

P.R. Smith, Histology - 2004. Kessel/Kardon

P.R. Smith, Histology - 2004.

from Wheater

P.R. Smith, Histology - 2004.

P.R. Smith, Histology - 2004.

P.R. Smith, Histology - 2004.

Actin

Myosin

Myofibril

Myofilaments

from Gray’s Anatomy

P.R. Smith, Histology - 2004.

immunoglobulin (Ig)

fibronectin type III (fnIII)

Titin

http://www.chemsoc.org/exemplarchem/entries/kscott/titin.htm

N C

P.R. Smith, Histology - 2004.

MZ Z

P.R. Smith, Histology - 2004.

P.R. Smith, Histology - 2004.

P.R. Smith, Histology - 2004.

Skeletal MuscleControl

P.R. Smith, Histology - 2004. from Gray’s Anatomy

P.R. Smith, Histology - 2004.

P.R. Smith, Histology - 2004.

Junctional folds

NerveTerminal

S

P.R. Smith, Histology - 2004.

P.R. Smith, Histology - 2004.

P.R. Smith, Histology - 2004.

T-tubule

Terminal Cisterna

Terminal Cisterna

CalsequestrinRyanodinereceptor

Ryanodinereceptor

Dihydropyridine receptor

P.R. Smith, Histology - 2004.

T-tubuleLumen

Muscle sarcoplasm

V

Ca2+

Ca2+

T-T

TC/SR

Dihydropyridine receptor

Ryanodinereceptor

CalsequestrincalciumATPase

P.R. Smith, Histology - 2004.

1

23

4

P.R. Smith, Histology - 2004.

P.R. Smith, Histology - 2004.

Vale, Milligan and Johnson, 2000

P.R. Smith, Histology - 2004.

Skeletal MuscleDevelopment

P.R. Smith, Histology - 2004.

P.R. Smith, Histology - 2004.

P.R. Smith, Histology - 2004.

Cardiac Muscle

P.R. Smith, Histology - 2004.

P.R. Smith, Histology - 2004.

P.R. Smith, Histology - 2004.

Intercalated Disk

P.R. Smith, Histology - 2004.

from

Ju

nq

ueir

a,

Fig

. 1

0-1

8

Intercalated Disk

A

B

A

C B

A

A Fasciaadherens

B Maculaadherens

(desmosome)

C Gapjunction

P.R. Smith, Histology - 2004.

MA

MA

Cx-43Cx-43

P.R. Smith, Histology - 2004. from Gray’s Anatomy

P.R. Smith, Histology - 2004.

from Gray’s Anatomy

from Gray’s Anatomy

PurkinjeFibers

P.R. Smith, Histology - 2004.

from Wheater

Cx-45Cx-45

P.R. Smith, Histology - 2004.

Smooth Muscle

P.R. Smith, Histology - 2004.

P.R. Smith, Histology - 2004.

P.R. Smith, Histology - 2004.

E.RobbinsE.Robbins

P.R. Smith, Histology - 2004.

P.R. Smith, Histology - 2004.

P.R. Smith, Histology - 2004.

DB

DBDB

CA

ColGJ

ME. RobbinsE. Robbins

P.R. Smith, Histology - 2004.

P.R. Smith, Histology - 2004.

P.R. Smith, Histology - 2004.

Cytoplasmic Matrix

P.R. Smith, Histology - 2004.

Actin Filament Attachment

P.R. Smith, Histology - 2004.

Smooth Muscle Contraction

S.J. Gunst, et al., 2003

P.R. Smith, Histology - 2004.

Getting ready for Lab.

P.R. Smith, Histology - 2004.

SkeletalSkeletal SmoothSmooth

P.R. Smith, Histology - 2004.

P.R. Smith, Histology - 2004.

Homework: for 17th Feb.Things to review …

Actin-Myosin ATPase cycleControl of the Actin-Myosin interaction (both striated and smooth muscle)Intra-cellular signaling: the role of CalciumMyosin isoforms, fast and slow muscle fibers [Sci.Am., Sep. 2000, 49-55]Check out the on-line POP-Quizzes